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Review Articles

Lithium – past, present, future

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Pages 330-340 | Received 09 Jan 2020, Accepted 25 May 2020, Published online: 17 Jun 2020

References

  • Adli M, Hollinde DL, Stamm T, Wiethoff K, Tsahuridu M, Kirchheiner J, Heinz A, Bauer M. 2007. Response to lithium augmentation in depression is associated with the glycogen synthase kinase 3-beta -50T/C single nucleotide polymorphism. Biol Psychiatry. 62(11):1295–1302. doi:10.1016/j.biopsych.2007.03.023
  • Altamura AC, Mundo E, Dell'Osso B, Tacchini G, Buoli M, Calabrese JR. 2008. Quetiapine and classical mood stabilizers in the long-term treatment of bipolar disorder: a 4-year follow-up naturalistic study. J Affect Disord. 110(1–2):135–141. doi:10.1016/j.jad.2008.01.017
  • Baastrup PC. 1964. The use of lithium in manic-depressive psychoses. Compr Psychiatry. 5(6):396–408. doi:10.1016/S0010-440X(64)80049-3
  • Baastrup PC, Schou M. 1967. Lithium as a prophylactic agents. Its effect against recurrent depressions and manic-depressive psychosis. Arch Gen Psychiatry. 16(2):162–172. doi:10.1001/archpsyc.1967.01730200030005
  • Bauer M, Adli M, Ricken R, Severus E, Pilhatsch M. 2014. Role of lithium augmentation in the management of major depressive disorder. CNS Drugs. 28(4):331–342. doi:10.1007/s40263-014-0152-8
  • Baldessarini RJ, Tondo L, Davis P, Pompili M, Goodwin FK, Hennen J. 2006. Decreased risk of suicides and attempts during long-term lithium treatment: a meta-analytic review. Bipolar Disord. 8(5p2):625–639. doi:10.1111/j.1399-5618.2006.00344.x
  • Baldessarini RJ, Leahy L, Arcona S, Gause D, Zhang W, Hennen J. 2007. Patterns of psychotropic drug prescription for U.S. patients with diagnoses of bipolar disorders. Psychiatr Serv. 58(1):85–91. doi:10.1176/ps.2007.58.1.85
  • Berk M, Dandash O, Daglas R, Cotton SM, Allott K, Fornito A, Suo C, Klauser P, Liberg B, Henry L, et al. 2017. Neuroprotection after a first episode of mania: a randomized controlled maintenance trial comparing the effects of lithium and quetiapine on grey and white matter volume. Transl Psychiatry. 7(1):e1011–e1011. doi:10.1038/tp.2016.281
  • Blackwell B, Shepherd M. 1968. Prophylactic lithium: another therapeutic myth? An examination of the evidence to date. Lancet. 291(7549):968–971. doi:10.1016/S0140-6736(68)90917-3
  • Blüml V, Regier MD, Hlavin G, Rockett IRH, König F, Vyssoki B, Bschor T, Kapusta ND. 2013. Lithium in the public water supply and suicide mortality in Texas. J Psychiatr Res. 47(3):407–411. doi:10.1016/j.jpsychires.2012.12.002
  • Brown KM, Tracy DK. 2013. Lithium: the pharmacodynamic actions of the amazing ion. Ther Adv Psychopharmacol. 3(3):163–176. doi:10.1177/2045125312471963
  • Cade JFK. 1949. Lithium salts in the treatment of psychotic excitement. Med J Aust. 2(10):349–352. doi:10.5694/j.1326-5377.1949.tb36912.x
  • Cipriani A, Barbui C, Salanti G, Rendell J, Brown R, Stockton S, Purgato M, Spineli LM, Goodwin GM, Geddes JR. 2011. Comparative efficacy and acceptability of antimanic drugs in acute mania: a multiple-treatments meta-analysis. Lancet. 378(9799):1306–1315. doi:10.1016/S0140-6736(11)60873-8
  • Cipriani A, Hawton K, Stockton S, Geddes JR. 2013. Lithium in the prevention of suicide in mood disorders: updated systematic review and meta-analysis. BMJ. 346:f3646. doi:10.1136/bmj.f3646
  • Coppen A, Standish-Barry H, Bailey J, Houston G, Silcocks P, Hermon C. 1991. Does lithium reduce the mortality of recurrent mood disorders? J Affect Disord. 23(1):1–7. doi:10.1016/0165-0327(91)90030-V
  • Costa L. d S, Alencar ÁP, Nascimento Neto PJ, dos Santos M. d S V, da Silva CGL, Pinheiro S. d F L, Silveira RT, Bianco BAV, Pinheiro RFF, de Lima MAP, et al. 2015. Risk factors for suicide in bipolar disorder: a systematic review. J Affect Disord. 170:237–254. doi:10.1016/j.jad.2014.09.003
  • Crossley NA, Bauer M. 2007. Acceleration and augmentation of antidepressants with lithium for depressive disorders: two meta-analyses of randomized, placebo-controlled trials. J Clin Psychiatry 68: 935–940.
