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Original Articles

Expectancy effect: Impact of pill administration on cognitive performance in healthy seniors

, , , , &
Pages 7-17 | Received 12 Jul 2006, Accepted 03 Oct 2006, Published online: 30 Dec 2007

REFERENCES

  • Ader , R. and Cohen , N. 1982 . Behaviorally conditioned immunosuppression and murine systemic lupus erythematosus . Science , 215 : 1534 – 1536 .
  • Amanzio , M. and Benedetti , F. 1999 . Neuropharmacological dissection of placebo analgesia: Expectation-activated opioid systems versus conditioning-activated specific subsystems . Journal of Neuroscience , 19 : 484 – 494 .
  • Amanzio , M. , Pollo , A. , Maggi , G. and Benedetti , F. 2001 . Response variability to analgesics: A role for non-specific activation of endogenous opioids . Pain , 90 : 205 – 215 .
  • American Psychological Association . 2002 . Ethical principles of psychologists and code of conduct . American Psychologist , 57 : 1060 – 1073 .
  • Asada , H. , Fukuda , Y. , Tsunoda , S. , Yamaguchi , M. and Tonoike , M. 1999 . Frontal midline theta rhythms reflect alternative activation of prefrontal cortex and anterior cingulate cortex in humans . Neuroscience Letters , 274 : 29 – 32 .
  • Bandura , A. 1997 . Self-efficacy: The exercise of control , New York : W. H. Freeman and Company .
  • Barsky , A. J. , Saintfort , R. , Rogers , M. P. and Borus , J. F. 2002 . Nonspecific medication side effects and the nocebo phenomenon . JAMA: The Journal of the American Medical Association , 287 : 622
  • Benedetti , F. , Arduino , C. , Costa , S. , Vighetti , S. , Tarenzi , L. Rainero , I. 2006 . Loss of expectation-related mechanisms in Alzheimer's disease makes analgesic therapies less effective . Pain , 121 : 133 – 144 .
  • Benedetti , F. , Mayberg , H. S. , Wager , T. D. , Stohler , C. S. and Zubieta , J.-K. 2005 . Neurobiological mechanisms of the placebo effect . The Journal of Neuroscience , 25 : 10390 – 10402 .
  • Benedetti , F. , Colloca , L. , Torre , E. , Lanotte , M. , Melcarne , A. Pesare , M. 2004 . Placebo-responsive Parkinson patients show decreased activity in single neurons of subthalamic nucleus . Nature Neuroscience , 7 : 587 – 588 .
  • Benedict , R. H. B. 1997 . Brief Visuospatial Memory Test–Revised , Lutz, FL : Psychological Assessment Resources, Inc. .
  • Benton , A. and Hamsher , K. 1989 . Multilingual Aphasia Examination , Iowa City, IA : AJA Associates .
  • Berry , J. M. , West , R. L. and Dennehey , D. 1989 . Reliability and validity of the Memory Self-Efficacy Questionnaire (MSEQ) . Developmental Psychology , 25 : 701 – 713 .
  • Birks , J. 2006 . Cholinesterase inhibitors for Alzheimer's disease . Cochrane Database of Systematic Reviews , Retrieved November 7 2007
  • Brody , H. M. 2000 . The placebo response . Journal of Family Practice , 49 : 649 – 654 .
  • Buckalew , L. 1972 . An analysis of experimental components in a placebo effect . The Psychological Record , 22 : 113 – 119 .
  • Buckalew , L. and Coffield , K. E. 1982 . An investigation of drug expectancy as a function of capsule color and size and preparation form . Journal of Clinical Psychopharmacology , 2 : 245 – 248 .
  • Buckalew , L. , Ross , S. and Starr , J. B. 1981 . Nonspecific factors in drug effects: Placebo personality . Psychological Reports , 48 : 3 – 8 .
  • Challis , G. B. and Stam , H. J. 1992 . A longitudinal study of the development of anticipatory nausea and vomiting in cancer chemotherapy patients: The role of absorption and autonomic perception . Health Psychology , 11 : 181 – 189 .
