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Aging & Mental Health Volume 26, 2022 - Issue 9
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Cognition

Centrally-acting anticholinergic drugs– associations with mortality, hospitalisation and cognitive decline following dementia diagnosis in people receiving antidepressant and antipsychotic drugs

Delia Bisharaa Mental Health for Older Adults and Dementia Clinical Academic Group, South London and Maudsley NHS Foundation Trust, London, UK;b Department of Old Age Psychiatry, Mental Health for Older Adults Research, Institute of Psychiatry, Psychology and Neuroscience, London, UKCorrespondence[email protected]
,
Gayan Pererab Department of Old Age Psychiatry, Mental Health for Older Adults Research, Institute of Psychiatry, Psychology and Neuroscience, London, UK
,
Daniel Harwooda Mental Health for Older Adults and Dementia Clinical Academic Group, South London and Maudsley NHS Foundation Trust, London, UK
,
David Taylorb Department of Old Age Psychiatry, Mental Health for Older Adults Research, Institute of Psychiatry, Psychology and Neuroscience, London, UK;c Pharmacy Department, South London and Maudsley NHS Foundation Trust, London, UK
,
Justin Sauera Mental Health for Older Adults and Dementia Clinical Academic Group, South London and Maudsley NHS Foundation Trust, London, UK;b Department of Old Age Psychiatry, Mental Health for Older Adults Research, Institute of Psychiatry, Psychology and Neuroscience, London, UK
,
Nicola Funnella Mental Health for Older Adults and Dementia Clinical Academic Group, South London and Maudsley NHS Foundation Trust, London, UK
,
Siobhan Geeb Department of Old Age Psychiatry, Mental Health for Older Adults Research, Institute of Psychiatry, Psychology and Neuroscience, London, UK;c Pharmacy Department, South London and Maudsley NHS Foundation Trust, London, UKORCID Iconhttps://orcid.org/0000-0003-1020-6777
ORCID Icon,
Robert Stewarta Mental Health for Older Adults and Dementia Clinical Academic Group, South London and Maudsley NHS Foundation Trust, London, UK;b Department of Old Age Psychiatry, Mental Health for Older Adults Research, Institute of Psychiatry, Psychology and Neuroscience, London, UKORCID Iconhttps://orcid.org/0000-0002-4435-6397
ORCID Icon &
Christoph Muellera Mental Health for Older Adults and Dementia Clinical Academic Group, South London and Maudsley NHS Foundation Trust, London, UK;b Department of Old Age Psychiatry, Mental Health for Older Adults Research, Institute of Psychiatry, Psychology and Neuroscience, London, UKORCID Iconhttps://orcid.org/0000-0001-9816-1686
ORCID Icon show all
Pages 1747-1755 | Received 15 Mar 2021, Accepted 20 Jun 2021, Published online: 26 Jul 2021

