Genetic polymorphisms of IL-23R (rs7517847) and LEP (rs7799039) among Egyptian patients with hepatocellular carcinoma

References

• Andrisani, O.M., Studach, L., and Merle, P., 2011. Gene signatures in hepatocellular carcinoma (HCC). Seminars in Cancer Biology, 21(1), 4–9.
   PubMed Web of Science ®Google Scholar
• Awasthi, A., et al., 2009. Cutting edge: IL-23 receptor gfp reporter mice reveal distinct populations of IL-17-producing cells. The Journal of Immunology, 182(10), 5904–5908.
   PubMed Web of Science ®Google Scholar
• Bouloumié, A., et al., 1998. Leptin, the product of Ob gene, promotes angiogenesis. Circulation Research, 83(10), 1059–1066.
   PubMed Web of Science ®Google Scholar
• Chen, J., et al., 2010. A nonsynonymous polymorphism in IL23R gene is associated with risk of gastric cancer in a Chinese population. Molecular Carcinogenesis, 49(10), 862–868.
   PubMed Web of Science ®Google Scholar
• Chien, M.H., et al., 2012. Interleukin-23 receptor polymorphism as a risk factor for oral cancer susceptibility. Head and Neck, 34(4), 551–556.
   PubMed Web of Science ®Google Scholar
• Chovanec, J., Bienertová-Vasků, J.A., and Dostálová, Z., 2009. Leptin-2548 g/A polymorphism in endometrial cancer. Klinicka Onkologie, 22(5), 223–227.
   PubMedGoogle Scholar
• Chu, H., et al., 2012. Potentially functional polymorphisms in IL-23 receptor and risk of esophageal cancer in a Chinese population. International Journal of Cancer, 130(5), 1093.
   PubMed Web of Science ®Google Scholar
• Considine, R.V., 2005. Human leptin: an adipocyte hormone with weight-regulatory and endocrine functions. Seminars in Vascular Medicine, 5(1), 15–24.
   PubMedGoogle Scholar
• Considine, R.V., et al., 1996. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. The New England Journal of Medicine, 334(5), 292–295.
   PubMed Web of Science ®Google Scholar
• de Luis, D.A., Perez Castrillón, J.L., and Dueñas, A., 2009. Leptin and obesity. Minerva Medica, 100(3), 229–236.
   PubMed Web of Science ®Google Scholar
• Gately, M.K., et al., 1998. The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses. Annual Review of Immunology, 16, 495–521.
   PubMed Web of Science ®Google Scholar
• Green, E.D., et al., 1995. The human obese (OB) gene: RNA expression pattern and mapping on the physical, cytogenetic, and genetic maps of chromosome 7. Genome Research, 5(1), 5–12.
   PubMed Web of Science ®Google Scholar
• Hayashi, P.H., and Di Bisceglie, A.M., 2005. The progression of hepatitis B- and C-infections to chronic liver disease and hepatocellular carcinoma: presentation, diagnosis, screening, prevention, and treatment of hepatocellular carcinoma. Medical Clinics of North America, 89(2), 345–369.
   PubMed Web of Science ®Google Scholar
• Hinuy, H.M., et al., 2008. Leptin G-2548A promoter polymorphism is associated with increased plasma leptin and BMI in Brazilian women. Arquivos Brasileiros de Endocrinologia Metabologia, 52(4), 611–616.
   PubMed Web of Science ®Google Scholar
• Hoffstedt, J., et al., 2002. A polymorphism in the leptin promoter region (-2548 G/A) influences gene expression and adipose tissue secretion of leptin. Hormone and Metabolic Research, 34(7), 355–359.
   PubMed Web of Science ®Google Scholar
• Hu, X., et al., 2002. Leptin-a growth factor in normal and malignant breast cells and for normal mammary gland development. Journal of National Cancer Institute, 94(22), 1704–1711.
   PubMedGoogle Scholar
• Isse, N., et al., 1995. Structural organization and chromosomal assignment of the human obese gene. The Journal of Biological Chemistry, 270(46), 27728–27733.
   PubMed Web of Science ®Google Scholar
• Iwakura, Y., and Ishigame, H., 2006. The IL-23/IL-17 axis in inflammation. The Journal of Clinical Investigation, 116(5), 1218–1222.
   PubMed Web of Science ®Google Scholar
• Kim, E.Y., et al., 2012. Susceptibility of gastric cancer according to leptin and leptin receptor gene polymorphisms in Korea. Journal of Korean Surgical Society, 83(1), 7–13.
