1,588
Views
25
CrossRef citations to date
0
Altmetric
Original Articles

Psychopharmacological treatment of patients with borderline personality disorder: comparing data from routine clinical care with recommended guidelines

, , , &
Pages 178-188 | Received 09 Mar 2018, Accepted 28 Jan 2019, Published online: 29 May 2019

References

  • American-Psychiatric-Association. (2013). Diagnostic and statistical manual of mental disorders (DSM-5®) Arlington, VA: American Psychiatric Publishing doi:10.1176/appi.books.9780890425596.
  • Benkert, O., & Hippius, H. (2017). Kompendium der psychiatrischen Pharmakotherapie. Berlin Heidelberg: Springer-Verlag.
  • Black, D. W., Blum, N., Pfohl, B., & Hale, N. (2004). Suicidal behavior in borderline personality disorder: prevalence, risk factors, prediction, and prevention. Journal of Personality Disorders, 18, 226–239. doi:10.1521/pedi.18.3.226.35445
  • Bridler, R., Häberle, A., Müller, S. T., Cattapan, K., Grohmann, R., Toto, S., … Greil, W. (2015). Psychopharmacological treatment of 2195 in-patients with borderline personality disorder: A comparison with other psychiatric disorders. European Journal of Neuropsychopharmacology, 25, 763–772. doi:10.1016/j.euroneuro.2015.03.017
  • Bullinger, M., Kirchberger, I., & Ware, J. (1995). Der deutsche SF-36 Health Survey. Übersetzung und psychometrische Testung eines krankheitsübergreifenden Instruments zur Erfassung der gesundheitsbezogenen Lebensqualität. Journal of Public Health, 3, 21. doi:10.1007/BF02959944
  • CBO. (2008). Dutch Multidisciplinary Guideline for the diagnosis and treatment of personality disorders. Utrecht, The Netherlands: Trimbos-instituut.
  • Cohen, J. (1988). Statistical power analysis for the behavioral sciences (Vol. 2). Hillsdale, NJ: Erlbaum Associates.
  • Coid, J., Yang, M., Tyrer, P., Roberts, A., & Ullrich, S. (2006). Prevalence and correlates of personality disorder in Great Britain. The British Journal of Psychiatry: The Journal of Mental Science, 188, 423–431. doi:10.1192/bjp.188.5.423
  • Coulston, C. M., Tanious, M., Mulder, R. T., Porter, R. J., & Malhi, G. S. (2012). Bordering on bipolar: the overlap between borderline personality and bipolarity. Australian & New Zealand Journal of Psychiatry, 46, 506–521. doi:10.1177/0004867412445528
  • Cuthbert, B. N. (2014). The RDoC framework: facilitating transition from ICD/DSM to dimensional approaches that integrate neuroscience and psychopathology. World Psychiatry, 13, 28–35. doi:10.1002/wps.20087
  • Davids, E., Bunk, C., Specka, M., & Gastpar, M. (2006). Psychotropic drug prescription in a psychiatric university hospital in Germany. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 30, 1109–1116. doi:10.1016/j.pnpbp.2006.04.015
  • Dilling, H., Mombour, W., Schmidt, M. H., & Organization, W. H. (2011). Internationale Klassifikation psychischer Sto¨rungen: ICD-10, Kapitel V (F, klinisch-diagnostische Leitlinien). Bern, Switzerland: Hans Huber.
  • El-Gabalawy, R., Katz, L. Y., & Sareen, J. (2010). Comorbidity and associated severity of borderline personality disorder and physical health conditions in a nationally representative sample. Psychosomatic Medicine, 72, 641–647. doi:10.1097/PSY.0b013e3181e10c7b
  • Franke, G. H., & Derogatis, L. R. (1995). Die Symptom-Checkliste von Derogatis-Deutsche Version Göttingen, Germany: Beltz.