  • Dandash O, Yücel M, Daglas R, Pantelis C, McGorry P, Berk M, Fornito A. 2018. Differential effect of quetiapine and lithium on functional connectivity of the striatum in first episode mania. Transl Psychiatry. 8(1):59. doi:10.1038/s41398-018-0108-8
  • De Montigny C, Grunberg F, Mayer A, Deschenes JP. 1981. Lithium induces rapid relief of depression in tricyclic antidepressant nonresponders. Br J Psychiatry. 138(3):252–256. doi:10.1192/bjp.138.3.252
  • Dickerson FB, Boronow JJ, Stallings C, Origoni AE, Cole S, Krivogorsky B, Yolken RH. 2004. Infection with herpes simplex virus type 1 is associated with cognitive deficits in bipolar disorder. Biol Psychiatry. 55(6):588–593. doi:10.1016/j.biopsych.2003.10.008
  • Donix M, Bauer M. 2016. Population studies of association between lithium and risk of neurodegenerative disorders. Curr Alzheimer Res. 13(8):873–878. doi:10.2174/1567205013666160219112957
  • Fajardo VA, Fajardo VA, LeBlanc PJ, MacPherson REK. 2017. Examining the relationship between trace lithium in drinking water and the rising rates of age-adjusted Alzheimer’s disease mortality in Texas. JAD. 61(1):425–434. doi:10.3233/JAD-170744
  • Ferensztajn-Rochowiak E, Kucharska-Mazur J, Tarnowski M, Samochowiec J, Ratajczak MZ, Rybakowski JK. 2018. Stem cells, pluripotency and glial cell markers in peripheral blood of bipolar patients on long-term lithium treatment. Prog Neuropsychopharmacol Biol Psychiatry. 80(Pt A):28–33. doi:10.1016/j.pnpbp.2017.06.013
  • Focosi D, Azzarà A, Kast RE, Carulli G, Petrini M. 2009. Lithium and hematology: established and proposed uses. J Leukoc Biol. 85(1):20–28. doi:10.1189/jlb.0608388
  • Franchini L, Zanardi R, Smeraldi E, Gasperini M. 1999. Early onset of lithium prophylaxis as a predictor of good long-term outcome. Eur Arch Psychiatry Clin Neurosci. 249(5):227–230. doi:10.1007/s004060050091
  • Garrod AB. 1859. Gout and rheumatic gout. London: Walton and Maberly.
  • Geddes JR, Burgess S, Hawton K, Jamison K, Goodwin GM. 2004. Long-term lithium therapy for bipolar disorder: systematic review and meta-analysis of randomized controlled trials. Am J Psychiatry. 161(2):217–222. doi:10.1176/appi.ajp.161.2.217
  • Germaná C, Kempton MJ, Sarnicola A, Christodoulou T, Haldane M, Hadjulis M, Girardi P, Tatarelli R, Frangou S. 2010. The effects of lithium and anticonvulsants on brain structure in bipolar disorder. Acta Psychiatr Scand. 122(6):481–487. doi:10.1111/j.1600-0447.2010.01582.x
  • Gillis A. 1983. Lithium in herpes simplex. Lancet. 321:516.
