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Original Articles

Agitation-associated behavioral symptoms in mild cognitive impairment and Alzheimer's dementia

, , , , , , & show all
Pages 247-257 | Received 03 Nov 2013, Accepted 13 Apr 2014, Published online: 25 Jun 2014

References

  • Albert, M.S., Dekosky, S.T., Dickson, D., Dubois, B., Feldman, H.H., Fox, N.C., … Phelps, C.H. (2011). The diagnosis of mild cognitive impairment due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimer's & Dementia, 7(3), 270–279.
  • Alexopoulos, G.S., Abrams, R.C., Young, R.C., & Shamoian, C.A. (1988a). Cornell Scale for Depression in Dementia. Biological Psychiatry, 23(3), 271–284.
  • Alexopoulos, G.S., Abrams, R.C., Young, R.C., & Shamoian, C.A. (1988b). Use of the Cornell scale in nondemented patients. Journal of the American Geriatrics Society, 36(3), 230–236.
  • American Psychiatric Association. (1994). DSM-IV: Diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: Author.
  • Apostolova, L.G., & Cummings, J.L. (2008). Neuropsychiatric manifestations in mild cognitive impairment: A systematic review of the literature. Dementia and Geriatric Cognitive Disorders, 25(2), 115–126.
  • Aries, M.J., Le Bastard, N., Debruyne, H., Van Buggenhout, M., Nagels, G., De Deyn, P.P., & Engelborghs, S. (2010). Relation between frontal lobe symptoms and dementia severity within and across diagnostic dementia categories. International Journal of Geriatric Psychiatry, 25(11), 1186–1195.
  • Azermai, M., Elseviers, M., Petrovic, M., Van Bortel, L., & Vander Stichele, R. (2011). Geriatric drug utilisation of psychotropics in Belgian nursing homes. Human Psychopharmacology: Clinical and Experimental, 26(1), 12–20.
  • Bonelli, R.M., & Cummings, J.L. (2007). Frontal-subcortical circuitry and behavior. Dialogues in Clinical Neuroscience, 9(2), 141–151.
  • Bruce, J.M., McQuiggan, M., Williams, V., Westervelt, H., & Tremont, G. (2008). Burden among spousal and child caregivers of patients with mild cognitive impairment. Dementia and Geriatric Cognitive Disorders, 25(4), 385–390.
  • Burns, A., Lawlor, B., & Craig, S. (2004). Assessment scales in old age psychiatry (2nd ed.). London: Martin Dunitz.
  • Chan, D.C., Kasper, J.D., Black, B.S., & Rabins, P.V. (2003). Prevalence and correlates of behavioral and psychiatric symptoms in community-dwelling elders with dementia or mild cognitive impairment: The Memory and Medical Care Study. International Journal of Geriatric Psychiatry, 18(2), 174–182.
  • Choy, C.N., Lam, L.C., Chan, W.C., Li, S.W., & Chiu, H.F. (2001). Agitation in Chinese elderly: Validation of the Chinese version of the Cohen-Mansfield Agitation Inventory. International Psychogeriatrics, 13(3), 325–335.
  • Cipriani, G., Vedovello, M., Nuti, A., & Di, F.M. (2011). Aggressive behavior in patients with dementia: Correlates and management. Geriatrics & Gerontology International, 11(4), 408–413.
  • Cohen-Mansfield, J. (1996). Conceptualization of agitation: Results based on the Cohen-Mansfield Agitation Inventory and the Agitation Behavior Mapping Instrument. International Psychogeriatrics, 8, 309–315.
  • Cohen-Mansfield, J., & Billig, N. (1986). Agitated behaviors in the elderly. I. A conceptual review. Journal of the American Geriatrics Society, 34(10), 711–721.
  • Cohen-Mansfield, J., Marx, M.S., & Rosenthal, A.S. (1989). A description of agitation in a nursing home. Journal of Gerontology, 44(3), M77–M84.
