614
Views
15
CrossRef citations to date
0
Altmetric
Original Paper

Escitalopram: a unique mechanism of action

&
Pages 11-13 | Published online: 12 Jul 2009

REFERENCES

  • Montgomery SA, Loft H, Sa´nchez C et al (2001) Escitalopram (S-enantiomer of citalopram): clinical efficacy and onset of action predicted from a rat model. Pharmacol Toxicol 88: 282–6.
  • Sa´nchez C, Gruca P, Papp M (2003) R-citalopram counteracts the antidepressant-like effect of escitalopram in a rat chronic mild stress model. Behav Pharmacol 14: 465–70.
  • Mørk A, Kreilgaard M, Sa´nchez C (2003) The R-enantiomer of citalopram counteracts escitalopram-induced increase in extracellular 5-HT in the frontal cortex of freely moving rats. Neuropharmacology 45: 167–73.
  • Owens MJ, Knight DL, Nemeroff CB (2001) Second-generation SSRIs: human monoamine transporter binding profile of escitalopram and R-fluoxetine. Biol Psychiatry 50: 345 -50.
  • Plenge P, Mellerup ET, Laursen H (1991) Affinity modulation of [3H]imipramine, [3H]paroxetine and [3H]citalopram binding to the 5-HT transporter from brain and platelets. Eur J Pharmacol 206: 243–50.
  • Chen F, Larsen MB, Sa´ nchez C, Wiborg O (2003) The S-enantiomer of citalopram increases inhibitor binding to the human serotonin transporter by an allosteric mechanism. Comparison with other serotonin transporter inhibitors. Poster presented at the 16th European College of Neuropsychopharmacology (ECNP), 20 -24 September 2003, Prague, Czech Republic.
  • Sa´nchez C, Bøgesø K, Ebert B et al (2004) Escitalopram versus citalopram: the surprising role of the R-enantiomer. Psychopharmacol 174: 163–76.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.