  • Giotakos O, Nisianakis P, Tsouvelas G, Giakalou VV. 2013. Lithium in the public water supply and suicide mortality in Greece. Biol Trace Elem Res. 156(1-3):376–399. doi:10.1007/s12011-013-9815-4
  • Grof P. 1999. Excellent lithium responders: people whose lives have been changed by lithium prophylaxis. In: Birch NJ, Gallicchio VS, Becker RW, editors. Lithium: 50 years of psychopharmacology, new perspectives in biomedical and clinical research. Cheshire, Connecticut: Weidner Publishing Group; p. 36–51.
  • Gitlin M. 2016. Lithium side effects and toxicity: prevalence and management strategies. Int J Bipolar Disord 4: 27.
  • Grof P. 2010. Sixty years of lithium responders. Neuropsychobiology. 62(1):8–35. doi:10.1159/000314305
  • Hajek T, Bauer M, Simhandl C, Rybakowski J, O'Donovan C, Pfennig A, König B, Suwalska A, Yucel K, Uher R, et al. 2014. Neuroprotective effect of lithium on hippocampal volumes in bipolar disorder independent of long-term treatment response. Psychol Med. 44(3):507–517. doi:10.1017/S0033291713001165
  • Hajek T, Weiner MW. 2016. Neuroprotective effects of lithium in human brain? Food for thought. Curr Alzheimer Res. 13(8):862–872. doi:10.2174/1567205013666160219112712
  • Hammond WA. 1871. Treatise on diseases of the nervous system. New York: Appleton.
  • Hartigan G. 1963. The use of lithium salts in affective disorders. Br J Psychiatry. 109:810–814. doi:10.1192/bjp.109.463.810
  • Hayes J, Prah P, Nazareth I, King M, Walters K, Petersen I, Osborn D. 2011. Prescribing trends in bipolar disorder: cohort study in the United Kingdom THIN primary care database 1995–2009. PLoS One. 6(12):e28725doi:10.1371/journal.pone.0028725
  • Hou L, Heilbronner U, Degenhardt F, Adli M, Akiyama K, Akula N, Ardau R, Arias B, Backlund L, Banzato CEM, et al. 2016. Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study. Lancet. 387(10023):1085–1093. doi:10.1016/S0140-6736(16)00143-4
  • Huang RY, Hsieh KP, Huang WW, Yang YH. 2016. Use of lithium and cancer risk in patients with bipolar disorder: population-based cohort study. Br J Psychiatry. 209(5):393–399. doi:10.1192/bjp.bp.116.181362
  • Hui TP, Kandola A, Shen L, Lewis G, Osborn DPJ, Geddes JR, Hayes JF. 2019. A systematic review and meta-analysis of clinical predictors of lithium response in bipolar disorder. Acta Psychiatr Scand. 140(2):94–115. doi:10.1111/acps.13062
  • Itzhaki RF. 2018. Corroboration of a major role for herpes simplex virus type 1 in Alzheimer’s disease. Front Aging Neurosci. 10:324. doi:10.3389/fnagi.2018.00324
  • Jope RS. 2011. Glycogen synthase kinase-3 in the etiology and treatment of mood disorders. Front Mol Neurosci. 4:16doi:10.3389/fnmol.2011.00016
  • Kapusta ND, Mossaheb N, Etzersdorfer E, Hlavin G, Thau K, Willeit M, Praschak-Rieder N, Sonneck G, Leithner-Dziubas K. 2011. Lithium in drinking water and suicide mortality. Br J Psychiatry. 198(5):346–350. doi:10.1192/bjp.bp.110.091041
  • Karanti A, Kardell M, Lundberg U, Landén M. 2016. Changes in mood stabilizer prescription patterns in bipolar disorder. J Affect Disord. 195:50–56. doi:10.1016/j.jad.2016.01.043
  • Katagiri H, Takita Y, Tohen M, Higuchi T, Kanba S, Takahashi M. 2012. Safety and efficacy of olanzapine monotherapy and olanzapine with a mood stabilizer in 18-week treatment of manic/mixed episodes for Japanese patients with bipolar I disorder. Curr Med Res Opin. 28(5):701–713. doi:10.1185/03007995.2012.666961
  • Kessing LV, Sondergard L, Forman JL, Andersen PK. 2008. Lithium treatment and risk of dementia. Arch Gen Psychiatry. 65(11):1331–1335. doi:10.1001/archpsyc.65.11.1331
  • Kessing LV, Forman JL, Andersen PK. 2010. Does lithium protect against dementia? Bipolar Disord. 12:97–94.
