Repeated postoperative adjuvant TACE after curative hepatectomy improves outcomes of patients with HCC

References

• Ferlay J, Shin HR, Bray F, et al. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 2010;127(12):2893–2917.
   PubMed Web of Science ®Google Scholar
• Dong ZR, Zhang PF, Wang CH, et al. Postoperative adjuvant transcatheter arterial chemoembolization for resectable multiple hepatocellular carcinoma beyond the Milan criteria: a retrospective analysis. Am J Cancer Res. 2015;5(1):450–457.
   PubMed Web of Science ®Google Scholar
• Yang JD, Roberts LR. Epidemiology and management of hepatocellular carcinoma. Infect Dis Clin North Am. 2010;24(4):899–919.
   PubMed Web of Science ®Google Scholar
• Jemal A, Ward E, Thun M. Declining death rates reflect progress against cancer. PLoS One. 2010;5(3):e9584.
   PubMed Web of Science ®Google Scholar
• Forner A, Llovet JM, Bruix J. Hepatocellular carcinoma. Lancet. 2012;379(9822):1245–1255.
   PubMed Web of Science ®Google Scholar
• Bruix J, Llovet JM. Prognostic prediction and treatment strategy in hepatocellular carcinoma. Hepatology. 2002;35(3):519–524.
   PubMed Web of Science ®Google Scholar
• Gomaa AI, Waked I. Recent advances in multidisciplinary management of hepatocellular carcinoma. WJH. 2015;7(4):673–687.
   PubMed Web of Science ®Google Scholar
• Zhang J, Jiang TY, Jiang BG, et al. RMP predicts survival and adjuvant TACE response in hepatocellular carcinoma. Oncotarget. 2015;6:3432–3442.
   PubMedGoogle Scholar
• Shim JH, Kim KM, Lee YJ, et al. Complete necrosis after transarterial chemoembolization could predict prolonged survival in patients with recurrent intrahepatic hepatocellular carcinoma after curative resection. Ann Surg Oncol. 2010;17(3):869–877.
   PubMed Web of Science ®Google Scholar
• Hsu CY, Huang YH, Chiou YY, et al. Comparison of radiofrequency ablation and transarterial chemoembolization for hepatocellular carcinoma within the Milan criteria: a propensity score analysis. Liver Transpl. 2011;17(5):556–566.
   PubMed Web of Science ®Google Scholar
• Zuo CH, Xia M, Liu JS, et al. Transcatheter arterial chemoembolization combined with interferon-α is safe and effective for patients with hepatocellular carcinoma after curative resection. Asian Pac J Cancer Prev. 2015;16(1):245–251.
   PubMedGoogle Scholar
• Fukumoto T, Tominaga M, Kido M, et al. Long-term outcomes and prognostic factors with reductive hepatectomy and sequential percutaneous isolated hepatic perfusion for multiple bilobar hepatocellular carcinoma. Ann Surg Oncol. 2014;21(3):971–978.
   PubMed Web of Science ®Google Scholar
• Chen K, Xia Y, Wang H, et al. Adjuvant iodine-125 brachytherapy for hepatocellular carcinoma after complete hepatectomy: a randomized controlled trial. PLoS One. 2013;8(2):e57397.
   PubMed Web of Science ®Google Scholar
• Liu C, Sun L, Xu J, et al. Clinical efficacy of postoperative adjuvant transcatheter arterial chemoembolization on hepatocellular carcinoma. World J Surg Onc. 2016;14(1):100.
   PubMedGoogle Scholar
• Ke-Wei L, Tian-Fu W, Xi L, et al. The effect of postoperative TACE on prognosis of HCC with microscopic venous invasion. Hepatogastroenterology. 2012;59:1944–1946.
   PubMedGoogle Scholar
• Li KW, Li X, Wen TF, et al. The effect of postoperative TACE on prognosis of HCC: an update. Hepatogastroenterology. 2013;60(122):248–251.
   PubMedGoogle Scholar
• Chen X, Zhang B, Yin X, et al. Lipiodolized transarterial chemoembolization in hepatocellular carcinoma patients after curative resection. J Cancer Res Clin Oncol. 2013;139(5):773–781.
   PubMed Web of Science ®Google Scholar
• Zheng Z, Liang W, Wang D, et al. Adjuvant chemotherapy for patients with primary hepatocellular carcinoma: a meta-analysis. Int J Cancer. 2015;136(6):E751–E759.
   PubMed Web of Science ®Google Scholar
• Lo CM, Liu CL, Chan SC, et al. A randomized, controlled trial of postoperative adjuvant interferon therapy after resection of hepatocellular carcinoma. Ann Surg. 2007;245(6):831–842.
