References
- Abram C L, Seals D F, Pass I, Salinsky D, Maurer L, Roth T M, Courtneidge S A. The adaptor protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed cells. J Biol Chem 2003; 278: 16844–16851
- Arcaro A, Volinia S, Zvelebil M J, Stein R, Watton S J, Layton M J, Gout I, Ahmadi K, Downward J, Waterfield M D. Human phosphoinositide 3-kinase C2beta, the role of calcium and the C2 domain in enzyme activity. J Biol Chem 1998; 273: 33082–33090
- Arcaro A, Zvelebil M J, Wallasch C, Ullrich A, Waterfield M D, Domin J. Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors. Mol Cell Biol 2000; 20: 3817–3830
- Arcaro A, Khanzada U K, Vanhaesebroeck B, Tetley T D, Waterfield M D, Seckl M J. Two distinct phosphoinositide 3-kinases mediate polypeptide growth factor-stimulated PKB activation. EMBO J 2002; 21: 5097–5108
- Baumeister M A, Martinu L, Rossman K L, Sondek J, Lemmon M A, Chou M M. Loss of phosphatidylinositol 3-phosphate binding by the C-terminal Tiam-1 pleckstrin homology domain prevents in vivo Rac1 activation without affecting membrane targeting. J Biol Chem 2003; 278: 11457–11464
- Byfield M P, Murray J T, Backer J M. hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase. J Biol Chem 2005; 280: 33076–33082
- Brown R A, Domin J, Arcaro A, Waterfield M D, Shepherd P R. Insulin activates the alpha isoform of class II phosphoinositide 3-kinase. J Biol Chem 1999; 274: 14529–14532
- Brown R A, Shepherd P R. Growth factor regulation of the novel class II phosphoinositide 3-kinases. Biochem Soc Trans 2001; 29: 535–537
- Brown G E, Stewart M Q, Liu H, Ha V L, Yaffe M B. A novel assay system implicates PtdIns(3,4)P(2), PtdIns(3)P, and PKC delta in intracellular production of reactive oxygen species by the NADPH oxidase. Mol Cell 2003; 11: 35–47
- Cantley L C. The phosphoinositide 3-kinase pathway. Science 2002; 296: 1655–1657
- Carlton J, Bujny M, Rutherford A, Cullen P. Sorting nexins-unifying trends and new perspectives. Traffic 2005; 6: 75–82
- Carlton J G, Cullen P J. Sorting nexins. Curr Biol 2005; 15: R819–R820
- Chaussade C, Pirola L, Bonnafous S, Blondeau F, Brenz-Verca S, Tronchere H, Portis F, Rusconi S, Payrastre B, Laporte J, Van Obberghen E. Expression of myotubularin by an adenoviral vector demonstrates its function as a phosphatidylinositol 3-phosphate [PtdIns(3)P] phosphatase in muscle cell lines: involvement of PtdIns(3)P in insulin-stimulated glucose transport. Mol Endocrinol 2003; 17: 2448–2460
- Cheever M L, Sato T K, de Beer T, Kutateladze T G, Emr S D, Overduin M. Phox domain interaction with PtdIns(3)P targets the Vam7 t-SNARE to vacuole membranes. Nat Cell Biol 2001; 3: 613–618
- Chua J, Deretic V. Mycobacterium tuberculosis reprograms waves of phosphatidylinositol 3-phosphate on phagosomal organelles. J Biol Chem 2004; 279: 36982–36992
- Condliffe A M, Hawkins P T, Stephens L R, Haslett C, Chilvers E R. Priming of human neutrophil superoxide generation by tumour necrosis factor-alpha is signalled by enhanced phosphatidylinositol 3,4,5-trisphosphate but not inositol 1,4,5-trisphosphate accumulation. FEBS Lett 1998; 439: 147–151