  • Cole, M.G., & Dastoor, D.P. (1987). A new hierarchic approach to the measurement of dementia. Accurate results within 15 to 30 minutes. Psychosomatics, 28(6), 298–301.
  • Coppen, A. (1967). The biochemistry of affective disorders. The British Journal of Psychiatry, 113(504), 1237–1264.
  • Crum, R.M., Anthony, J.C., Bassett, S.S., & Folstein, M.F. (1993). Population-based norms for the Mini-Mental State Examination by age and educational level. Journal of the American Medical Association, 269(18), 2386–2391.
  • Cummings, J.L., McRae, T., & Zhang, R. (2006). Effects of donepezil on neuropsychiatric symptoms in patients with dementia and severe behavioral disorders. American Journal of Geriatric Psychiatry, 14(7), 605–612.
  • De Deyn, P.P., Engelborghs, S., Saerens, J., Goeman, J., Marien, P., Maertens, K., … Pickut, B.A. (2005). The Middelheim Frontality Score: A behavioural assessment scale that discriminates frontotemporal dementia from Alzheimer's disease. International Journal of Geriatric Psychiatry, 20(1), 70–79.
  • Di Giovanni, G., Esposito, E., & Di Matteo, V. (2010). Role of serotonin in central dopamine dysfunction. CNS Neuroscience & Therapeutics, 16(3), 179–194.
  • Dubois, B., Feldman, H.H., Jacova, C., Hampel, H., Molinuevo, J.L., Blennow, K., … Cummings, J.L. (2014). Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria. Lancet Neurology, 13, 614–629.
  • Engelborghs, S., Vloeberghs, E., Le, B.N., Van, B.M., Marien, P., Somers, N., … De Deyn, P.P. (2008). The dopaminergic neurotransmitter system is associated with aggression and agitation in frontotemporal dementia. Neurochemistry International, 52(6), 1052–1060.
  • Finkel, S.I., Costa e Silva, J., Cohen, G., Miller, S., & Sartorius, N. (1996). Behavioral and psychological signs and symptoms of dementia: A consensus statement on current knowledge and implications for research and treatment. International Psychogeriatrics, 8, 497–500.
  • Folstein, M.F., Folstein, S.E., & McHugh, P.R. (1975). ‘Mini-mental state’. A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12(3), 189–198.
  • Frank, L., Lloyd, A., Flynn, J.A., Kleinman, L., Matza, L.S., Margolis, M.K., … Bullock, R. (2006). Impact of cognitive impairment on mild dementia patients and mild cognitive impairment patients and their informants. International Psychogeriatrics, 18(1), 151–162.
  • Frisoni, G.B., Rozzini, L., Gozzetti, A., Binetti, G., Zanetti, O., Bianchetti, A., … Cummings, J.L. (1999). Behavioral syndromes in Alzheimer's disease: Description and correlates. Dementia and Geriatric Cognitive Disorders, 10(2), 130–138.
  • Garand, L., Dew, M.A., Eazor, L.R., Dekosky, S.T., & Reynolds, C.F., III. (2005). Caregiving burden and psychiatric morbidity in spouses of persons with mild cognitive impairment. International Journal of Geriatric Psychiatry, 20(6), 512–522.
  • Garand, L., Dew, M.A., Urda, B., Lingler, J.H., Dekosky, S.T., & Reynolds, C.F. (2007). Marital quality in the context of mild cognitive impairment. Western Journal of Nursing Research, 29(8), 976–992.
  • Gaugler, J.E., Yu, F., Krichbaum, K., & Wyman, J.F. (2009). Predictors of nursing home admission for persons with dementia. Medical Care, 47(2), 191–198.
  • Goldman-Rakic, P.S., Lidow, M.S., & Gallager, D.W. (1990). Overlap of dopaminergic, adrenergic, and serotoninergic receptors and complementarity of their subtypes in primate prefrontal cortex. The Journal of Neuroscience, 10(7), 2125–2138.
