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Drospirenone: a Latin American perspective for oestrogen-free oral contraception

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Pages 73-78 | Received 16 Jul 2020, Accepted 07 Oct 2020, Published online: 06 Nov 2020

References

  • Brynhildsen J. Combined hormonal contraceptives: prescribing patterns, compliance, and benefits versus risks. Ther Adv Drug Saf. 2014;5(5):201–213.
  • United Nations, Department of Economic and Social Affairs, Population Division. 2018. World Contraceptive Use 2018 (POP/DB/CP/Rev2018).
  • Ponce de León RG, Ewerling F, Serruya SJ, et al. Contraceptive use in Latin America and the Caribbean with a focus on long-acting reversible contraceptives: prevalence and inequalities in 23 countries. Lancet Glob Health. 2019;7(2):e227–e235.
  • Beller JP, McCartney CR. Cardiovascular risk and combined oral contraceptives: clinical decisions in settings of uncertainty. Am J Obstet Gynecol. 2013;208(1):39–41.
  • Kaminski P, Szpotanska-Sikorska M, Wielgos M. Cardiovascular risk and the use of oral contraceptives. Neuro Endocrinol Lett. 2013;34(7):587–589.
  • World Health Organization. Medical eligibility criteria for contraceptive use. Fifth Edition, 2015. Disponible en; [cited 2020 Jul]. Available from: https://bit.ly/2SNhZJg
  • ACOG. ACOG Practice Bulletin No. 206: use of hormonal contraception in women with coexisting medical conditions. Obstet Gynecol. 2019;133(2):e128–e150.
  • Quesada-Moreno M. Sociedad Española de Ginecología y Obstetricia. Protocolos SEGO/SEC: Anticoncepción con Sólo Gestágenos. Disponible en; [cited 2020 Jul]. Available from: https://bit.ly/2CbadUd.
  • Archer DF, Ahrendt HJ, Drouin D. Drospirenone-only oral contraceptive: results from a multicenter noncomparative trial of efficacy, safety and tolerability. Contraception. 2015;92(5):439–444.
  • Tepper NK, Whiteman MK, Marchbanks PA, et al. Progestin-only contraception and thromboembolism: a systematic review. Contraception. 2016;94(6):678–700.
  • Glisic M, Shahzad S, Tsoli S, et al. Association between progestin-only contraceptive use and cardiometabolic outcomes: a systematic review and meta-analysis. Eur J Prev Cardiol. 2018;25(10):1042–1052.
  • Raymond EG. Progestin-only pills. In: Hatcher RA, Trussell J, Nelson AL, Cates W Jr, Stewart F, Kowal D, editor. Contraceptive technology, 19th ed. New York: Ardent Media, Inc.; 2007. p. 181–191.
  • Shulman LP. A review of drospirenone for safety and tolerability and effects on endometrial safety and lipid parameters contrasted with medroxyprogesterone acetate, levonorgestrel, and micronized progesterone. J Womens Health. 2006;15(5):584–590.
  • Sitruk-Ware R. Pharmacology of different progestogens: the special case of drospirenone. Climacteric. 2005;8(Suppl 3):4–12.
  • Duijkers IJ, Heger-Mahn D, Drouin D, et al. A randomised study comparing the effect on ovarian activity of a progestogen-only pill (POP) containing desogestrel and a new POP containing drospirenone in a 24/4 regimen. Eur J Contracept Reprod Health Care. 2015;20(6):419–427.
  • Palacios S, Colli E, Regidor PA. Multicenter, phase III trials on the contraceptive efficacy, tolerability and safety of a new drospirenone-only pill. Acta Obstet Gynecol Scand. 2019;98(12):1549–1557.
  • Duijkers IJM, Heger-Mahn D, Drouin D, et al. Maintenance of ovulation inhibition with a new progestogen-only pill containing drospirenone after scheduled 24-h delays in pill intake. Contraception. 2016;93(4):303–309.
  • Aubeny E, Buhler M, Colau JC, et al. Oral contraception: patterns of non-compliance. The Coraliance study. Eur J Contracept Reprod Health Care. 2002;7(3):155–161.
  • Słopień R, Milewska E, Rynio P, et al. Use of oral contraceptives for management of acne vulgaris and hirsutism in women of reproductive and late reproductive age. Prz Menopauzalny. 2018;17(1):1–4.
  • Lortscher D, Admani S, Satur N, et al. Hormonal contraceptives and acne: a retrospective analysis of 2147 patients. J Drugs Dermatol. 2016;15(6):670–674.
  • De Leo V, Morgante G, Piomboni P, et al. Evaluation of effects of an oral contraceptive containing ethinylestradiol combined with drospirenone on adrenal steroidogenesis in hyperandrogenic women with polycystic ovary syndrome. Fertil Steril. 2007;88(1):113–117.
  • González-Hernando C, Souza de Almeida M, Martín-Villamor P, et al. La píldora anticonceptiva a debate. Enfermería Universitaria. 2013;10(3):98–104.
  • Dragoman MV, Tepper NK, Fu R, et al. A systematic review and meta-analysis of venous thrombosis risk among users of combined oral contraception. Int J Gynaecol Obstet. 2018;141(3):287–294.
  • Regidor PA, Colli E, Schindler AE. Drospirenone as estrogen-free pill and hemostasis: coagulatory study results comparing a novel 4 mg formulation in a 24 + 4 cycle with desogestrel 75 μg per day. Gynecol Endocrinol. 2016;32(9):749–751.
  • Hruby A, Hu FB. The epidemiology of obesity: a big picture. Pharmacoeconomics. 2015;33(7):673–689.
