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Review Article

Choosing among second-generation antidepressant treatments for depressed patients with cardiac diseases

Pages 134-148 | Received 18 May 2018, Accepted 13 Aug 2018, Published online: 01 Feb 2019

References

  • Amsterdam, J. D., Garcia-Espana, F., Fawcett, J., Quitkin, F. M., Reimherr, F. W., Rosenbaum, J. F., … Beasley, C. (1999). Blood pressure changes during short-term fluoxetine treatment. Journal of Clinical Psychopharmacology, 19, 9–14. doi:10.1097/00004714-199902000-00004
  • An, L., Ravindran, P. P., Renukunta, S., & Denduluri, S. (2013). Co-medication of pravastatin and paroxetine-a categorical study. Journal of Clinical Pharmacology, 53, 1212–1219. doi:10.1002/jcph.151
  • Azaz-Livshits, T. L. & Danenberg, H. D. (1997). Tachycardia, orthostatic hypotension and profound weakness due to concomitant use of fluoxetine and nifedipine. Pharmacopsychiatry, 30, 274–275. doi:10.1055/s-2007-979508
  • Baker, B., Dorian, P., Sandor, P., Shapiro, C., Schell, C., Mitchell, J., … Irvine, M. J. (1997). Electrocardiographic effects of fluoxetine and doxepin in patients with major depressive disorder. Journal of Clinical Psychopharmacology, 17, 15–21 doi:10.1097/00004714-199702000-00004
  • Bauer, M., Severus, E., Kohler, S., Whybrow, P. C., Angst, J., & Moller, H. J. (2015). World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of unipolar depressive disorders. Part 2: Maintenance treatment of major depressive disorder-update 2015. World Journal of Biological Psychiatry, 16, 76–95. doi:10.3109/15622975.2014.1001786
  • Bavle, A. D. & Phatak, A. S. (2013). Bupropion-warfarin combination: A serious complication. Indian Journal of Psychological Medicine, 35, 311–313. doi:10.4103/0253-7176.119488
  • Benfield, P. & Ward, A. (1986). Fluvoxamine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness. Drugs, 32, 313–334. doi:10.2165/00003495-198632040-00002
  • Briciu, C., Neag, M., Muntean, D., Vlase, L., Bocsan, C., Buzoianu, A., … Popa, A. (2014). A pharmacokinetic drug interaction study between nebivolol and paroxetine in healthy volunteers. Journal of Clinical Pharmacy and Therapeutics, 39, 535–540. doi:10.1111/jcpt.12180
  • Brosen, K. & Naranjo, C. A. (2001). Review of pharmacokinetic and pharmacodynamic interaction studies with citalopram. European Neuropsychopharmacology, 11, 275–283. doi:10.1016/S0924-977X(01)00101-8
  • Carney, R. M. & Freedland, K. E. (2017). Depression and coronary heart disease. Nature Reviews Cardiology, 14, 145–155. doi:10.1038/nrcardio.2016.181
  • Castro, V. M., Clements, C. C., Murphy, S. N., Gainer, V. S., Fava, M., Weilburg, J. B., … Perlis, R. H. (2013). QT interval and antidepressant use: A cross sectional study of electronic health records. British Medical Journal, 346, f288. doi:10.1136/bmj.f288
  • Chang, C. C., Tzeng, N. S., Yeh, C. B., Kuo, T. B. J., Huang, S. Y., & Chang, H. A. (2017). Effects of depression and melatonergic antidepressant treatment alone and in combination with sedative-hypnotics on heart rate variability: Implications for cardiovascular risk. The World Journal of Biological Psychiatry, 1–11.
  • Chappell, J., He, J., Knadler, M. P., Mitchell, M., Lee, D., & Lobo, E. (2009). Effects of duloxetine on the pharmacodynamics and pharmacokinetics of warfarin at steady state in healthy subjects. Journal of Clinical Pharmacology, 49, 1456–1466. doi:10.1177/0091270009344335
  • Chen, G., Zhang, W., & Serenko, M. (2015). Lack of effect of multiple doses of vortioxetine on the pharmacokinetics and pharmacodynamics of aspirin and warfarin. Journal of Clinical Pharmacology, 55, 671–679. doi:10.1002/jcph.456
  • Cohen, H. W., Gibson, G., & Alderman, M. H. (2000). Excess risk of myocardial infarction in patients treated with antidepressant medications: Association with use of tricyclic agents. The American Journal of Medicine, 108, 2–8. doi:10.1016/S0002-9343(99)00301-0
  • Coupland, C., Dhiman, P., Morriss, R., Arthur, A., Barton, G., & Hippisley-Cox, J. (2011). Antidepressant use and risk of adverse outcomes in older people: Population based cohort study. British Medical Journal, 343, d4551. doi:10.1136/bmj.d4551
  • Coupland, C., Hill, T., Morriss, R., Moore, M., Arthur, A., & Hippisley-Cox, J. (2016). Antidepressant use and risk of cardiovascular outcomes in people aged 20 to 64: Cohort study using primary care database. British Medical Journal, 352, i1350.
  • Cupp, M. J. & Tracy, T. S. (1998). Cytochrome P450: New nomenclature and clinical implications. American Family Physician, 57, 107–116.
