Assessment of biomarkers in women with endometriosis-associated pain using the ENG contraceptive implant or the 52 mg LNG-IUS: a non-inferiority randomised clinical trial

References

• American Society for Reproductive Medicine. Revised American Society for Reproductive Medicine classification of endometriosis: 1996. Fertil Steril. 1997;67:817–821.
   PubMed Web of Science ®Google Scholar
• Dunselman GAJ, Vermeulen N, Becker C. ESHRE guideline: management of women with endometriosis. Hum Reprod. 2014;29:400–412.
   PubMed Web of Science ®Google Scholar
• Haas D, Shebl O, Shamiyeh A, et al. The rASRM score and the Enzian classification for endometriosis: their strengths and weaknesses. Acta Obstet Gynecol Scand. 2013;92:3–7.
   PubMed Web of Science ®Google Scholar
• Gupta D, Hull ML, Fraser I, et al. Endometrial biomarkers for the non-invasive diagnosis of endometriosis. Cochrane Database Syst Rev. 2016;4:CD012165.
   PubMed Web of Science ®Google Scholar
• Ahn SH, Singh V, Tayade C. Biomarkers in endometriosis: challenges and opportunities. Fertil Steril. 2017;107:523–532.
   PubMed Web of Science ®Google Scholar
• Fassbender A, Burney RO, O DF, et al. Update on biomarkers for the detection of endometriosis. Biomed Res Int. 2015;2015:130854.
   PubMed Web of Science ®Google Scholar
• Rosa e Silva ACJS, Rosa e Silva JC, Ferriani RA. Serum CA-125 in the diagnosis of endometriosis. Int J Gynaecol Obstet. 2007;96:206–207.
   PubMed Web of Science ®Google Scholar
• Hirsch M, Duffy J, Davis C, et al. Diagnostic accuracy of cancer antigen 125 for endometriosis: a systematic review and meta-analysis. BJOG. 2016;123:1761–1768.
   PubMed Web of Science ®Google Scholar
• Odukoya O-A, Bansal A, Wilson P, et al. Soluble CD23 protein in the peritoneal fluid of patients with endometriosis. Hum Reprod. 1996;11:2018–2021.
   PubMed Web of Science ®Google Scholar
• Practice Committee of the American Society for Reproductive Medicine. Treatment of pelvic pain associated with endometriosis: a committee opinion. Fertil Steril. 2014;101:927–935.
   PubMed Web of Science ®Google Scholar
• Máximo MM, Silva PS, Vieira CS, et al. Low-dose progestin-releasing contraceptives are associated with a higher pain threshold in healthy women. Fertil Steril. 2015;104:1182–1189.
   PubMed Web of Science ®Google Scholar
• Al-Jefout M, Dezarnaulds G, Cooper M, et al. Diagnosis of endometriosis by detection of nerve fibres in an endometrial biopsy: a double blind study. Hum Reprod. 2009;24:3019–3024.
   PubMed Web of Science ®Google Scholar
• Tarjanne S, Ng CHM, Manconi F, et al. Use of hormonal therapy is associated with reduced nerve fiber density in deep infiltrating, rectovaginal endometriosis. Acta Obstet Gynecol Scand. 2015;94:693–700.
   PubMed Web of Science ®Google Scholar
• de Sá Rosa e Silva AC, Rosa e, Silva JC, Nogueira AA, et al. The levonorgestrel-releasing intrauterine device reduces CA-125 serum levels in patients with endometriosis. Fertil Steril. 2006;86:742–744.
   PubMed Web of Science ®Google Scholar
• Matalliotakis IM, Neonaki MA KYG, et al. A randomized comparison of danazol and leuprolide acetate suppression of serum-soluble CD23 levels in endometriosis. Obstet Gynecol. 2000;95:810–813.
   PubMed Web of Science ®Google Scholar
• Petta CA, Ferriani RA, Abrao MS, et al. Randomized clinical trial of a levonorgestrel-releasing intrauterine system and a depot GnRH analogue for the treatment of chronic pelvic pain in women with endometriosis. Hum Reprod. 2005;20:1993–1998.
   PubMed Web of Science ®Google Scholar
• Vercellini P, Aimi G, Panazza S, et al. A levonorgestrel-releasing intrauterine system for the treatment of dysmenorrhea associated with endometriosis: a pilot study. Fertil Steril. 1999;72:505–508.
   PubMed Web of Science ®Google Scholar
• Walch K, Unfried G, Huber J, et al. Implanon versus medroxyprogesterone acetate: effects on pain scores in patients with symptomatic endometriosis – a pilot study. Contraception. 2009;79:29–34.
   PubMed Web of Science ®Google Scholar
• Carvalho N, Margatho D, Cursino K, et al. Control of endometriosis-associated pain with etonogestrel-releasing contraceptive implant and 52 mg levonorgestrel-releasing intrauterine system: randomized clinical trial. Fertil Steril. doi: 10.1016/j.fertnstert.2018.07.003
   Web of Science ®Google Scholar
• Guerriero S, Condous G, van den Bosch T, et al. Systematic approach to sonographic evaluation of the pelvis in women with suspected endometriosis, including terms, definitions and measurements: a consensus opinion from the International Deep Endometriosis Analysis (IDEA) group. Ultrasound Obstet Gynecol. 2016;48:318–332.
