Publication Cover
Archives of Physiology and Biochemistry
The Journal of Metabolic Diseases
Volume 112, 2006 - Issue 1
229
Views
29
CrossRef citations to date
0
Altmetric
Research Article

Ceramide mediates TNF-α-induced insulin resistance on GLUT4 gene expression in brown adipocytes

, , , , &
Pages 13-22 | Received 11 Oct 2005, Accepted 25 Nov 2005, Published online: 10 Oct 2008

References

  • Birnbaum M J, Haspel H C, Rosen O M. Cloning and characterization of a cDNA encoding the rat brain glucose-transporter protein. Proc Natl Acad Sci USA 1986; 83: 5784–5788
  • Brindley D N, Wang C N, Mei J, Xu J, Hanna A N. Tumor necrosis factor-alpha and ceramides in insulin resistance. Lipids 1999; 34: S85–S88
  • Burow M E, Weldon C B, Collins-Burow B M, Ramsey N, McKee A, Klippel A, McLachlan J A, Clejan S, Beckman B S. Cross-talk between phosphatidylinositol 3-kinase and sphingomyelinase pathways as a mechanism for cell survival/death decisions. J Biol Chem 2000; 275: 9628–9635
  • de Alvaro C, Teruel T, Hernandez R, Lorenzo M. Tumor necrosis factor alpha produces insulin resistance in skeletal muscle by activation of inhibitor kappaB kinase in a p38 MAPK-dependent manner. J Biol Chem 2004; 279: 17070–17078
  • El-Jack A K, Hamm J K, Pilch P F, Farmer S R. Reconstitution of insulin-sensitive glucose transport in fibroblasts requires expression of both PPARgamma and C/EBPalpha. J Biol Chem 1999; 274: 7946–7951
  • Ezaki O. Regulatory elements in the insulin-responsive glucose transporter (GLUT4) gene. Biochem Biophys Res Commun 1997; 241: 1–6
  • Garvey W T, Maianu L, Huecksteadt T P, Birnbaum M J, Molina J M, Ciaraldi T P. Pretranslational suppression of a glucose transporter protein causes insulin resistance in adipocytes from patients with non-insulin-dependent diabetes mellitus and obesity. J Clin Invest 1991; 87: 1072–1081
  • Hannun Y A, Obeid L M. Ceramide: an intracellular signal for apoptosis. Trends Biochem Sci 1995; 20: 73–77
  • Hernandez R, Teruel T, Lorenzo M. Akt mediates insulin induction of glucose uptake and up-regulation of GLUT4 gene expression in brown adipocytes. FEBS Lett 2001; 494: 225–231
  • Hernandez R, Teruel T, Lorenzo M. Insulin and dexamethasone induce GLUT4 gene expression in foetal brown adipocytes: synergistic effect through CCAAT/enhancer-binding protein alpha. Biochem J 2003; 372: 617–624
  • Hernandez R, Teruel T, de Alvaro C, Lorenzo M. Rosiglitazone ameliorates insulin resistance in brown adipocytes of Wistar rats by impairing TNF-alpha induction of p38 and p42/p44 mitogen-activated protein kinases. Diabetologia 2004; 47: 1615–1624
  • Hotamisligil G S. Mechanisms of TNF-alpha-induced insulin resistance [see comments]. Exp Clin Endocrinol Diabetes 1999; 107: 119–125
  • Hotamisligil G S, Shargill N S, Spiegelman B M. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 1993; 259: 87–91
  • Hotamisligil G S, Murray D L, Choy L N, Spiegelman B M. Tumor necrosis factor alpha inhibits signaling from the insulin receptor. Proc Natl Acad Sci USA 1994; 91: 4854–4858
  • Jain R, Police S, Phelps K, Pekala P H. Tumour necrosis factor-alpha regulates expression of the CCAAT-enhancer-binding proteins (C/EBPs) alpha and beta and determines the occupation of the C/EBP site in the promoter of the insulin-responsive glucose-transporter gene in 3T3-L1 adipocytes. Biochem J 1999; 338: 737–743
  • Kudo M, Sugawara A, Uruno A, Takeuchi K, Ito S. Transcription suppression of peroxisome proliferator-activated receptor gamma2 gene expression by tumor necrosis factor alpha via an inhibition of CCAAT/enhancer-binding protein delta during the early stage of adipocyte differentiation. Endocrinology 2004; 145: 4948–4956
  • Landschulz W H, Johnson P F, Adashi E Y, Graves B J, McKnight S L. Isolation of a recombinant copy of the gene encoding C/EBP. Genes Dev 1988; 2: 786–800
  • Liu L S, Spelleken M, Rohrig K, Hauner H, Eckel J. Tumor necrosis factor-alpha acutely inhibits insulin signaling in human adipocytes: implication of the p80 tumor necrosis factor receptor. Diabetes 1998; 47: 515–522
  • Livak K J, Schmittgen T D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001; 25: 402–408
  • Lofgren P, van H V, Reynisdottir S, Naslund E, Ryden M, Rossner S, Arner P. Secretion of tumor necrosis factor-alpha shows a strong relationship to insulin-stimulated glucose transport in human adipose tissue. Diabetes 2000; 49: 688–692
