Pharmacological characterization of α₁- and β-adrenergic synergism of 5′DII activity in rat brown adipocytes

References

• Argiles J M, Busquets S, Lopez-Soriano F J. The role of uncoupling proteins in pathophysiological states. Biochem Biophys Res Commun 2002; 17: 1145–1152
   Google Scholar
• Argyropoulos G, Harper M E. Uncoupling proteins and thermoregulation. J Appl Physiol 2002; 92: 2187–2198
   PubMed Web of Science ®Google Scholar
• Arch J RS, Ainsworth A T, Cawthorne M A, Piercy V, Sennitt M V, Thody V E, Wilson C, Wilson S. Atypical beta-adrenoceptor on brown adipocytes as target for anti-obesity drugs. Nature 1984; 309: 163–165
   PubMed Web of Science ®Google Scholar
• Bianco A, Silva J E. Intracellular conversion of thyroxine to triiodothyronine is required for the optimal thermogenic function of brown adipose tissue. J Clin Invest 1987a; 79: 295–300
   PubMed Web of Science ®Google Scholar
• Bianco A, Silva J E. Optimal response of key enzymes and uncoupling protein to cold in BAT depends on local T3 generation. Am J Physiol 1987b; 253: E255–E263
   PubMed Web of Science ®Google Scholar
• Bradford M M. A rapid and sensitive method for the quantitation of microgram quantities of protein using the principle of protein-dye binding. Anal Biochem 1976; 72: 248–254
   PubMed Web of Science ®Google Scholar
• Bylund D B, Eikenberg D C, Hieble J P, Langer S Z, Lefkowitz R J, Minneman K P, Molinoff P B, Ruffolo R R, Jr., Trendelenburg U. IV. International Union of Pharmacology Nomenclature of Adrenoceptors. Pharmacol Rev 1994; 46: 121–136
   PubMed Web of Science ®Google Scholar
• Dicker A, Raasmaja A, Cannon B, Nedergaard J. Increased α1-adrenoceptor density in brown adipose tissue indicates recruitment drive in hypothyroid rats. Am J Physiol 1992; 263: E654–E662
   PubMed Web of Science ®Google Scholar
• Eugenia M, Torres-Marquez M, Romero-Avila T, Gonzales-Espinosa C, Garcia-Sainz A. Characterization of rat white fat cell alpha1B-adrenoceptors. Mol Pharmacol 1992; 41: 403–406
   Google Scholar
• Garcia-Sainz J A. α1-Adrenergic action: receptor subtypes, signal transduction and regulation. Cell Signal 1993; 5: 539–547
   PubMed Web of Science ®Google Scholar
• Goldberg J, Ehrmann B, Katzeff H L. Altered triiodothyronine metabolism in Zucker fatty rats. Endocrinol 1988; 122: 689–693
   PubMed Web of Science ®Google Scholar
• Granneman J G, Zhai Y, Lahners K N. Selective up-regulation of alpha1a-adrenergic receptor protein and mRNA in brown adipose tissue by neural and beta3-adrenergic stimulation. Mol Pharmacol 1997; 51: 644–650
   PubMed Web of Science ®Google Scholar
• Hieble J P, Bylund D B, Clarke D E, Eikenburg D C, Langer S Z, Lefkowitz R J, Minneman K P, Ruffolo R R, Jr. International Union of Pharmacology X. Recommendation for nomenclature of α1-adrenoceptors: consensus update. Pharmacol Rev 1995; 47: 267–270
   PubMed Web of Science ®Google Scholar
• Himms-Hagen J. Thyroid hormones and thermogenesis. Mammalian Thermogenesis, L Girardier, M J Stock. Chapman and Hall, London 1984; 141–177
   Google Scholar
• Katzeff H L, Selgrad C. Impaired peripheral thyroid hormone metabolism in genetic obesity. Endocrinology 1993; 132: 989–995
   PubMed Web of Science ®Google Scholar
• Kikuchi-Utsumi K, Kikuchi-Utsumi M, Cannon B, Nedergaard J. Differential regulation of the expression of alpha1-adrenergic receptor subtype genes in brown adipose tissue. Biochem J 1997; 322: 417–424
   PubMed Web of Science ®Google Scholar
• Konkar A A, Zhai Y, Granneman J G. Beta1-adrenergic receptors mediate beta3-adrenergic-independent effects of CGP 12177 in brown adipose tissue. Mol Pharmacol 2000; 57: 252–258
   PubMed Web of Science ®Google Scholar
• Levin B E, Comai K, O'Brien R A, Sullivan A C. Abnormal brown adipose tissue composition and beta-adrenoceptor binding in obese Zucker rats. Am Physiol 1982; 243: E217–E224
   PubMed Web of Science ®Google Scholar
• Leonard J L, Mellen S A, Larsen P R. Thyroxine 5′-deiodinase activity in brown adipose tissue. Endocrinology 1983; 112: 1153–1155
   PubMed Web of Science ®Google Scholar
• Marie V, Dupuy F, Bazin R. Decreased T4-to-T3 conversion in brown adipose tissue of Zucker fa/fa pups before onset of obesity. Am J Physiol 1992; 263: E115–E120
   PubMed Web of Science ®Google Scholar
• Michell M, Kerker J, Branchek T A, Forray C. Selective irreversible binding of chloroethylclonidine at alpha1- and alpha-2-adrenoceptor subtypes. Mol Pharmacol 1993; 44: 1165–1170