   PubMed Web of Science ®Google Scholar
• Johnson NP, Hummelshoj L, Adamson GD, et al. World Endometriosis Society consensus on the classification of endometriosis. Hum Reprod. 2017;32:315–324.
   PubMed Web of Science ®Google Scholar
• Gerlinger C, Schumacher U, Faustmann T, et al. Defining a minimal clinically important difference for endometriosis-associated pelvic pain measured on a visual analog scale: analyses of two placebo-controlled, randomized trials. Health Qual Life Outcomes. 2010;8:138.
   PubMed Web of Science ®Google Scholar
• Department of Reproductive Health, World Health Organization. Medical eligibility criteria for contraceptive use. 5th ed. Geneva: WHO; 2015.
   Google Scholar
• Howard F. Chronic pelvic pain. Obstet Gynecol. 2003;101:594–611.
   PubMed Web of Science ®Google Scholar
• Belsey EM, Machin D, d'Arcangues C. The analysis of vaginal bleeding patterns induced by fertility regulating methods. World Health Organization Special Programme of Research, Development and Research Training in Human Reproduction. Contraception. 1986;34:253–260.
   PubMed Web of Science ®Google Scholar
• Newman TA, Bailey JL, Stocker LJ, et al. Expression of neuronal markers in the endometrium of women with and those without endometriosis. Hum Reprod. 2013;28:2502–2510.
   PubMed Web of Science ®Google Scholar
• Gordts S, Koninckx P, Brosens I. Pathogenesis of deep endometriosis. Fertil Steril. 2017;108:872–885.
   PubMed Web of Science ®Google Scholar
• Strowitzki T, Marr J, Gerlinger C, et al. Dienogest is as effective as leuprolide acetate in treating the painful symptoms of endometriosis: a 24-week, randomized, multicentre, open-label trial. Hum Reprod. 2010;25:633–641.
   PubMed Web of Science ®Google Scholar
• Koninckx PR, Ussia A, Adamyan L, et al. Deep endometriosis: definition, diagnosis, and treatment. Fertil Steril. 2012;98:564–571.
   PubMed Web of Science ®Google Scholar
• Yucel N, Baskent E, Karamustafaoglu Balci B, et al. The levonorgestrel-releasing intrauterine system is associated with a reduction in dysmenorrhoea and dyspareunia, a decrease in CA 125 levels, and an increase in quality of life in women with suspected endometriosis. Aust N Z J Obstet Gynaecol. 2018;58:560–563.
   PubMed Web of Science ®Google Scholar
• Mol BWJ, Bayram N, Lijmer JG, et al. The performance of CA-125 measurement in the detection of endometriosis: a meta-analysis. Fertil Steril. 1998;70:1101–1108.
   PubMed Web of Science ®Google Scholar
• Niloff JM, Knapp RC, Schaetzl E, et al. CA125 antigen levels in obstetric and gynecologic patients. Obstet Gynecol. 1984;64:703–707.
   PubMed Web of Science ®Google Scholar
• Masahashi T, Matsuzawa K, Narita O, et al. Serum CA-125 levels in patients with endometriosis: changes in CA-125 levels during menstruation. Obstet Gynecol. 1988;72:328–331.
   PubMed Web of Science ®Google Scholar
• Tokushige N, Markham R, Russell P, et al. Different types of small nerve fibers in eutopic endometrium and myometrium in women with endometriosis. Fertil Steril. 2007;88:795–803.
   PubMed Web of Science ®Google Scholar
• Tokushige N, Markham R, Russell P, et al. Effect of progestogens and combined oral contraceptives on nerve fibers in peritoneal endometriosis. Fertil Steril. 2009;92:1234–1239.
   PubMed Web of Science ®Google Scholar
• Zevallos HB, McKinnon B, Tokushige N, et al. Detection of the pan neuronal marker PGP9.5 by immuno-histochemistry and quantitative PCR in eutopic endometrium from women with and without endometriosis. Arch Gynecol Obstet. 2015;291:85–91.
   PubMed Web of Science ®Google Scholar
• Ellett L, Readman E, Newman M, et al. Are endometrial nerve fibres unique to endometriosis? A prospective case-control study of endometrial biopsy as a diagnostic test for endometriosis in women with pelvic pain. Hum Reprod. 2015;30:2808–2815.
   PubMed Web of Science ®Google Scholar
• Fraser IS. Added health benefits of the levonorgestrel contraceptive intrauterine system and other hormonal contraceptive delivery systems. Contraception. 2013;87:273–279.
   PubMed Web of Science ®Google Scholar
• Nisenblat V, Prentice L, Bossuyt PMM, et al. Combination of the non-invasive tests for the diagnosis of endometriosis. Cochrane Database Syst Rev. 2016;7:CD012281.
   PubMedGoogle Scholar