  • Kessing LV, Vradi E, Andersen PK. 2014. Starting lithium prophylaxis early v. late in bipolar disorder. Br J Psychiatry. 205(3):214–220. doi:10.1192/bjp.bp.113.142802
  • Kessing LV, Vradi E, Andersen PK. 2016. Nationwide and population-based prescription patterns in bipolar disorder. Bipolar Disord. 18(2):174–182. doi:10.1111/bdi.12371
  • Kessing LV, Gerds TA, Knudsen NN, Jørgensen LF, Kristiansen SM, Voutchkova D, Ernstsen V, Schullehner J, Hansen B, Andersen PK, et al. 2017. Association of lithium in drinking water with the incidence of dementia. JAMA Psychiatry. 74(10):1005–1010. doi:10.1001/jamapsychiatry.2017.2362
  • Kessing LV, Bauer M, Nolen WA, Severus E, Goodwin GM, Geddes J. 2018. Effectiveness of maintenance therapy of lithium vs other mood stabilizers in monotherapy and in combinations: a systematic review of evidence from observational studies. Bipolar Disord. 20(5):419–431. doi:10.1111/bdi.12623
  • Kliwicki S, Chłopocka-Woźniak M, Rudnicka E, Rybakowski J. 2014. Efficacy of long-term lithium treatment in bipolar affective illness (in Polish). Pharmakother Psychiatry Neurol. 30:5–13.
  • Kraepelin E. 1899. Psychiatrie. Ein Lehrbuch für Studierende und Ärzte. 6 Auflage. Leipzig: Barth.
  • Kraszewska A, Ziemnicka K, Jończyk-Potoczna K, Sowiński J, Rybakowski JK. 2019a. Thyroid structure and function in long-term lithium-treated and lithium-naïve bipolar patients. Hum Psychopharmacol. 34(4):e2708doi:10.1002/hup.2708
  • Kraszewska A, Ziemnicka K, Sowiński J, Ferensztajn-Rochowiak E, Rybakowski JK. 2019b. No connection between long-term lithium treatment and antithyroid antibodies. Pharmacopsychiatry. 52(5):232–236. doi:10.1055/a-0838-6062
  • Lange C. 1886. Om Periodiske Depressionstilstande og deres Patogenese. Lund, Copenhagen.
  • Lähteenvuo M, Tanskanen A, Taipale H, Hoti F, Vattulainen P, Vieta E, Tiihonen J. 2018. Real-world effectiveness of pharmacologic treatments for the prevention of rehospitalization in a Finnish nationwide cohort of patients with bipolar disorder. JAMA Psychiatry. 75(4):347–355. doi:10.1001/jamapsychiatry.2017.4711
  • Lewitzka U, Severus E, Bauer R, Ritter P, Müller-Oerlinghausen B, Bauer M. 2015. The suicide prevention effect of lithium: more than 20 years of evidence-a narrative review. Int J Bipolar Disord. 3(1):32. doi:10.1186/s40345-015-0032-2
  • Lieb J. 1979. Remission of recurrent herpes infection during therapy with lithium. N Engl J Med. 301:942.
