12,367
Views
89
CrossRef citations to date
0
Altmetric
Review Article

Epidemiology and risk factors of lower urinary tract symptoms/benign prostatic hyperplasia and erectile dysfunction

, , , & ORCID Icon
Pages 12-19 | Received 26 Dec 2017, Accepted 28 Jan 2018, Published online: 02 Feb 2018

References

  • Musicki B, Bella AJ, Bivalacqua TJ, et al. Basic science evidence for the link between erectile dysfunction and cardiometabolic dysfunction. J Sex Med. 2015;12:2233–2255.
  • Pontin D, Porter T, McDonagh R. Investigating the effect of erectile dysfunction on the lives of men: a qualitative research study. J Clin Nurs. 2002;11:264–272.
  • McCabe M, Matic H. Severity of ED: relationship to treatment-seeking and satisfaction with treatment using PDE5 inhibitors. J Sex Med. 2007;4:145–151.
  • Shabsigh R, Kaufman J, Magee M, et al. Lack of awareness of erectile dysfunction in many men with risk factors for erectile dysfunction. BMC Urol. 2010;10:18.
  • Rosen RC, Wei JT, Althof SE, et al. BPH registry and patient survey steering committee. Association of sexual dysfunction with lower urinary tract symptoms of BPH and BPH medical therapies: results from the BPH Registry. Urology. 2009;73:562–566.
  • Ozayar A, Zumrutbas AE, Yaman O. The relationship between lower urinary tract symptoms (LUTS), diagnostic indicators of benign prostatic hyperplasia (BPH), and erectile dysfunction in patients with moderate to severely symptomatic BPH. Int Urol Nephrol. 2008;40:933–939.
  • Seftel AD, De la Rosette J, Birt J, et al. Coexisting lower urinary tract symptoms and erectile dysfunction: a systematic review of epidemiological data. Int J Clin Pract. 2013;67:32–45.
  • Singam P, Hong GE, Ho C, et al. Nocturia in patients with benign prostatic hyperplasia: evaluating the significance of ageing, co-morbid illnesses, lifestyle and medical therapy in treatment outcome in real life practice. Aging Male. 2015;18:112–117.
  • Park SG, Yeo JK, Cho DY, et al. Impact of metabolic status on the association of serum vitamin D with hypogonadism and lower urinary tract symptoms/benign prostatic hyperplasia. Aging Male. 2017;17:1–5.
  • Asiedu B, Anang Y, Nyarko A, et al. The role of sex steroid hormones in benign prostatic hyperplasia. Aging Male. 2017;20:17–22.
  • Allen S, Aghajanyan I. Use of thermobalancing therapy in ageing male with benign prostatic hyperplasia with a focus on etiology and pathophysiology. Aging Male. 2017;20:28–32.
  • Ren H, Li X, Cheng G, et al. The effects of ROS in prostatic stromal cells under hypoxic environment. Aging Male. 2015;18:84–88.
  • Ferreira FT, Daltoé L, Succi G, et al. Relation between glycemic levels and low tract urinary symptoms in elderly. Aging Male. 2015;18:34–37.
  • Kaplan SA, Lee JY, O'Neill EA, et al. Prevalence of low testosterone and its relationship to body mass index in older men with lower urinary tract symptoms associated with benign prostatic hyperplasia. Aging Male. 2013;16:169–172.
  • Kaplan SA, O'Neill E, Lowe R, et al. Prevalence of low testosterone in aging men with benign prostatic hyperplasia: data from the Proscar Long-term Efficacy and Safety Study (PLESS). Aging Male. 2013;16:48–51.
  • Aktas BK, Gokkaya CS, Bulut S, et al. Impact of metabolic syndrome on erectile dysfunction and lower urinary tract symptoms in benign prostatic hyperplasia patients. Aging Male. 2011;14:48–52.
  • Amano T, Earle C, Imao T, et al. Administration of daily 5 mg tadalafil improves endothelial function in patients with benign prostatic hyperplasia. Aging Male. 2017;22:1–6.
  • Ko WJ, Han HH, Ham WS, et al. Daily use of sildenafil 50mg at night effectively ameliorates nocturia in patients with lower urinary tract symptoms associated with benign prostatic hyperplasia: an exploratory multicenter, double-blind, randomized, placebo-controlled study. Aging Male. 2017;20:81–88.
  • Favilla V, Russo GI, Privitera S, et al. Impact of combination therapy 5-alpha reductase inhibitors (5-ARI) plus alpha-blockers (AB) on erectile dysfunction and decrease of libido in patients with LUTS/BPH: a systematic review with meta-analysis. Aging Male. 2016;19:175–181.
  • Yassin A, Nettleship JE, Talib RA, et al. Effects of testosterone replacement therapy withdrawal and re-treatment in hypogonadal elderly men upon obesity, voiding function and prostate safety parameters. Aging Male. 2016;19:64–69.
  • Kaufman JM. The effect of androgen supplementation therapy on the prostate. Aging Male. 2003;6:166–174.