- Dang H, Li Z, Skolnik E Y, Fares H. Disease-related myotubularins function in endocytic traffic in Caenorhabditis elegans. Mol Biol Cell 2004; 15: 189–196
- Didichenko S A, Thelen M. Phosphatidylinositol 3-kinase c2alpha contains a nuclear localization sequence and associates with nuclear speckles. J Biol Chem 2001; 276: 48135–48142
- Divecha N, Halstead J R. Of yeast and men. The evolution of PtdIns(3,4,5)P(3) synthesis. EMBO Rep 2004; 5: 865–866
- Domin J, Pages F, Volinia S, Rittenhouse S E, Zvelebil M J, Stein R C, Waterfield M D. Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin. Biochem J 1997; 326: 139–147
- Dowler S, Currie R A, Campbell D G, Deak M, Kular G, Downes C P, Alessi D R. Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities. Biochem J 2000; 351: 19–31
- Ellson C D, Anderson K E, Morgan G, Chilvers E R, Lipp P, Stephens L R, Hawkins P T. Phosphatidylinositol 3-phosphate is generated in phagosomal membranes. Curr Biol 2001a; 11: 1631–1635
- Ellson C D, Gobert-Gosse S, Anderson K E, Davidson K, Erdjument-Bromage H, Tempst P, Thuring J W, Cooper M A, Lim Z Y, Holmes A B, Gaffney P R, Coadwell J, Chilvers E R, Hawkins P T, Stephens L R. PtdIns(3)P regulates the neutrophil oxidase complex by binding to the PX domain of p40(phox). Nat Cell Biol 2001b; 3: 679–682
- Ellson C D, Davidson K, Ferguson G J, O'Connor R, Stephens L R, Hawkins P T. Neutrophils from p40phox-/- mice exhibit severe defects in NADPH oxidase regulation and oxidant-dependent bacterial killing. J Exp Med 2006; 203: 1927–1937
- Foster F M, Traer C J, Abraham S M, Fry M J. The phosphoinositide (PI) 3-kinase family. J Cell Sci 2003; 116: 3037–3040
- Gaidarov I, Smith M E, Domin J, Keen J H. The class II phosphoinositide 3-kinase C2alpha is activated by clathrin and regulates clathrin-mediated membrane trafficking. Mol Cell 2001; 7: 443–449
- Gaidarov I, Zhao Y, Keen J H. Individual phosphoinositide 3-kinase C2alpha domain activities independently regulate clathrin function. J Biol Chem 2005; 280: 40766–40772
- Gillooly D J, Morrow I C, Lindsay M, Gould R, Bryant N J, Gaullier J M, Parton R G, Stenmark H. Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells. EMBO J 2000; 19: 4577–4588
- Haft C R, de la Luz Sierra M, Barr V A, Haft D H, Taylor S I. Identification of a family of sorting nexin molecules and characterization of their association with receptors. Mol Cell Biol 1998; 18: 7278–7287
- Halstead J R, Roefs M, Ellson C D, D'Andrea S, Chen C, D'Santos C S, Divecha N. A novel pathway of cellular phosphatidylinositol(3,4,5)-trisphosphate synthesis is regulated by oxidative stress. Curr Biol 2001; 11: 386–395
- Haslam R J, Koide H B, Hemmings B A. Pleckstrin domain homology. Nature 1993; 363: 309–310
- Ishiki M, Randhawa V K, Poon V, Jebailey L, Klip A. Insulin regulates the membrane arrival, fusion, and C-terminal unmasking of glucose transporter-4 via distinct phosphoinositides. J Biol Chem 2005; 280: 28792–28802
- Kanda H, Tamori Y, Shinoda H, Yoshikawa M, Sakaue M, Udagawa J, Otani H, Tashiro F, Miyazaki J, Kasuga M. Adipocytes from Munc18c-null mice show increased sensitivity to insulin-stimulated GLUT4 externalization. J Clin Inves 2005; 115: 291–301
