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Archives of Physiology and Biochemistry
The Journal of Metabolic Diseases
Volume 125, 2019 - Issue 2
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Original Article

Long-term metabolic cage housing increases anxiety/depression-related behaviours in adult male rats

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Pages 122-127 | Received 29 Aug 2017, Accepted 12 Feb 2018, Published online: 20 Feb 2018

References

  • Björntorp, P., and Rosmond, R., 1999. Hypothalamic origin of the metabolic syndrome X. Annals of the New York academy of sciences, 892, 297–307.
  • Brunner, L.J., Dipiro, J.T., and Feldman, S., 1994. Metabolic cage isolation reduces antipyrine clearance in rats. Journal of pharmacy and pharmacology, 46, 581–584.
  • Cakan, P., Ozgocer, T., and Yildiz, S., 2016. Development and validation of a corticosterone enzyme immunoassay for rat plasma. Acta physiologica, 217( S708), 76–77.
  • Can, A., et al., 2012. The mouse forced swim test. Journal of visualized experiments, 59, e3638.
  • Canpolat, S., et al., 2016. Studies on the reproductive effects of chronic treatment with agomelatine in the rat. European journal of pharmacology, 770, 33–39.
  • Clement, Y., et al., 1997. Genetic factors regulate processes related to anxiety in mice. Brain research, 752, 127–135.
  • Cryan, J.F., and Mombereau, C., 2004. In search of a depressed mouse: utility of models for studying depression-related behavior in genetically modified mice. Molecular psychiatry, 9, 326–357.
  • Cryan, J.F., Page, M.E., and Lucki, I., 2005. Differential behavioral effects of the antidepressants reboxetine, fluoxetine, and moclobemide in a modified forced swim test following chronic treatment. Psychopharmacology, 182, 335–344.
  • Deacon, R.M., 2006. Housing, husbandry and handling of rodents for behavioral experiments. Nature protocols, 1, 936–946.
  • Denmark, A., et al., 2010. The effects of chronic social defeat stress on mouse self-grooming behavior and its patterning. Behavioural brain research, 208, 553–559.
  • Eriksson, E., et al., 2004. Effect of metabolic cage housing on immunoglobulin A and corticosterone excretion in faeces and urine of young male rats. Experimental physiology, 89, 427–433.
  • EU Directive. 2010. Directive 2010/63 EU of the European Parliament and of the Council of 22 September 2010 on the protection of animals used for scientific purposes. Official journal of the European communities, L276, 33–79.
  • Gershenfeld, H.K., and Paul, S.M., 1997. Mapping quantitative trait loci for fear-like behaviors in mice. Genomics, 46, 1–8.
  • Gil, M.C., et al., 1999. Influence of age on stress responses to metabolic cage housing in rats. Cellular and molecular neurobiology, 19, 625–633.
  • Heidbreder, C.A., et al., 2000. Behavioral, neurochemical and endocrinological characterization of the early social isolation syndrome. Neuroscience, 100, 749–768.
  • Henderson, N.D., et al., 2004. QTL analysis of multiple behavioral measures of anxiety in mice. Behavior genetics, 34, 267–293.
  • Hoppe, C.C., et al., 2009. Transient hypertension and sustained tachycardia in mice housed individually in metabolism cages. Physiology research, 58, 69–75.
  • Hunt, C., and Hambly, C., 2006. Faecal corticosterone concentrations indicate that separately housed male mice are not more stressed than group housed males. Physiology behavior, 87, 519–526.
  • Jorgensen, A., 2013. Oxidatively generated DNA/RNA damage in psychological stress states. Danish medical journal, 60, B4685.
  • Kalliokoski, O., et al., 2013. Mice do not habituate to metabolism cage housing – a three week study of male BALB/c mice. PLoS one, 8, e58460.
  • Kalueff, A.V., and Tuohimaa, P., 2004. Grooming analysis algorithm for neurobehavioural stress research. Brain research protocols, 13, 151–158.
  • Kalueff, A.V., and Tuohimaa, P., 2005. The grooming analysis algorithm discriminates between different levels of anxiety in rats: potential utility for neurobehavioural stress research. Journal of neuroscience methods, 143, 169–177.
  • Kalueff, A.V., et al., 2007. Analyzing grooming microstructure in neurobehavioral experiments. Nature Protocols, 2, 2538–2544.
