Protective effect of saxagliptin against renal ischaemia reperfusion injury in rats

References

• Abdelrahman, A.M., et al., 2019. The renoprotective effect of the dipeptidyl peptidase-4 inhibitor sitagliptin on adenine-induced kidney disease in rats. Biomedicine & pharmacotherapy, 110, 667–676.
   PubMed Web of Science ®Google Scholar
• Aebi, H., 1974. