794
Views
32
CrossRef citations to date
0
Altmetric
Original Articles

Neurobehavioral differences between Alzheimer's disease and frontotemporal dementia: A meta-analysis

&
Pages 682-698 | Received 20 Aug 2009, Accepted 20 Oct 2009, Published online: 08 Jan 2010

REFERENCES

  • American Psychiatric Association . 1994 . Diagnostic and statistical manual of mental disorders: DSM-IV , 4th , Washington, DC : Author . ed.
  • American Psychiatric Association . 2000 . Diagnostic and statistical manual of mental disorders: DSM-IV-TR , 4th , Washington, DC : Author . text rev.
  • Assal , F. and Cummings , J. 2002 . Neuropsychiatric symptoms in the dementias . Current Opinion in Neurology , 15 ( 4 ) : 445 – 450 .
  • Bathgate , D. , Snowden , J. S. , Blackshaw , V. A. and Neary , D. 2001 . Behaviour in frontotemporal dementia, Alzheimer's disease and vascular dementia . Acta Neurologica Scandinavica , 103 : 367 – 378 .
  • Boone , K. , Miller , B. L. , Swartz , R. J. , Lu , P. and Lee , A. 2003 . Relationship between positive and negative symptoms and neuropsychological scores in frontotemporal dementia and Alzheimer's disease . Journal of the International Neuropsychological Society , 9 : 698 – 709 .
  • Brun , A. , Englund , E. , Gustafson , L. , Passant , U. , Mann , D. M. Neary , D. 1994 . Clinical and neuropathological criteria for frontotemporal dementia: The Lund and Manchester groups . Journal of Neurology, Neurosurgery, and Psychiatry , 57 : 416 – 418 .
  • Burns , A. , Jacoby , R. and Levy , R. 1990a . Psychiatric phenomena in Alzheimer's disease: I. Disorders of thought content . British Journal of Psychiatry , 157 : 72 – 76 .
  • Burns , A. , Jacoby , R. and Levy , R. 1990b . Psychiatric phenomena in Alzheimer's disease: II. Disorders of perception . British Journal of Psychiatry , 157 : 76 – 81 .
  • Burns , A. , Jacoby , R. and Levy , R. 1990c . Psychiatric phenomena in Alzheimer's disease: III. Disorders of mood . British Journal of Psychiatry , 157 : 81 – 86 .
  • Burns , A. , Jacoby , R. and Levy , R. 1990d . Psychiatric phenomena in Alzheimer's disease: IV. Disorders of behaviour . British Journal of Psychiatry , 157 : 86 – 94 .
  • Chinn , S. 2000 . A simple method for converting an odds ratio to effect size for use in meta-analysis . Statistics in Medicine , 19 : 3127 – 3131 .
  • Chow , T. W. 2000 . Personality in frontal lobe disorders . Current Psychiatry Reports , 2 : 446 – 451 .
  • Chow , T. W. , Miller , B. L. , Boone , K. , Mishkin , F. and Cummings , J. L. 2002 . Frontotemporal dementia classification and neuropsychiatry . Neurologist , 8 : 263 – 269 .
  • Cohen , J. 1988 . Statistical power analysis for the behavioral sciences , 2nd , New York : Academic Press . ed.
  • Cummings , J. L. 2004 . Drug therapy: Alzheimer's disease . New England Journal of Medicine , 351 : 56 – 67 .
  • Cummings , J. L. 2003 . Use of cholinesterase inhibitors in clinical practice: Evidence-based recommendations . American Journal of Geriatric Psychiatry, , 11 : 131 – 145 .
  • De Deyn , P. P. , Engelborghs , S. , Saerens , J. , Goeman , J. , Mariën , P. Maertens , K. 2005 . The Middelheim Frontality Score: A behavioural assessment scale that discriminates frontotemporal dementia from Alzheimer's disease . International Journal of Geriatric Psychiatry , 20 : 70 – 79 .