  • Davidson, K. W. (2012). Depression and coronary heart disease. International Scholarly Research Notices Cardiology, 2012, 743813. doi:10.5402/2012/743813
  • de Abajo, F. J. (2011). Effects of selective serotonin reuptake inhibitors on platelet function: Mechanisms, clinical outcomes and implications for use in elderly patients. Drugs Aging, 28, 345–367. doi:10.2165/11589340-000000000-00000
  • de Boer, R. A., van Dijk, T. H., Holman, N. D., & van Melle, J. P. (2005). QT interval prolongation after sertraline overdose: A case report. BMC Emergency Medicine, 5, 5. doi:10.1186/1471-227X-5-5
  • de Jonge, P., Spijkerman, T. A., van den Brink, R. H., & Ormel, J. (2006). Depression after myocardial infarction is a risk factor for declining health related quality of life and increased disability and cardiac complaints at 12 months. Heart, 92, 32–39. doi:10.1136/hrt.2004.059451
  • Delavenne, X., Magnin, M., Basset, T., Piot, M., Mallouk, N., Ressnikoff, D., … Mismetti, P. (2013). Investigation of drug-drug interactions between clopidogrel and fluoxetine. Fundamental & Clinical Pharmacology, 27, 683–689. doi:10.1111/fcp.12021
  • Dent, L. A. & Orrock, M. W. (1997). Warfarin-fluoxetine and diazepam-fluoxetine interaction. Pharmacotherapy, 17, 170–172.
  • Dezsi, C. A. & Szentes, V. (2017). The real role of beta-blockers in daily cardiovascular therapy. American Journal of Cardiovascular Drugs, 17, 361–373. doi:10.1007/s40256-017-0221-8
  • Diaper, A., Rich, A. S., Wilson, S. J., Craig, K., Dourish, C. T., Dawson, G. R., … Bailey, J. E. (2013). Changes in cardiovascular function after venlafaxine but not pregabalin in healthy volunteers: a double-blind, placebo-controlled study of orthostatic challenge, blood pressure and heart rate. Human Psychopharmacology, 28, 562–575. doi:10.1002/hup.2346
  • Dold, M. & Kasper, S. (2017). Evidence-based pharmacotherapy of treatment-resistant unipolar depression. International Journal of Psychiatry in Clinical Practice, 21, 13–23. doi:10.1080/13651501.2016.1248852
  • Donazzolo, Y., Latreille, M., Caillaud, M. A., Mocaer, E., & Seguin, L. (2014). Evaluation of the effects of therapeutic and supratherapeutic doses of agomelatine on the QT/QTc interval: A phase I, randomized, double-blind, placebo-controlled and positive-controlled, crossover thorough QT/QTc study conducted in healthy volunteers. Journal of Cardiovascular Pharmacology, 64, 440–451. doi:10.1097/FJC.0000000000000136
  • Druteika, D. & Zed, P. J. (2002). Cardiotoxicity following bupropion overdose. The Annals of Pharmacotherapy, 36, 1791–1795. doi:10.1345/aph.1C045
  • Egede, L. E. (2007). Major depression in individuals with chronic medical disorders: Prevalence, correlates and association with health resource utilization, lost productivity and functional disability. General Hospital Psychiatry, 29, 409–416. doi:10.1016/j.genhosppsych.2007.06.002
  • Ellison, J. M., Milofsky, J. E., & Ely, E. (1990). Fluoxetine-induced bradycardia and syncope in two patients. The Journal of Clinical Psychiatry, 51, 385–386.
  • Fayssoil, A., Issi, J., Guerbaa, M., Raynaud, J. C., & Heroguelle, V. (2011). Torsade de pointes induced by citalopram and amiodarone. Annales De Cardiologie Et D Angeiologie, 60, 165–168. doi:10.1016/j.ancard.2010.12.002
  • Franco, V. (2015). Wide complex tachycardia after bupropion overdose. The American Journal of Emergency Medicine, 33, 1540–1545. doi:S0735-6757(15)00619-1
  • Frasure-Smith, N., Lesperance, F., Gravel, G., Masson, A., Juneau, M., Talajic, M., & Bourassa, M. G. (2000). Depression and health-care costs during the first year following myocardial infarction. The Journal of Psychosomatic Research, 48, 471–478. doi:10.1016/S0022-3999(99)00088-4
  • Frasure-Smith, N., Lesperance, F., & Talajic, M. (1993). Depression following myocardial infarction. Impact on 6-month survival. The Journal of the American Medical Association, 270, 1819–1825. doi:10.1001/jama.1993.03510150053029
  • Gelenberg, A. J., Freeman, M. P., Markowitz, J. C., Rosenbaum, J. F., Thase, M. E., Trivedi, M. H. et al. (2010). Practice guideline for the treatment of patients with major depressive disorder. (3rd ed.). Washington, DC: American Psychiatric Association.