  • Haider KS, Haider A, Doros G, et al. Long-term testosterone therapy improves urinary and sexual function, and quality of life in men with hypogonadism: results from a propensity matched subgroup of a controlled registry study. J Urol. 2018;199:257–265.
  • Kosilov K, Kuzina I, Kuznetsov V, et al. Cognitive functions and health-related quality of life in men with benign prostatic hyperplasia and symptoms of overactive bladder when treated with a combination of tamsulosin and solifenacin in a higher dosage. Aging Male. 2017;7:1–9.
  • Henningsohn L, Kilany S, Svensson M, et al. Patient-perceived effectiveness and impact on quality of life of solifenacin in combination with an α-blocker in men with overactive bladder in Sweden: a non-interventional study. Aging Male. 2017;20:266–276.
  • Rosen R, Carson C, Giuliano F. Sexual dysfunction and lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH). Eur Urol. 2005;47:824–837.
  • Marshall LM, Holton KF, Parsons JK, Osteoporotic Fractures in Men (MrOS) Study Group, et al. Lifestyle and health factors associated with progressing and remitting trajectories of untreated lower urinary tract symptoms among elderly men. Prostate Cancer Prostatic Dis. 2014;17:265–272.
  • Esposito K, Giugliano F, Di Palo C, et al. Effect of lifestyle changes on erectile dysfunction in obese men: a randomized controlled trial. JAMA. 2004;291:2978–2984.
  • Shiyi C, Xiaoxu Y, Yunxia W, et al. Smoking and risk of erectile dysfunction: systematic review of observational studies with meta-analysis. PLoS One. 2013;8:e60443.
  • Shaarawy M, Mahmoud KZ. Endocrine profile and semen characteristics in male smokers. Fertil Steril. 1982;38:255–257.
  • Celermajer DS, Sorensen KE, Georgakopoulos D, et al. Cigarette smoking is associated with dose-related and potentially reversible impairment of endothelium-dependent dilation in healthy young adults. Circulation. 1993;88:2149–2155.
  • Huang YC, Chin CC, Chen CS, et al. Chronic cigarette smoking impairs erectile function through increased oxidative stress and apoptosis, decreased nNOS, endothelial and smooth muscle contents in a rat model. PLoS One. 2015;10:e0140728.
  • Narkiewicz K, Van de Borne PJ, Hausberg M, et al. Cigarette smoking increases sympathetic outflow in humans. Circulation. 1998;98:528–534.
  • Rohrmann S, Crespo CJ, Weber JR, et al. Association of cigarette smoking, alcohol consumption and physical activity with lower urinary tract symptoms in older American men: findings from the third National Health and Nutrition Examination Survey. BJU Int. 2005;96:77–82.
  • Maserejian NN, Kupelian V, Miyasato G, et al. Are physical activity, smoking and alcohol consumption associated with lower urinary tract symptoms in men or women? Results from a population based observational study. J Urol. 2012;188:490–495.
  • Knuutinen A, Kokkonen N, Risteli J, et al. Smoking affects collagen synthesis and extracellular matrix turnover in human skin. Br J Dermatol. 2002;146:588–594.
  • Bacon CG, Mittleman MA, Kawachi I, et al. Sexual function in men older than 50 years of age: results from the health professionals follow-up study. Ann Intern Med. 2003;139:161–168.
  • Kalter-Leibovici O, Wainstein J, Ziv A, et al. Clinical, socioeconomic, and lifestyle parameters associated with erectile dysfunction among diabetic men. Diabetes Care. 2005;28:1739–1744.
  • Martin SA, Atlantis E, Lange K, et al. Predictors of sexual dysfunction incidence and remission in men. J Sex Med. 2014;11:1136–1147.
  • Chew KK, Bremner A, Stuckey B, et al. Alcohol consumption and male erectile dysfunction: an unfounded reputation for risk? J Sex Med. 2009;6:1386–1394.
  • Cheng JY, Ng EM, Chen RY, et al. Alcohol consumption and erectile dysfunction: meta-analysis of population-based studies. Int J Impot Res. 2007;19:343–352.
  • Parsons JK, Im R. Alcohol consumption is associated with a decreased risk of benign prostatic hyperplasia. J Urol. 2009;182:1463–1468.
  • Wong SY, Woo J, Leung JC, et al. Depressive symptoms and lifestyle factors as risk factors of lower urinary tract symptoms in Southern Chinese men: a prospective study. Aging Male. 2010;13:113–119.
  • Kristal AR, Arnold KB, Schenk JM, et al. Dietary patterns, supplement use, and the risk of symptomatic benign prostatic hyperplasia: results from the prostate cancer prevention trial. Am J Epidemiol. 2008;167:925–934.
  • Eggleton MG. The diuretic action of alcohol in man. J Physiol (Lond). 1942;101:172–191.
  • Van de Borne P, Mark AL, Montano N, et al. Effects of alcohol on sympathetic activity, hemodynamics, and chemoreflex sensitivity. Hypertension. 1997;29:1278–1283.
  • Araujo AB, Durante R, Feldman HA, et al. The relationship between depressive symptoms and male erectile dysfunction: cross-sectional results from the Massachusetts Male Aging Study. Psychosom Med. 1998;60:458–465.