   PubMedGoogle Scholar
• Kudo, M., 2011. Diagnostic imaging of hepatocellular carcinoma: recent progress. Oncology, 81(Suppl 1), 73–85.
   PubMed Web of Science ®Google Scholar
• Labib, H.A., et al., 2015. Genetic polymorphism of IL-23R influences susceptibility to HCV-related hepatocellular carcinoma. Cellular Immunology, 294(1), 21–24.
   PubMed Web of Science ®Google Scholar
• Langowski, J.L., et al., 2006. IL-23 promotes tumour incidence and growth. Nature, 442(7101), 461–465.
   PubMed Web of Science ®Google Scholar
• Lankford, C.S., and Frucht, D.M., 2003. A unique role for IL-23 in promoting cellular immunity. Journal of Leukocyte Biology, 73(1), 49–56.
   PubMed Web of Science ®Google Scholar
• Le Stunff, C., et al., 2000. A common promoter variant of the leptin gene is associated with changes in the relationship between serum leptin and fat mass in obese girls. Diabetes, 49(12), 2196–2200.
   PubMed Web of Science ®Google Scholar
• Li, W. D., et al., 1999. Sequence variants in the 5' flanking region of the leptin gene are associated with obesity in women. Annals of Human Genetics, 63(Pt 3), 227–234.
   PubMed Web of Science ®Google Scholar
• Mahmoudi, R., et al., 2015. Polymorphisms of Leptin (-2548 G/A) and Leptin Receptor (Q223R) Genes in Iranian Women with Breast Cancer. International Journal of Genomics, 2015, 132720.
   PubMed Web of Science ®Google Scholar
• Mammès, O., et al., 1998. Novel polymorphisms in the 5' region of the LEP gene: association with leptin levels and response to low-calorie diet in human obesity. Diabetes, 47(3), 487–489.
   PubMed Web of Science ®Google Scholar
• Mammès, O., et al., 2000. Association of the G-2548A polymorphism in the 5' region of the LEP gene with overweight. Annals of Human Genetics, 64(Pt 5), 391–394.
   PubMed Web of Science ®Google Scholar
• Marcello, M.A., et al., 2015. Polymorphism in LEP and LEPR may modify leptin levels and represent risk factors for thyroid cancer. International Journal of Endocrinology, 2015, 173218.
   PubMed Web of Science ®Google Scholar
• McGlynn, K.A., and London, W.T., 2011. The global epidemiology of hepatocellular carcinoma: present and future. Clinical Liver Disease, 15(2), 223–243.
   PubMed Web of Science ®Google Scholar
• McKenzie, B.S., Kastelein, R.A., and Cua, D.J., 2006. Understanding the IL-23-IL-17 immune pathway. Trends in Immunology, 27(1), 17–23.
   PubMed Web of Science ®Google Scholar
• Mohamed, A.A., et al., 2015. Hepatitis C virus: A global view. World Journal of Hepatology, 7(26), 2676–2680.
   PubMed Web of Science ®Google Scholar
• Mohammadzadeh, G., et al., 2015. The relationship between -2548 G/A leptin gene polymorphism and risk of breast cancer and serum leptin levels in Ahvazian women. Iran Journal of Cancer Prevention, 8(2), 100–108.
   PubMed Web of Science ®Google Scholar
• Moore, K.P., and Aithal, G.P., 2006. Guidelines on the management of ascites in cirrhosis. Gut, 55(Suppl 6), vi1–v12.
   PubMed Web of Science ®Google Scholar
• Oppmann, B., et al., 2000. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity, 13(5), 715–725.
   PubMed Web of Science ®Google Scholar
• Parham, C., et al., 2002. receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R. The Journal of Immunology, 168(11), 5699–5708.
   PubMed Web of Science ®Google Scholar
• Parkin, D.M., et al., 2005. Global cancer statistics, 2002. CA: A Cancer Journal for Clinicians, 55(2), 74–108.
   PubMed Web of Science ®Google Scholar
• Partida-Pérez, M., et al., 2010. Association of LEP and ADIPOQ common variants with colorectal cancer in Mexican patients. Cancer Biomark, 7(3), 117–121.
   PubMed Web of Science ®Google Scholar
• Poitou, C., et al., 2005. Relationship between single nucleotide polymorphisms in leptin, IL6 and adiponectin genes and their circulating product in morbidly obese subjects before and after gastric banding surgery. Obesity Surgery, 15(1), 11–23.
