More than a third of middle-aged adults (50–65) have understated executive dysfunction

References

• Battle, D. E. (2013). Diagnostic and statistical manual of mental disorders (DSM). Codas, 25(2), 191–192. https://doi.org/10.1590/s2317-17822013000200017
   PubMedGoogle Scholar
• Bokura, H., Nagai, A., Oguro, H., Kobayashi, S., & Yamaguchi, S. (2010). The association of metabolic syndrome with executive dysfunction independent of subclinical ischemic brain lesions in Japanese adults. Dementia and Geriatric Cognitive Disorders, 30(6), 479–485. https://doi.org/10.1159/000322057
   PubMed Web of Science ®Google Scholar
• Brigola, A. G., Manzini, C. S. S., Oliveira, G. B. S., Ottaviani, A. C., Sako, M. P., & Vale, F. A. C. (2015). Subjective memory complaints associated with depression and cognitive impairment in the elderly: A systematic review. Dementia & Neuropsychologia, 9(1), 51–57. https://doi.org/10.1590/s1980-57642015dn91000009
   PubMedGoogle Scholar
• Carlson, M. C., Xue, Q. L., Zhou, J., & Fried, L. P. (2009). Executive decline and dysfunction precedes declines in memory: The Women’s Health and Aging Study II. The Journals of Gerontology Series A Biological Sciences and Medical Sciences, 64(1), 110–117. https://doi.org/10.1093/gerona/gln008
   PubMed Web of Science ®Google Scholar
• Creavin, S. T., Wisniewski, S., Noel-Storr, A. H., Trevelyan, C. M., Hampton, T., Rayment, D., Thom, V. M., Nash, K. J. E., Elhamoui, H., Milligan, R., Patel, A. S., Tsivos, D. V., Wing, T., Phillips, E., Kellman, S. M., Shackleton, H. L., Singleton, G. F., Neale, B. E., Watton, M. E., & Cullum, S. (2016). Mini-mental state examination (MMSE) for the detection of dementia in clinically unevaluated people aged 65 and over in community and primary care populations. Cochrane Database of Systematic Reviews, (1), CD011145. https://doi.org/10.1002/14651858.CD011145.pub2
   Google Scholar
• David, J. P., Ferrat, E., Parisot, J., Naga, H., Lakroun, S., Menasria, F., Saddedine, S., Natella, P. A., Paillaud, E., Fromentin, I., & Bastuji-Garin, S. (2016). White Matter Lesions: Prevalence and Clinical Phenotype in Asymptomatic Individuals Aged >/=50 Years. Dementia and Geriatric Cognitive Disorders, 42(3/4), 159–168. https://doi.org/10.1159/000448991
   PubMed Web of Science ®Google Scholar
• De Jager, C., Blackwell, A. D., Budge, M. M., & Sahakian, B. J. (2005). Predicting Cognitive Decline in Healthy Older Adults. The American Journal of Geriatric Psychiatry, 13(8), 735–740. https://doi.org/10.1097/00019442-200508000-00014
   PubMed Web of Science ®Google Scholar
• de Noronha, ., F. C., Barreto, S.D.S., & Ortiz, K. Z. (2018). The influence of education on performance of adults on the Clock Drawing Test. Dementia & Neuropsychologia, 12(1), 61–67. https://doi.org/10.1590/1980-57642018dn12-010009
   PubMedGoogle Scholar
• Dennis, M., Kadri, A., & Coffey, J. (2012). Depression in older people in the general hospital: A systematic review of screening instruments. Age Ageing, 41(2), 148–154. https://doi.org/10.1093/ageing/afr169
   PubMed Web of Science ®Google Scholar
• Dubois, B., Slachevsky, A., Litvan, I., & Pillon, B. (2000). The FAB: A frontal assessment battery at bedside. Neurology, 55(11), 1621–1626. https://doi.org/10.1212/WNL.55.11.1621
   PubMed Web of Science ®Google Scholar
• Dunne, R. A., Aarsland, D., O’Brien, J. T., Ballard, C., Banerjee, S., Fox, N. C., Isaacs, J. D., Underwood, B. R., Perry, R. J., Chan, D., Dening, T., Thomas, A. J.,Schryer, J.,Jones, A. N., Evans, A. R., Alessi, C., Coulthard, E. J., Pickett, J., Elton, P., … Burns, A. (2021). Mild cognitive impairment: The Manchester consensus. Age Ageing, 50(1), 72–80. https://doi.org/10.1093/ageing/afaa228