  • Long S D, Pekala P H. Lipid mediators of insulin resistance: ceramide signalling down-regulates GLUT4 gene transcription in 3T3-L1 adipocytes. Biochem J 1996; 319: 179–184
  • Lorenzo M, Valverde A M, Teruel T, Benito M. IGF-I is a mitogen involved in differentiation-related gene expression in fetal rat brown adipocytes. J Cell Biol 1993; 123: 1567–1575
  • Lorenzo M, Teruel T, Hernandez R, Kayali A G, Webster N J. PLCgamma participates in insulin stimulation of glucose uptake through activation of PKCzeta in brown adipocytes. Exp Cell Res 2002; 278: 146–157
  • McGowan K M, Police S, Winslow J B, Pekala P H. Tumor necrosis factor-alpha regulation of glucose transporter (GLUT1) mRNA turnover. Contribution of the 3′-untranslated region of the GLUT1 message. J Biol Chem 1997; 272: 1331–1337
  • Mei J, Holst L S, Landstrom T R, Holm C, Brindley D, Manganiello V, Degerman E. C(2)-ceramide influences the expression and insulin-mediated regulation of cyclic nucleotide phosphodiesterase 3B and lipolysis in 3T3-L1 adipocytes. Diabetes 2002; 51: 631–637
  • Merrill A H, Jr, Sullards M C, Wang E, Voss K A, Riley R T. Sphingolipid metabolism: roles in signal transduction and disruption by fumonisins. Environ Health Perspect 2001; 109(Suppl 2)283–289
  • Petersen S, Bahr M, Eckel J. Insulin-dependent regulation of Glut4 gene expression in ventricular cardiomyocytes: evidence for a direct effect on Glut4 transcription. Biochem Biophys Res Commun 1995; 213: 533–540
  • Pirola L, Johnston A M, Van Obberghen E. Modulation of insulin action. Diabetologia 2004; 47: 170–184
  • Qi C, Pekala P H. Tumor necrosis factor-alpha-induced insulin resistance in adipocytes. Proc Soc Exp Biol Med 2000; 223: 128–135
  • Ruan H, Hacohen N, Golub T R, Van Parijs L, Lodish H F. Tumor necrosis factor-alpha suppresses adipocyte-specific genes and activates expression of preadipocyte genes in 3T3-L1 adipocytes: nuclear factor-kappaB activation by TNF-alpha is obligatory. Diabetes 2002; 51: 1319–1336
  • Schmitz-Peiffer C, Craig D L, Biden T J. Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate. J Biol Chem 1999; 274: 24202–24210
  • Teruel T, Valverde A M, Benito M, Lorenzo M. Insulin-like growth factor I and insulin induce adipogenic-related gene expression in fetal brown adipocyte primary cultures. Biochem J 1996; 319: 627–632
  • Teruel T, Hernandez R, Lorenzo M. Ceramide mediates insulin resistance by tumor necrosis factor-alpha in brown adipocytes by maintaining Akt in an inactive dephosphorylated state. Diabetes 2001; 50: 2563–2571
  • Uysal K T, Wiesbrock S M, Marino M W, Hotamisligil G S. Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature 1997; 389: 610–614
  • Valverde A M, Teruel T, Navarro P, Benito M, Lorenzo M. Tumor necrosis factor-alpha causes insulin receptor substrate-2-mediated insulin resistance and inhibits insulin-induced adipogenesis in fetal brown adipocytes. Endocrinology 1998; 139: 1229–1238
  • Valverde A M, Navarro P, Teruel T, Conejo R, Benito M, Lorenzo M. Insulin and insulin-like growth factor I up-regulate GLUT4 gene expression in fetal brown adipocytes, in a phosphoinositide 3-kinase-dependent manner. Biochem J 1999; 337: 397–405
  • Valverde A M, Lorenzo M, Navarro P, Mur C, Benito M. Okadaic acid inhibits insulin-induced glucose transport in fetal brown adipocytes in an Akt-independent and protein kinase C zeta-dependent manner. FEBS Lett 2000; 472: 153–158
  • Valverde A M, Arribas M, Mur C, Navarro P, Pons S, Cassard-Doulcier A M, Kahn C R, Benito M. Insulin-induced up-regulated uncoupling protein-1 expression is mediated by insulin receptor substrate 1 through the phosphatidylinositol 3-kinase/Akt signaling pathway in fetal brown adipocytes. J Biol Chem 2003; 278: 10221–10231
  • Vinals F, Ferre J, Fandos C, Santalucia T, Testar X, Palacin M, Zorzano A. Cyclic adenosine 3′,5′-monophosphate regulates GLUT4 and GLUT1 glucose transporter expression and stimulates transcriptional activity of the GLUT1 promoter in muscle cells. Endocrinology 1997; 138: 2521–2529
  • White M F. Insulin signaling in health and disease. Science 2003; 302: 1710–1711

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.