  • Cloninger , C. R. 1987 . Tridimensional Personality Questionnaire Version 4 , St. Louis, MO : Washington University Press .
  • Cohen , S. , Karmarck , T. and Mermelstein , R. 1983 . A global measure of perceived stress . Journal of Health and Social Behavior , 24 : 385 – 396 .
  • Costa , P. T. and McCrae , R. R. 1992 . Professional manual: Revised NEO Personality Inventory (NEO PI-R) and NEO Five-Factor Inventory (NEO-FFI) , Lutz, FL : Psychological Assessment Resources .
  • Crow , R. , Gage , H. , Hampson , S. , Hart , J. , Kimber , A. and Thomas , H. 1999 . The role of expectancies in the placebo effect and their use in the delivery of health care: A systematic review . Health Technology Assessment , 3 : 1 – 48 .
  • Daffner , K. R. , Scinto , L. F. M. , Weintraub , S. , Guinessy , J. and Mesulam , M. M. 1994 . The impact of aging on curiosity as measured by exploratory eye movements . Archives of Neurology , 51 : 368 – 376 .
  • de Craen , A. J. , Moerman , D. E. , Heisterkamp , S. H. , Tytgat , G. N. , Tijssen , J. G. and Kleijnen , J. 1999 . Placebo effect in the treatment of duodenal ulcer . Journal of Clinical Pharmacology , 48 : 853 – 860 .
  • de la Fuente-Fernandez , R. , Ruth , T. J. , Sossi , V. , Schulzer , M. , Calne , D. B. and Stoessl , A. J. 2001 . Expectation and dopamine release: Mechanism of the placebo effect in Parkinson's disease . Science , 293 : 1164 – 1166 .
  • Di Blasi , Z. , Harkness , E. , Ernst , E. , Georgiou , A. and Kleijnen , J. 2001 . Influence of context effects on health outcomes: A systematic review . Lancet , 357 : 757 – 762 .
  • Dodrill , C. 1978 . A neuropsychological battery for epilepsy . Epilepsia , 19 : 611 – 623 .
  • Dodrill , C. 1981 . An economical method for evaluation of general intelligence in adults . Journal of Consulting and Clinical Psychology , 49 : 668 – 673 .
  • Freund , J. , Krupp , G. , Goodenough , D. and Preston , L. W. 1972 . The doctor–patient relationship and drug effect . Clinical Pharmacology and Therapeutics , 13 : 172 – 180 .
  • Gevins , A. , Smith , M. , McEvoy , L. and Yu , D. 1997 . High resolution EEG mapping of cortical activation related to working memory: Effects of task difficulty, type of processing, and practice . Cerebral Cortex , 7 : 374 – 385 .
  • Gracely , R. H. , Dubner , R. , Wolskee , P. J. and Deeter , W. R. 1983 . Placebo and naloxone can alter postsurgical pain by separate mechanisms . Nature , 306 : 264 – 265 .
  • Griesar , W. S. , Zajdel , D. P. and Oken , B. S. 2002 . Nicotine effects on alertness and attention in non-smokers . Nicotine and Tobacco Research , 4 : 185 – 194 .
  • Harrington , A. 2002 . “Seeing” the placebo effect: Historical legacies and present opportunities ” . In The science of placebo , Edited by: Guess , H. A. , Kleinman , A. , Kusek , J. W. and Engel , L. W. 35 – 51 . London : BMJ Books .
  • Hoddes , E. , Zarcone , V. , Smythe , H. , Phillips , R. and Dement , W. C. 1973 . Quantification of sleepiness: A new approach . Psychophysiology , 10 : 431 – 436 .
  • Kaptchuk , T. J. 1998a . Concerns about run-in periods in randomized trials . JAMA: The Journal of the American Medical Association , 279 : 1526 – 1527 .
