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Exploring the relationship between perceived loneliness and subjective cognitive decline in older individuals

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Pages 73-82 | Received 25 Apr 2023, Accepted 12 Jul 2023, Published online: 04 Aug 2023

References

  • Apostolova, L. G., & Cummings, J. L. (2008). Neuropsychiatric manifestations in mild cognitive impairment: A systematic review of the literature. Dementia and Geriatric Cognitive Disorders, 25(2), 115–126. https://doi.org/10.1159/000112509[PMC]
  • Baumgart, M., Snyder, H. M., Carrillo, M. C., Fazio, S., Kim, H., & Johns, H. (2015). Summary of the evidence on modifiable risk factors for cognitive decline and dementia: A population-based perspective. Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, 11(6), 718–726. https://doi.org/10.1016/j.jalz.2015.05.016
  • Boffo, M., Mannarini, S., & Munari, C. (2012). Exploratory structure equation modelling of the UCLA loneliness scale: A contribution to the Italian adaptation. TPM Testing Psychometrics Methodology in Applied Psychology, 19(4), 345–363. https://doi.org/10.4473/TPM19.4.7
  • Bolla, K. I., Lindgren, K. N., Bonaccorsy, C., & Bleecker, M. L. (1991). Memory complaints in older adults: Fact or fiction? Archives of Neurology, 48(1), 61–64. https://doi.org/10.1001/archneur.1991.00530130069022
  • Boss, L., Kang, D. H., & Branson, S. (2015). Loneliness and cognitive function in the older adult: A systematic review. International Psychogeriatrics, 27(4), 541–553. https://doi.org/10.1017/S1041610214002749
  • Bottari, C., Dassa, C., Rainville, C., & Dutil, E. (2009). The factorial validity and internal consistency of the Instrumental Activities of Daily Living Profile in individuals with a traumatic brain injury. Neuropsychological Rehabilitation, 19(2), 177–207. https://doi.org/10.1080/09602010802188435
  • Bottesi, G., Ghisi, M., Altoè, G., Conforti, E., Melli, G., & Sica, C. (2015). The Italian version of the Depression Anxiety Stress Scales-21: Factor structure and psychometric properties on community and clinical samples. Comprehensive Psychiatry, 60, 170–181. https://doi.org/10.1016/j.comppsych.2015.04.005
  • Cacioppo, J. T., Cacioppo, S., Capitanio, J. P., & Cole, S. W. (2015). The neuroendocrinology of social isolation. Annual Review of Psychology, 66, 733–767. https://doi.org/10.1146/annurev-psych-010814-015240
  • Cacioppo, J. T., Hawkley, L. C., & Thisted, R. A. (2010). Perceived social isolation makes me sad: 5-year cross-lagged analyses of loneliness and depressive symptomatology in the Chicago Health, Aging, and Social Relations Study. Psychology and Aging, 25(2), 453–463. https://doi.org/10.1037/a0017216.
  • Cacioppo, J. T., & Hawkley, L. C. (2009). Perceived social isolation and cognition. Trends in Cognitive Sciences, 13(10), 447–454. https://doi.org/10.1016/j.tics.2009.06.005
  • Cacioppo, J. T., & Cacioppo, S. (2018). The growing problem of loneliness. Lancet (London, England), 391(10119), 426. https://doi.org/10.1016/S0140-6736(18)30142-9
  • Cacioppo, J. T., & Cacioppo, S. (2018). Loneliness in the modern age: An evolutionary theory of loneliness (ETL). In J. M. Olson (Ed.), Advances in Experimental Social Psychology (vol. 58, pp. 127–197). Academic Press. https://doi.org/10.1016/bs.aesp.2018.03.003
  • Cacioppo, S., Bangee, M., Balogh, S., Cardenas-Iniguez, C., Qualter, P., & Cacioppo, J. T. (2016). Loneliness and implicit attention to social threat: A high-performance electrical neuroimaging study. Cognitive Neuroscience, 7(1-4), 138–159. https://doi.org/10.1080/17588928.2015.1070136