References

  • Andrade, C. (2019). Anticholinergic drug exposure and the risk of dementia: There is modest evidence for an association but not for causality. The Journal of Clinical Psychiatry, 80, 19f13000.
  • Bishara, D., Harwood, D., Sauer, J., & Taylor, D. M. (2017). Anticholinergic effect on cognition (AEC) of drugs commonly used in older people. International Journal of Geriatric Psychiatry, 32(6), 650–656. https://doi.org/10.1002/gps.4507
  • Bishara, D., Perera, G., Harwood, D., Taylor, D., Sauer, J., Stewart, R., & Mueller, C. (2020). The anticholinergic effect on cognition (AEC) Scale: Associations with mortality, hospitalisation and cognitive decline following dementia diagnosis. International Journal of Geriatric Psychiatry, 35(9), 1069–1077. https://doi.org/10.1002/gps.5330
  • Coupland, C. A. C., Hill, T., Dening, T., Morriss, R., Moore, M., & Hippisley-Cox, J. (2019). Anticholinergic drug exposure and the risk of dementia: A nested case-control study. JAMA Internal Medicine, 179(8), 1084–1093. https://doi.org/10.1001/jamainternmed.2019.0677
  • Cunningham, H. (2002). GATE, a general architecture for text engineering. Computers and the Humanities, 36(2), 223–254. https://doi.org/10.1023/A:1014348124664
  • Folstein, M. F., Folstein, S. E., & Mchugh, P. R. (1975). Mini-mental state. A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12(3), 189–198. https://doi.org/10.1016/0022-3956(75)90026-6
  • Fox, C., Livingston, G., Maidment, I. D., Coulton, S., Smithard, D. G., Boustani, M., & Katona, C. (2011a). The impact of anticholinergic burden in Alzheimer’s Dementia: The Laser-AD Study. Age and Ageing, 40(6), 730–735. https://doi.org/10.1093/ageing/afr102
  • Fox, C., Richardson, K., Maidment, I. D., Savva, G. M., Matthews, F. E., Smithard, D., Coulton, S., Katona, C., Boustani, M. A., & Brayne, C. (2011b). Anticholinergic medication use and cognitive impairment in the older population: The medical research council cognitive function and ageing study. Journal of the American Geriatrics Society, 59(8), 1477–1483. https://doi.org/10.1111/j.1532-5415.2011.03491.x
  • Jorge, R. E., Robinson, R. G., Arndt, S., & Starkstein, S. (2003). Mortality and poststroke depression: A placebo-controlled trial of antidepressants. American Journal of Psychiatry, 160(10), 1823–1829. https://doi.org/10.1176/appi.ajp.160.10.1823
  • Liang, K.-Y., & Zeger, S. L. (1986). Longitudinal data analysis using generalized linear models. Biometrika, 73(1), 13–22. https://doi.org/10.1093/biomet/73.1.13
  • Mcmichael, A. J., Zafeiridi, E., Ryan, M., Cunningham, E. L., Passmore, A. P., & Mcguinness, B. (2020). Anticholinergic drug use and risk of mortality for people with dementia in Northern Ireland. Aging & Mental Health, 1–8. https://doi.org/10.1080/13607863.2020.1830028
  • Monroe, T., & Carter, M. (2012). Using the Folstein Mini Mental State Exam (MMSE) to explore methodological issues in cognitive aging research. European Journal of Ageing, 9(3), 265–274. https://doi.org/10.1007/s10433-012-0234-8
  • Mueller, C., Huntley, J., Stubbs, B., Sommerlad, A., Carvalho, A. F., Perera, G., Stewart, R., & Veronese, N. (2017). Associations of neuropsychiatric symptoms and antidepressant prescription with survival in Alzheimer’s disease. Journal of the American Medical Directors Association, 18(12), 1076–1081. https://doi.org/10.1016/j.jamda.2017.07.001
  • Mueller, C., John, C., Perera, G., Aarsland, D., Ballard, C., & Stewart, R. (2020). Antipsychotic use in dementia: The relationship between neuropsychiatric symptom profiles and adverse outcomes. European Journal of Epidemiology, 36(1), 89–101.
  • Mueller, C., John, C., Perera, G., Aarsland, D., Ballard, C., & Stewart, R. (2021). Antipsychotic use in dementia: The relationship between neuropsychiatric symptom profiles and adverse outcomes. European Journal of Epidemiology, 36(1), 89–101. https://doi.org/10.1007/s10654-020-00643-2
