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The European Journal of Contraception & Reproductive Health Care Volume 27, 2022 - Issue 4
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Research Articles

Combination of mifepristone and misoprostol vs misoprostol monotherapy for treatment of second-trimester pregnancy loss

Irene Valeroa Department of Obstetrics and Gynaecology, Juan Ramon Jimenez Hospital, Huelva, Spain
,
Rocio Garcia-Jimenezb Department of Obstetrics and Gynaecology, Virgen de Valme University Hospital, Seville, SpainCorrespondence[email protected]
,
Ana Maria Weber-Fernandeza Department of Obstetrics and Gynaecology, Juan Ramon Jimenez Hospital, Huelva, Spain
,
Rocio Diaz-Acedoc Department of Pharmacy, Virgen de Valme University Hospital, Seville, Spain
,
Maria Jose Fobelo-Lozanoc Department of Pharmacy, Virgen de Valme University Hospital, Seville, Spain
,
Lucas Cerrillosd Department of Obstetrics and Gynaecology, Virgen del Rocio University Hospital, Seville, Spain
&
Rosa Ostosb Department of Obstetrics and Gynaecology, Virgen de Valme University Hospital, Seville, Spain
 show all
Pages 341-344 | Received 13 Aug 2021, Accepted 10 Mar 2022, Published online: 11 Apr 2022

References

  • Gemzell-Danielsson K, Lalitkumar S. Second trimester medical abortion with mifepristone–misoprostol and misoprostol alone: a review of methods and management. Reprod Health Matters. 2008;16(31 Suppl):162–172.
  • Schreiber CA, Creinin MD, Atrio J, et al. Mifepristone pretreatment for the medical management of early pregnancy loss. N Engl J Med. 2018;378(23):2161–2170.
  • Agencia Española de Medicamentos y Productos Sanitarios (AEMPS). 2021. Technical data sheet Mifegyne 200 mg tablets [in Spanish]; [cited 2021 July 15]. Available from: https://cima.aemps.es/cima/dochtml/ft/62728/FT_62728.html#5-propiedades-farmacol-gicas.
  • Henkel A, Shaw KA. Advances in the management of early pregnancy loss. Curr Opin Obstet Gynecol. 2018;30(6):419–424.
  • Chaudhuri P, Datta S. Mifepristone and misoprostol compared with misoprostol alone for induction of labor in intrauterine fetal death: a randomized trial. J Obstet Gynaecol Res. 2015;41(12):1884–1890.
  • Kapp N, Borgatta L, Stubblefield P, et al. Mifepristone in second-trimester medical abortion: a randomized controlled trial. Obstet Gynecol. 2007;110(6):1304–1310.
  • Kaushal A, Kaur K, Kaur P, et al. Mifepristone plus misoprostol versus misoprostol for second trimester termination of pregnancy. Int J Curr Adv Res. 2017;6:4472–4475.
  • Kulkarni KK. Pre-induction with mifepristone for second trimester termination of pregnancy. J Obstet Gynaecol India. 2014;64(2):102–104.
  • Bedi PK, Saini A. Randomized control trial to compare the effectiveness of mifepristone followed by misoprostol at 12 hours interval versus misoprostol alone in second trimester medical termination of pregnancy. Int J Reprod Contracept Obstet Gynecol. 2018;7(8):3299–3304.

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