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Original Articles

Information processing speed, neural efficiency, and working memory performance in multiple sclerosis: Differential relationships with structural magnetic resonance imaging

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Pages 1129-1145 | Received 05 Apr 2011, Accepted 03 Aug 2011, Published online: 03 Nov 2011

REFERENCES

  • Amato , M. P. , Bartolozzi , M. L. , Zipoli , V. , Portaccio , E. , Mortilla , M. Guidi , L. 2004 . Neocortical volume decrease in relapsing–remitting MS patients with mild cognitive impairment . Neurology , 63 : 89 – 93 .
  • Archibald , C. J. and Fisk , J. D. 2000 . Information processing efficiency in patients with multiple sclerosis . Journal of Clinical and Experimental Neuropsychology , 22 : 686 – 701 .
  • Baddeley , A. D. 1986 . Working memory , Oxford, , UK : Clarendon Press .
  • Baddeley , A. 2003 . Working memory: Looking back and looking forward . Nature Reviews Neuroscience , 4 : 829 – 839 .
  • Baddeley , A. D. and Hitch , G. J. 1974 . “ Working memory ” . In The psychology of learning and motivation , Edited by: Bower , G. 129 – 148 . San Diego, CA : Academic Press .
  • Bagert , B. , Camplair , P. and Bourdette , D. 2002 . Cognitive dysfunction in multiple sclerosis: Natural history, pathophysiology and management . CNS Drugs , 16 : 445 – 455 .
  • Beck , A. T. , Steer , R. A. and Brown , G. K. 1996 . Manual for the Beck Depression Inventory: II , San Antonio, TX : Psychological Corporation .
  • Benedict , R. H. B. , Bakshi , R. , Simon , J. H. , Priore , R. , Miller , C. and Munschauer , F. 2002 . Frontal cortex atrophy predicts cognitive impairment in multiple sclerosis . Journal of Neuropsychiatry and Clinical Neurosciences , 14 : 44 – 51 .
  • Benedict , R. H. B. , Bruce , J. M. , Dwyer , M. G. , Abdelrahman , N. , Hussein , S. Weinstock-Guttman , B. 2006 . Neocortical atrophy, third ventricular width, and cognitive dysfunction in multiple sclerosis . Archives of Neurology , 63 : 1301 – 1306 .
  • Benedict , R. H. B. , Weinstock-Guttman , B. , Fishman , I. , Sharma , J. , Tjoa , C. W. and Bakshi , R. 2004 . Prediction of neuropsychological impairment in multiple sclerosis . Archives of Neurology , 61 : 226 – 230 .
  • Bielak , A. M. , Hultsch , D. F. , Strauss , E. , MacDonald , S. W. S. and Hunter , M. A. 2010 . Intraindividual variability in reaction time predicts cognitive outcomes 5 years later . Neuropsychology , 24 : 731 – 741 .
  • Blair , J. R. and Spreen , O. 1989 . Predicting premorbid IQ: A revision of the National Adult Reading Test . Clinical Neuropsychologist , 3 : 129 – 136 .
  • Chiaravalloti , N. D. and DeLuca , J. 2008 . Cognitive impairment in multiple sclerosis . Lancet Neurology , 7 : 1139 – 1151 .
  • Correia , S. , Lee , S. Y. , Voorn , T. , Tate , D. F. , Paul , R. H. Zhang , S. 2008 . Quantitative tractography metrics of white matter integrity in diffusion-tensor MRI . NeuroImage , 42 : 568 – 581 .
  • Deary , I. J. , Bastin , M. E. , Pattie , A. , Clayden , J. D. , Whalley , L. J. Starr , J. M. 2006 . White matter integrity and cognition in childhood and old age . Neurology , 66 : 505 – 512 .
  • Deloire , M. S. A. , Salort , E. , Bonnet , M. , Arimone , Y. , Boudineau , M. Amieva , H. 2005 . Cognitive impairment as marker of diffuse brain abnormalities in early relapsing remitting multiple sclerosis . Journal of Neurology, Neurosurgery, and Psychiatry , 76 : 519 – 526 .
  • DeLuca , J. , Chelune , G. J. , Tulsky , D. S. , Lengenfelder , J. and Chiaravalloti , N. D. 2004 . Is speed of processing or working memory the primary information processing deficit in multiple sclerosis? . Journal of Clinical and Experimental Neuropsychology , 26 : 550 – 562 .