- Kavran J M, Klein D E, Lee A, Falasca M, Isakoff S J, Skolnik E Y, Lemmon M A. Specificity and promiscuity in phosphoinositide binding by pleckstrin homology domains. J Biol Chem 1998; 273: 30497–30508
- Katso R M, Pardo O E, Palamidessi A, Franz C M, Marinov M, De Laurentiis A, Downward J, Scita G, Ridley A J, Waterfield M D, Arcaro A. Phosphoinositide 3-Kinase C2beta Regulates Cytoskeletal Organization and Cell Migration via Rac-dependent Mechanisms. Mol Biol Cell 2006; 17: 3729–3744
- Kim S A, Taylor G S, Torgersen K M, Dixon J E. Myotubularin and MTMR2, phosphatidylinositol 3-phosphatases mutated in myotubular myopathy and type 4B Charcot-Marie-Tooth disease. J Biol Chem 2002; 277: 4526–4531
- Kong A M, Horan K A, Sriratana A, Bailey C G, Collyer L J, Nandurkar H H, Shisheva A, Layton M J, Rasko J E, Rowe T, Mitchell C A. Phosphatidylinositol 3-phosphate [PtdIns(3)P] is generated at the plasma membrane by an inositol polyphosphate 5-phosphatase: endogenous PtdIns(3)P can promote GLUT4 translocation to the plasma membrane. Mol Cell Biol 2006; 26: 6065–6081
- Ktori C, Shepherd P R, O'Rourke L. TNF-alpha and leptin activate the alpha-isoform of class II phosphoinositide 3-kinase. Biochem Biophys Res Commun 2003; 306: 139–143
- Laporte J, Blondeau F, Gansmuller A, Lutz Y, Vonesch J L, Mandel J L. The PtdIns3P phosphatase myotubularin is a cytoplasmic protein that also localizes to Rac1-inducible plasma membrane ruffles. J Cell Sci 2002; 115: 3105–3117
- Lindmo K, Stenmark H. Regulation of membrane traffic by phosphoinositide 3-kinases. J Cell Sci 2006; 119: 605–614
- MaCaulay S L, Stoichevska V, Grusovin J, Gough K H, Castelli L A, Ward C W. Insulin stimulates movement of sorting nexin 9 between cellular compartments: a putative role mediating cell surface receptor expression and insulin action. Biochem J 2003; 376: 123–134
- Maehama T, Dixon J E. PTEN: a tumour suppressor that functions as a phospholipid phosphatase. Trends Cell Biol 1999; 9: 125–128
- Maffucci T, Falasca M. Specificity in pleckstrin homology (PH) domain membrane targeting: a role for a phosphoinositide-protein co-operative mechanism. FEBS Lett 2001; 506: 173–179
- Maffucci T, Brancaccio A, Piccolo E, Stein R C, Falasca M. Insulin induces phosphatidylinositol-3-phosphate formation through TC10 activation. EMBO J 2003a; 22: 4178–4189
- Maffucci T, Razzini G, Ingrosso A, Chen H, Iacobelli S, Sciacchitano S, Quon M J, Falasca M. Role of pleckstrin homology domain in regulating membrane targeting and metabolic function of insulin receptor substrate 3. Mol Endocrinol 2003b; 17: 1568–1579
- Maffucci T, Cooke F T, Foster F M, Traer C J, Fry M J, Falasca M. Class II phosphoinositide 3-kinase defines a novel signaling pathway in cell migration. J Cell Biol 2005; 169: 789–799
- Mayer B J, Ren R, Clark K L, Baltimore D. A putative modular domain present in diverse signaling proteins. Cell 1993; 73: 629–630
- Meunier F A, Osborne S L, Hammond G R, Cooke F T, Parker P J, Domin J, Schiavo G. Phosphatidylinositol 3-kinase C2alpha is essential for ATP-dependent priming of neurosecretory granule exocytosis. Mol Biol Cell 2005; 16: 4841–4851