  • Ghanizadeh, A. & Hedayati, A. (2013). Augmentation of fluoxetine with lovastatin for treating major depressive disorder, a randomized double-blind placebo controlled-clinical trial. Depression and Anxiety, 30, 1084–1088. doi:10.1002/da.22195
  • Gheldiu, A. M., Popa, A., Neag, M., Muntean, D., Bocsan, C., Buzoianu, A., … Briciu, C. (2016). Assessment of a potential pharmacokinetic interaction between nebivolol and bupropion in healthy volunteers. Pharmacology, 98, 190–198. doi:10.1159/000447266
  • Gheldiu, A. M., Vlase, L., Popa, A., Briciu, C., Muntean, D., Bocsan, C., … Neag, M. (2017). Investigation of a potential pharmacokinetic interaction between nebivolol and fluvoxamine in healthy volunteers. Journal of Pharmacy and Pharmaceutical Sciences, 20, 68–80. doi:10.18433/J3B61H
  • Girardin, F. R., Gex-Fabry, M., Berney, P., Shah, D., Gaspoz, J. M., & Dayer, P. (2013). Drug-induced long QT in adult psychiatric inpatients: The 5-year cross-sectional ECG screening outcome in psychiatry study. The American Journal of Psychiatry, 170, 1468–1476. doi:10.1176/appi.ajp.2013.12060860
  • Glassman, A. H., O'Connor, C. M., Califf, R. M., Swedberg, K., Schwartz, P., Bigger, J. T., Jr., … Mclvor, M. (2002). Sertraline treatment of major depression in patients with acute MI or unstable angina. The Journal of the American Medical Association, 288, 701–709. doi:10.1001/jama.288.6.701
  • Goldstein, C. M., Gathright, E. C., & Garcia, S. (2017). Relationship between depression and medication adherence in cardiovascular disease: the perfect challenge for the integrated care team. Patient Preference and Adherence, 11, 547–559. doi:10.2147/PPA.S127277
  • Goryachkina, K., Burbello, A., Boldueva, S., Babak, S., Bergman, U., & Bertilsson, L. (2008). Inhibition of metoprolol metabolism and potentiation of its effects by paroxetine in routinely treated patients with acute myocardial infarction (AMI). The European Journal of Clinical Pharmacology, 64, 275–282. doi:10.1007/s00228-007-0404-3
  • Gougol, A., Zareh-Mohammadi, N., Raheb, S., Farokhnia, M., Salimi, S., Iranpour, N., … Akhondzadeh, S. (2015). Simvastatin as an adjuvant therapy to fluoxetine in patients with moderate to severe major depression: A double-blind placebo-controlled trial. Journal of Psychopharmacology, 29, 575–581. doi:10.1177/0269881115578160
  • Graff, D. W., Williamson, K. M., Pieper, J. A., Carson, S. W., Adams, K. F., Jr., Cascio, W. E., … Patterson, J. H. (2001). Effect of fluoxetine on carvedilol pharmacokinetics, CYP2D6 activity, and autonomic balance in heart failure patients. Journal of Clinical Pharmacology, 41, 97–106. doi:10.1177/00912700122009746
  • Hanash, J. A., Hansen, B. H., Hansen, J. F., Nielsen, O. W., Rasmussen, A., & Birket-Smith, M. (2012). Cardiovascular safety of one-year escitalopram therapy in clinically nondepressed patients with acute coronary syndrome: Results from the depression in patients with Coronary Artery Disease (DECARD) trial. Journal of Cardiovascular Pharmacology, 60, 397–405. doi:10.1097/FJC.0b013e3182677041
  • Hansen, R. A., Khodneva, Y., Glasser, S. P., Qian, J., Redmond, N., & Safford, M. M. (2016). Antidepressant medication use and its association with cardiovascular disease and all-cause mortality in the reasons for geographic and racial differences in stroke (REGARDS) study. The Annals of Pharmacotherapy, 50, 253–261. doi:10.1177/1060028015625284
  • Hemeryck, A., Lefebvre, R. A., De, V. C., & Belpaire, F. M. (2000). Paroxetine affects metoprolol pharmacokinetics and pharmacodynamics in healthy volunteers. Clinical Pharmacology and Therapeutics, 67, 283–291. doi:10.1067/mcp.2000.104788
  • Hewer, W., Rost, W., & Gattaz, W. F. (1995). Cardiovascular effects of fluvoxamine and maprotiline in depressed patients. European Archives of Psychiatry and Clinical Neuroscience, 246, 1–6. doi:10.1007/BF02191808
  • Ho, J. M., Gomes, T., Straus, S. E., Austin, P. C., Mamdani, M., & Juurlink, D. N. (2014). Adverse cardiac events in older patients receiving venlafaxine: A population-based study. The Journal of Clinical Psychiatry, 75, e552–e558. doi:10.4088/JCP.13m08508
  • Hohnloser, S. H., Klingenheben, T., & Singh, B. N. (1994). Amiodarone-associated proarrhythmic effects. A review with special reference to torsade de pointes tachycardia. Annals of Internal Medicine, 121, 529–535. doi:10.7326/0003-4819-121-7-199410010-00009
  • Howell, C., Wilson, A. D., & Waring, W. S. (2007). Cardiovascular toxicity due to venlafaxine poisoning in adults: A review of 235 consecutive cases. British Journal of Clinical Pharmacology, 64, 192–197. doi:10.1111/j.1365-2125.2007.02849.x
  • Jiang, W. & Davidson, J. R. (2005). Antidepressant therapy in patients with ischemic heart disease. American Heart Journal, 150, 871–881. doi:10.1016/j.ahj.2005.01.041
  • Kaar, J. L., Luberto, C. M., Campbell, K. A., & Huffman, J. C. (2017). Sleep, health behaviors, and behavioral interventions: Reducing the risk of cardiovascular disease in adults. The World Journal of Cardiology, 9, 396–406. doi:10.4330/wjc.v9.i5.396
  • Kaplan, N. M. (2004). The place of diuretics in preventing cardiovascular events. Journal Of Human Hypertension, 18 Suppl 2, S29–S32.