  • Frankenburg, F. R., & Zanarini, M. C. (2004). The association between borderline personality disorder and chronic medical illnesses, poor health-related lifestyle choices, and costly forms of health care utilization. The Journal of Clinical Psychiatry, 65, 1660–1665. doi:10.4088/JCP.v65n1211
  • Frankenburg, F. R., & Zanarini, M. C. (2006). Personality disorders and medical comorbidity. Current Opinion in Psychiatry, 19, 428–431. doi:10.1097/01.yco.0000228766.33356.44
  • Grant, B. F., Chou, S. P., Goldstein, R. B., Huang, B., Stinson, F. S., Saha, T. D., … Ruan, W. J. (2008). Prevalence, correlates, disability, and comorbidity of DSM-IV borderline personality disorder: results from the Wave 2 National Epidemiologic Survey on Alcohol and Related Conditions. The Journal of Clinical Psychiatry, 69, 533. doi:10.4088/JCP.v69n0404
  • Gross, R., Olfson, M., Gameroff, M., Shea, S., Feder, A., Fuentes, M., … Weissman, M. M. (2002). Borderline personality disorder in primary care. Archives of Internal Medicine, 162, 53–60. doi:10.1001/archinte.162.1.53
  • Gunderson, J. G., Stout, R. L., McGlashan, T. H., Shea, M. T., Morey, L. C., Grilo, C. M., … Skodol, A. E. (2011). Ten-year course of borderline personality disorder: Psychopathology and function from the Collaborative Longitudinal Personality Disorders study. Archives of General Psychiatry, 68, 827–837. doi:10.1001/archgenpsychiatry.2011.37
  • Haw, C., & Stubbs, J. (2011). Medication for borderline personality disorder: a survey at a secure hospital. International Journal of Psychiatry in Clinical Practice, 15, 270–274. doi:10.3109/13651501.2011.590211
  • Herpertz, S. C. (2011). Was bringt das DSM-V Neues zur Klassifikation der Persönlichkeitsstörungen?. Zeitschrift Für Psychiatrie, Psychologie Und Psychotherapie, 59, 261–266. doi:10.1024/1661-4747/a000080
  • Herpertz, S. C., Bohus, M., & Buchheim, P. (2008). S2-Leitlinien Persönlichkeitsstörungen. Retrieved from https://www.dgppn.de/_Resources/Persistent/b642eee188e70d80f260400da7417915d931105d/s2-LL-persoenlichkeitsstoerungen.pdf
  • Herpertz, S. C., Zanarini, M., Schulz, C. S., Siever, L., Lieb, K., Möller, H.-J., & Wfsbp Task Force On Personality, D. (2007). World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for biological treatment of personality disorders. The World Journal of Biological Psychiatry, 8, 212–244. doi:10.1080/15622970701685224
  • Horowitz, L. M., Strauß, B., & Kordy, H. (1994). IIP-D. Inventar zur Erfassung interpersonaler Probleme. Deutsche Version. Göttingen, Germany: Beltz.
  • Hörz, S., Zanarini, M. C., Frankenburg, F. R., Reich, D. B., & Fitzmaurice, G. (2010). Ten-year use of mental health services by patients with borderline personality disorder and with other axis II disorders. Psychiatric Services, 61, 612–616. doi:10.1176/ps.2010.61.6.612
  • Ingenhoven, T. J. (2015). Pharmacotherapy for borderline patients: business as usual or by default?. The Journal of Clinical Psychiatry, 76, 522–523.
  • Ingenhoven, T. J., & Duivenvoorden, H. J. (2011). Differential effectiveness of antipsychotics in borderline personality disorder: meta-analyses of placebo-controlled, randomized clinical trials on symptomatic outcome domains. Journal of Clinical Psychopharmacology, 31, 489–496. doi:10.1097/JCP.0b013e3182217a69
  • Ingenhoven, T. J., Lafay, P., Rinne, T., Passchier, J., & Duivenvoorden, H. (2010). Effectiveness of pharmacotherapy for severe personality disorders: meta-analyses of randomized controlled trials. The Journal of Clinical Psychiatry, 71, 14–25. doi:10.4088/JCP.08r04526gre)
  • Knoblich, N., Gundel, F., Brückmann, C., Becker-Sadzio, J., Frischholz, C., & Nieratschker, V. (2018). DNA methylation of APBA3 and MCF2 in borderline personality disorder: Potential biomarkers for response to psychotherapy. European Neuropsychopharmacology, 28, 252–263. doi:10.1016/j.euroneuro.2017.12.010
  • Korzekwa, M. I., Dell, P. F., Links, P. S., Thabane, L., & Webb, S. P. (2008). Estimating the prevalence of borderline personality disorder in psychiatric outpatients using a two-phase procedure. Comprehensive Psychiatry, 49, 380–386. doi:10.1016/j.comppsych.2008.01.007
  • Kroeze, W. K., & Roth, B. L. (2012). Polypharmacological drugs: “Magic Shotguns” for psychiatric diseases. In J. Peters (Ed.), Polypharmacology in drug discovery (pp. 133–148). Hoboken, NJ: Wiley.