- Mitra P, Zhang Y, Rameh L E, Ivshina M P, McCollum D, Nunnari J J, Hendricks G M, Kerr M L, Field S J, Cantley L C, Ross A H. A novel phosphatidylinositol(3,4,5)P3 pathway in fission yeast. J Cell Biol 2004; 166: 205–211
- Nagata K, Driessens M, Lamarche N, Gorski J L, Hall A. Activation of G1 progression, JNK mitogen-activated protein kinase, and actin filament assembly by the exchange factor FGD1. J Biol Chem 1998; 273: 15453–15457
- Nandurkar H H, Layton M, Laporte J, Selan C, Corcoran L, Caldwell K K, Mochizuki Y, Majerus P W, Mitchell C A. Identification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAP. Proc Natl Acad Sci U S A 2003; 100: 8660–8665
- Nielsen E, Christoforidis S, Uttenweiler-Joseph S, Miaczynska M, Dewitte F, Wilm M, Hoflack B, Zerial M. Rabenosyn-5, a novel Rab5 effector, is complexed with hVPS45 and recruited to endosomes through a FYVE finger domain. J Cell Biol 2000; 151: 601–612
- Nobukuni T, Joaquin M, Roccio M, Dann S G, Kim S Y, Gulati P, Byfield M P, Backer J M, Natt F, Bos J L, Zwartkruis F J, Thomas G. Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase. Proc Natl Acad Sci U S A 2005; 102: 14238–14243
- Parks W T, Frank D B, Huff C, Renfrew Haft C, Martin J, Meng X, de Caestecker M P, McNally J G, Reddi A, Taylor S I, Roberts A B, Wang T, Lechleider R J. Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases. J Biol Chem 2001; 276: 19332–19339
- Rameh L E, Cantley L C. The role of phosphoinositide 3-kinase lipid products in cell function. J Biol Chem 1999; 274: 8347–8350
- Razzini G, Brancaccio A, Lemmon M A, Guarnieri S, Falasca M. The role of the pleckstrin homology domain in membrane targeting and activation of phospholipase Cbeta(1). J Biol Chem 2000a; 275: 14873–14881
- Razzini G, Ingrosso A, Brancaccio A, Sciacchitano S, Esposito D L, Falasca M. Different subcellular localization and phosphoinositides binding of insulin receptor substrate protein pleckstrin homology domains. Mol Endocrinol 2000b; 14: 823–826, 2000
- Robinson F L, Dixon J E. Myotubularin phosphatases:policing 3-phosphoinositides. Trends in Cell Biol 2006; 16: 403–412
- Safi A, Vandromme M, Caussanel S, Valdacci L, Baas D, Vidal M, Brun G, Schaeffer L, Goillot E. Role for the pleckstrin homology domain-containing protein CKIP-1 in phosphatidylinositol 3-kinase-regulated muscle differentiation. Mol Cell Biol 2004; 24: 1245–1255
- Schnatwinkel C, Christoforidis S, Lindsay M R, Uttenweiler-Joseph S, Wilm M, Parton R G, Zerial M. The Rab5 effector Rabankyrin-5 regulates and coordinates different endocytic mechanisms. PLoS Biol 2004; 2: E261
- Schu P V, Takegawa K, Fry M J, Stack J H, Waterfield M D, Emr S D. Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting. Science 1993; 260: 88–91
- Seals D F, Azucena E F, Jr, Pass I, Tesfay L, Gordon R, Woodrow M, Resau J H, Courtneidge S A. The adaptor protein Tks5/Fish is required for podosome formation and function, and for the protease-driven invasion of cancer cells. Cancer Cell 2005; 7: 155–165
- Simonsen A, Lippe R, Christoforidis S, Gaullier J M, Brech A, Callaghan J, Toh B H, Murphy C, Zerial M, Stenmark H. EEA1 links PI(3)K function to Rab5 regulation of endosome fusion. Nature 1998; 394: 494–498