  • Gruber-Baldini, A.L., Boustani, M., Sloane, P.D., & Zimmerman, S. (2004). Behavioral symptoms in residential care/assisted living facilities: Prevalence, risk factors, and medication management. Journal of the American Geriatrics Society, 52(10), 1610–1617.
  • Hazzan, A.A., Ploeg, J., Shannon, H., Raina, P., & Oremus, M. (2013). Association between caregiver quality of life and the care provided to persons with Alzheimer's disease: Protocol for a systematic review. Systematic Reviews, 2, 17.
  • Hollingworth, P., Hamshere, M.L., Moskvina, V., Dowzell, K., Moore, P.J., Foy, C., … Williams, J. (2006). Four components describe behavioral symptoms in 1120 individuals with late-onset Alzheimer's disease. Journal of the American Geriatrics Society, 54(9), 1348–1354.
  • Kang, H.S., Ahn, I.S., Kim, J.H., & Kim, D.K. (2010). Neuropsychiatric symptoms in Korean patients with Alzheimer's disease: Exploratory factor analysis and confirmatory factor analysis of the neuropsychiatric inventory. Dementia and Geriatric Cognitive Disorders, 29(1), 82–87.
  • Levy, K., Lanctot, K.L., Farber, S.B., Li, A., & Herrmann, N. (2012). Does pharmacological treatment of neuropsychiatric symptoms in Alzheimer's disease relieve caregiver burden? Drugs Aging, 29(3), 167–179.
  • Luppa, M., Luck, T., Brahler, E., Konig, H.H., & Riedel-Heller, S.G. (2008). Prediction of institutionalisation in dementia. A systematic review. Dementia and Geriatric Cognitive Disorders, 26(1), 65–78.
  • Lyketsos, C.G., Lopez, O., Jones, B., Fitzpatrick, A.L., Breitner, J., & DeKosky, S. (2002). Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment: Results from the cardiovascular health study. Journal of the American Medical Association, 288(12), 1475–1483.
  • Lyketsos, C.G., Steinberg, M., Tschanz, J.T., Norton, M.C., Steffens, D.C., & Breitner, J.C. (2000). Mental and behavioral disturbances in dementia: Findings from the Cache County Study on Memory in Aging. The American Journal of Psychiatry, 157(5), 708–714.
  • Margallo-Lana, M., Swann, A., O’Brien, J., Fairbairn, A., Reichelt, K., Potkins, D., … Ballard, C. (2001). Prevalence and pharmacological management of behavioural and psychological symptoms amongst dementia sufferers living in care environments. International Journal of Geriatric Psychiatry, 16(1), 39–44.
  • McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E.M. (1984). Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology, 34(7), 939–944.
  • Mirakhur, A., Craig, D., Hart, D.J., McLlroy, S.P., & Passmore, A.P. (2004). Behavioural and psychological syndromes in Alzheimer's disease. International Journal of Geriatric Psychiatry, 19(11), 1035–1039.
  • Monastero, R., Mangialasche, F., Camarda, C., Ercolani, S., & Camarda, R. (2009). A systematic review of neuropsychiatric symptoms in mild cognitive impairment. Journal of Alzheimer's Disease, 18(1), 11–30.
  • Petersen, R.C. (2004). Mild cognitive impairment as a diagnostic entity. Journal of Internal Medicine, 256(3), 183–194.
  • Pitkala, K.H., Laurila, J.V., Strandberg, T.E., & Tilvis, R.S. (2004). Behavioral symptoms and the administration of psychotropic drugs to aged patients with dementia in nursing homes and in acute geriatric wards. International Psychogeriatrics, 16(1), 61–74.
  • The Psychological Corporation. (1998). WAIS-III-WMS-III technical manual. London: Harcourt Brace & Company.
  • Randolph, C., Tierney, M.C., Mohr, E., & Chase, T.N. (1998). The repeatable battery for the assessment of neuropsychological status (RBANS): Preliminary clinical validity. Journal of Clinical and Experimental Neuropsychology, 20(3), 310–319.