  • de Vugt , M. E. , Riedijk , S. R. , Aalten , P. , Tibben , A. , van Swiaten , J. C. and Verhey , F. R. 2006 . Impact of behavioural problems on spousal caregivers: A comparison between Alzheimer's disease and frontotemporal dementia . Dementia and Geriatric Cognitive Disorders , 22 : 35 – 41 .
  • Engelborghs , S. , Dermaut , B. , Mariën , P. , Symons , A. , Vloeberghs , E. Maertens , K. 2006a . Dose dependent effect of APOE ϵ4 on behavioral symptoms in frontal lobe dementia . Neurobiology of Aging , 27 : 285 – 292 .
  • Engelborghs , S. , Maertens , K. , Mariën , P. , Vloeberghs , E. , Somers , N. Nagels , G. 2006b . Behavioural and neuropsychological correlates of frontal lobe features in dementia . Psychological Medicine , 36 : 1173 – 1182 .
  • Engelborghs , S. , Maertens , K. , Nagels , G. , Vloeberghs , E. , Mariën , P. Symons , A. 2005 . Neuropsychiatric symptoms of dementia: Cross-sectional analysis from a prospective, longitudinal Belgian study . International Journal of Geriatric Psychiatry , 20 : 1028 – 1037 .
  • Engelborghs , S. , Maertens , K. , Vloeberghs , E. , Aerts , T. , Somers , N. Mariën , P. 2006c . Neuropsychological and behavioural correlates of CSF biomarkers in dementia . Neurochemistry International , 48 : 286 – 295 .
  • Engelborghs , S. , Vloeberghs , E. , Le Bastard , N. , Van Buggenhout , M. V. , Marien , P. Somers , N. 2008 . The dopaminergic neurotransmitter system is associated with aggression and agitation in frontotemporal dementia . Neurochemistry International , 52 : 1052 – 1060 .
  • Engelborghs , S. , Vloeberghs , E. , Maertens , K. , Mariën , P. , Somers , N. Symons , A. 2004 . Correlations between cognitive, behavioural and psychological findings and levels of vitamin B12 and folate in patients with dementia . International Journal of Geriatric Psychiatry , 19 : 365 – 370 .
  • Farlow , M. R. and Cummings , J. L. 2007 . Effective pharmacologic management of Alzheimer's disease . American Journal of Medicine , 120 : 388 – 397 .
  • Figiel , G. and Sadowsky , C. 2008 . A systematic review of the effectiveness of rivastigmine for the treatment of behavioral disturbances in dementia and other neurological disorders . Current Medical Research and Opinion , 24 ( 1 ) : 157 – 166 .
  • Forman , M. S. , Farmer , J. , Johnson , J. K. , Clark , C. M. , Arnold , S. E. Branch , H. 2006 . Frontotemporal dementia: Clinicopathological correlations . Annals of Neurology , 59 : 952 – 962 .
  • Galton , C. J. , Patterson , K. , Xuereb , J. and Hodges , J. R. 2000 . Atypical and typical presentations of Alzheimer's disease: A clinical, neuropsychological, neuroimaging and pathological study of 13 cases . Brain , 123 : 484 – 498 .
  • Greene , J. D. , Patterson , K. , Xuereb , J. and Hodges , J. R. 1996 . Alzheimer disease and nonfluent progressive aphasia . Archives of Neurology , 53 : 1072 – 1078 .
  • Greicius , M. D. , Geschwind , M. D. and Miller , B. L. 2002 . Presenile dementia syndromes: An update on taxonomy and diagnosis . Journal of Neurology, Neurosurgery, and Psychiatry , 72 : 691 – 700 .
  • Hedges , L. V. and Olkin , I. 1985 . Statistical methods for meta-analysis , Orlando, FL : Academic Press .
  • Hirono , N. , Mori , E. , Tanimukai , S. , Kazui , H. , Hashimoto , M. Hanihara , T. 1999 . Distinctive neurobehavioral features among neurodegenerative dementias . Journal of Neuropsychiatry & Clinical Neurosciences , 11 : 498 – 503 .
  • Hodges , J. R. , Davies , R. R. , Xuereb , J. H. , Casey , B. , Broe , M. Bak , T. H. 2004 . Clinicopathological correlates in frontotemporal dementia . Annals of Neurology , 56 : 399 – 406 .