  • Mueller, C., Molokhia, M., Perera, G., Veronese, N., Stubbs, B., Shetty, H., Codling, D., Huntley, J., & Stewart, R. (2018a). Polypharmacy in people with dementia: Associations with adverse health outcomes. Experimental Gerontology, 106, 240–245. https://doi.org/10.1016/j.exger.2018.02.011
  • Mueller, C., Perera, G., Hayes, R. D., Shetty, H., & Stewart, R. (2018b). Associations of acetylcholinesterase inhibitor treatment with reduced mortality in Alzheimer’s disease: A retrospective survival analysis. Age and Ageing, 47(1), 88–94. https://doi.org/10.1093/ageing/afx098
  • Noble, M., Mclennan, D., Wilkinson, K., Whitworth, A., Exley, S., Barnes, H., Dibben, C., & Mclennan, D. (2007). The English Indices of Deprivation, 2007. Unknown Publisher.
  • Oudshoorn, C. G. M., Buuren, S., & Rijckevorsel, J. L. A. (1999). Flexible multiple imputation by chained equations of the AVO-95 survey. TNO Prevention and Health Leiden.
  • Paton, C., & Ferrier, I. N. (2005). SSRIs and gastrointestinal bleeding. BMJ, 331(7516), 529–530. https://doi.org/10.1136/bmj.331.7516.529
  • Perera, G., Broadbent, M., Callard, F., Chang, C. K., Downs, J., Dutta, R., Fernandes, A., Hayes, R. D., Henderson, M., Jackson, R., Jewell, A., Kadra, G., Little, R., Pritchard, M., Shetty, H., Tulloch, A., & Stewart, R. (2016). Cohort profile of the South London and Maudsley NHS Foundation Trust Biomedical Research Centre (SLaM BRC) Case Register: Current status and recent enhancement of an Electronic Mental Health Record-derived data resource. BMJ Open, 6(3), e008721. https://doi.org/10.1136/bmjopen-2015-008721
  • Perera, G., Khondoker, M., Broadbent, M., Breen, G., & Stewart, R. (2014). Factors associated with response to acetylcholinesterase inhibition in dementia: A cohort study from a secondary mental health care case register in London. PLOS One, 9(11), e109484. https://doi.org/10.1371/journal.pone.0109484
  • Richardson, K., Fox, C., Maidment, I., Steel, N., Loke, Y. K., Arthur, A., Myint, P. K., Grossi, C. M., Mattishent, K., Bennett, K., Campbell, N. L., Boustani, M., Robinson, L., Brayne, C., Matthews, F. E., & Savva, G. M. (2018). Anticholinergic drugs and risk of dementia: Case-control study. BMJ (Clinical Research ed.), 361, k1315. https://doi.org/10.1136/bmj.k1315
  • Rubin, D. B. (2004). Multiple imputation for nonresponse in surveys. John Wiley & Sons.
  • Saczynski, J. S., Beiser, A., Seshadri, S., Auerbach, S., Wolf, P. A., & Au, R. (2010). Depressive symptoms and risk of dementia: The Framingham Heart Study. Neurology, 75(1), 35–41. https://doi.org/10.1212/WNL.0b013e3181e62138
  • Stewart, R., Soremekun, M., Perera, G., Broadbent, M., Callard, F., Denis, M., Hotopf, M., Thornicroft, G., & Lovestone, S. (2009). The South London and Maudsley NHS Foundation Trust Biomedical Research Centre (SLAM BRC) case register: Development and descriptive data. BMC Psychiatry, 9, 51. https://doi.org/10.1186/1471-244X-9-51
  • Tan, E., Eriksdotter, M., García-Ptacek, S., Fastbom, J., & Johnell, K. (2018). Anticholinergic burden and risk of stroke and death in people with different types of dementia. Journal of Alzheimer’s Disease, 65(2), 588–589. https://doi.org/10.3233/JAD-180353
  • Taylor, C. B., Youngblood, M. E., Catellier, D., Veith, R. C., Carney, R. M., Burg, M. M., Kaufmann, P. G., Shuster, J., Mellman, T., Blumenthal, J. A., Krishnan, R., Jaffe, A. S., & ENRICHD Investigators. (2005). Effects of antidepressant medication on morbidity and mortality in depressed patients after myocardial infarction. Archives of General Psychiatry, 62(7), 792–798. https://doi.org/10.1001/archpsyc.62.7.792
  • Tsamakis, K., Gadelrab, R., Wilson, M., Bonnici-Mallia, A. M., Hussain, L., Perera, G., Rizos, E., Das-Munshi, J., Stewart, R., & Mueller, C. (2021). Dementia in people from ethnic minority backgrounds: Disability, functioning, and pharmacotherapy at the time of diagnosis. Journal of the American Medical Directors Association, 22(2), 446–452. https://doi.org/10.1016/j.jamda.2020.06.026

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