   PubMed Web of Science ®Google Scholar
• Edmonds, E. C., Delano-Wood, L., Galasko, D. R., Salmon, D. P., Bondi, M. W., & Alzheimer’s Disease Neuroimaging, I (2014). Subjective cognitive complaints contribute to misdiagnosis of mild cognitive impairment. Journal of the International Neuropsychological Society: JINS, 20(8), 836–847. https://doi.org/10.1017/S135561771400068X
   PubMed Web of Science ®Google Scholar
• Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). (2001). JAMA, 285(19), 2486–2497. https://doi.org/10.1001/jama.285.19.2486
   PubMed Web of Science ®Google Scholar
• Flicker, C., Ferris, S. H., & Reisberg, B. (1991). Mild cognitive impairment in the elderly: Predictors of dementia. Neurology, 41(7), 1006–1009. https://doi.org/10.1212/wnl.41.7.1006
   PubMed Web of Science ®Google Scholar
• Gunstad, J., Paul, R. H., Cohen, R. A., Tate, D. F., Spitznagel, M. B., & Gordon, E. (2007). Elevated body mass index is associated with executive dysfunction in otherwise healthy adults. Compr Psychiatry, 48(1), 57–61. https://doi.org/10.1016/j.comppsych.2006.05.001
   PubMed Web of Science ®Google Scholar
• Johnson, J. K., Lui, L.-Y., & Yaffe, K. (2007). Executive function, more than global cognition, predicts functional decline and mortality in elderly women. The Journals of Gerontology: Series A, 62(10), 1134–1141. https://doi.org/10.1093/gerona/62.10.1134
   PubMed Web of Science ®Google Scholar
• Leissing-Desprez, C., Thomas, E., Segaux, L., Broussier, A., Oubaya, N., Marie-Nelly, N., Laurent, M., de Langavant, L. C., Fromentin, I., David, J. P., & Bastuji-Garin, S. (2020, November). Understated cognitive impairment assessed with the clock-drawing test in community-dwelling individuals aged ≥50 Years. Journal of the American Medical Directors Association, 21(11), 1658–1664. https://doi.org/10.1016/j.jamda.2020.03.016
   Google Scholar
• McEvoy, C. T., Leng, Y., Peeters, G. M., Kaup, A. R., Allen, I. E., & Yaffe, K. (2019). Interventions involving a major dietary component improve cognitive function in cognitively healthy adults: A systematic review and meta-analysis. Nutrition Research, 66, 1–12. https://doi.org/10.1016/j.nutres.2019.02.008
   PubMed Web of Science ®Google Scholar
• Mormont, E., Jamart, J., & Robaye, L. (2012). Validity of the five-word test for the evaluation of verbal episodic memory and dementia in a memory clinic setting. Journal of Geriatric Psychiatry and Neurology, 25(2), 78–84. https://doi.org/10.1177/0891988712445088
   PubMed Web of Science ®Google Scholar
• Morris, J. C., Storandt, M., Miller, J. P., McKeel, D. W., Price, J. L., Rubin, E. H., & Berg, L. (2001). Mild cognitive impairment represents early-stage Alzheimer disease. Archives of Neurology, 58(3), 397–405. https://doi.org/10.1001/archneur.58.3.397
   PubMedGoogle Scholar
• Murman, D. L. (2015). The impact of age on cognition. Seminars in Hearing, 36(3), 111–121. https://doi.org/10.1055/s-0035-1555115
   PubMedGoogle Scholar
• Petersen, R. C., Caracciolo, B., Brayne, C., Gauthier, S., Jelic, V., & Fratiglioni, L. (2014). Mild cognitive impairment: A concept in evolution. Journal of Internal Medicine, 275(3), 214–228. https://doi.org/10.1111/joim.12190
   PubMed Web of Science ®Google Scholar
• Pinto, E., & Peters, R. (2009). Literature review of the Clock Drawing Test as a tool for cognitive screening. Dementia and Geriatric Cognitive Disorders, 27(3), 201–213. https://doi.org/10.1159/000203344
   PubMed Web of Science ®Google Scholar