  • Hou , C. E. , Carlin , D. and Miller , B. L. 2004 . Non-Alzheimer's disease dementias: Anatomic, clinical, and molecular correlates . Canadian Journal of Psychiatry , 49 : 164 – 171 .
  • Hunter , J. E. , Schmidt , F. L and Jackson , G. B. 1982 . Meta-analysis: Cumulating research findings across studies , Beverly Hills, CA : Sage .
  • Hutchinson , A. D. and Mathias , J. L. 2007 . Neuropsychological deficits in frontotemporal dementia and Alzheimer's disease: A meta-analytic review . Journal of Neurology, Neurosurgery, and Psychiatry , 78 : 917 – 928 .
  • Ikeda , M. , Brown , J. , Holland , A. J. , Fukuhara , R. and Hodges , J. R. 2002 . Changes in appetite, food preference, and eating habits in frontotemporal dementia and Alzheimer's disease . Journal of Neurology, Neurosurgery, and Psychiatry , 73 : 371 – 376 .
  • Jalbert , J. J. , Daiello , L. A. and Lapane , K. L. 2008 . Dementia of the Alzheimer type . Epidemiological Reviews , 30 : 15 – 34 .
  • Jenner , C. , Reali , G. and Silveri , M. C. 2006 . Can cognitive and behavioural disorders differentiate frontal variant-frontotemporal dementia from Alzheimer's disease at early stages? . Behavioural Neurology , 17 : 89 – 95 .
  • Jorm , A. F. and Jolley , D. 1998 . The incidence of dementia: A meta-analysis . Neurology , 51 : 728 – 733 .
  • Kertesz , A. , Davidson , W. and Fox , H. 1997 . Frontal Behavioral Inventory: Diagnostic criteria for frontal lobe dementia . Canadian Journal of Neurological Sciences , 24 : 29 – 36 .
  • Kertesz , A. , Davidson , W. , McCabe , P. and Munoz , D. 2003 . Behavioral quantitation is more sensitive than cognitive testing in frontotemporal dementia . Alzheimer Disease and Associated Disorders , 17 : 223 – 229 .
  • Kertesz , A. , Nadkarni , N. , Davidson , W. and Thomas , A. W. 2000 . The Frontal Behavioral Inventory in the differential diagnosis of frontotemporal dementia . Journal of the International Neuropsychological Society , 6 : 460 – 468 .
  • Levy , M. L. , Cummings , J. , Fairbanks , L. A. , Masterman , D. , Miller , B. L. Craig , A. 1998 . Apathy is not depression . Journal of Neuropsychiatry & Clinical Neurosciences , 10 : 314 – 319 .
  • Levy , M. , Miller , B. L. , Cummings , J. , Fairbanks , L. A. and Craig , A. 1996 . Alzheimer disease and frontotemporal dementias: Behavioral distinctions . Archives of Neurology , 53 : 687 – 690 .
  • Lezak , M. D. , Howieson , D. B. , Loring , D. W. , Hannay , H. J. and Fischer , J. S. 2004 . Neuropsychological Assessment , 4th , New York : Oxford University Press .
  • Libon , D. J. , Massimo , L. , Moore , P. , Coslett , H. B. , Chatterjee , A. Aguirre , G. K. 2007 . Screening for frontotemporal dementias and Alzheimer's disease with the Philadelphia Brief Assessment of Cognition: A preliminary analysis . Dementia and Geriatric Cognitive Disorders , 24 : 441 – 447 .
  • Lipsey , M. W. and Wilson , D. B. 2001 . Practical meta-analysis Thousand Oaks, CA Sage.
  • Liu , W. , Miller , B. L. , Kramer , J. H. , Rankin , K. P. , Wyss-Coray , C. Gearhart , R. 2004 . Behavioral disorders in the frontal and temporal variants of frontotemporal dementia . Neurology , 62 : 742 – 748 .