  • Cardona, M., & Andrés, P. (2023). Are social isolation and loneliness associated with cognitive decline in ageing? Frontiers in Aging Neuroscience, 15, 1075563. https://doi.org/10.3389/fnagi.2023.1075563
  • Charrad, M., Ghazzali, N., Boiteau, V., & Niknafs, A. (2014). NbClust: An R package for determining the relevant number of clusters in a data set. Journal of Statistical Software, 61(6), 1–36. https://doi.org/10.18637/jss.v061.i06
  • Chen, Y., Hu, N., Yang, J., & Gao, T. (2022). Prefrontal cortical circuits in anxiety and fear: An overview. Frontiers of Medicine, 16(4), 518–539. https://doi.org/10.1007/s11684-022-0941-2
  • Diaz-Galvan, P., Ferreira, D., Cedres, N., Falahati, F., Hernández-Cabrera, J. A., Ames, D., Barroso, J., & Westman, E. (2021). Comparing different approaches for operationalizing subjective cognitive decline: Impact on syndromic and biomarker profiles. Scientific Reports, 11(1), 4356. https://doi.org/10.1038/s41598-021-83428-1
  • Donovan, N. J., & Blazer, D. (2020). Social isolation and loneliness in older adults: Review and commentary of a national academies report. The American Journal of Geriatric Psychiatry: Official Journal of the American Association for Geriatric Psychiatry, 28(12), 1233–1244. https://doi.org/10.1016/j.jagp.2020.08.005
  • Duan, D., Dong, Y., Zhang, H., Zhao, Y., Diao, Y., Cui, Y., Wang, J., Chai, Q., & Liu, Z. (2017). Empty-nest-related psychological distress is associated with progression of brain white matter lesions and cognitive impairment in the elderly. Scientific Reports, 7, 43816. https://doi.org/10.1038/srep43816
  • Eisenberger, N. I., & Lieberman, M. D. (2004). Why rejection hurts: A common neural alarm system for physical and social pain. Trends in Cognitive Sciences, 8(7), 294–300. https://doi.org/10.1016/j.tics.2004.05.010
  • Galvez-Hernandez, P., González-de Paz, L., & Muntaner, C. (2022). Primary care-based interventions addressing social isolation and loneliness in older people: A scoping review. BMJ Open, 12(2), e057729. https://doi.org/10.1136/bmjopen-2021-057729
  • Gow, A. J., Pattie, A., Whiteman, M. C., Whalley, L. J., & Deary, I. J. (2007). Social support and successful aging: Investigating the relationships between lifetime cognitive change and life satisfaction. Journal of Individual Differences, 28(3), 103–115. https://doi.org/10.1027/1614-0001.28.3.103
  • Guariglia, P., Giaimo, F., Palmiero, M., & Piccardi, L. (2020). Normative data and validation of the Italian translation of the Working Memory Questionnaire (WMQ). Applied Neuropsychology. Adult, 27(4), 376–389. https://doi.org/10.1080/23279095.2018.1552147
  • Guo, H., Zheng, L., Xu, H., Pang, Q., Ren, Z., Gao, Y., & Wang, T. (2022). Neurobiological links between stress, brain injury, and disease. Oxidative Medicine and Cellular Longevity, 2022, 8111022. https://doi.org/10.1155/2022/8111022
  • Hanfelt, J. J., Wuu, J., Sollinger, A. B., Greenaway, M. C., Lah, J. J., Levey, A. I., & Goldstein, F. C. (2011). An exploration of subgroups of mild cognitive impairment based on cognitive, neuropsychiatric, and functional features: Analysis of data from the National Alzheimer’s Coordinating Center. The American Journal of Geriatric Psychiatry: Official Journal of the American Association for Geriatric Psychiatry, 19(11), 940–950. https://doi.org/10.1097/JGP.0b013e31820ee9d2
  • Hartigan, J. A., & Wong, M. A. (1979). Algorithm AS 136: A K-means clustering algorithm. Journal of the Royal Statistical Society. Series C (Applied Statistics), 28(1), 100–108. https://doi.org/10.2307/2346830