  • Cominato L, Di Biagio GF, Lellis D, et al. Obesity prevention: strategies and challenges in Latin America. Curr Obes Rep. 2018;7(2):97–104.
  • Spinedi E, Cardinali DP. The polycystic ovary syndrome and the metabolic syndrome: a possible chronobiotic-cytoprotective adjuvant therapy. Int J Endocrinol. 2018;2018:1349868.
  • Horton LG, Simmons KB, Curtis KM. Combined hormonal contraceptive use among obese women and risk for cardiovascular events: a systematic review. Contraception. 2016;94(6):590–604.
  • Merki-Feld GS, Skouby S, Serfaty D, et al. European society of contraception statement on contraception in obese women. Eur J Contracept Reprod Health Care. 2015;20(1):19–28.
  • Lopez LM, Ramesh S, Chen M, et al. Progestin-only contraceptives: effects on weight. Cochrane Database Syst Rev. 2016;(8):CD008815.
  • Lanas F, Bazzano L, Rubinstein A, et al. Prevalence, distributions and determinants of obesity and central obesity in the Southern Cone of America. PLoS One. 2016;11(10):e0163727.
  • West R. Tobacco smoking: health impact, prevalence, correlates and interventions. Psychol Health. 2017;32(8):1018–1036.
  • Lim SS, Vos T, Flaxman AD, et al. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380(9859):2224–2260.
  • Bardach A, Perdomo HA, Gándara RA, et al. Income and smoking prevalence in Latin America: a systematic review and meta-analysis. Rev Panam Salud Publica. 2016;40(4):263–271.
  • Organización Panamericana de la Salud. Informe sobre Control del Tabaco para la Región de las Américas, 2011. Disponible en; [cited 2020 Jul]. Available from: https://bit.ly/2Hd4MIH.
  • Valdés-Salgado R, Hernández-Avila M, Sepúlveda-Amor J. El consumo de tabaco en la Región Americana: elementos para un programa de acción. Salud Pública Méx. 2002;44 (Supl 1):S125–S135.
  • Tanis BC, van den Bosch MA, Kemmeren JM, et al. Oral contraceptives and the risk of myocardial infarction. N Engl J Med. 2001;345(25):1787–1793.
  • Rosenberg L, Palmer JR, Rao RS, et al. Low-dose oral contraceptive use and the risk of myocardial infarction. Arch Intern Med. 2001;161(8):1065–1070.
  • Khader YS, Rice J, John L, et al. Oral contraceptives use and the risk of myocardial infarction: a meta-analysis. Contraception. 2003;68(1):11–17.
  • Wang Q, Würtz P, Auro K, et al. Effects of hormonal contraception on systemic metabolism: cross-sectional and longitudinal evidence. Int J Epidemiol. 2016;45(5):1445–1457.
  • Ponte-Negretti CI, Isea-Perez JE, Lorenzatti AJ, et al. Atherogenic dyslipidemia in Latin America: prevalence, causes and treatment: expert’s position paper made by The Latin American Academy for the Study of Lipids (ALALIP) Endorsed by the Inter-American Society of Cardiology (IASC), the South American Society of Cardiology (SSC), the Pan-American College of Endothelium (PACE), and the International Atherosclerosis Society (IAS). Int J Cardiol. 2017;243:516–522.
  • Preston RA, White WB, Pitt B, et al. Effects of drospirenone/17-beta estradiol on blood pressure and potassium balance in hypertensive postmenopausal women. Am J Hypertens. 2005;18(6):797–804.
  • Rubinstein AL, Irazola VE, Calandrelli M, et al. Prevalence, awareness, treatment, and control of hypertension in the southern cone of Latin America. Am J Hypertens. 2016;29(12):1343–1352.
  • Neal S, Harvey C, Chandra-Mouli V, et al. Trends in adolescent first births in five countries in Latin America and the Caribbean: disaggregated data from demographic and health surveys. Reprod Health. 2018;15(1):146.
  • Cibula D, Skrenkova J, Hill M, et al. Lowdose estrogen combined oral contraceptives may negatively influence physiological bone mineral density acquisition during adolescence. Eur J Endocrinol. 2012;166(6):1003–1011.
  • Pikkarainen E, Lehtonen-Veromaa M, Mottonen T, et al. Estrogen-progestin contraceptive use during adolescence prevents bone mass acquisition: a 4-year follow-up study. Contraception. 2008;78(3):226–231.
  • Ott MA, Sucato GS, Committee on Adolescence. Contraception for adolescents. Pediatrics. 2014;134(4):e1257–e1281.
  • Hadji P, Colli E, Regidor PA. Bone health in estrogen-free contraception. Osteoporos Int. 2019;30(12):2391–2400.
  • Palacios S, López J, Celis C, et al. Multicentre, open-label trial to assess the safety and tolerability of LF111 (Drospirenone 4.0 mg) over 6 cycles in female adolescents, with a 7-cycle extension phase. Clinical Trial Report CF111/304 In press.
  • Monterrosa A. Anticonceptivos orales de solo progestina. Rev Colomb Obstet Ginecol. 2006;57(1):45–53.
  • Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Drospirenone [updated 2020 Feb 17]. Disponible en; [cited 2020 Jul]. Available from: https://bit.ly/2z9nfmW.
  • Del Savio MC, De Fata R, Facchinetti F, et al. Drospirenone 4 mg-only pill (DOP) in 24 + 4 regimen: a new option for oral contraception. Expert Rev Clin Pharmacol. 2020;13(7):685–694.

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