  • Ahn TY, Park JK, Lee SW, et al. Prevalence and risk factors for erectile dysfunction in Korean men: results of an epidemiological study. J Sex Med. 2007;4:1269–1276.
  • Shiri R, Koskimäki J, Tammela TL, et al. Bidirectional relationship between depression and erectile dysfunction. J Urol. 2007;177:669–673.
  • Maes M, Yirmyia R, Noraberg J, et al. The inflammatory & neurodegenerative hypothesis of depression: leads for future research and new drug developments in depression. Metab Brain Dis. 2009;24:27–53.
  • Hung SF, Chung SD, Kuo HC. Increased serum C-reactive protein level is associated with increased storage lower urinary tract symptoms in men with benign prostatic hyperplasia. PLoS One. 2014;9:e85588.
  • Kim SW, Paick JS, Park DW, et al. Potential predictors of asymptomatic ischemic heart disease in patients with vasculogenic erectile dysfunction. Urology. 2001;58:441–445.
  • Thompson IM, Tangen CM, Goodman PJ, et al. Erectile dysfunction and subsequent cardiovascular disease. JAMA. 2005;294:2996–3002.
  • Grimm RH Jr, Grandits GA, Prineas RJ, et al. Long-term effects on sexual function of five antihypertensive drugs and nutritional hygienic treatment in hypertensive men and women: treatment of mild hypertension study (TOMHS). Hypertension. 1997;29:8–14.
  • Newman HF, Marcus H. Erectile dysfunction in diabetes and hypertension. Urology. 1985;26:135–137.
  • Javaroni V, Neves MF. Erectile dysfunction and hypertension: impact on cardiovascular risk and treatment. Int J Hypertens. 2012;2012:627278.
  • Ito H, Yoshiyasu T, Yamaguchi O, et al. Male lower urinary tract symptoms: hypertension as a risk factor for storage symptoms, but not voiding symptoms. Low Urin Tract Symptoms. 2012;4:68–72.
  • Hwang EC, Kim SO, Nam DH, et al. Men with hypertension are more likely to have severe lower urinary tract symptoms and large prostate volume. Low Urin Tract Symptoms. 2015;7:32–36.
  • DeLay KJ, Haney N, Hellstrom WJ. Modifying risk factors in the management of erectile dysfunction: a review. World J Mens Health. 2016;34:89–100.
  • Swyer G. Cholesterol content of normal and enlarged prostates. Cancer Res. 1942;2:372–375.
  • Nandeesha H, Koner BC, Dorairajan LN, et al. Hyperinsulinemia and dyslipidemia in non-diabetic benign prostatic hyperplasia. Clin Chim Acta. 2006;370:89–93.
  • Corona G, Vignozzi L, Rastrelli G, et al. Benign prostatic hyperplasia: a new metabolic disease of the aging male and its correlation with sexual dysfunctions. Int J Endocrinol. 2014;2014:329456.
  • Bourke JB, Griffin JP. Diabetes mellitus in patients with benign prostatic hyperplasia. BMJ. 1968;4:492–493.
  • Lotti F, Corona G, Vignozzi L, et al. Metabolic syndrome and prostate abnormalities in male subjects of infertile couples. Asian J Androl. 2014;16:295–304.
  • Lotti F, Corona G, Colpi GM, et al. Elevated body mass index correlates with higher seminal plasma interleukin 8 levels and ultrasonographic abnormalities of the prostate in men attending an andrology clinic for infertility. J Endocrinol Investig. 2011;34:336–342.
  • La Vignera S, Condorelli RA, Russo GI, et al. Endocrine control of benign prostatic hyperplasia. Andrology. 2016;4:404–411.
  • Marmorston J, Lombardo LJ Jr, Myers SM, et al. Urinary excretion of estrone, estradiol and estriol by patients with prostatic cancer and benign prostate hypertrophy. J Urol. 1965;93:287–295.
  • Kullmann FA, Birder LA, Andersson KE. Translational research and functional changes in voiding function in older adults. Clin Geriatr Med. 2015;31:535–548.
  • Yoshimura N, Kato R, Chancellor MB, et al. Gene therapy as future treatment of erectile dysfunction. Expert Opin Biol Ther. 2010;10:1305–1314.
  • Bechis SK, Otsetov AG, Ge R, et al. Personalized medicine for the management of benign prostatic hyperplasia. J Urol. 2014;192:16–23.
  • Wei JT, Calhoun E, Jacobsen SJ. Urologic diseases in America project: benign prostatic hyperplasia. J Urol. 2005;173:1256–1261.
  • Parsons JK. Lifestyle factors, benign prostatic hyperplasia, and lower urinary tract symptoms. Curr Opin Urol. 2011;21:1–4.
  • Park HJ, Won J, Sorsaburu S, et al. Urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH) and LUTS/BPH with erectile dysfunction in Asian men: a systematic review focusing on tadalafil. World J Mens Health. 2013;31:193–207.
  • La Vignera S, Condorelli R, Vicari E, et al. Physical activity and erectile dysfunction in middle-aged men. J Androl. 2012;33:154–161.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.