  • D'Esposito , M. , Onishi , K. , Thompson , H. , Robinson , K. , Armstrong , C. and Grossman , M. 1996 . Working memory impairments in multiple sclerosis: Evidence from a dual-task paradigm . Neuropsychology , 10 : 51 – 56 .
  • Dineen , R. A. , Vilisaar , J. , Hlinka , J. , Bradshaw , C. M. , Morgan , P. S. Constantinescu , C. S. 2009 . Disconnection as a mechanism for cognitive dysfunction in multiple sclerosis . Brain , 132 : 239 – 249 .
  • Drew , M. A. , Starkey , N. J. and Isler , R. B. 2009 . Examining the link between information processing speed and executive functioning in multiple sclerosis . Archives of Clinical Neuropsychology , 24 : 47 – 58 .
  • Engel , A. K. , König , P. , Kreiter , A. K. , Schillen , T. B. and Singer , W. 1992 . Temporal coding in the visual cortex: New vistas on integration in the nervous system . Trends in Neuroscience , 15 : 218 – 226 .
  • Ferguson , B. , Matyszak , M. K. , Esiri , M. M. and Perry , V. H. 1997 . Axonal damage in acute multiple sclerosis lesions . Brain , 120 : 393 – 399 .
  • Finkel , D. , Reynolds , C. A. , McArdle , J. J. and Pedersen , N. L. 2007 . Age changes in processing speed as a leading indicator of cognitive aging . Psychology and Aging , 22 : 558 – 568 .
  • Foong , J. , Rozewicz , L. , Quaghebeur , G. , Davie , C. A. , Kartsounis , L. D. Thompson , A. J. 1997 . Executive function in multiple sclerosis: The role of frontal lobe pathology . Brain , 120 : 15 – 26 .
  • Forn , C. , Belenguer , A. , Parcet-Ibars , M. A. and Avila , C. 2008 . Information-processing speed is the primary deficit underlying the poor performance of multiple sclerosis patients in the Paced Auditory Serial Addition Test (PASAT) . Journal of Clinical and Experimental Neuropsychology , 30 : 789 – 796 .
  • Friend , K. B. and Grattan , L. 2000 . Use of the North American Adult Reading Test to estimate premorbid intellectual function in patients with multiple sclerosis . Journal of Clinical and Experimental Neuropsychology , 20 : 846 – 851 .
  • Garcia , M. C. , Plasencia , P. M. , Benito , Y. A. , Gomez , J. J. and Marcos , A. R. 2009 . Executive function and memory in patients with relapsing–remitting multiple sclerosis . Psicothema , 21 : 416 – 420 .
  • Gray , C. M. and Singer , W. 1989 . Stimulus-specific neuronal oscillations in orientation columns of cat visual cortex . Proceedings of the National Academy of Sciences , 86 : 1698 – 1702 .
  • Hoddes , E. , Zarcone , V. , Smythe , H. , Phillips , R. and Dement , W. C. 1973 . Quantification of sleepiness: A new approach . Psychophysiology , 10 : 431 – 436 .
  • Janculjak , D. , Mubrin , Z. , Brinar , V. and Spilich , G. 2002 . Changes of attention and memory in a group of patients with multiple sclerosis . Clinical Neurology and Neurosurgery , 104 : 221 – 227 .
  • Jensen , A. R. 1998 . The g factor: The science of mental ability , Westport, CT : Praeger .
  • Jensen , A. R. 2006 . Clocking the mind: Mental chronometry and individual differences , New York, NY : Elsevier .
  • Kail , R. 1998 . Speed of information processing in patients with multiple sclerosis . Journal of Clinical and Experimental Neuropsychology , 20 : 98 – 106 .
  • Kozora , E. and Filley , C. M. 2011 . Cognitive dysfunction and white matter abnormalities in systemic lupus erythematosus . Journal of the International Neuropsychological Society , 17 : 1 – 8 .
  • Kurtzke , J. F. 1983 . Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS) . Neurology , 33 : 1444 – 1452 .
  • Landrø , N. I. , Celius , E. G. and Sletvold , H. 2004 . Depressive symptoms account for deficient information processing speed but not for impaired working memory in early phase multiple sclerosis (MS) . Journal of the Neurological Sciences , 217 : 211 – 216 .
  • Lengenfelder , J. , Bryant , D. , Diamond , B. J. , Kalmar , J. H. , Moore , N. B. and DeLuca , J. 2006 . Processing speed interacts with working memory efficiency in multiple sclerosis . Archives of Clinical Neuropsychology , 21 : 229 – 238 .
