46
Views
1
CrossRef citations to date
0
Altmetric
Original

Hemoglobin is an effective inducer of hyphal differentiation in Candidaalbicans

&
Pages 61-71 | Received 12 Jul 2006, Published online: 09 Jul 2009

References

  • Odds FC. Candida and candidosis2nd edn. Bailliere Tindall, Philadelphia 1988
  • Slutsky B, Staebell M, Anderson J, et al. “White-opaque transition”: a second high-frequency switching system in Candida albicans. J Bacteriol 1987; 169: 189–197
  • Brown AJ, Gow NA. Regulatory networks controlling Candida albicans morphogenesis. Trends Microbiol 1999; 7: 333–338
  • Ernst JF. Transcription factors in Candida albicans – environmental control of morphogenesis. Microbiology 2000; 146: 1763–1774
  • Sudbery P, Gow N, Berman J. The distinct morphogenic states of Candida albicans. Trends Microbiol 2004; 12: 317–324
  • Kumamoto CA, Vinces MD. Contributions of hyphae and hypha-co-regulated genes to Candida albicans virulence. Cell Microbiol 2005; 7: 1546–1554
  • Garcia-Sanchez S, Mavor AL, Russell CL, et al. Global roles of Ssn6 in Tup1- and Nrg1-dependent gene regulation in the fungal pathogen, Candida albicans. Mol Biol Cell 2005; 16: 2913–2925
  • Bignell E, Rogers T, Haynes K. Host Recognition by Fungal Pathogens. Pathogenic Fungi: Host Interactions and Emerging Strategies for Control, G San-Blas, RA Calderone. Caister, Norfolk 2004; 3–48
  • Brown AJP. Expression of Growth Form-Specific Factors during Morphogenesis in Candida albicans. ASM Press, Washington, DC 2002
  • Lo HJ, Kohler JR, DiDomenico B, et al. Nonfilamentous C. albicans mutants are avirulent. Cell 1997; 90: 939–949
  • Stoldt VR, Sonneborn A, Leuker CE, Ernst JF. Efg1p, an essential regulator of morphogenesis of the human pathogen Candida albicans, is a member of a conserved class of bHLH proteins regulating morphogenetic processes in fungi. EMBO J 1997; 16: 1982–1991
  • Lane S, Zhou S, Pan T, Dai Q, Liu H. The basic helix-loop-helix transcription factor Cph2 regulates hyphal development in Candida albicans partly via TEC1. Mol Cell Biol 2001; 21: 6418–6428
  • Vinces MD, Haas C, Kumamoto CA. Expression of the Candida albicans morphogenesis regulator gene CZF1 and its regulation by Efg1p and Czf1p. Eukaryot Cell 2006; 5: 825–835
  • El Barkani A, Kurzai O, Fonzi WA, et al. Dominant active alleles of RIM101 (PRR2) bypass the pH restriction on filamentation of Candida albicans. Mol Cell Biol 2000; 20: 4635–4647
  • Lee KL, Buckley HR, Campbell CC. An amino acid liquid synthetic medium for the development of mycelial and yeast forms of Candida albicans. Sabouraudia 1975; 13: 148–153
  • Sherman F. Getting started with yeast. Method Enzymol. 1991; 191: 3–21
  • Daniels R. Delmar's guide to laboratory and diagnostic tests. http://online.statref.com/Document/Document.aspx?FxId=59&DocId=1&SessionId=719F50TQXZNTHSOH: Delmar/Thomson Learning; 2002.
  • Feng Q, Summers E, Guo B, Fink G. Ras signaling is required for serum-induced hyphal differentiation in Candida albicans. J Bacteriol 1999; 181: 6339–6346
  • Hudson DA, Sciascia QL, Sanders RJ, et al. Identification of the dialysable serum inducer of germ-tube formation in Candida albicans. Microbiology 2004; 150: 3041–3049
  • Noverr MC, Huffnagle GB. Regulation of Candida albicans morphogenesis by fatty acid metabolites. Infect Immun 2004; 72: 6206–6210
  • Genco CA, Dixon DW. Emerging strategies in microbial haem capture. Mol Microbiol 2001; 39: 1–11
  • Seery VL, Muller-Eberhard U. Binding of porphyrins to rabbit hemopexin and albumin. J Biol Chem 1973; 248: 3796–3800
  • Casanova M, Cervera AM, Gozalbo D, Martinez JP. Hemin induces germ tube formation in Candida albicans. Infect Immun 1997; 65: 4360–4364
  • Fradin C, Kretschmar M, Nichterlein T, et al. Stage-specific gene expression of Candida albicans in human blood. Mol Microbiol 2003; 47: 1523–1543
  • Barelle CJ, Priest CL, Maccallum DM, et al. Niche-specific regulation of central metabolic pathways in a fungal pathogen. Cell Microbiol 2006; 8: 961–971
  • Pendrak ML, Yan SS, Roberts DD. Sensing the host environment: recognition of hemoglobin by the pathogenic yeast Candida albicans. Arch Biochem Biophys 2004; 426: 148–156
  • Yan S, Rodrigues RG, Cahn-Hidalgo D, Walsh TJ, Roberts DD. Hemoglobin induces binding of several extracellular matrix proteins to Candida albicans. Identification of a common receptor for fibronectin, fibrinogen, and laminin. J Biol Chem 1998; 273: 5638–5644
  • Pendrak ML, Krutzsch HC, Roberts DD. Structural requirements for hemoglobin to induce fibronectin receptor expression in Candida albicans. Biochemistry 2000; 39: 16110–16118
