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The Aging Male Volume 27, 2024 - Issue 1
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Research Article

Testosterone therapy over 60 months improves aging male symptoms scores in all men with adult-onset testosterone deficiency

Karim Sultan Haidera Urological Practice Dr Haider, Bremerhaven, GermanyORCID Iconhttps://orcid.org/0000-0003-4396-9324View further author information
ORCID Icon,
Michael Zitzmannb Department of Clinical and Surgical Andrology, Centre of Reproductive Medicine and Andrology, Münster University Hospital, Münster, GermanyORCID Iconhttps://orcid.org/0000-0003-3629-7160View further author information
ORCID Icon,
Pravinath Ramachandranc College of Psychology, Birmingham City University, Birmingham, UKORCID Iconhttps://orcid.org/0000-0003-2502-3105View further author information
ORCID Icon,
Carola S. Königd Department of Mechanical and Aerospace Engineering, Brunel University London, London, UKORCID Iconhttps://orcid.org/0000-0002-9289-3154View further author information
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Geoffrey Hackette School of Health and Life Sciences, Aston University, Birmingham, UKORCID Iconhttps://orcid.org/0000-0003-2073-3001View further author information
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Ahmad Haidera Urological Practice Dr Haider, Bremerhaven, GermanyORCID Iconhttps://orcid.org/0000-0001-9252-0588View further author information
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Farid Saadf Research Department, Gulf Medical University, Ajman, U.A.EORCID Iconhttps://orcid.org/0000-0002-0449-6635View further author information
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Pieter Desnerckg Department of Engineering, University of Cambridge, Cambridge, UKORCID Iconhttps://orcid.org/0000-0002-8042-9741View further author information
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Richard Strangeh School of Pharmacy and Bioengineering, Keele University, Staffordshire, UKORCID Iconhttps://orcid.org/0000-0002-0980-6348View further author information
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Amar Manni Department of Clinical Biochemistry, University Hospitals Birmingham NHS Foundation Trust, West Midlands, UKORCID Iconhttps://orcid.org/0000-0002-7972-4794View further author information
ORCID Icon &
Sudarshan Ramachandrand Department of Mechanical and Aerospace Engineering, Brunel University London, London, UK;h School of Pharmacy and Bioengineering, Keele University, Staffordshire, UK;i Department of Clinical Biochemistry, University Hospitals Birmingham NHS Foundation Trust, West Midlands, UKCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-2299-4133View further author information
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Article: 2357548 | Received 28 Mar 2024, Accepted 14 May 2024, Published online: 29 May 2024

References

  • Antonio L, Wu FCW, Moors H, et al. Erectile dysfunction predicts mortality in Middle-aged and older men independent of their sex steroid status. Age Ageing. 2022;51(4):afac094.
  • Hackett G, Kirby M, Rees RW, et al. The british society for sexual medicine guidelines on male adult testosterone deficiency, with statements for practice. World J Mens Health. 2023;41(3):e33–537. doi: 10.5534/wjmh.221027.
  • Heinemann LA, Saad F, Zimmermann T, et al. The aging males’ symptoms (AMS) scale: update and compilation of international versions. Health Qual Life Outcomes. 2003;1(1):15. 1 doi: 10.1186/1477-7525-1-15.
  • Akehi Y, Tanabe M, Yano H, et al. A simple questionnaire for the detection of testosterone deficiency in men with late-onset hypogonadism. Endocr J. 2022;69(11):1303–1312. doi: 10.1507/endocrj.EJ22-0073.
  • Lunenfeld B, Mskhalaya G, Zitzmann M, et al. Recommendations on the diagnosis, treatment and monitoring of hypogonadism in men. Aging Male. 2015;18(1):5–15. doi: 10.3109/13685538.2015.1004049.
  • Morley JE, Perry HM, 3rd, Kevorkian RT, et al. Comparison of screening questionnaires for the diagnosis of hypogonadism. Maturitas. 2006;53(4):424–429. doi: 10.1016/j.maturitas.2005.07.004.
  • Moore C, Huebler D, Zimmermann T, et al. The aging males’ symptoms scale (AMS) as outcome measure for treatment of androgen deficiency. Eur Urol. 2004;46(1):80–87. doi: 10.1016/j.eururo.2004.01.009.
  • Diem SJ, Greer NL, MacDonald R, et al. Efficacy and safety of testosterone treatment in men: an evidence report for a clinical practice guideline by the American college of physicians. Ann Intern Med. 2020;172(2):105–118. doi: 10.7326/M19-0830.
  • Elliott J, Kelly SE, Millar AC, et al. Testosterone therapy in hypogonadal men: a systematic review and network meta-analysis. BMJ Open. 2017;7(11):e015284. doi: 10.1136/bmjopen-2016-015284.
  • Saad F, Yassin A, Doros G, et al. Effects of long-term treatment with testosterone on weight and waist size in 411 hypogonadal men with obesity classes I-III: observational data from two registry studies. Int J Obes (Lond). 2016;40(1):162–170. doi: 10.1038/ijo.2015.139.
  • Haider KS, Haider A, Doros G, et al. Design and conduct of a real-world single center registry study on testosterone therapy in men with hypogonadism. Androgen Clin Res Ther. 2021;2(1):1–17. doi: 10.1089/andro.2020.0011.
  • Messerli FH, Bangalore S, Schmieder RE. Wilder’s principle: pre-treatment value determines post-treatment response. Eur Heart J. 2015;36(9):576–579.
  • Traish AM, Haider A, Haider KS, et al. Long-Term testosterone therapy improves cardiometabolic function and reduces risk of cardiovascular disease in men with hypogonadism: a Real-Life observational registry study setting comparing treated and untreated (control) groups. J Cardiovasc Pharmacol Ther. 2017;22(5):414–433. doi: 10.1177/1074248417691136.
  • Hackett G, Mann A, Haider A, et al. Testosterone replacement therapy. Effects on blood pressure in hypogonadal men. World J Mens Health. 2024 [cited 2024 Feb 14].
  • Lee CP, Jiang JR, Chen Y, et al. The "aging males’ symptoms" (AMS) scale assesses depression and anxiety. Aging Male. 2013;16(3):97–101.
  • Hackett G, Cole N, Bhartia M, et al. Testosterone replacement therapy with long-acting testosterone undecanoate improves sexual function and quality-of-life parameters vs. placebo in a population of men with type 2 diabetes. J Sex Med. 2013;10(6):1612–1627. doi: 10.1111/jsm.12146.
  • Zitzmann M, Nieschlag E. Androgen receptor gene CAG repeat length and body mass index modulate the safety of long-term intramuscular testosterone undecanoate therapy in hypogonadal men. J Clin Endocrinol Metab. 2007;92(10):3844–3853. doi: 10.1210/jc.2007-0620.
  • Ramachandran P, Zitzmann M, König CS, et al. Testosterone undecanoate is associated with improved ageing male symptoms score in men with type 2 diabetes and adult-onset testosterone deficiency: re-analyzed results from a randomised controlled trial. Explor Endocr Metab Dis. 2024. (in press).

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