  • Lakens, D. (2013). Calculating and reporting effect sizes to facilitate cumulative science: a practical primer for t-tests and ANOVAs. Front Psychol, 4, 863. doi:10.3389/fpsyg.2013.00863
  • Lenzenweger, M. F. (2008). Epidemiology of personality disorders. Psychiatric Clinics of North America, 31, 395–403, vi. doi:10.1016/j.psc.2008.03.003
  • Lieb, K., Vollm, B., Rucker, G., Timmer, A., & Stoffers, J. M. (2010). Pharmacotherapy for borderline personality disorder: Cochrane systematic review of randomised trials. British Journal of Psychiatry, 196, 4–12. doi:10.1192/bjp.bp.108.062984
  • Loranger, A. W., Sartorius, N., Andreoli, A., Berger, P., Buchheim, P., Channabasavanna, S., … Ferguson, B. (1994). The international personality disorder examination: The World Health Organization/Alcohol, Drug Abuse, and Mental Health Administration international pilot study of personality disorders. Archives of General Psychiatry, 51, 215–224. doi:10.1001/archpsyc.1994.03950030051005
  • Matthies, S. D., & Philipsen, A. (2014). Common ground in attention deficit hyperactivity disorder (ADHD) and borderline personality disorder (BPD)–review of recent findings. Borderline Personality Disorder and Emotion Dysregulation, 1, 3. doi:10.1186/2051-6673-1-3
  • McGirr, A., Paris, J., Lesage, A., Renaud, J., & Turecki, G. (2009). An examination of DSM-IV borderline personality disorder symptoms and risk for death by suicide: a psychological autopsy study. The Canadian Journal of Psychiatry, 54, 87–92. doi:10.1177/070674370905400206
  • Mercer, D., Douglass, A. B., & Links, P. S. (2009). Meta-analyses of mood stabilizers, antidepressants and antipsychotics in the treatment of borderline personality disorder: effectiveness for depression and anger symptoms. Journal of Personality Disorders, 23, 156–174. doi:10.1521/pedi.2009.23.2.156
  • National-Collaborating-Centre-for-Mental-Health. (2009). Borderline personality disorder: Treatment and management. Retrieved from https://www.nice.org.uk/guidance/cg78/evidence/bpd-full-guideline-pdf-242147197
  • National-Health-and-Medical-Research-Council. (2012). Clinical practice guideline for the management of borderline personality disorder. Retrieved from https://www.nhmrc.gov.au/_files_nhmrc/publications/attachments/mh25_borderline_personality_guideline.pdf
  • Nelson, K. J., & Schulz, S. C. (2012). Treatment advances in borderline personality disorder. Psychiatric Annals, 42, 59–64. doi:10.3928/00485713-20120124-06
  • Nemeroff, C. B. (2014). Polypharmacology in psychiatry: Good or bad? CNS Spectrums, 3, 19–19. doi:10.1017/S1092852900005800
  • Oldham, J. M. (2005). Guideline watch: practice guideline for the treatment of patients with borderline personality disorder. FOCUS, 3, 396–400. doi:10.1176/foc.3.3.396
  • Oldham, J. M., Gabbard, G. O., Goin, M. K., Gunderson, J. G., Soloff, P., Spiegel, D., … Phillips, K. A. (2001). Practice guideline for the treatment of patients with borderline personality disorder. The American Journal of Psychiatry, 158, 1–52. Retrieved from http://psychiatryonline.org/pb/assets/raw/sitewide/practice_guidelines/guidelines/bpd.pdf
  • Olejnik, S., & Algina, J. (2003). Generalized eta and omega squared statistics: measures of effect size for some common research designs. Psychol Methods, 8, 434–447. doi:10.1037/1082-989X.8.4.434
  • Pagura, J., Stein, M. B., Bolton, J. M., Cox, B. J., Grant, B., & Sareen, J. (2010). Comorbidity of borderline personality disorder and posttraumatic stress disorder in the U.S. population. Journal of Psychiatric Research, 44, 1190–1198. doi:10.1016/j.jpsychires.2010.04.016
  • Paolini, E., Mezzetti, F. A. F., Pierri, F., & Moretti, P. (2017). Pharmacological treatment of borderline personality disorder: a retrospective observational study at inpatient unit in Italy. International Journal of Psychiatry in Clinical Practice, 21, 75–79. doi:10.1080/13651501.2016.1235202
  • Paton, C., Crawford, M. J., Bhatti, S. F., Patel, M. X., & Barnes, T. R. (2015). The use of psychotropic medication in patients with emotionally unstable personality disorder under the care of UK mental health services. The Journal of Clinical Psychiatry, 76, 512–518. doi:10.4088/JCP.14m09228
  • Peters, J.U. (2013). Polypharmacology – foe or friend?. Journal of Medicinal Chemistry, 56, 8955–8971. Retrieved from https://doi.org/10.1021/jm400856t doi:10.1021/jm400856t
  • Powers, A. D., & Oltmanns, T. F. (2013). Borderline personality pathology and chronic health problems in later adulthood: The mediating role of obesity. Personality Disorders: Theory, Research, and Treatment, 4, 152–159. doi:10.1037/a0028709
  • Renneberg, B., Schmitz, B., Doering, S., Herpertz, S. C., & Bohus, M. (2010). Leitlinienkommission-Persönlichkeitsstörungen Behandlungsleitlinie Persönlichkeitsstörungen. Psychotherapeut, 55, 339–354. doi:10.1007/s00278-010-0748-5
  • Richardson, J. T. E. (2011). Eta squared and partial eta squared as measures of effect size in educational research. Educational Research Review, 6, 135–147. doi:10.1016/j.edurev.2010.12.001
  • Riffer, F., Kaiser, E., & Fellinger, B. (2016). Stationäre Therapie psychosomatischer Erkrankungen-ein Modell für Österreich. JATROS Neurologie & Psychiatrie, 24, 38–40.