• Purser, J. L., Fillenbaum, G. G., & Wallace, R. B. (2006). Memory complaint is not necessary for diagnosis of mild cognitive impairment and does not predict 10-year trajectories of functional disability, word recall, or short portable mental status questionnaire limitations. Journal of the American Geriatrics Society, 54(2), 335–338. https://doi.org/10.1111/j.1532-5415.2005.00589.x
   PubMed Web of Science ®Google Scholar
• Roberts, R. O., Geda, Y. E., Knopman, D. S., Cha, R. H., Boeve, B. F., Ivnik, R. J., Pankratz, V. S., Tangalos, E. G., & Petersen, R. C. (2010). Metabolic syndrome, inflammation, and nonamnestic mild cognitive impairment in older persons: A population-based study. Alzheimer Disease and Associated Disorders, 24(1), 11–18. https://doi.org/10.1097/WAD.0b013e3181a4485c
   PubMed Web of Science ®Google Scholar
• Sabia, S., Elbaz, A., Dugravot, A., Head, J., Shipley, M., Hagger-Johnson, G., Kivimaki, M., & Singh-Manoux, A. (2012). Impact of smoking on cognitive decline in early old age: The Whitehall II Cohort Study. Archives of General Psychiatry, 69(6), 627–635. https://doi.org/10.1001/archgenpsychiatry.2011.2016
   PubMed Web of Science ®Google Scholar
• Sachs-Ericsson, N., & Blazer, D. G. (2015). The new DSM-5 diagnosis of mild neurocognitive disorder and its relation to research in mild cognitive impairment. Aging and Mental Health, 19(1), 2–12. https://doi.org/10.1080/13607863.2014.920303
   PubMed Web of Science ®Google Scholar
• Solomon, P. R., Hirschoff, A., Kelly, B., Relin, M., Brush, M., DeVeaux, R. D., & Pendlebury, W. W. (1998). A 7 minute neurocognitive screening battery highly sensitive to Alzheimer’s disease. Archives of Neurology., 55(3), 349–355. https://doi.org/10.1001/archneur.55.3.349
   PubMedGoogle Scholar
• Sterniczuk, R., Theou, O., Rusak, B., & Rockwood, K. (2015). Cognitive test performance in relation to health and function in 12 European Countries: The SHARE Study. Canadian Geriatrics Journal, 18(3), 144–151. https://doi.org/10.5770/cgj.18.154
   PubMed Web of Science ®Google Scholar
• Takayama, Y. (2010). A delayed recall battery as a sensitive screening for mild cognitive impairment: Follow-up study of memory clinic patients after 10 years. Journal of Medical and Dental Sciences, 57(2), 177–184. doi: 10.11480/jmds.570207
   PubMedGoogle Scholar
• Turner, D. T., Hu, M. X., Generaal, E., Bos, D., Ikram, M. K., Heshmatollah, A., Fani, L., Ikram, M. A., Penninx, B. W. J. H., & Cuijpers, P. (2021, March). Physical exercise interventions targeting cognitive functioning and the cognitive domains in nondementia samples: A systematic review of meta-analyses. Journal of Geriatric Psychiatry and Neurology, 34(2), 91–101. https://doi.org/10.1177/0891988720915523
   Google Scholar
• Vieira, J. R., Elkind, M. S., Moon, Y. P., Rundek, T., Boden-Albala, B., Paik, M. C., Sacco, R. L., & Wright, C. B. (2011). The metabolic syndrome and cognitive performance: The Northern Manhattan Study. Neuroepidemiology, 37(3-4), 153–159. https://doi.org/10.1159/000332208
   PubMed Web of Science ®Google Scholar
• Winblad, B., Amouyel, P., Andrieu, S., Ballard, C., Brayne, C., Brodaty, H., Cedazo-Minguez, A., Dubois, B., Edvardsson, D., Feldman, H., Fratiglioni, L., Frisoni, G. B., Gauthier, S., Georges, J., Graff, C., Iqbal, K., Jessen, F., Johansson, G., Jönsson, L., … Zetterberg, H. (2016). Defeating Alzheimer’s disease and other dementias: A priority for European science and society. Lancet Neurology., 15(5), 455–532. https://doi.org/10.1016/S1474-4422(16)00062-4
   PubMed Web of Science ®Google Scholar
• Yaffe, K. (2007). Metabolic syndrome and cognitive disorders: Is the sum greater than its parts? Alzheimer Disease and Associated Disorders, 21(2), 167–171. https://doi.org/10.1097/WAD.0b013e318065bfd6
   PubMed Web of Science ®Google Scholar