  • Reisberg, B., Borenstein, J., Salob, S.P., Ferris, S.H., Franssen, E., & Georgotas, A. (1987). Behavioral symptoms in Alzheimer's disease: Phenomenology and treatment. Journal of Clinical Psychiatry, 48, 9–15.
  • Reisberg, B., Ferris, S.H., de Leon, M.J., & Crook, T. (1982). The global Deterioration Scale (GDS) for assessment of primary degenerative dementia. American Journal of Psychiatry, 139, 1136–1139.
  • Selbaek, G., Kirkevold, O., & Engedal, K. (2007). The prevalence of psychiatric symptoms and behavioural disturbances and the use of psychotropic drugs in Norwegian nursing homes. International Journal of Geriatric Psychiatry, 22(9), 843–849.
  • Spalletta, G., Baldinetti, F., Buccione, I., Fadda, L., Perri, R., Scalmana, S., … Caltagirone, C. (2004). Cognition and behaviour are independent and heterogeneous dimensions in Alzheimer's disease. Journal of Neurology, 251(6), 688–695.
  • Spalletta, G., Musicco, M., Padovani, A., Rozzini, L., Perri, R., Fadda, L., … Palmer, K. (2010). Neuropsychiatric symptoms and syndromes in a large cohort of newly diagnosed, untreated patients with Alzheimer disease. American Journal of Geriatric Psychiatry, 18(11), 1026–1035.
  • Suh, G.H. (2004). Agitated behaviours among the institutionalized elderly with dementia: Validation of the Korean version of the Cohen-Mansfield Agitation Inventory. International Journal of Geriatric Psychiatry, 19(4), 378–385.
  • Testad, I., Aasland, A.M., & Aarsland, D. (2007). Prevalence and correlates of disruptive behavior in patients in Norwegian nursing homes. International Journal of Geriatric Psychiatry, 22(9), 916–921.
  • Trzepacz, P.T., Yu, P., Bhamidipati, P.K., Willis, B., Forrester, T., Tabas, L., … Saykin, A.J. (2013). Frontolimbic atrophy is associated with agitation and aggression in mild cognitive impairment and Alzheimer's disease. Alzheimer's & Dementia, 9(5), S95–S104.
  • Tsai, C.F., Hung, C.W., Lirng, J.F., Wang, S.J., & Fuh, J.L. (2013). Differences in brain metabolism associated with agitation and depression in Alzheimer's disease. East Asian Archives of Psychiatry, 23(3), 86–90.
  • Van der Mussele, S., Bekelaar, K., Le Bastard, N., Vermeiren, Y., Saerens, J., Somers, N., … Engelborghs, S. (2013). Prevalence and associated behavioral symptoms of depression in mild cognitive impairment and dementia due to Alzheimer's disease. International Journal of Geriatric Psychiatry, 28(9), 947–958.
  • Van der Mussele, S., Le Bastard, N., Vermeiren, Y., Saerens, J., Somers, N., Marien, P., … Engelborghs, S. (2012). Behavioral symptoms in mild cognitive impairment as compared with Alzheimer's disease and healthy older adults. International Journal of Geriatric Psychiatry, 28(3), 265–275.
  • Vilalta-Franch, J., Lopez-Pousa, S., Turon-Estrada, A., Lozano-Gallego, M., Hernandez-Ferrandiz, M., Pericot-Nierga, I., … Garre-Olmo, J. (2010). Syndromic association of behavioral and psychological symptoms of dementia in Alzheimer disease and patient classification. American Journal of Geriatric Psychiatry, 18(5), 421–432.
  • Zuidema, S.U., de Jonghe, J.F., Verhey, F.R., & Koopmans, R.T. (2010). Environmental correlates of neuropsychiatric symptoms in nursing home patients with dementia. International Journal of Geriatric Psychiatry, 25(1), 14–22.
  • Zuidema, S.U., Derksen, E., Verhey, F.R., & Koopmans, R.T. (2007). Prevalence of neuropsychiatric symptoms in a large sample of Dutch nursing home patients with dementia. International Journal of Geriatric Psychiatry, 22(7), 632–638.

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