  • López-Jaramillo C, Lopera-Vásquez J, Ospina-Duque J, García J, Gallo A, Cortez V, Palacio C, Torrent C, Martínez-Arán A, Vieta E, et al. 2010. Lithium treatment effects on the neuropsychological functioning of patients with bipolar I disorder. J Clin Psychiatry. 71(8):1055–1060. doi:10.4088/JCP.08m04673yel
  • Lyoo IK, Dager SR, Kim JE, Yoon SJ, Friedman SD, Dunner DL, Renshaw PF. 2010. Lithium-induced gray matter volume increase as a neural correlate of treatment response in bipolar disorder: a longitudinal brain imaging study. Neuropsychopharmacology. 35(8):1743–1750. doi:10.1038/npp.2010.41
  • Manchia M, Adli M, Akula N, Ardau R, Aubry J-M, Backlund L, Banzato CE, Baune BT, Bellivier F, Bengesser S, et al. 2013. Assessment of response to lithium maintenance treatment in bipolar disorder: a Consortium on Lithium Genetics (ConLiGen) report. PLoS One. 8(6):e65636. doi:10.1371/journal.pone.0065636
  • Marcus R, Khan A, Rollin L, Morris B, Timko K, Carson W, Sanchez R. 2011. Efficacy of aripiprazole adjunctive to lithium or valproate in the long-term treatment of patients with bipolar I disorder with an inadequate response to lithium or valproate monotherapy: a multicenter, double-blind, randomized study. Bipolar Disord. 13(2):133–144. doi:10.1111/j.1399-5618.2011.00898.x
  • Matsunaga S, Kishi T, Annas P, Basun H, Hampel H, Iwata N. 2015. Lithium as a treatment for Alzheimer's disease: a systematic review and meta-analysis. J Alzheimers Dis. 48(2):403–410. doi:10.3233/JAD-150437
  • Mendels J. 1976. Lithium in the treatment of depression. Am J Psychiatry. 133(4):373–378. doi:10.1176/ajp.133.4.373
  • Moore GJ, Bebchuk JM, Wilds IB, Chen G, Manji HK, Menji HK. 2000. Lithium-induced increase in human brain grey matter. Lancet. 356(9237):1241–1242. doi:10.1016/S0140-6736(00)02793-8
  • Morris G, Berk M. 2016. The putative use of lithium in Alzheimer's disease. Curr Alzheimer Res. 13(8):853–861. doi:10.2174/1567205013666160219113112
  • Munk-Olsen T, Liu X, Viktorin A, Brown HK, Di Florio A, D'Onofrio BM, Gomes T, Howard LM, Khalifeh H, Krohn H, et al. 2018. Maternal and infant outcomes associated with lithium use in pregnancy: an international collaborative meta-analysis of six cohort studies. Lancet Psychiatry. 5(8):644–652. doi:10.1016/S2215-0366(18)30180-9
  • Müller-Oerlinghausen B, Ahrens B, Grof E, Grof P, Lenz G, Schou M, Simhandl C, Thau K, Volk J, Wolf R. 1992. The effect of long-term lithium treatment on the mortality of patients with manic-depressive and schizoaffective illness. Acta Psychiatr Scand. 86(3):218–222. doi:10.1111/j.1600-0447.1992.tb03255.x
  • Müller-Oerlinghausen B, Wolf T, Ahrens B, Schou M, Grof E, Grof P, Lenz G, Simhandl C, Thau K, Wolf R, et al. 1994. Mortality during initial and during later lithium treatment. A collaborative study by the International Group for the Study of Lithium-treated patients. Acta Psychiatr Scand. 90(4):295–297. doi:10.1111/j.1600-0447.1994.tb01596.x
  • Nassar A, Azab AN. 2014. Effects of lithium on inflammation. ACS Chem Neurosci. 5(6):451–458. doi:10.1021/cn500038f
  • Nivoli AMA, Murru A, Vieta E. 2010. Lithium: still a cornerstone in the long-term treatment in bipolar disorder? Neuropsychobiology. 62(1):27–35. doi:10.1159/000314307