   PubMed Web of Science ®Google Scholar
• Sun HC, Tang ZY, Li XM, et al. Microvessel density of hepatocellular carcinoma: its relationship with prognosis. J Cancer Res Clin Oncol. 1999;125(7):419–426.
   PubMed Web of Science ®Google Scholar
• Wang K, Liu J, Yan ZL, et al. Overexpression of aspartyl‐(asparaginyl)‐β‐hydroxylase in hepatocellular carcinoma is associated with worse surgical outcome. Hepatology. 2010;52(1):164–173.
   PubMed Web of Science ®Google Scholar
• Sun JJ, Wang K, Zhang CZ, et al. Postoperative adjuvant transcatheter arterial chemoembolization after R0 Hepatectomy improves outcomes of patients who have hepatocellular carcinoma with microvascular invasion. Ann Surg Oncol. 2016;23(4):1344–1351.
   PubMed Web of Science ®Google Scholar
• Bruix J, Sherman M, Llovet JM, et al. Clinical management of hepatocellular carcinoma. Conclusions of the Barcelona-2000 EASL conference. European Association for the Study of the Liver. J Hepatol. 2001;35(3):421–430.
   PubMed Web of Science ®Google Scholar
• Lee KK, Kim DG, Moon IS, et al. Liver transplantation versus liver resection for the treatment of hepatocellular carcinoma. J Surg Oncol. 2010;101(1):47–53.
   PubMed Web of Science ®Google Scholar
• Guglielmi A, Ruzzenente A, Conci S, et al. Hepatocellular carcinoma: surgical perspectives beyond the Barcelona clinic liver cancer recommendations. WJG. 2014;20(24):7525–7533.
   PubMed Web of Science ®Google Scholar
• Yang XD, Pan LH, Wang L, et al. Systematic Review of Single Large and/or Multinodular Hepatocellular Carcinoma: Surgical Resection Improves Survival. Asian Pac J Cancer Prev. 2015;16(13):5541–5547.
   PubMedGoogle Scholar
• Park JH, Han JK, Chung JW, et al. Postoperative recurrence of hepatocellular carcinoma: results of transcatheter arterial chemoembolization. Cardiovasc Intervent Radiol. 1993;16(1):21–24.
   PubMed Web of Science ®Google Scholar
• Morino M, Miglietta C, Grosso M, et al. Preoperative chemoembolization for hepatocellular carcinoma. J Surg Oncol. 1993;3(Suppl):91–93.
   Google Scholar
• Zu QQ, Liu S, Zhou CG, et al. Chemoembolization of recurrent hepatoma after curative resection: prognostic factors. AJR Am J Roentgenol. 2015;204(6):1322–1328.
   PubMed Web of Science ®Google Scholar
• Jiang JH, Guo Z, Lu HF, et al. Adjuvant transarterial chemoembolization after curative resection of hepatocellular carcinoma: propensity score analysis. WJG. 2015;21(15):4627–4634.
   PubMed Web of Science ®Google Scholar
• Kojiro M, Nakashima O. Histopathologic evaluation of hepatocellular carcinoma with special reference to small early stage tumors. Semin Liver Dis. 1999;19 (03):287–296.
   PubMedGoogle Scholar
• Maeda T, Takenaka K, Taguchi K, et al. Clinicopathological characteristics of surgically resected minute hepatocellular carcinomas. Hepatogastroenterology. 2000;47(32):498–503.
   PubMedGoogle Scholar
• Nakashima Y, Nakashima O, Tanaka M, et al. Portal vein invasionand intrahepatic micrometastasis in small hepatocellular carcinoma by gross type. Hepatol Res. 2003;26(2):142–147.
   PubMed Web of Science ®Google Scholar
• Okusaka T, Okada S, Ueno H, et al. Satellite lesions in patients with small hepatocellular carcinoma with reference to clinicopathologic features. Cancer. 2002;95(9):1931–1937.
   PubMed Web of Science ®Google Scholar
• Roayaie S, Obeidat K, Sposito C, et al. Resection of hepatocellular cancer ≤2 cm: results from two Western centers. Hepatology. 2013;57(4):1426–1435.
   PubMed Web of Science ®Google Scholar
• Zhu J, Yang Y, Ma C, et al. CEACAM1 cytoplastic expression is closely related to tumor angiogenesis and poorer relapse-free survival after curative resection of hepatocellular carcinoma. World J Surg. 2011;35(10):2259–2265.
   PubMed Web of Science ®Google Scholar
• Miksad RA, Ogasawara S, Xia F, et al. Liver function changes after transarterial chemoembolization in US hepatocellular carcinoma patients: the LiverT study. BMC Cancer. 2019; Aug 1319(1):795.
   PubMed Web of Science ®Google Scholar