  • Lucchinetti , C. , Brück , W. , Parisi , J. , Scheithauer , B. , Rodriguez , M. and Lassman , H. 2000 . Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination . Annals of Neurology , 47 : 707 – 717 .
  • MacDonald , S. W. S. , Nyberg , L. and Backman , L. 2006 . Intra-individual variability in behavior: Links to brain structure, neurotransmission and neuronal activity . Trends in Neurosciences , 29 : 474 – 480 .
  • Martínez , K. and Colom , R. 2009 . Working memory capacity and processing efficiency predict fluid but not crystallized and spatial intelligence: Evidence supporting the neural noise hypothesis . Personality and Individual Differences , 46 : 281 – 286 .
  • McCarthy , M. , Beaumont , J. G. , Thompson , R. and Peacock , S. 2005 . Modality-specific aspects of sustained and divided attentional performance in multiple sclerosis . Archives of Clinical Neuropsychology , 20 : 705 – 718 .
  • McDonald , W. I. , Compston , A. , Edan , G. , Goodkin , D. , Hartung , H. P. Lublin , F. D. 2001 . Recommended diagnostic criteria for multiple sclerosis: Guidelines from the international panel on the diagnosis of multiple sclerosis . Annals of Neurology , 50 : 121 – 127 .
  • Park , D. C. and Reuter-Lorenz , P. 2009 . The adaptive brain: Aging and neurocognitive scaffolding . Annual Review of Psychology , 60 : 173 – 196 .
  • Parmenter , B. A. , Shucard , J. L. , Benedict , R. H. B. and Shucard , D. W. 2006 . Working memory deficits in multiple sclerosis: Comparison between the n-back task and the Paced Auditory Serial Addition Test . Journal of the International Neuropsychological Society , 12 : 677 – 687 .
  • Parmenter , B. A. , Shucard , J. L. and Shucard , D. W. 2007 . Information processing deficits in multiple sclerosis: A matter of complexity . Journal of the International Neuropsychological Society , 13 : 417 – 423 .
  • Pelletier , J. , Suchet , L. , Witjas , T. , Habib , M. , Guttmann , C. R. G. Salamon , G. 2001 . A longitudinal study of callosal atrophy and interhemispheric dysfunction in relapsing–remitting multiple sclerosis . Archives of Neurology , 58 : 105 – 111 .
  • Pelosi , L. , Geesken , J. M. , Holly , M. , Hayward , M. and Blumhardt , L. D. 1997 . Working memory impairment in early multiple sclerosis . Brain , 120 : 2039 – 2058 .
  • Penke , L. , Munoz-Maniega , S. , Murray , C. , Gow , A. J. , Valdez-Hernandez , M. C. Clayden , J. D. 2010 . A general factor of brain white matter integrity predicts information processing speed in healthy older people . The Journal of Neuroscience , 30 : 7569 – 7574 .
  • Pesonen , M. , Hamalainen , H. and Krause , C. M. 2007 . Brain oscillatory 4–30 Hz responses during a visual n-back memory task with varying memory load . Brain Research , 1138 : 171 – 177 .
  • Polman , C. H. , Reingold , S. C. , Edan , G. , Filippi , M. , Hartung , H. P. Kappos , L. 2005 . Diagnostic criteria for multiple sclerosis: 2005 revisions to the “McDonald criteria.” . Annals of Neurology , 58 : 840 – 846 .
  • Rao , S. M. , Grafman , J. , DiGiulio , D. , Mittenberg , W. , Bernardin , L. Leo , G. J. 1993 . Memory dysfunction in multiple sclerosis: Its relation to working memory, semantic encoding, and implicit learning . Neuropsychology , 7 : 364 – 374 .
  • Rao , S. , Leo , G. , Bernardin , L. and Unverzagt , F. 1991 . Cognitive dysfunction in multiple sclerosis: Frequency, patterns, and predictions . Neurology , 41 : 94 – 97 .
  • Reuter , F. , Del Cul , A. , Malikova , I. , Naccache , L. , Confort-Gouny , S. Cohen , L. 2009 . White matter damage impairs access to consciousness in multiple sclerosis . NeuroImage , 44 : 590 – 599 .
  • Roca , M. , Torralva , T. , Meli , F. , Fiol , M. , Calcagno , M. L. Carpintiero , S. 2008 . Cognitive deficits in multiple sclerosis correlate with changes in fronto-subcortical tracts . Multiple Sclerosis , 14 : 364 – 369 .