  • Keller, T. T., Squizzato, A., & Middeldorp, S. (2007). Clopidogrel plus aspirin versus aspirin alone for preventing cardiovascular disease. Cochrane Database of Systematic Reviews, CD005158.
  • Kim, J. M., Bae, K. Y., Stewart, R., Jung, B. O., Kang, H. J., Kim, S. W. et al. (2015). Escitalopram treatment for depressive disorder following acute coronary syndrome: A 24-week double-blind, placebo-controlled trial. The Journal of Clinical Psychiatry, 76, 62–68.
  • Kleiger, R. E., Miller, J. P., Bigger, J. T., Jr., & Moss, A. J. (1987). Decreased heart rate variability and its association with increased mortality after acute myocardial infarction. American Journal of Cardiology, 59, 256–262. doi:10.1016/0002-9149(87)90795-8
  • Koide, T., Wakabayashi, T., Matsuda, T., Horiike, S., & Watanabe, K. (2010). Hyponatremia associated with paroxetine induced by sodium-restricted diet and hypotonic saline. Pharmacy World & Science, 32, 19–21. doi:10.1007/s11096-009-9353-5
  • Konig, F., Hafele, M., Hauger, B., Loble, M., Wossner, S., & Wolfersdorf, M. (1996). Bradycardia after beginning therapy with metoprolol and paroxetine. Psychiatrische Praxis, 23, 244–245.
  • Krishnan, K. R., Doraiswamy, P. M., & Clary, C. M. (2001). Clinical and treatment response characteristics of late-life depression associated with vascular disease: A pooled analysis of two multicenter trials with sertraline. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 25, 347–361. doi:10.1016/S0278-5846(00)00168-8
  • Kubota, T. & Miyata, A. (2006). Syndrome of inappropriate secretion of antidiuretic hormone associated with paroxetine. The Journal of Anesthesia, 20, 126–128. doi:10.1007/s00540-005-0381-6
  • Laird, L. K., Lydiard, R. B., Morton, W. A., Steele, T. E., Kellner, C., Thompson, N. M., & Ballenger, J. C. (1993). Cardiovascular effects of imipramine, fluvoxamine, and placebo in depressed outpatients. The Journal of Clinical Psychiatry, 54, 224–228.
  • Larsen, F., Priskorn, M., & Overo, K. F. (2001). Lack of citalopram effect on oral digoxin pharmacokinetics. Journal of Clinical Pharmacology, 41, 340–346. doi:10.1177/00912700122010041
  • Leibovitz, A., Bilchinsky, T., Gil, I., & Habot, B. (1998). Elevated serum digoxin level associated with coadministered fluoxetine. Archives of Internal Medicine, 158, 1152–1153. doi:10.1001/archinte.158.10.1152
  • Leonard, C. E., Bilker, W. B., Newcomb, C., Kimmel, S. E., & Hennessy, S. (2011). Antidepressants and the risk of sudden cardiac death and ventricular arrhythmia. Pharmacoepidemiology and Drug Safety, 20, 903–913. doi:10.1002/pds.2181
  • Letsas, K., Korantzopoulos, P., Pappas, L., Evangelou, D., Efremidis, M., & Kardaras, F. (2006). QT interval prolongation associated with venlafaxine administration. The International Journal of Cardiology, 109, 116–117. doi:10.1016/j.ijcard.2005.03.065
  • Li, Z., Li, Y., Chen, L., Chen, P., & Hu, Y. (2015). Prevalence of depression in patients with hypertension: A systematic review and meta-analysis. Medicine (Baltimore), 94, e1317.
  • Lichtman, J. H., Bigger, J. T., Jr., Blumenthal, J. A., Frasure-Smith, N., Kaufmann, P. G., Lesperance, F. et al. (2008). Depression and coronary heart disease: recommendations for screening, referral, and treatment: A science advisory from the American Heart Association Prevention Committee of the Council on Cardiovascular Nursing, Council on Clinical Cardiology, Council on Epidemiology and Prevention, and Interdisciplinary Council on Quality of Care and Outcomes Research: Endorsed by the American Psychiatric Association. Circulation, 118, 1768–1775.