  • Silk, K. R. (2015). Management and effectiveness of psychopharmacology in emotionally unstable and borderline personality disorder. The Journal of Clinical Psychiatry, 76, 524–525. doi:10.4088/JCP.14com09534
  • Soloff, P. H. (1998). Algorithms for pharmacological treatment of personality dimensions: symptom-specific treatments for cognitive-perceptual, affective, and impulsive-behavioral dysregulation. Bulletin of the Menninger Clinic, 62, 195–214.
  • Soloff, P. H. (2000). Psychopharmacology of borderline personality disorder. Psychiatric Clinics of North America, 23, 169–192. Retrieved from http://www.sciencedirect.com/science/article/pii/S0193953X05701507 doi:10.1016/S0193-953X(05)70150-7
  • Starcevic, V., & Janca, A. (2018). Pharmacotherapy of borderline personality disorder: replacing confusion with prudent pragmatism. Current Opinions in Psychiatry, 31, 69–73. doi:10.1097/YCO.0000000000000373
  • Torgersen, S., Kringlen, E., & Cramer, V. (2001). The prevalence of personality disorders in a community sample. Archives of General Psychiatry, 58, 590–596. doi:10.1001/archpsyc.58.6.590
  • Tyrer, P., & Silk, K. R. (2011). A comparison of UK and US guidelines for drug treatment in borderline personality disorder. International Review of Psychiatry, 23, 388–394. doi:10.3109/09540261.2011.606540
  • Vita, A., De Peri, L., & Sacchetti, E. (2011). Antipsychotics, antidepressants, anticonvulsants, and placebo on the symptom dimensions of borderline personality disorder: A meta-analysis of randomized controlled and open-label trials. Journal of Clinical Psychopharmacology, 31, 613–624. doi:10.1097/JCP.0b013e31822c1636
  • Widom, C. S., Czaja, S. J., & Paris, J. (2009). A prospective investigation of borderline personality disorder in abused and neglected children followed up into adulthood. Journal of Personality Disorders, 23, 433–446. doi:10.1521/pedi.2009.23.5.433
  • Winsper, C. (2018). The aetiology of borderline personality disorder (BPD): contemporary theories and putative mechanisms. Current Opinion in Psychology, 21, 105–110. doi:10.1016/j.copsyc.2017.10.005
  • Witt, S. H., Streit, F., Jungkunz, M., Frank, J., Awasthi, S., Reinbold, C. S., … Rietschel, M. (2017). Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia. Translational Psychiatry, 7, e1155. doi:10.1038/tp.2017.115
  • World-Health-Organization. (1992). The ICD-10 classification of mental and behavioural disorders: clinical descriptions and diagnostic guidelines. Geneva, Switzerland: World Health Organization.
  • Zanarini, M. C., Frankenburg, F. R., Hennen, J., Reich, D. B., & Silk, K. R. (2006). Prediction of the 10-year course of borderline personality disorder. American Journal of Psychiatry, 163, 827–832. doi:10.1176/ajp.2006.163.5.827
  • Zanarini, M. C., Frankenburg, F. R., Hennen, J., & Silk, K. R. (2004). Mental health service utilization by borderline personality disorder patients and axis ii comparison subjects followed prospectively for 6 years. The Journal of Clinical Psychiatry, 65, 28–36. doi:10.4088/JCP.v65n0105
  • Zanarini, M. C., Frankenburg, F. R., Reich, D. B., Silk, K. R., Hudson, J. I., & McSweeney, L. B. (2007). The subsyndromal phenomenology of borderline personality disorder: A 10-year follow-up study. American Journal of Psychiatry, 164, 929–935. doi:10.1176/ajp.2007.164.6.929
  • Zanarini, M. C., Reichman, C. A., Frankenburg, F. R., Reich, D. B., & Fitzmaurice, G. (2010). The course of eating disorders in patients with borderline personality disorder: A 10-year follow-up study. The International Journal of Eating Disorders, 43, 226–232. doi:10.1002/eat.20689
  • Zimmerman, M., Rothschild, L., & Chelminski, I. (2005). The prevalence of DSM-IV personality disorders in psychiatric outpatients. American Journal of Psychiatry, 162, 1911–1918. doi:10.1176/appi.ajp.162.10.1911

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.