- Srivastava S, Ko K, Choudhury P, Li Z, Johnson A K, Nadkarni V, Unutmaz D, Coetzee W A, Skolnik E Y. Phosphatidylinositol-3 phosphatase myotubularin-related protein 6 negatively regulates CD4 T cells. Mol Cell Biol 2006a; 26: 5595–5602
- Srivastava S, Choudhury P, Li Z, Liu G, Nadkarni V, Ko K, Coetzee W A, Skolnik E Y. Phosphatidylinositol 3-phosphate indirectly activates KCa3.1 via 14 amino acids in the carboxy terminus of KCa3.1. Mol Biol Cell 2006b; 17: 146–154
- Stenmark H, Aasland R, Driscoll P C. The phosphatidylinositol 3-phosphate-binding FYVE finger. FEBS Lett 2002; 513: 77–84
- Suh C I, Stull N D, Li X J, Tian W, Price M O, Grinstein S, Yaffe M B, Atkinson S, Dinauer M C. The phosphoinositide-binding protein p40phox activates the NADPH oxidase during Fc{gamma}IIA receptor-induced phagocytosis. J Exp Med 2006; 203: 1915–1925
- Tsukazaki T, Chiang T A, Davison A F, Attisano L, Wrana J L. SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor. Cell 1998; 95: 779–791
- Turner S J, Domin J, Waterfield M D, Ward S G, Westwick J. The CC chemokine monocyte chemotactic peptide-1 activates both the class I p85/p110 phosphatidylinositol 3-kinase and the class II PI3K-C2alpha. J Biol Chem 1998; 273: 25987–25995
- Vanhaesebroeck B, Leevers S J, Ahmadi K, Timms J, Katso R, Driscoll P C, Woscholski R, Parker P J, Waterfield M D. Synthesis and function of 3-phosphorylated inositol lipids. Annu Rev Biochem 2001; 70: 535–602
- Vergne I, Chua J, Deretic V. Tuberculosis toxin blocking phagosome maturation inhibits a novel Ca2+/calmodulin-PI3K hVPS34 cascade. J Exp Med 2003; 198: 653–659
- Vieira O V, Botelho R J, Rameh L, Brachmann S M, Matsuo T, Davidson H W, Schreiber A, Backer J M, Cantley L C, Grinstein S. Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation. J Cell Biol 2001; 155: 19–25
- Virbasius J V, Song X, Pomerleau D P, Zhan Y, Zhou G W, Czech M P. Activation of the Akt-related cytokine-independent survival kinase requires interaction of its phox domain with endosomal phosphatidylinositol 3-phosphate. Proc Natl Acad Sci U S A 2001; 98: 12908–12913
- Wang Y, Yoshioka K, Azam M A, Takuwa N, Sakurada S, Kayaba Y, Sugimoto N, Inoki I, Kimura T, Kuwaki T, Takuwa Y. Class II phosphoinositide 3-kinase alpha-isoform regulates Rho, myosin phosphatase and contraction in vascular smooth muscle. Biochem J 2006; 394: 581–592
- Xu Y, Hortsman H, Seet L, Wong S H, Hong W. SNX3 regulates endosomal function through its PX-domain-mediated interaction with PtdIns(3)P. Nat Cell Biol 2001a; 3: 658–666
- Xu J, Liu D, Gill G, Songyang Z. Regulation of cytokine-independent survival kinase (CISK) by the Phox homology domain and phosphoinositides. J Cell Biol 2001b; 154: 699–705
- Yamaguchi H, Pixley F, Condeelis J. Invadopodia and podosomes in tumor invasion. Eur J Cell Biol 2006; 85: 213–218
- Zhang J, Banfic H, Straforini F, Tosi L, Volinia S, Rittenhouse S E. A type II phosphoinositide 3-kinase is stimulated via activated integrin in platelets. A source of phosphatidylinositol 3-phosphate. J Biol Chem 1998; 273: 14081–14084
- Zheng B, Ma Y C, Ostrom R S, Lavoie C, Gill G N, Insel P A, Huang X Y, Farquhar M G. RGS-PX1, a GAP for GalphaS and sorting nexin in vesicular trafficking. Science 2001; 294: 1939–1942