  • Yan S, Rodrigues RG, Roberts DD. Hemoglobin-induced binding of Candida albicans to the cell-binding domain of fibronectin is independent of the Arg-Gly-Asp sequence. Infect Immun 1998; 66: 1904–1909
  • Yan S, Negre E, Cashel JA, et al. Specific induction of fibronectin binding activity by hemoglobin in Candida albicans grown in defined media. Infect Immun 1996; 64: 2930–2935
  • Negre E, Vogel T, Levanon A, et al. The collagen binding domain of fibronectin contains a high affinity binding site for Candida albicans. J Biol Chem 1994; 269: 22039–22045
  • Pendrak ML, Chao MP, Yan SS, Roberts DD. Heme oxygenase in Candida albicans is regulated by hemoglobin and is necessary for metabolism of exogenous heme and hemoglobin to alpha-biliverdin. J Biol Chem 2004; 279: 3426–3433
  • Pendrak ML, Yan SS, Roberts DD. Hemoglobin regulates expression of an activator of mating-type locus alpha genes in Candida albicans. Eukaryot Cell 2004; 3: 764–775
  • Bennett RJ, Johnson AD. Mating in Candida albicans and the search for a sexual cycle. Annu Rev Microbiol 2005; 59: 233–255
  • Weissman Z, Kornitzer D. A family of Candida cell surface haem-binding proteins involved in haemin and haemoglobin-iron utilization. Mol Microbiol 2004; 53: 1209–1220
  • Bensen ES, Filler SG, Berman J. A forkhead transcription factor is important for true hyphal as well as yeast morphogenesis in Candida albicans. Eukaryotic Cell 2002; 1: 787–798
  • Köhrer K, Domdey H. Preparation of High Molecular Weight RNA. Yeast Genetics and Molecular Biology, C Guthrie, GR Fink. Academic Press, San Diego 1991; 398–405
  • Kalendar R. A computer program ‘Oligos’ for PCR primers design. In: Skovde (ed.). The Third International Bioinformatics Meeting in Scandinavia: Bioinformatics, 2001. Version 3.06, University of Helsinki; 2001.
  • Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 2001; 29: e45
  • Sharkey LL, McNemar MD, Saporito-Irwin SM, Sypherd PS, Fonzi WA. HWP1 functions in the morphological development of Candida albicans downstream of EFG1, TUP1, and RBF1. J Bacteriol 1999; 181: 5273–5279
  • Birse CE, Irwin MY, Fonzi WA, Sypherd PS. Cloning and characterization of ECE1, a gene expressed in association with cell elongation of the dimorphic pathogen Candida albicans. Infect Immun 1993; 61: 3648–3655
  • Biswas K, Morschhauser J. The Mep2p ammonium permease controls nitrogen starvation-induced filamentous growth in Candida albicans. Mol Microbiol 2005; 56: 649–669
  • Braun BR, Johnson AD. TUP1, CPH1 and EFG1 make independent contributions to filamentation in Candida albicans. Genetics 2000; 155: 57–67
  • Hasenclever HF. The in vitro interactions of Candida albicans with nonspecific serum proteins. Mycopathologia 1978; 65: 169–176
  • Barlow AJ, Aldersley T, Chattaway FW. Factors present in serum and seminal plasma which promote germ-tube formation and mycelial growth of Candida albicans. J Gen Microbiol 1974; 82: 261–272
  • Na N, Ouyang J, Taes YE, Delanghe JR. Serum free hemoglobin concentrations in healthy individuals are related to haptoglobin type. Clin Chem 2005; 51: 1754–1755
  • Shuster A, Osherov N, Rosenberg M. Alcohol-mediated haemolysis in yeast. Yeast 2004; 21: 1335–1342
  • Luo G, Samaranayake LP, Yau JY. Candida species exhibit differential in vitro hemolytic activities. J Clin Microbiol 2001; 39: 2971–2974
  • Manns JM, Mosser DM, Buckley HR. Production of a hemolytic factor by Candida albicans. Infect Immun 1994; 62: 5154–5156
  • Werner-Washburne M, Braun E, Johnston GC, Singer RA. Stationary phase in the yeast Saccharomyces cerevisiae. Microbiol Rev 1993; 57: 383–401
  • Shepherd MG, Yin CY, Ram SP, Sullivan PA. Germ tube induction in Candida albicans. Can J Microbiol 1980; 26: 21–26
  • Gimeno CJ, Ljungdahl PO, Styles CA, Fink GR. Unipolar cell divisions in the yeast S. cerevisiae lead to filamentous growth: regulation by starvation and RAS. Cell 1992; 68: 1077–1090
  • Magasanik B. Regulation of Nitrogen Utilization. Molecular and Cellular Biology of the Yeast Saccharomyces: Gene Expression, E Jones, J Pringle, J Broach. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY 1992; 283–317
  • Protchenko O, Rodriguez-Suarez R, Androphy R, Bussey H, Philpott CC. A screen for genes of heme uptake identifies the FLC family required for import of FAD into the endoplasmic reticulum. J Biol Chem 2006; 281: 21445–21457
  • Santos R, Buisson N, Knight S, et al. Haemin uptake and use as an iron source by Candida albicans: role of CaHMX1-encoded haem oxygenase. Microbiology 2003; 149: 579–588
  • Liu H, Kohler J, Fink G. Suppression of hyphal formation in Candida albicans by mutation of a STE12 homolog. Science 1994; 266: 1723–1725

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.