  • Limke, K. K., Shelton, A. R., & Elliott, E. S. (2002). Fluvoxamine interaction with warfarin. The Annals of Pharmacotherapy, 36, 1890–1892. doi:10.1345/aph.1C112
  • LoVecchio, F., Riley, B., Pizon, A., & Brown, M. (2008). Outcomes after isolated mirtazapine (Remeron) supratherapeutic ingestions. The Journal of Emergency Medicine, 34, 77–78. doi:10.1016/j.jemermed.2007.03.006
  • May, H. T., Bair, T. L., Reiss-Brennan, B., Knight, S., Anderson, J. L., Horne, B. D., & Muhlestein, J. B. (2017a). The association of antidepressant and statin use with death and incident cardiovascular disease varies by depression severity. Psychology, Health & Medicine, 22, 919–931. doi:10.1080/13548506.2017.1281975
  • May, H. T., Horne, B. D., Carlquist, J. F., Sheng, X., Joy, E., & Catinella, A. P. (2009). Depression after coronary artery disease is associated with heart failure. Journal of the American College of Cardiology, 53, 1440–1447.
  • May, H. T., Horne, B. D., Knight, S., Knowlton, K. U., Bair, T. L., Lappe, D. L., … Muhlestein, J. B. (2017b). The association of depression at any time to the risk of death following coronary artery disease diagnosis. European Heart Journal - Quality of Care & Clinical Outcomes, 3, 296–302. doi:10.1093/ehjqcco/qcx017
  • Mbaya, P., Alam, F., Ashim, S., & Bennett, D. (2007). Cardiovascular effects of high dose venlafaxine XL in patients with major depressive disorder. Human Psychopharmacology, 22, 129–133. doi:10.1002/hup.834
  • McCollum, D. L., Greene, J. L., & McGuire, D. K. (2004). Severe sinus bradycardia after initiation of bupropion therapy: A probable drug-drug interaction with metoprolol. Cardiovascular Drugs and Therapy, 18, 329–330. doi:10.1023/B:CARD.0000041254.15807.98
  • Medvedev, V. E. (2017). Agomelatine in the treatment of mild-to-moderate depression in patients with cardiovascular disease: Results of the national multicenter observational study PULSE. Neuropsychiatric Disease and Treatment, 13, 1141–1151. doi:10.2147/NDT.S129793
  • Meng, L., Chen, D., Yang, Y., Zheng, Y., & Hui, R. (2012). Depression increases the risk of hypertension incidence: A meta-analysis of prospective cohort studies. Journal of Hypertension, 30, 842–851. doi:10.1097/HJH.0b013e32835080b7
  • Mermi, O. & Atmaca, M. (2016). Duloxetine-induced hypertension: A case report. Turkish journal of psychiatry, 27, 67–69.
  • Molnari, J. C., Hassan, H. E., Moeller, B. M., & Myers, A. L. (2011). Drug interaction study between bupropion and ticlopidine in male CF-1 mice. Biological and Pharmaceutical Bulletin, 34, 447–451. doi:JST.JSTAGE/bpb/34.447
  • Mori, M., Koide, T., Imanishi, Y., Matsui, Y., & Matsuda, T. (2014). Duloxetine-induced hyponatremia in an elderly patient treated with thiazide diuretics. Indian Journal of Pharmacology, 46, 657–659. doi:10.4103/0253-7613.144947
  • Olfson, M. & Marcus, S. C. (2009). National patterns in antidepressant medication treatment. Archives of General Psychiatry, 66, 848–856. doi:10.1001/archgenpsychiatry.2009.81
  • Onalan, O., Cumurcu, B. E., & Bekar, L. (2008). Complete atrioventricular block associated with concomitant use of metoprolol and paroxetine. Mayo Clinic Proceedings, 83, 595–599.
  • Orsolini, L., Tomasetti, C., Valchera, A., Iasevoli, F., Buonaguro, E. F., Fornaro, M., … Berardis, D. (2017). Current and future perspectives on the major depressive disorder: Focus on the new multimodal antidepressant vortioxetine. CNS & Neurological Disorders - Drug Targets, 16, 65–92. doi:10.2174/1871527315666161025140111
  • Parker, R. B. & Soberman, J. E. (2011). Effects of paroxetine on the pharmacokinetics and pharmacodynamics of immediate-release and extended-release metoprolol. Pharmacotherapy, 31, 630–641. doi:10.1592/phco.31.7.630
  • Paz-Filho, G., Licinio, J., & Wong, M. L. (2010). Pathophysiological basis of cardiovascular disease and depression: A chicken-and-egg dilemma. Revista Brasileira de Psiquiatria, 32, 181–191. doi:S1516-44462010000200015
  • Penninx, B. W. (2017). Depression and cardiovascular disease: Epidemiological evidence on their linking mechanisms. Neuroscience and Biobehavioral Reviews, 74, 277–286. doi:10.1016/j.neubiorev.2016.07.003
  • Perucca, E., Gatti, G., & Spina, E. (1994). Clinical pharmacokinetics of fluvoxamine. Clinical Pharmacokinetics, 27, 175–190. doi:10.2165/00003088-199427030-00002
  • Preskorn, S. H., Greenblatt, D. J., Flockhart, D., Luo, Y., Perloff, E. S., Harmatz, J. S., … Burt, T. (2007). Comparison of duloxetine, escitalopram, and sertraline effects on cytochrome P450 2D6 function in healthy volunteers. Journal of Clinical Psychopharmacology, 27, 28–34. doi:10.1097/00004714-200702000-00005
  • Priskorn, M., Sidhu, J. S., Larsen, F., Davis, J. D., Khan, A. Z., & Rolan, P. E. (1997). Investigation of multiple dose citalopram on the pharmacokinetics and pharmacodynamics of racemic warfarin. British Journal of Clinical Pharmacology, 44, 199–202.