  • Kaptchuk , T. J. 1998b . Powerful placebo: The dark side of the randomised controlled trial . Lancet , 351 : 1722 – 1725 .
  • Kaptchuk , T. J. , Goldman , P. , Stone , D. A. and Stason , W. B. 2000 . Do medical devices have enhanced placebo effects? . Journal of Clinical Epidemiology , 53 : 786 – 792 .
  • Katzman , R. , Brown , T. , Fuld , P. , Schechter , R. and Schimmel , H. 1983 . Validation of a short orientation-memory-concentration test of cognitive impairment . American Journal of Psychiatry , 140 : 734 – 739 .
  • Kienle , G. S. and Kiene , H. 1997 . The powerful placebo effect: Fact or fiction? . Journal of Clinical Epidemiology , 50 : 1311 – 1318 .
  • Levine , J. D. , Gordon , N. C. and Fields , H. L. 1978 . The mechanism of placebo analgesia . Lancet , 2 ( 8091 ) September 23 : 654 – 657 .
  • Lotshaw , S. C. , Bradley , J. R. and Brooks , L. R. 1996 . Illustrating caffeine's pharmacological and expectancy effects utilizing a balanced placebo design . Journal of Drug Education , 26 : 13 – 24 .
  • McDonald , C. J. and Mazzuca , S. A. 1983 . How much of the placebo “effect” is really statistical regression? . Statistics in Medicine , 2 : 417 – 427 .
  • McNair , D. M. and Barrett , J. E. 1979 . Two bass scale factors and response to placebo and anxiolytic drugs . Psychopharmacology , 65 : 165 – 170 .
  • Mitchell , S. H. , Laurent , C. L. and de Witt , H. 1996 . Interaction of expectancy and the pharmacological effects of d-amphetamine: Subjective effects and self-administration . Psychopharmacologia , 125 : 371 – 378 .
  • Moerman , D. E. 2002 . “ Explanatory mechanisms for placebo effects: Cultural influences and the meaning response ” . In The science of the placebo , Edited by: Guess , H. A. , Kleinman , A. , Kusek , J. W. and Engel , L. W. 77 – 107 . London : BMJ Books .
  • Montgomery , G. and Kirsch , I. 1996 . Mechanisms of placebo pain reduction: An empirical investigation . Psychological Science , 7 : 174 – 176 .
  • Morris , J. , Heyman , A. , Mohs , R. and Hughes , M. 1989 . The Consortium to Establish a Registry for Alzheimer's Disease (CERAD) Part 1. Clinical and neuropsychological assessment of Alzheimer's disease . Neurology , 39 : 1159 – 1165 .
  • National Bioethics Advisory Commission. (2001). Ethical and policy issues in research involving human participants. In N. B. A. Commission (Ed.) (pp. 135) http://bioethics.georgetown.edu/nbac/human/oversumm.html
  • Oken , B. S. 2004 . “ Placebo effect: Clinical perspectives and potential mechanisms ” . In Complementary therapies in neurology: An evidence-based approach , Edited by: Oken , B. S. 199 – 230 . New York : Parthenon Publishing .
  • Pablos-Mâendez , A. , Barr , R. G. and Shea , S. 1998 . Run-in periods in randomized trials: Implications for the application of results in clinical practice . JAMA: The Journal of the American Medical Association , 279 : 222 – 225 .
  • Perry , N. S. , Bollen , C. , Perry , E. K. and Ballard , C. 2003 . Salvia for dementia therapy: Review of pharmacological activity and pilot tolerability clinical trial . Pharmacology, Biochemistry, and Behavior , 75 : 651 – 659 .
  • Petrovic , P. , Kalso , E. , Petersson , K. M. and Ingvar , M. 2002 . Placebo and opioid analgesia—imaging a shared neuronal network . Science , 295 : 1737 – 1740 .
  • Pocock , S. J. and Simon , R. 1975 . Sequential treatment assignment with balancing for prognostic factors in the controlled clinical trial . Biometrics , 31 : 103 – 115 .