  • Lopez , O. L. , Gonzales , M. , Becker , J. T. , Reynolds , C. F. , Sudilovski , A. and DeKosky , S. 1996 . Symptoms of depression and psychosis in Alzheimer's disease and frontotemporal dementia: Exploration of underlying mechanisms . Neuropsychiatry, Neuropsychology and Behavioral Neurology , 9 : 154 – 161 .
  • Mann , D. M. , South , P. W. , Snowden , J. S. and Neary , D. 1993 . Dementia of frontal lobe type: Neuropathology and immunohistochemistry . Journal of Neurology, Neurosurgery, and Psychiatry , 56 : 605 – 614 .
  • McKhann , G. , Drachman , D. , Folstein , M. , Katzman , R. , Price , D. and Stadlan , E. M. 1984 . Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group, Department of Health and Human Services Task Force on Alzheimer's disease . Neurology , 34 : 939 – 944 .
  • Mega , M. S. , Cummings , J. L. , Fiorello , T. and Gornbein , J. 1996 . The spectrum of behavioral changes in Alzheimer's disease . Neurology , 46 : 130 – 135 .
  • Mendez , M. F. , McMurtray , A. , Licht , E. , Shapira , J. , Saul , R. E. and Miller , B. L. 2006 . The Scale for Emotional Blunting in patients with frontotemporal dementia . Neurocase, , 12 : 242 – 246 .
  • Mendez , M. F. , Perryman , K. M. , Miller , B. L. and Cummings , J. 1998 . Behavioral differences between frontotemporal dementia and Alzheimer's disease: A comparison on the BEHAVE-AD Rating Scale . International Psychogeriatrics , 10 : 155 – 162 .
  • Miller , B. L. , Darby , A. , Benson , D. F. , Cummings , J. and Miller , M. H. 1997a . Aggressive, socially disruptive and antisocial behaviour associated with fronto-temporal dementia . British Journal of Psychiatry , 170 : 150 – 154 .
  • Miller , B. L. , Diehl , J. , Freedman , M. , Kertesz , A. , Mendez , M. F. and Rascovsky , K. 2003 . International approaches to frontotemporal dementia diagnosis: From social cognition to neuropsychology . Annals of Neurology , 54 ( Suppl. 5 ) : S7 – S10 .
  • Miller , B. L. , Ikonte , C. , Ponton , M. , Levy , M. , Boone , K. Darby , A. 1997b . A study of the Lund–Manchester research criteria for frontotemporal dementia: Clinical and single-photon emission CT correlations . Neurology , 48 : 937 – 942 .
  • Miller , B. L. , Seeley , W. W. , Mychack , P. , Rosen , H. J. , Mena , I. and Boone , K. 2001 . Neuroanatomy of the self: Evidence from patients with frontotemporal dementia . Neurology , 57 : 817 – 821 .
  • Mourik , J. C. , Rosso , S. M. , Niermeijer , M. F. , Duivenvoorden , H. J. , Van Swieten , J. C. and Tibben , A. 2004 . Frontotemporal dementia: Behavioral symptoms and caregiver distress . Dementia and Geriatric Cognitive Disorders , 18 : 299 – 306 .
  • Mychack , P. , Rosen , H. J. and Miller , B. L. 2001 . Novel applications of social-personality measures to the study of dementia . Neurocase , 7 : 131 – 143 .
  • Nagahama , Y. , Okina , T. , Suzuki , N. and Matsuda , M. 2006 . The Cambridge Behavioral Inventory: Validation and application in a memory clinic . Journal of Geriatric Psychiatry and Neurology , 19 : 220 – 225 .
  • Neary , D. , Snowden , J. S. , Gustafson , L. , Passant , U. , Stuss , D. Black , S. 1998 . Frontotemporal lobar degeneration: A consensus on clinical diagnostic criteria . Neurology , 51 : 1546 – 1554 .
  • Ott , B. R. and Fogel , B. S. 1992 . Measurement of depression in dementia: Self vs clinician rating . International Journal of Geriatric Psychiatry , 7 : 899 – 904 .
  • Rabinowitz , J. , Katz , I. R. , Deyn , P. P. D. , Brodaty , H. , Greenspan , A. and Davidson , M. 2004 . Behavioral and psychological symptoms in patients with dementia as a target for pharmacotherapy with risperidone . Journal of Clinical Psychiatry , 65 : 1329 – 1334 .