  • Hawkley, L. C., & Cacioppo, J. T. (2010). Loneliness matters: A theoretical and empirical review of consequences and mechanisms. Annals of Behavioral Medicine: A publication of the Society of Behavioral Medicine, 40(2), 218–227. https://doi.org/10.1007/s12160-010-9210-8
  • Holwerda, T. J., Deeg, D. J., Beekman, A. T., van Tilburg, T. G., Stek, M. L., Jonker, C., & Schoevers, R. A. (2014). Feelings of loneliness, but not social isolation, predict dementia onset: Results from the Amsterdam Study of the Elderly (AMSTEL). Journal of Neurology, Neurosurgery, and Psychiatry, 85(2), 135–142. https://doi.org/10.1136/jnnp-2012-302755
  • Jessen, F., Amariglio, R. E., van Boxtel, M., Breteler, M., Ceccaldi, M., Chételat, G., Dubois, B., Dufouil, C., Ellis, K. A., van der Flier, W. M., Glodzik, L., van Harten, A. C., de Leon, M. J., McHugh, P., Mielke, M. M., Molinuevo, J. L., Mosconi, L., Osorio, R. S., Perrotin, A., … Wagner, M. (2014). A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer’s disease. Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, 10(6), 844–852. https://doi.org/10.1016/j.jalz.2014.01.001
  • Jessen, F., Amariglio, R. E., Buckley, R. F., van der Flier, W. M., Han, Y., Molinuevo, J. L., Rabin, L., Rentz, D. M., Rodriguez-Gomez, O., Saykin, A. J., Sikkes, S. A. M., Smart, C. M., Wolfsgruber, S., & Wagner, M. (2020). The characterisation of subjective cognitive decline. The Lancet. Neurology, 19(3), 271–278. https://doi.org/10.1016/s1474-4422(19)30368-0
  • Lara, E., Caballero, F. F., Rico-Uribe, L. A., Olaya, B., Haro, J. M., Ayuso-Mateos, J. L., & Miret, M. (2019). Are loneliness and social isolation associated with cognitive decline? International Journal of Geriatric Psychiatry, 34(11), 1613–1622. https://doi.org/10.1002/gps.5174
  • Lara, E., Martín-María, N., De la Torre-Luque, A., Koyanagi, A., Vancampfort, D., Izquierdo, A., & Miret, M. (2019). Does loneliness contribute to mild cognitive impairment and dementia? A systematic review and meta-analysis of longitudinal studies. Ageing Research Reviews, 52, 7–16. https://doi.org/10.1016/j.arr.2019.03.002
  • Li, S., Zhang, M., Han, D., Wu, Y., Zhao, J., Liao, H., Ma, Y., Yan, C., & Wang, J. (2023). The effects of loneliness and social isolation on cognitive impairment-free life expectancy in older adults. Aging & Mental Health, 1–8. https://doi.org/10.1080/13607863.2023.2191926
  • Livingston, G., Huntley, J., Sommerlad, A., Ames, D., Ballard, C., Banerjee, S., Brayne, C., Burns, A., Cohen-Mansfield, J., Cooper, C., Costafreda, S. G., Dias, A., Fox, N., Gitlin, L. N., Howard, R., Kales, H. C., Kivimäki, M., Larson, E. B., Ogunniyi, A., … Mukadam, N. (2020). Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. Lancet (London, England), 396(10248), 413–446. https://doi.org/10.1016/s0140-6736(20)30367-6
  • Lockwood, K. A., Alexopoulos, G. S., Kakuma, T., & Van Gorp, W. G. (2000). Subtypes of cognitive impairment in depressed older adults. The American Journal of Geriatric Psychiatry, 8(3), 201–208. https://doi.org/10.1097/00019442-200008000-00004
  • Lovibond, P. F., & Lovibond, S. H. (1995). The structure of negative emotional states: Comparison of the Depression Anxiety Stress Scales (DASS) with the Beck Depression and Anxiety Inventories. Behaviour Research and Therapy, 33(3), 335–343. https://doi.org/10.1016/0005-7967(94)00075-u
  • Luchetti, M., Terracciano, A., Aschwanden, D., Lee, J. H., Stephan, Y., & Sutin, A. R. (2020). Loneliness is associated with risk of cognitive impairment in the survey of health, ageing and retirement in Europe. International Journal of Geriatric Psychiatry, 35(7), 794–801. https://doi.org/10.1002/gps.5304
  • Maes, M., Qualter, P., Vanhalst, J., Van den Noortgate, W., & Goossens, L. (2019). Gender differences in loneliness across the lifespan: A meta–analysis. European Journal of Personality, 33(6), 642–654. https://doi.org/10.1002/per.2220