   PubMed Web of Science ®Google Scholar
• Ribeiro, R., et al., 2004. Overexpressing leptin genetic polymorphism (-2548 G/A) is associated with susceptibility to prostate cancer and risk of advanced disease. Prostate, 59(3), 268–274.
   PubMed Web of Science ®Google Scholar
• Ribeiro, R., et al., 2006. A functional polymorphism in the promoter region of leptin gene increases susceptibility for non-small cell lung cancer. European Journal of Cancer, 42(8), 1188–1193.
   PubMed Web of Science ®Google Scholar
• Rostami, S., Kohan, L., and Mohammadianpanah, M., 2015. The LEP G-2548A gene polymorphism is associated with age at menarche and breast cancer susceptibility. Gene, 557(2), 154–157.
   PubMed Web of Science ®Google Scholar
• Skibola, C.F., et al., 2004. Body mass index, leptin and leptin receptor polymorphisms, and non-hodgkin lymphoma. Cancer Epidemiology, Biomarkers and Prevention, 13(5), 779–786.
   PubMed Web of Science ®Google Scholar
• Snoussi, K., et al., 2006. Leptin and leptin receptor polymorphisms are associated with increased risk and poor prognosis of breast carcinoma. BMC Cancer, 6, 38.
   PubMed Web of Science ®Google Scholar
• Tang, T., et al., 2014. Association of interleukin-23 receptor gene polymorphisms with risk of bladder cancer in Chinese. Familial Cancer, 13(4), 619–623.
   PubMed Web of Science ®Google Scholar
• Unsal, M., et al., 2014. Effects of leptin and leptin receptor gene polymorphisms on lung cancer. Tumour Biology, 35(10), 10231–10236.
   PubMed Web of Science ®Google Scholar
• Wang, L., et al., 2012. A miRNA binding site single-nucleotide polymorphism in the 3'-UTR region of the IL23R gene is associated with breast cancer. PLoS One, 7(12), e49823.
   PubMed Web of Science ®Google Scholar
• Wang, X.J., et al., 2004. Potential involvement of leptin in carcinogenesis of hepatocellular carcinoma. World Journal of Gastroenterology, 10(17), 2478–2481.
   PubMed Web of Science ®Google Scholar
• Wauters, M., et al., 2002 Leptin levels, leptin receptor gene polymorphisms, and energy metabolism in women. Obesity Research, 10(5), 394–400.
   PubMedGoogle Scholar
• Xu, Y., et al., 2013. IL-23R polymorphisms, HBV infection, and risk of hepatocellular carcinoma in a high-risk Chinese population. Journal of Gastroenterology, 48(1), 125–131.
   PubMed Web of Science ®Google Scholar
• Yang, H.I., et al., 2002. Taiwan Community-Based Cancer Screening Project Group. Hepatitis B e antigen and the risk of hepatocellular carcinoma. The New England Journal of Medicine, 347(3), 168–174.
   PubMed Web of Science ®Google Scholar
• Yao, J., Liu, L., and Yang, M., 2014. Interleukin-23 receptor genetic variants contribute to susceptibility of multiple cancers. Gene, 533(1), 21–25.
   PubMed Web of Science ®Google Scholar
• Yapijakis, C., et al., 2009. Association of leptin -2548G/A and leptin receptor Q223R polymorphisms with increased risk for oral cancer. Journal of Cancer Research Clinical Oncology, 135(4), 603–612.
   PubMed Web of Science ®Google Scholar
• Zhang, X. Y., et al., 2006. Identification and expression analysis of alternatively spliced isoforms of human interleukin-23 receptor gene in normal lymphoid cells and selected tumor cells. Immunogenetics, 57(12), 934–943.
   PubMed Web of Science ®Google Scholar
• Zhang, Y., et al., 1994. Positional cloning of the mouse obese gene and its human homologue. Nature, 372(6505), 425–432.
   PubMed Web of Science ®Google Scholar
• Zhang, Z., et al., 2010. Association of interleukin-23 receptor gene polymorphisms with risk of ovarian cancer. Cancer Genetics and Cytogenetics, 196(2), 146–152.
   PubMedGoogle Scholar
• Zhou, H., et al., 2010. Polymorphisms of IL23R and Fuchs' syndrome in a Chinese Han population. Molecular Vision, 16, 2585–2589.
   PubMed Web of Science ®Google Scholar