  • Noack CH, Trautner EM. 1951. The lithium treatment of maniacal psychosis. Med J Aust. 2(7):219–222. doi:10.5694/j.1326-5377.1951.tb68249.x
  • Nunes MA, Viel TA, Buck HS. 2013. Microdose lithium treatment stabilized cognitive impairment in patients with Alzheimer's disease. Curr Alzheimer Res. 10(1):104–107. doi:10.2174/1567205011310010014
  • Ohgami H, Terao T, Shiotsuki I, Ishii N, Iwata N. 2009. Lithium levels in drinking water and risk of suicide. Br J Psychiatry. 194(5):464–465. doi:10.1192/bjp.bp.108.055798
  • Palacios J, Yildiz A, Young AH, Taylor MJ. 2019. Tamoxifen for bipolar disorder: systematic review and meta-analysis. J Psychopharmacol (Oxford). 33(2):177–184. doi:10.1177/0269881118822167
  • Permoda-Osip A, Abramowicz M, Kraszewska A, Suwalska A, Chlopocka-Wozniak M, Rybakowski JK. 2016. Kidney, thyroid and other organ functions after 40 years or more of lithium therapy: a case series of five patients. Ther Adv Psychopharmacol. 6(4):277–282. doi:10.1177/2045125316643299
  • Poolsup N, Li Wan Po A, de Oliveira IR. 2000. Systematic overview of lithium treatment in acute mania. J Clin Pharm Ther. 25(2):139–156. doi:10.1046/j.1365-2710.2000.00278.x
  • Post RM. 2018. The new news about lithium: an underutilized treatment in the United States. Neuropsychopharmacology. 43(5):1174–1179. doi:10.1038/npp.2017.238
  • Radomski J, Fuyat HN, Nelson AA, Smith PK. 1950. The toxic effects, excretion and distribution of lithium chloride. J Pharmacol Exp Ther. 100(4:1):429–440.
  • Rybakowski JK, Amsterdam JD. 1991. Lithium prophylaxis and recurrent labial herpes infections. Lithium 2: 43–47.
  • Rybakowski JK. 2000. Antiviral and immunomodulatory effect of lithium. Pharmacopsychiatry. 33(5):159–164.
  • Rybakowski JK. 2007. Two generations of mood stabilizers. Int J Neuropsychopharmacol. 10(5):709–711. doi:10.1017/s146114570700795x
  • Rybakowski JK. 2014. Response to lithium in bipolar disorder: clinical and genetic findings. ACS Chem Neurosci. 5(6):413–421. doi:10.1021/cn5000277
  • Rybakowski JK. 2016. Effect of lithium on neurocognitive functioning. Curr Alzheimer Res. 13(8):887–893. doi:10.2174/1567205013666160415154701
  • Rybakowski JK. 2018a. Challenging the negative perception of lithium and optimizing its long-term administration. Front Mol Neurosci. 11:349. doi:10.3389/fnmol.2018.00349
  • Rybakowski JK. 2018b. Meaningful aspects of the term ‘mood stabilizer’. Bipolar Disord. 20(4):391–392. doi:10.1111/bdi.12608
  • Rybakowski JK. 2019. Commentary: Corroboration of a major role for herpes simplex virus type 1 in Alzheimer’s disease. Front Aging Neurosci. 10:433. doi:10.3389/fnagi.2018.00433
  • Rybakowski JK, Borkowska A, Skibinska M, Hauser J. 2006. Illness-specific association of Val66met BDNF polymorphism with performance on Wisconsin Card Sorting Test in bipolar mood disorder. Mol Psychiatry. 11(2):122–124. doi:10.1038/sj.mp.4001765
  • Rybakowski JK, Checinska K. 2018. The use of lithium in Poland in 2004-2017. Pharmacother Psychiatry Neurol. 34:85–94.
  • Rybakowski J, Chłopocka M, Lisowska J, Czerwiński A. 1974. The study on the efficacy of lithium in endogenous depressive syndromes (in Polish). Psychiatr Pol. 8:129–135.