  • Rajpurohit, N., Aryal, S. R., Khan, M. A., Stys, A. T., & Stys, T. P. (2014). Propafenone associated severe central nervous system and cardiovascular toxicity due to mirtazapine: A case of severe drug interaction. South Dakota Journal of Medicine, 67, 137–139.
  • Rapeport, W. G., Coates, P. E., Dewland, P. M., & Forster, P. L. (1996). Absence of a sertraline-mediated effect on digoxin pharmacokinetics and electrocardiographic findings. The Journal of Clinical Psychiatry, 57, 16–19.
  • Ray, W. A., Chung, C. P., Murray, K. T., Hall, K., & Stein, C. M. (2017). High-dose citalopram and escitalopram and the risk of out-of-hospital death. The Journal of Clinical Psychiatry, 78, 190–195. doi:10.4088/JCP.15m10324
  • Renshaw, P. F., Parsegian, A., Yang, C. K., Novero, A., Yoon, S. J., Lyoo, I. K., … Carlezon, W. A., Jr. (2009). Lovastatin potentiates the antidepressant efficacy of fluoxetine in rats. Pharmacology Biochemistry & Behavior, 92, 88–92. doi:10.1016/j.pbb.2008.10.017
  • Reznik, I., Rosen, Y., & Rosen, B. (1999). An acute ischaemic event associated with the use of venlafaxine: A case report and proposed pathophysiological mechanisms. Journal of Psychopharmacology, 13, 193–195. doi:10.1177/026988119901300212
  • Roos, J. C. (1983). Cardiac effects of antidepressant drugs. A comparison of the tricyclic antidepressants and fluvoxamine. British Journal of Clinical Pharmacology, 15, 439S–445S. doi:10.1111/j.1365-2125.1983.tb02135.x
  • Roose, S. P., Dalack, G. W., Glassman, A. H., Woodring, S., Walsh, B. T., & Giardina, E. G. (1991). Cardiovascular effects of bupropion in depressed patients with heart disease. The American Journal of Psychiatry, 148, 512–516. doi:10.1176/ajp.148.4.512
  • Roose, S. P., Glassman, A. H., Attia, E., Woodring, S., Giardina, E. G., & Bigger, J. T., Jr. (1998a). Cardiovascular effects of fluoxetine in depressed patients with heart disease. The American Journal of Psychiatry, 155, 660–665. doi:10.1176/ajp.155.5.660
  • Roose, S. P., Laghrissi-Thode, F., Kennedy, J. S., Nelson, J. C., Bigger, J. T., Jr., Pollock, B. G., … Gergel, I. (1998b). Comparison of paroxetine and nortriptyline in depressed patients with ischemic heart disease. The Journal of the American Medical Association, 279, 287–291. doi:10.1001/jama.279.4.287
  • Rutledge, T., Reis, V. A., Linke, S. E., Greenberg, B. H., & Mills, P. J. (2006). Depression in heart failure a meta-analytic review of prevalence, intervention effects, and associations with clinical outcomes. Journal of the American College of Cardiology, 48, 1527–1537. doi:10.1016/j.jacc.2006.06.055
  • Santangelo, A., Testai, M., Barbagallo, P., Crisafulli, C., Grasso, S., Manuele, S. et al. (2009). Use of specific serotonin reuptake inhibitors (SSRIs) (Sertraline or Citalopram) in the treatment of depression reduces the cardiovascular risk in the elderly: Evidence from a Sicilian population >80 years recovered in the assisted sanitary residences (RSA). Archives of Gerontology and Geriatrics, 48, 350–352.
  • Serebruany, V. L., Glassman, A. H., Malinin, A. I., Nemeroff, C. B., Musselman, D. L., van Zyl, L. T., … O'Connor, C. M. (2003). Platelet/endothelial biomarkers in depressed patients treated with the selective serotonin reuptake inhibitor sertraline after acute coronary events: The Sertraline AntiDepressant Heart Attack Randomized Trial (SADHART) Platelet Substudy. Circulation, 108, 939–944. doi:10.1161/01.CIR.0000085163.21752.0A
  • Servier Laboratories. (2015). Summary of product characteristics: Valdoxan. Retrieved from https://www.medicines.org.uk/emc/medicine/21830
  • Shah, S. U., Anjum, S., & Littler, W. A. (2004a). Use of diuretics in cardiovascular disease: (2) hypertension. Postgraduate Medical Journal, 80, 271–276. doi:10.1136/pgmj.2003.010843
  • Shah, S. U., Anjum, S., & Littler, W. A. (2004b). Use of diuretics in cardiovascular diseases: (1) heart failure. Postgrad. Med. J, 80, 201–205.