  • McHugh Power, J., Tang, J., Kenny, R. A., Lawlor, B. A., & Kee, F. (2020). Mediating the relationship between loneliness and cognitive function: The role of depressive and anxiety symptoms. Aging & Mental Health, 24(7), 1071–1078. https://doi.org/10.1080/13607863.2019.1599816
  • Montejo, P., Prada, D., Pedrero-Perez, E., & Montenegro-Pena, M. (2020). Subjective cognitive decline: Mental health, loneliness, pain and quality of life. Poblational study. Journal of Aging Science, 8, 218. https://doi.org/10.35248/2329-8847.20.08.218
  • Neto, S. A., & Nitrini, R. (2016). Subjective cognitive decline: The first clinical manifestation of Alzheimer’s disease? Dementia & Neuropsychologia, 10(3), 170–177. https://doi.org/10.1590/s1980-5764-2016dn1003002
  • Nichols, E., Steinmetz, J. D., Vollset, S. E., Fukutaki, K., Chalek, J., Abd-Allah, F., Abdoli, A., Abualhasan, A., Abu-Gharbieh, E., Akram, T. T., Al Hamad, H., Alahdab, F., Alanezi, F. M., Alipour, V., Almustanyir, S., Amu, H., Ansari, I., Arabloo, J., Ashraf, T., … Vos, T. (2022). Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019. Lancet Public Health, 7(2), e105–25–e125. https://doi.org/10.1016/S2468-2667(21)00249-8
  • O’Luanaigh, C., O’Connell, H., Chin, A.-V., Hamilton, F., Coen, R., Walsh, C., Walsh, J. B., Caokley, D., Cunningham, C., & Lawlor, B. A. (2012). Loneliness and cognition in older people: The Dublin healthy ageing study. Aging & Mental Health, 16(3), 347–352. https://doi.org/10.1080/13607863.2011.628977
  • Philippot, P., & Agrigoroaei, S. (2017). Repetitive thinking, executive functioning, and depressive mood in the elderly. Aging & Mental Health, 21(11), 1192–1196. https://doi.org/10.1080/13607863.2016.1211619
  • Pizzio, A. P. G., Yankouskaya, A., Alessandri, G., Loreto, S., & Pecchinenda, A. (2022). Social contacts and loneliness affect the own age bias for emotional faces. Scientific Reports, 12(1), 16134. https://doi.org/10.1038/s41598-022-20220-9
  • Pluim, C. F., Anzai, J. A. U., Martinez, J. E., Munera, D., Garza-Naveda, A. P., Vila-Castelar, C., Guzmán-Vélez, E., Ramirez-Gomez, L., Bustin, J., Serrano, C. M., Babulal, G. M., Okada de Oliveira, M., & Quiroz, Y. T. (2023). Associations among loneliness, purpose in life and subjective cognitive decline in ethnoracially diverse older adults living in the United States. Journal of Applied Gerontology: The Official Journal of the Southern Gerontological Society, 42(3), 376–386. https://doi.org/10.1177/07334648221139479
  • Qiao, L., Wang, G., Tang, Z., Zhou, S., Min, J., Yin, M., & Li, M. (2022). Association between loneliness and dementia risk: A systematic review and meta-analysis of cohort studies. Frontiers in Human Neuroscience, 16, 899814. https://doi.org/10.3389/fnhum.2022.899814
  • Reynolds, G. O., Manning, L., Kirn, D., Klein, H., Hampton, O., Burke, O., Jr, Buckley, R., Rentz, D., Sperling, R., Marshall, G. A., & Amariglio, R. E. (2022). Subjective cognitive decline in a registry sample: Relation to psychiatric history, loneliness, and personality. The Journal of Prevention of Alzheimer’s Disease, 9(3), 435–440. https://doi.org/10.14283/jpad.2022.31
  • Reisberg, B., Shulman, M. B., Torossian, C., Leng, L., & Zhu, W. (2010). Outcome over seven years of healthy adults with and without subjective cognitive impairment. Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, 6(1), 11–24. https://doi.org/10.1016/j.jalz.2009.10.002
  • Ren, Y., Savadlou, A., Park, S., Siska, P., Epp, J. R., & Sargin, D. (2023). The impact of loneliness and social isolation on the development of cognitive decline and Alzheimer’s Disease. Frontiers in Neuroendocrinology, 69, 101061. https://doi.org/10.1016/j.yfrne.2023.101061