  • Pollo , A. , Amanzio , M. , Arslanian , A. , Casadio , C. , Maggi , G. and Benedetti , F. 2001 . Response expectancies in placebo analgesia and their clinical relevance . Pain , 93 : 77 – 84 .
  • Radloff , L. 1977 . The CES-D scale: A self-report depression scale for research in the general population . Applied Psychological Measurement , 1 : 385 – 401 .
  • Roberts , A. H. , Kewman , D. G. , Mercier , L. and Hovell , M. 1993 . The power of nonspecific effects in healing: Implications for psychosocial and biological treatments . Clinical Psychology Review , 13 : 375 – 391 .
  • Rypma , B. and D'Esposito , M. 2000 . Isolating the neural mechanisms of age-related changes in human working memory . Nature Neuroscience , 3 : 509 – 515 .
  • Salinsky , M. C. , Oken , B. S. , Storzbach , D. and Dodrill , C. B. 2003 . Assessment of CNS effects of antiepileptic drugs using quantitative EEG measures . Epilepsia , 44 : 1042 – 1050 .
  • Scheier , M. F. and Carver , C. S. 1994 . Distinguishing optimism from neuroticism (and trait anxiety, self-mastery, and self-esteem): A re-evaluation of the Life Orientation Test . Journal of Personality and Social Psychology , 67 : 1063 – 1078 .
  • Schwarzer , R. and Jerusalem , M. 1995 . “ Generalized self-efficacy scale ” . In Measures in health psychology: A user's portfolio. Causal and control beliefs , Edited by: Weinman , J. , Wright , S. and Johnston , M. 35 – 37 . Windsor, UK : NFER-Nelson .
  • Siegel , S. 1985 . “ Drug anticipatory responses in animals ” . In Placebo: Theory, research and mechanisms , Edited by: White , L. , Tursky , B. and Schwartz , G. E. 288 – 305 . New York : Guilford Press .
  • Smets , E. M. , Garssen , B. , Bonke , B. and De Haes , J. C. 1995 . The Multidimensional Fatigue Inventory (MFI) psychometric qualities of an instrument to assess fatigue . Journal of Psychosomatic Research , 39 : 315 – 325 .
  • Spiegel , H. 1997 . Nocebo: The power of suggestibility . Preventive Medicine , 26 : 616 – 621 .
  • Stoessl , A. J. and de la Fuente-Fernandez , R. 2004 . Willing oneself better on placebo—effective in its own right . The Lancet , 364 : 227 – 228 .
  • Tellegen , A. and Atkinson , G. 1974 . Openness to absorbing and self-altering experiences (“absorption”), a trait related to hypnotic susceptibility . Journal of Abnormal Psychology , 83 : 268 – 277 .
  • Thong , T. , Yung , I. O. , Zajdel , D. P. , Ellingson , R. M. , McNames , J. Aboy , M. Heart rate variability analysis of effects of nicotine using Lomb–Welch periodograms . Paper presented at the 26th Annual IEEE Engineering in Medicine and Biology Society . San Francisco.
  • van Dongen , M. , van Rossum , E. , Kessels , A. , Sielhorst , H. and Knipschild , P. 2000 . The efficacy of ginkgo for elderly people with dementia and age-associated memory impairment: New results of a randomized clinical trial . Journal of the American Geriatric Society , 48 : 1183 – 1194 .
  • Voudouris , N. J. , Peck , C. L. and Coleman , G. 1989 . Conditioned response models of placebo phenomena: Further support . Pain , 38 : 109 – 116 .
  • Wilkinson , G. S. 1993 . Wide Range Achievement Test–Revision 3 administration manual , Wilmington, DE : Wide Range, Inc. .
  • Zubieta , J.-K. , Bueller , J. A. , Jackson , L. R. , Scott , D. J. , Xu , Y. Koeppe , R. A. 2005 . Placebo effects mediated by endogenous opioid activity on mu opioid receptors . Journal of Neuroscience , 25 : 7754 – 7762 .

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