  • Shah, S. U., Anjum, S., & Littler, W. A. (2004). Use of diuretics in cardiovascular diseases: (1) heart failure. Postgraduate Medical Journal, 80, 201–205. doi:10.1136/pgmj.2003.010835
  • Shao, H., Mohammed, M. U., Thomas, N., Babazadeh, S., Yang, S., Shi, Q., & Shi, L. (2017). Evaluating excessive burden of depression on health status and health care utilization among patients with hypertension in a nationally representative sample from the medial expenditure panel survey (MEPS 2012). Journal of Nervous and Mental Disease, 205, 397–404. doi:10.1097/NMD.0000000000000618
  • Shapiro, P. A., Lesperance, F., Frasure-Smith, N., O'Connor, C. M., Baker, B., Jiang, J. W., … Glassman, A. H. (1999). An open-label preliminary trial of sertraline for treatment of major depression after acute myocardial infarction (the SADHAT Trial). Sertraline anti-depressant heart attack trial. American Heart Journal, 137, 1100–1106. doi:10.1016/S0002-8703(99)70369-8
  • Shin, D., Oh, Y. H., Eom, C. S., & Park, S. M. (2014). Use of selective serotonin reuptake inhibitors and risk of stroke: A systematic review and meta-analysis. The Journal of the Neurological Sciences, 261, 686–695. doi:10.1007/s00415-014-7251-9
  • Spindelegger, C. J., Papageorgiou, K., Grohmann, R., Engel, R., Greil, W., Konstantinidis, A., … Kasper, S. (2014). Cardiovascular adverse reactions during antidepressant treatment: A drug surveillance report of German-speaking countries between 1993 and 2010 11. International Journal of Neuropsychopharmacology, 18, 1–9. doi:10.1093/ijnp/pyu080
  • Squizzato, A., Keller, T., Romualdi, E., & Middeldorp, S. (2011). Clopidogrel plus aspirin versus aspirin alone for preventing cardiovascular disease. Cochrane Database of Systematic Reviews, CD005158. doi:10.1002/14651858.CD005158.pub3
  • Stefanska, E., Wendolowicz, A., Cwalina, U., Konarzewska, B., Waszkiewicz, N., & Ostrowska, L. (2016). Eating habits and the risk of cardiovascular disease in patients with recurrent depressive disorders. Psychiatria Polska, 50, 1119–1133. doi:10.12740/PP/62682
  • Stevens, D. L. (2008). Duloxetine-associated tachycardia. Annals of Pharmacotherapy, 42, 1511–1513. 10.1345/aph.1L108
  • Stout, S. M., Nielsen, J., Bleske, B. E., Shea, M., Brook, R., Kerber, K., & Welage, L. S. (2010). The impact of paroxetine coadministration on stereospecific carvedilol pharmacokinetics. Journal of Cardiovascular Pharmacology and Therapeutics, 15, 373–379. doi:10.1177/1074248410372926
  • Stout, S. M., Nielsen, J., Welage, L. S., Shea, M., Brook, R., Kerber, K. (2011). Influence of metoprolol dosage release formulation on the pharmacokinetic drug interaction with paroxetine. Journal of Clinical Pharmacology, 51, 389–396. doi:10.1177/0091270010365559
  • Straneva-Meuse, P. A., Light, K. C., Allen, M. T., Golding, M., & Girdler, S. S. (2004). Bupropion and paroxetine differentially influence cardiovascular and neuroendocrine responses to stress in depressed patients. The Journal of Affective Disorders, 79, 51–61.
  • Strik, J. J., Honig, A., Lousberg, R., Lousberg, A. H., Cheriex, E. C., Tuynman-Qua, H. G., & Bleske, B. E. (2000). Efficacy and safety of fluoxetine in the treatment of patients with major depression after first myocardial infarction: Findings from a double-blind, placebo-controlled trial. Psychosomatic Medicine, 62, 783–789. doi:10.1097/00006842-200011000-00007
  • Swenson, J. R. (2004). Quality of life in patients with coronary artery disease and the impact of depression. Current Psychiatry Reports, 6, 438–445. doi:10.1007/s11920-004-0008-x
  • Swenson, J. R., Doucette, S., & Fergusson, D. (2006). Adverse cardiovascular events in antidepressant trials involving high-risk patients: A systematic review of randomized trials. The Canadian Journal of Psychiatry, 51, 923–929. doi:10.1177/070674370605101408
  • Tatonetti, N. P., Denny, J. C., Murphy, S. N., Fernald, G. H., Krishnan, G., Castro, V., … Altman, R. B. (2011). Detecting drug interactions from adverse-event reports: Interaction between paroxetine and pravastatin increases blood glucose levels. Clinical Pharmacology & Therapeutics, 90, 133–142. doi:10.1038/clpt.2011.83
  • Terhardt, J., Lederbogen, F., Feuerhack, A., Hamann-Weber, B., Gilles, M., Schilling, C. et al. (2013). Heart rate variability during antidepressant treatment with venlafaxine and mirtazapine. Clinical Neuropharmacology, 36, 198–202.
  • Terpening, C. (2009). An appraisal of dual antiplatelet therapy with clopidogrel and aspirin for prevention of cardiovascular events. The Journal of the American Board of Family Medicine, 22, 51–56. doi:10.3122/jabfm.2009.01.070282
  • Thase, M. E. (1998). Effects of venlafaxine on blood pressure: A meta-analysis of original data from 3744 depressed patients. The Journal of Clinical Psychiatry, 59, 502–508.
