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Archives of Physiology and Biochemistry
The Journal of Metabolic Diseases
Volume 112, 2006 - Issue 1
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Research Article

The diabetes-prone NZO/Hl strain. Proliferation capacity of beta cells in hyperinsulinemia and hyperglycemia

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Pages 49-58 | Received 04 Jul 2005, Accepted 30 Dec 2005, Published online: 10 Oct 2008

References

  • Augstein P, Stephens L A, Allison J, Elefanty A G, Ekberg M, Kay T W, Harrison L C. Beta-cell apoptosis in an accelerated model of autoimmune diabetes. Mol Med 1998; 4: 495–501
  • Bonner-Weir S. Regulation of pancreatic β-cell mass in vivo. Recent Progr Horm Res 1994; 49: 91–104
  • Bonner-Weir S. Islet growth and development in the adult. J Mol Endocrinol 2000; 24: 297–302
  • Bonner-Weir S. β-Cell turnover. Its assessment and implications. Diabetes 2001; 50(Suppl. 1)S20–S24
  • Bonner-Weir S, Deery D, Leahy J L, Weir G C. Compensatory growth of pancreatic β-cells in adult rats after short-term glucose infusion. Diabetes 1989; 38: 49–53
  • Bouwens L, Pipeleers D G. Extra-insular beta cells associated with ductules are frequent in adult human pancreas. Diabetologia 1998; 41: 629–633
  • Bruno S, Darzynkiewicz Z. Cell cycle dependent expression and stability of the nuclear protein detected by Ki-67 antibody in HL-60 cells. Cell Prolif 1992; 25: 31–40
  • Donath M Y, Halban P A. Decreased beta-cell mass in diabetes: significance, mechanisms and therapeutic implications. Diabetologia 2004; 47: 581–589
  • Dor Y, Brown J, Martinez O I, Melton D A. Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation. Nature 2004; 429: 41–46
  • Ehrie M G, Swartz F J. Polyploidy in the pancreas of the normal and diabetic mutant mouse. Diabetologia 1976; 12: 167–170
  • Finegood D T, Scaglia L, Bonner-Weir S. Dynamics of ß-cell mass in the growing rat pancreas. Estimation with a simple mathematical model. Diabetes 1995; 44: 249–256
  • Gerdes J, Lemke H, Baisch H, Wacker H -H, Schwab U, Stein H. Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. J Immunol 1984; 133: 1710–1715
  • Hall P A, McKee P H, Menage H P, Dover R, Lane D P. High levels of of p53 protein in UV irradiated normal human skin. Oncogene 1993; 8: 203–207
  • Häussinger D. The role of cellular hydration in the regulation of cell function. Biochem J 1996; 313: 697–710
  • Jonas J -Ch, Sharma A, Hasenkamp W, Ilkova H, Patane G, Laybutt R, Bonner-Weir S, Weir G C. Chronic hyperglycemia triggers loss of pancreatic β cell differentiation in an animal model of diabetes. J Biol Chem 1999; 274: 14112–14121
  • Junger E, Herberg L, Jeruschke K, Leiter E H. The diabetes-prone NZO/Hl strain. II. Pancreatic immunopathology. Lab Invest 2002; 82: 843–853
  • Koza R A, Flurkey K, Graunke D M, Braun Ch, Pan H -J, Reifsnyder P C, Kozak L P, Leiter E H. Contributions of dysregulated energy metabolism to type 2 diabetes development in NZO/HlLt mice with polygenic obesity. Metabolism 2004; 53: 799–808
  • Kurrer M O, Pakala S V, Hanson H L, Katz J D. β cell apoptosis in T cell-mediated autoimmune diabetes. Proc Natl Acad Sci USA 1997; 94: 213–218
  • Leahy J L, Cooper H E, Weir G C. Impaired insulin secretion associated with near normoglycemia. Study in normal rats with 96-h in vivo glucose infusions. Diabetes 1987; 36: 459–464
  • Leiter E H, Reifsnyder P C. Different levels of diabetogenic stress in two new mouse models of obesity and type 2 diabetes. Diabetes 2004; 53(Suppl. 1)S4–S11
  • Leiter E H, Reifsnyder P C, Flurkey K, Partke H -J, Junger E, Herberg L. Non-insulin dependent diabetes genes in mice: Deleterious synergism by both parental genomes contributes to diabetogenic thresholds. Diabetes 1998; 47: 1287–1295
  • Montanya E, Nacher V, Biarnes M, Soler J. Linear correlation between β-cell mass and body weight throughout the lifespan in Lewis rats. Role of β-cell hyperplasia and hypertrophy. Diabetes 2000; 49: 1341–1346
  • Plum L, Giesen K, Kluge R, Junger E, Linnartz K, Schürmann A, Becker W, Joost H -G. Characterisation of the mouse diabetes susceptibility locus Nidd/SJL: islet cell destruction, interaction with the obesity QTL Nob1, and effect of dietary fat. Diabetologia 2002; 45: 823–830
  • Reifsnyder P C, Churchill G, Leiter E H. Maternal environment and genotype interact to establish diabesity in mice. Genome Res 2000; 10: 1568–1578
  • Sachs L. Angewandte Statistik11th ed. Springer, Berlin, Heidelberg, NewYork 2004
  • Schlüter C, Duchrow M, Wohlenberg C, Becker M HG, Key G, Flad H -D, Gerdes J. The cell proliferation-associated antigen of antibody Ki-67: a very large, ubiquitous nuclear protein with numerous repeated elements, representing a new kind of cell cycle-maintaining proteins. J Cell Biol 1993; 123: 513–522
  • Scholzen T, Gerdes J. The Ki-67 protein: from the known and the unknown. J Cell Physiol 2000; 182: 311–322
  • Starborg M, Gell K, Brundell E, Höög Ch. The murine Ki-67 cell proliferation antigen accumulates in the nucleolar and heterochromatin regions of interphase cells and at the periphery of mitotic chromosomes in a process essential for cell cycle progression. J Cell Sci 1996; 109: 143–153
  • Steil G M, Trivedi N, Jonas J -Ch, Hasenkamp W M, Sharma A, Bonner-Weir S, Weir G C. Adaptation of β-cell mass to substrate oversupply: enhanced function with normal gene expression. Am J Physiol Endocrinol Metab 2001; 280: E788–E796
  • Veroni M C, Proietto J, Larkins R. Evolution of insulin resistance in New Zealand Obese mice. Diabetes 1991; 40: 1480–1487
  • Weibel E R, Bolender R P. Stereological techniques for electron microscopic morphometry. Principles and Techniques of Electron Microscopy, M A Hayat. Van Nostrand Reinhold, New York 1973; 239–296
  • White J W, Swartz F J, Swartz A F. Excess glucose intake induces accelerated β-cell polyploidization in normal mice: a possible deleterious effect. J Nutr 1985; 115: 271–278
  • Williams M A. Quantitative methods in biology. Practical Methods in Electron Microscopy, A M Glauert. North Holland Publishing Company, Amsterdam, New York, Oxford 1977; 36–37
  • Willingham M C. Cytochemical methods for the detection of apoptosis. J Histochem Cytochem 1999; 47: 1101–1109
  • Wolf G, Shankland S J. Cell cycle control in glomerular disease. Progr Cell Cycle Res 2003; 5: 71–79

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