  • Rybakowski JK, Chlopocka-Wozniak M, Suwalska A. 2001. The prophylactic effect of long-term lithium administration in bipolar patients entering treatment in the 1970s and 1980s. Bipolar Disord. 3(2):63–67. doi:10.1034/j.1399-5618.2001.030203.x
  • Rybakowski JK, Dmitrzak-Weglar M, Kliwicki S, Hauser J. 2014. Polymorphism of circadian clock genes and prophylactic lithium response. Bipolar Disord. 16(2):151–158. doi:10.1111/bdi.12136
  • Rybakowski J, Matkowski K. 1992. Adding lithium to antidepressant therapy: factors related to therapeutic potentiation. Eur Neuropsychopharmacol. 2(2):161–165. doi:10.1016/0924-977X(92)90027-6
  • Rybakowski JK, Permoda-Osip A, Borkowska A. 2009. Response to prophylactic lithium in bipolar disorder may be associated with a preservation of executive cognitive functions. Eur Neuropsychopharmacol. 19(11):791–795. doi:10.1016/j.euroneuro.2009.06.002
  • Rybakowski JK, Suwalska A. 2010. Excellent lithium responders have normal cognitive functions and plasma BDNF levels. Int J Neuropsychopharmacol. 13(5):617–622. doi:10.1017/S1461145710000404
  • Rybakowski JK. 2013. Genetic influences on response to mood stabilizers in bipolar disorder: current status of knowledge. CNS Drugs 27: 165–173.
  • Rybakowski JK, Suwalska A, Hajek T. 2018. Clinical perspectives of lithium's neuroprotective effect. Pharmacopsychiatry. 51(5):194–199. doi:10.1055/s-0043-124436
  • Rybakowski JK, Suwalska A, Skibinska M, Szczepankiewicz A, Leszczynska-Rodziewicz A, Permoda A, Czerski PM, Hauser J. 2005. Prophylactic lithium response and polymorphism of the brain-derived neurotrophic factor gene. Pharmacopsychiatry. 38(4):166–170. doi:10.1055/s-2005-871239
  • Rybakowski J, Cubała WJ, Gałecki P, Rymaszewska J, Samochowiec J, Szulc A, Dudek D. 2019. Recommendations of the Polish Psychiatric Association regarding the treatment of affective disorders in women of childbearing age. Part II: Bipolar disorder. Psychiatr Pol. 53(2):263–276. doi:10.12740/PP/103555
  • Schou M, Juel-Nielsen N, Stromgren E, Voldby H. 1954. The treatment of manic psychoses by the administration of lithium salts. J Neurol Neurosurg Psychiatry. 17(4):250–260. doi:10.1136/jnnp.17.4.250
  • Schou M, Thompsen K. 1975. Lithium prophylaxis of recurrent endogenous affective disorders. In: Johnson FN, editor. Lithium research and therapy. London: Academic Press; p. 63–84.