  • Thase, M. E., Larsen, K. G., Reines, E., & Kennedy, S. H. (2013). The cardiovascular safety profile of escitalopram. European Neuropsychopharmacology, 23, 1391–1400. doi:10.1016/j.euroneuro.2013.05.011
  • Thase, M. E., Tran, P. V., Wiltse, C., Pangallo, B. A., Mallinckrodt, C., & Detke, M. J. (2005). Cardiovascular profile of duloxetine, a dual reuptake inhibitor of serotonin and norepinephrine. Journal of Clinical Psychopharmacology, 25, 132–140. doi:00004714-200504000-00005
  • Turnheim, K. (2003). When drug therapy gets old: Pharmacokinetics and pharmacodynamics in the elderly. Experimental Gerontology, 38, 843–853. doi:S0531556503001335
  • Turpeinen, M., Tolonen, A., Uusitalo, J., Jalonen, J., Pelkonen, O., & Laine, K. (2005). Effect of clopidogrel and ticlopidine on cytochrome P450 2B6 activity as measured by bupropion hydroxylation. Clinical Pharmacology & Therapeutics, 77, 553–559.
  • van Zyl, L. T., Lesperance, F., Frasure-Smith, N., Malinin, A. I., Atar, D., Laliberte, M. A., & Serebruany, V. L. (2009). Platelet and endothelial activity in comorbid major depression and coronary artery disease patients treated with citalopram: The Canadian Cardiac Randomized Evaluation of Antidepressant and Psychotherapy Efficacy Trial (CREATE) biomarker sub-study. The Journal of Thrombosis and Thrombolysis, 27, 48–56. doi:10.1007/s11239-007-0189-3
  • Vanhoutte, P. M. & Gao, Y. (2013). Beta blockers, nitric oxide, and cardiovascular disease. The Current Opinion Journals, 13, 265–273. doi:10.1016/j.coph.2012.12.002
  • Vassallo, P. & Trohman, R. G. (2007). Prescribing amiodarone: An evidence-based review of clinical indications. The Journal of the American Medical Association, 298, 1312–1322. doi:10.1001/jama.298.11.1312
  • Waring, W. S., Rhee, J. Y., Bateman, D. N., Leggett, G. E., & Jamie, H. (2008). Impaired heart rate variability and altered cardiac sympathovagal balance after antidepressant overdose. The European Journal of Pharmacology, 64, 1037–1041. doi:10.1007/s00228-008-0505-7
  • Weber, M. A. (2005). The role of the new beta-blockers in treating cardiovascular disease. American Journal of Hypertension, 18, 169S–176S.
  • Wenger, T. L. & Stern, W. C. (1983). The cardiovascular profile of bupropion. The Journal of Clinical Psychiatry, 44, 176–182.
  • Wernicke, J., Lledo, A., Raskin, J., Kajdasz, D. K., & Wang, F. (2007). An evaluation of the cardiovascular safety profile of duloxetine: Findings from 42 placebo-controlled studies. Drug Safety, 30, 437–455. doi:10.2165/00002018-200730050-00007
  • Weston, C. & Rao, U. (2003). Antiplatelet drugs in cardiovascular diseases. International Journal of Clinical Practice, 57, 898–905.
  • Yap, K. B. & Low, S. T. (1999). Interaction of fluvoxamine with warfarin in an elderly woman. Singapore Medical Journal, 40, 480–482.
  • Yeh, T. C., Kao, L. C., Tzeng, N. S., Kuo, T. B., Huang, S. Y., Chang, C. C., & Chang, H. A. (2016). Heart rate variability in major depressive disorder and after antidepressant treatment with agomelatine and paroxetine: Findings from the Taiwan Study of Depression and Anxiety (TAISDA). Progress in Neuro-Psychopharmacology & Biological Psychiatry, 64, 60–67. doi:10.1016/j.pnpbp.2015.07.007
  • Yeragani, V. K., Pesce, V., Jayaraman, A., & Roose, S. (2002). Major depression with ischemic heart disease: Effects of paroxetine and nortriptyline on long-term heart rate variability measures. Biological Psychiatry, 52, 418–429. doi:10.1016/S0006-3223(02)01394-X
  • Ziegler, M. G. & Wilner, K. D. (1996). Sertraline does not alter the beta-adrenergic blocking activity of atenolol in healthy male volunteers. The Journal of Clinical Psychiatry, 57, 12–15.
  • Zimmer, B., Kant, R., Zeiler, D., & Brilmyer, M. (1997). Antidepressant efficacy and cardiovascular safety of venlafaxine in young vs old patients with comorbid medical disorders. The International Journal of Psychiatry in Medicine, 27, 353–364. doi:10.2190/UDRD-99CB-T6KH-EDKP
  • Zivin, K., Pfeiffer, P. N., Bohnert, A. S., Ganoczy, D., Blow, F. C., Nallamothu, B. K., & Kales, H. C. (2013). Evaluation of the FDA warning against prescribing citalopram at doses exceeding 40 mg. The American Journal of Psychiatry, 170, 642–650. doi:10.1176/appi.ajp.2013.12030408

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