   PubMed Web of Science ®Google Scholar
• Mills I, Raasmaja A, Moolten N, Lemack G, Silva J E, Larsen P R. Effect of thyroid status on catecholamine stimulation of thyroxine 5′-deiodinase in brown adipocytes. Am J Physiol 1989; 256: E74–E79
   PubMed Web of Science ®Google Scholar
• Mohell N. Alpha1-adrenergic receptors in brown adipose tissue. Thermogenic significance and mode of action. Acta Physiol Scand 1984; 530: 1–64
   Google Scholar
• Mohell N, Dicker A. The beta-adrenergic radioligand (3H)CGP-12177, generally classified as an antagonist, is a thermogenic agonist in brown adipose tissue. Biochem J 1989; 261: 401–405
   PubMed Web of Science ®Google Scholar
• Mohell N, Raasmaja A, Nedergaard J. Pharmacological characterization of alpha1-and beta-adrenergic receptors in brown adipose tissue: a comparative study with the radioligands (3H)prazosin and (3H)CGP-12177. Thermoregulation: Research and Clinical Applications, P Lomax, E Schönbaum. Karger, Basel 1988; 35–38
   Google Scholar
• Nicholls D G. A history of UCP1. Biochem Soc Trans 2001; 29: 751–755
   PubMed Web of Science ®Google Scholar
• Raasmaja A. Alpha1- and beta-adrenergic receptors in brown adipose tissue and the adrenergic regulation of thyroxine 5′-deiodinase. Acta Physiol Scand 1990; 139: 1–61
   PubMedGoogle Scholar
• Raasmaja A, Larsen P R. Alpha1- and beta-adrenergic agents cause synergistic stimulation of the iodothyronine deiodinase in rat brown adipocytes. Endocrinology 1989; 125: 2502–2509
   PubMed Web of Science ®Google Scholar
• Raasmaja A, York D A. Alpha1- and beta-adrenergic receptors in brown adipose tissue of lean (Fa/?) and obese (fa/fa) Zucker rats. Effects of cold acclimation, sucrose feeding and adrenalectomy. Biochem J 1987; 249: 831–838
   Web of Science ®Google Scholar
• Raasmaja A, Mohell N, Nedergaard J. Increased alpha1-adrenergic receptor density in brown adipose tissue of cafeteria-fed rats. Eur J Pharmacol 1984; 106: 489–498
   PubMed Web of Science ®Google Scholar
• Raasmaja A, Mohell N, Nedergaard J. Increased alpha1-adrenergic receptor density in brown adipose tissue of cold-acclimated rats and hamsters. Eur J Pharmacol 1985; 106: 489–498
   Web of Science ®Google Scholar
• Rubio A, Raasmaja A, Maia A L, Kim K -R, Silva J E. Effects of thyroid hormone on norepinephrine signaling in brown adipose tissue. I. β1- and β2-adrenergic receptors and cyclic adenosine 3′, 5′-monophosphate generation. Endocrinology 1995a; 136: 3267–3276
   PubMed Web of Science ®Google Scholar
• Rubio A, Raasmaja A, Silva J E. Effects of thyroid hormone on norepinephrine signaling in brown adipose tissue. II. Differential effects of thyroid hormone on β3-adrenergic receptors in brown and white adipose tissue. Endocrinology 1995b; 136: 3277–3284
   PubMed Web of Science ®Google Scholar
• Silva J E. Full expression of uncoupling protein gene requires the concurrence of norepinehrine and triiodothyronine. Mol Endocrinol 1988; 2: 706–713
   PubMed Web of Science ®Google Scholar
• Silva J E, Larsen P R. Adrenergic activation of triiodothyronine production in brown adipose tissue. Nature 1983; 305: 712–713
   PubMed Web of Science ®Google Scholar
• Silva J E, Larsen P R. Potential of brown adipose tissue type II thyroxine 5′-deiodinase as a local and systemic source of triiodothyronine in rats. J Clin Invest 1985; 76: 2296–2305
   PubMed Web of Science ®Google Scholar
• Staehelin M, Muller-Bardey E, Muller P. Regulation of beta-adrenergic receptors. Pharmacology of Adrenoceptors, E Szabadi, C M Bradshaw, S R Nahorski. MacMillan Press Ltd., London 1985; 69–77
   Google Scholar
• Sundin U, Mills I, Fain J N. Thyroid-catecholamine interactions in isolated rat brown adipocytes. Metabolism 1984; 33: 1028–1033
   PubMed Web of Science ®Google Scholar
• Trayhurn P, Nicholls D. Brown adipose tissue. Edward Arnold Ltd., London 1986; 1–374
   Google Scholar
• Young J B, Landsberg L. Diminished sympathetic nervous system activity in genetically obese (ob/ob) mouse. Am J Physiol 1983; 245: E148–E154
   PubMed Web of Science ®Google Scholar
• Young J B, Saville E, Rothwell N J, Stock M J, Landsberg L. Effect of diet and cold exposure on norepinephrine turnover in brown adipose tissue of the rat. J Clin Invest 1982; 69: 1061–1071
   PubMed Web of Science ®Google Scholar
• Zaninovich A A. Thyroid hormones, obesity and brown adipose tissue thermogenesis. Medicina 2001; 61: 597–602
   PubMed Web of Science ®Google Scholar