  • Rodríguez-Romero, R., Herranz-Rodríguez, C., Kostov, B., Gené-Badia, J., & Sisó-Almirall, A. (2021). Intervention to reduce perceived loneliness in community-dwelling older people. Scandinavian Journal of Caring Sciences, 35(2), 366–374. https://doi.org/10.1111/scs.12852
  • Sin, E., Shao, R., & Lee, T. M. C. (2021). The executive control correlate of loneliness in healthy older people. Aging & Mental Health, 25(7), 1224–1231. https://doi.org/10.1080/13607863.2020.1749832
  • Shahnawaz, Z., Reppermund, S., Brodaty, H., Crawford, J. D., Draper, B., Trollor, J. N., & Sachdev, P. S. (2013). Prevalence and characteristics of depression in mild cognitive impairment: The Sydney Memory and Ageing Study. Acta Psychiatrica Scandinavica, 127(5), 394–402. https://doi.org/10.1111/acps.12008
  • Solé-Padullés, C., Macià, D., Andersson, M., Stiernstedt, M., Pudas, S., Düzel, S., Zsoldos, E., Ebmeier, K. P., Binnewies, J., Drevon, C. A., Brandmaier, A. M., Mowinckel, A. M., Fjell, A. M., Madsen, K. S., Baaré, W. F. C., Lindenberger, U., Nyberg, L., Walhovd, K. B., & Bartrés-Faz, D. (2022). No association between loneliness, episodic memory, and hippocampal Vol. change in young and healthy older adults: A longitudinal European multicenter study. Frontiers in Aging Neuroscience, 14, 795764. Article 795764. https://doi.org/10.3389/fnagi.2022.795764
  • Tilvis, R. S., Kähönen-Väre, M. H., Jolkkonen, J., Valvanne, J., Pitkala, K. H., & Strandberg, T. E. (2004). Predictors of cognitive decline and mortality of 164 aged people over a 10-year period. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 59(3), 268–274. https://doi.org/10.1093/gerona/59.3.M268
  • Thompson, C., Halcomb, E., & Masso, M. (2023). The contribution of primary care practitioners to interventions reducing loneliness and social isolation in older people—An integrative review. Scandinavian Journal of Caring Sciences, 00, 1– 17. https://doi.org/10.1111/scs.13151
  • Vallat-Azouvi, C., Pradat-Diehl, P., & Azouvi, P. (2012). The Working Memory Questionnaire: A scale to assess everyday life problems related to deficits of working memory in brain injured patients. Neuropsychological Rehabilitation, 22(4), 634–649. https://doi.org/10.1080/09602011.2012.681110
  • Vannini, P., Hanseeuw, B., Munro, C. E., Amariglio, R. E., Marshall, G. A., Rentz, D. M., Pascual-Leone, A., Johnson, K. A., & Sperling, R. A. (2017). Anosognosia for memory deficits in mild cognitive impairment: Insight into the neural mechanism using functional and molecular imaging. NeuroImage: Clinical, 15, 408–414. https://doi.org/10.1016/j.nicl.2017.05.020
  • Viviani, G., De Luca, F., Antonucci, G., Yankouskaya, A., & Pecchinenda, A. (2022). It is not always positive: Emotional bias in young and older adults. Psychological Research, 86(6), 2045–2057. https://doi.org/10.1007/s00426-021-01614-2
  • Wilson, R. S., Krueger, K. R., Arnold, S. E., Schneider, J. A., Kelly, J. F., Barnes, L. L., Tang, Y., & Bennett, D. A. (2007). Loneliness and risk of Alzheimer disease. Archives of General Psychiatry, 64(2), 234–240. https://doi.org/10.1001/archpsyc.64.2.234
  • World Health Organization. (2021). New advocacy brief highlights serious consequences of social isolation and loneliness on the health of older people, calls for greater political priority to the issue. https://www.who.int/news/item/29-07-2021-new-advocacy-brief-highlights-serious-consequences-of-social-isolation-and-loneliness-on-the-health-of-older-people-calls-for-greater-political-priority-to-the-issue