  • Schulze TG, Alda M, Adli M, Akula N, Ardau R, Bui ET, Chillotti C, Cichon S, Czerski P, Del Zompo M, et al. 2010. The International Consortium on Lithium Genetics (ConLiGen): an initiative by the NIMH and IGSLI to study the genetic basis of response to lithium treatment. Neuropsychobiology. 62(1):72–78. doi:10.1159/000314708
  • Scott J, Hidalgo-Mazzei D, Strawbridge R, Young A, Resche-Rigon M, Etain B, Andreassen OA, Bauer M, Bennabi D, Blamire AM, et al. 2019. Prospective cohort study of early biosignatures of response to lithium in bipolar-I-disorders: overview of the H2020-funded R-LiNK initiative. Int J Bipolar Disord. 7(1):20. doi:10.1186/s40345-019-0156-x
  • Severus E, Bauer M. 2013. Managing the risk of lithium-induced nephropathy in the long-term treatment of patients with recurrent affective disorders. BMC Med. 11:34. doi:10.1186/1741-7015-11-34
  • Severus E, Taylor MJ, Sauer C, Pfennig A, Ritter P, Bauer M, Geddes JR. 2014. Lithium for prevention of mood episodes in bipolar disorders: systematic review and meta-analysis. Int J Bipolar Disord. 2:15. doi:10.1186/s40345-014-0015-8
  • Skinner GRB, Hartley C, Buchan A, Harper L, Gallimore P. 1980. The effect of lithium chloride on the replication of herpes simplex virus. Med Microbiol Immunol. 168(2):139–265. doi:10.1007/BF02121762
  • Souza FG, Goodwin GM. 1991. Lithium treatment and prophylaxis in unipolar depression: a meta-analysis. Br J Psychiatry. 158:666–675. doi:10.1192/bjp.158.5.666
  • Stambolic V, Ruel L, Woodgett JR. 1996. Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells. Curr Biol. 6(12):1664–1668. doi:10.1016/S0960-9822(02)70790-2
  • Stephenson CP, Karanges E, McGregor IS. 2013. Trends in the utilisation of psychotropic medications in Australia from 2000 to 2011. Aust N Z J Psychiatry. 47(1):74–87. doi:10.1177/0004867412466595
  • Storosum JG, Wohlfarth T, Schene A, Elferink A, van Zwieten BJ, van den Brink W. 2007. Magnitude of effect of lithium in short-term efficacy studies of moderate to severe manic episode. Bipolar Disord. 9(8):793–798. doi:10.1111/j.1399-5618.2007.00445.x
  • Suppes T, Vieta E, Gustafsson U, Ekholm B. 2013. Maintenance treatment with quetiapine when combined with either lithium or divalproex in bipolar I disorder: analysis of two large randomized, placebo-controlled trials. Depress Anxiety. 30(11):1089–1098. doi:10.1002/da.22136
  • Tiihonen J, Tanskanen A, Hoti F, Vattulainen P, Taipale H, Mehtälä J, Lähteenvuo M. 2017. Pharmacological treatments and risk of readmission to hospital for unipolar depression in Finland: a nationwide cohort study. Lancet Psychiatry. 4(7):547–553. doi:10.1016/S2215-0366(17)30134-7
  • Tondo L, Abramowicz M, Alda M, Bauer M, Bocchetta A, Bolzani L, Calkin CV, Chillotti C, Hidalgo-Mazzei D, Manchia M, et al. 2017. Long-term lithium treatment in bipolar disorder: effects on glomerular filtration rate and other metabolic parameters. Int J Bipolar Disord. 5(1):27. doi:10.1186/s40345-017-0096-2
  • Tondo L, Alda M, Bauer M, Bergink V, Grof P, Hajek T, Lewitka U, Licht RW, Manchia M, Müller-Oerlinghausen B, et al. 2019. Clinical use of lithium salts: guide for users and prescribers. Int J Bipolar Disord. 7(1):16. doi:10.1186/s40345-019-0151-2
  • Undurraga J, Sim K, Tondo L, Gorodischer A, Azua E, Tay KH, Tan D, Baldessarini RJ. 2019. Lithium treatment for unipolar major depressive disorder: systematic review. J Psychopharmacol. 33(2):167–176. doi:10.1177/0269881118822161
  • Vestergaard P, Rejnmark L, Mosekilde L. 2005. Reduced relative risk of fractures among users of lithium. Calcif Tissue Int. 77(1):1–8. doi:10.1007/s00223-004-0258-y
  • Williams R, Ryves WJ, Dalton EC, Eickholt B, Shaltiel G, Agam G, Harwood AJ. 2004. A molecular cell biology of lithium. Biochem Soc Trans. 32 (Pt 5):799–802. doi:10.1042/BST0320799
  • Zamani A, Omrani GR, Nasab MM. 2009. Lithium’s effect on bone mineral density. Bone. 44(2):331–334. doi:10.1016/j.bone.2008.10.001

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