  • Rankin , K. P. , Gorno-Tempini , M. L. , Allison , S. C. , Stanley , C. M. , Glenn , S. Weiner , M. 2006 . Structural anatomy of empathy in neurodegenerative disease . Brain , 129 : 2945 – 2956 .
  • Rankin , K. P. , Kramer , J. H. and Miller , B. L. 2005 . Patterns of cognitive and emotional empathy in frontotemporal lobar degeneration . Cognitive and Behavioral Neurology , 18 : 28 – 36 .
  • Rankin , K. P. , Kramer , J. H. , Mychack , P. and Miller , B. L. 2003 . Double dissociation of social functioning in frontotemporal dementia . Neurology , 60 : 266 – 271 .
  • Rankin , K. P. , Santos-Modesitt , W. , Kramer , J. H. , Pavlic , D. , Beckman , V. and Miller , B. L. 2008 . Spontaneous social behaviors discriminate behavioral dementias from psychiatric disorders and other dementias . Journal of Clinical Psychiatry , 69 : 60 – 73 .
  • Raskind , M. A. , Peskind , E. R. , Wessel , T. and Yuan , W. 2000 . Galantamine in AD: A 6-month randomized, placebo-controlled trial with a 6-month extension. The Galantamine USA-1 Study Group . Neurology , 54 : 2261 – 2268 .
  • Riedijk , S. R. , De Vugt , M. E. , Duivenvoorden , H. J. , Niermeijer , M. F. , Van Swieten , J. C. Verhey , F. R. 2006 . Caregiver burden, health-related quality of life and coping in dementia caregivers: A comparison of frontotemporal dementia and Alzheimer's disease . Dementia and Geriatric Cognitive Disorders , 22 : 405 – 412 .
  • Rosen , H. J. , Allison , S. C. , Ogar , J. M. , Amici , S. , Rose , K. Dronkers , N. 2006 . Behavioral features in semantic dementia vs other forms of progressive aphasias . Neurology , 67 : 1752 – 1756 .
  • Rosenthal , R. 1979 . The “file drawer” problem and tolerance for null results . Psychological Bulletin , 86 : 638 – 641 .
  • Rosenthal , R. 1995 . Writing meta-analytic reviews . Psychological Bulletin , 118 : 183 – 192 .
  • Shinagawa , S. , Ikeda , M. , Fukuhara , R. and Tanabe , H. 2006 . Initial symptoms in frontotemporal dementia and semantic dementia compared with Alzheimer's disease . Dementia and Geriatric Cognitive Disorders , 21 : 74 – 80 .
  • Swartz , R. J. , Miller , B. L. , Lesser , I. M. , Booth , R. , Darby , A. Wohl , M. 1997 . Behavioral phenomenology in Alzheimer's disease, frontotemporal dementia and late-life depression: A retrospective analysis . Journal of Geriatric Psychiatry and Neurology , 10 : 67 – 74 .
  • Walker , A. J. , Meares , S. , Sachdev , P. S. and Brodaty , H. 2005 . The differentiation of mild frontotemporal dementia from Alzheimer's disease and healthy aging by neuropsychological tests . International Psychogeriatrics , 17 : 57 – 68 .
  • Wittenberg , D. , Possin , K. L. , Rascovsky , K. , Rankin , K. P. , Miller , B. L. and Kramer , J. H. 2008 . The early neuropsychological and behavioural characteristics of frontotemporal dementia . Neuropsychology Review , 18 : 91 – 102 .
  • Zakzanis , K. K. 2001 . Statistics to tell the truth, the whole truth, and nothing but the truth: Formulae, illustrative numerical examples, and heuristic interpretation of effect size analyses for neuropsychological researchers . Archives of Clinical Neuropsychology , 16 : 653 – 667 .
  • Zakzanis , K. K. , Leach , L. and Kaplan , E. 1999 . Neuropsychological differential diagnosis , Lisse, , The Netherlands : Swets & Zetilinger .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.