  • Sadovnick , A. D. , Remick , R. A. , Allen , J. , Swartz , E. , Yee , I. M. L. Eisen , K. 1996 . Depression and multiple sclerosis . Neurology , 46 : 628 – 632 .
  • Salthouse , T. A. and Ferrer-Caja , E. 2003 . What needs to be explained to account for age-related effects on multiple cognitive variables? . Psychology and Aging , 18 : 91 – 110 .
  • Sanfilipo , M. P. , Benedict , R. H. B. , Sharma , J. , Weinstock-Guttman , B. and Bakshi , R. 2005 . The relationship between whole brain volume and disability in multiple sclerosis: A comparison of normalized gray vs. white matter with misclassification correction . NeuroImage , 26 : 1068 – 1077 .
  • Sanfilipo , M. P. , Benedict , R. H. B. , Weinstock-Gutmann , B. and Bakshi , R. 2006 . Gray and white matter brain atrophy and neuropsychological impairment in multiple sclerosis . Neurology , 66 : 685 – 692 .
  • Smith , S. M. , Zhang , Y. , Jenkinson , M. , Chen , J. , Matthews , P. M. Federico , A. 2002 . Accurate, robust, and automated longitudinal and cross-sectional brain change analysis . NeuroImage , 17 : 479 – 489 .
  • Stablum , F. , Meligrana , L. , Sgaramella , T. , Bortolon , F. and Toso , V. 2004 . Endogenous task shift processes in relapsing–remitting multiple sclerosis . Brain and Cognition , 56 : 328 – 331 .
  • Strauss , E. , Bielak , A. A. M. , Bunce , D. , Hunter , M. A. and Hultsch , D. F. 2007 . Within-person variability in response speed as an indicator of cognitive impairment in older adults . Aging, Neuropsychology, and Cognition , 14 : 608 – 630 .
  • Tekok-Kilic , A. , Benedict , R. H. B. , Wienstock-Guttman , B. , Dwyer , M. G. , Carone , D. Srinivasaraghavan , B. 2007 . Independent contributions of cortical gray matter atrophy and ventricle enlargement for predicting neuropsychological impairment in multiple sclerosis . NeuroImage , 36 : 1294 – 1300 .
  • Trapp , B. D. , Peterson , J. , Ransohoff , R. M. , Rudick , R. , Mörk , S. and Bö , L. 1998 . Axonal transection in the lesions of multiple sclerosis . The New England Journal of Medicine , 338 : 278 – 285 .
  • Vernon , P. A. , Wickett , J. C. , Bazana , P. G. and Stelmack , R. M. 2000 . “ The neuropsychology and neurophysiology of human intelligence ” . In Handbook of intelligence , Edited by: Sternberg , R. J. Cambridge, UK : Cambridge University Press .
  • Vernooij , M. W. , Ikram , M. A. , Vrooman , H. A. , Wielopolski , P. A. , Krestin , G. P. Hoffman , A. 2009 . White matter microstructural integrity and cognitive function in a general elderly population . Archives of General Psychiatry , 66 : 543 – 553 .
  • Ward , L. M. 2003 . Synchronous neural oscillations and cognitive processes . Trends in Cognitive Sciences , 7 : 553 – 559 .
  • Watter , S. , Geffen , G. M. and Geffen , L. B. 2001 . The n-back as a dual-task: P300 morphology under divided attention . Psychophysiology , 38 : 998 – 1003 .
  • Wiener , M. C. , Oram , M. W. , Liu , Z. and Richmond , B. J. 2001 . Consistency of encoding in monkey visual cortex . The Journal of Neuroscience , 21 : 8210 – 8221 .
  • Zivadinov , R. , Sepcic , J. , Nasuelli , D. , De Masi , R. , Monti Bragadin , L. Tommasi , M. A. 2001 . A longitudinal study of brain atrophy and cognitive disturbances in the early phase of relapsing–remitting multiple sclerosis . Journal of Neurology, Neurosurgery, and Psychiatry , 70 : 773 – 780 .
  • Zivadinov , R. , Weinstock-Guttman , B. , Benedict , R. , Tamano-Blanco , M. , Hussein , S. Abdelrahman , N. 2007 . Preservation of gray matter volume in multiple sclerosis patients with the Met allele of the rs6265 (Val66Met) SNP of brain derived neurotrophic factor . Human Molecular Genetics , 16 : 2659 – 2668 .

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