  • Karatsoreos, I.N., et al., 2010. Endocrine and physiological changes in response to chronic corticosterone: a potential model of the metabolic syndrome in mouse. Endocrinology, 151, 2117–2127.
  • Krohn, T.C., Hansen, A.K., and Dragsted, N., 2003. Telemetry as a method for measuring the impact of housing conditions on rat´s welfare. Animal welfare, 12, 53–62.
  • Kurien, B.T., Everds, N.E., and Scofield, R.H., 2004. Experimental animal urine collection: a review. Laboratory animals, 38, 333–361.
  • Manser, C.E., Morris, T.H., and Broom, D.M., 1995. An investigation into the effects of solid or grid cage flooring on the welfare of laboratory rats. Laboratory animals, 29, 353–363.
  • Miyajima, K., et al., 2015. Effect of Isolation stress on glucose/lipid metabolism in Spontaneously Diabetic Torii (SDT) fatty rats. British journal of medicine and medical research, 8, 588–594.
  • Mizisin, A.P., et al., 1998. Tactile hyperesthesia, altered epidermal innervation and plantar nerve injury in the hindfeet of rats housed on wire grates. Brain research, 788, 13–19.
  • Nagy, T.R., et al., 2002. Effect of group vs. single housing on phenotypic variance in C57BL/6J mice. Obesity research, 10, 412–415.
  • Ollson, I.A.S., and Westlund, K., 2007. More than numbers matter: the effect of social factors on behaviour and welfare of laboratory rodents and non-human primates. Applied animal behaviour science, 103, 229–254.
  • Ozgocer, T., Yildiz, T., and Ucar, C., 2017. Development and validation of an enzyme-linked immunosorbent assay for detection of cortisol in human saliva. Journal of immunoassay and immunochemistry, 38, 147–164.
  • Pinelli, C.J., Leri, F., and Turner, P.V., 2017. Long term physiologic and behavioural effects of housing density and environmental resource provision for adult male and female sprague dawley rats. Animals, 7, E44.
  • Porsolt, R.D., Le Pichon, M., and Jalfre, M., 1977. Depression: a new animal model sensitive to antidepressant treatments. Nature, 266, 730–732.
  • Prut, L., and Belzung, C., 2003. The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review. European journal of pharmacology, 463, 3–33.
  • Simon, P., Dupuis, R., and Costentin, J., 1994. Thigmotaxis as an index of anxiety in mice. Influence of dopaminergic transmissions. Behavioural brain research, 61, 59–64.
  • Sorensen, D.B., et al., 2008. Enriching the metabolic cage: effects on rat physiology and behavior. Animal welfare, 17, 395–403.
  • Spangenberg, E.M.F., et al., 2005. Housing related activity in rats: effects on body weight, urinary corticosterone levels, muscle properties and performance. Laboratory animals, 39, 45–57.
  • Tintos, A., et al., 2006. Development of a microtitre plate indirect ELISA for measuring cortisol in teleosts, and evaluation of stress responses in rainbow trout and gilthead sea bream. Journal of fish biology, 68, 251–263.
  • Tuli, J.S., Smith, J.A., and Morton, D.B., 1995. Stress measurements in mice after transportation. Laboratory animals, 29, 132–138.
  • Van Abeelen, J.H.F., 1975. Genetic analysis of behavioural responses to novelty in mice. Nature, 254, 239–241.
  • Volodina, M.A., et al., 2012. Correction of long-lasting negative effects of neonatal isolation in white rats using semax. Acta naturae, 4, 86–92.
  • Whittaker, A.L., Lymn, K.A., and Howarth, G.S., 2016. Effects of metabolic cage housing on rat behavior and performance in the social interaction test. Journal of applied animal welfare science, 19, 363–374.
  • Xu, H.Y., et al., 2012. Inactivation of the bed nucleus of the stria terminalis suppresses the innate fear responses of rats induced by the odor of cat urine. Neuroscience, 221, 21–27.
  • Yamada, K., Ohki-Hamazaki, H., and Wada, K., 2000. Differential effects of social isolation upon body weight, food consumption, and responsiveness to novel and social environment in bombesin receptor subtype-3 (BRS-3) deficient mice. Physiology behavior, 68, 555–561.
  • Yankelevitch-Yahav, R., et al., 2015. The forced swim test as a model of depressive-like behavior. Journal of visualized experiments, 97, e52587.
  • Zymantiene, J., et al., 2016. Influence of metabolic cage on wistar rat physiological state. Macedonian veterinary review, 39, 33–38.

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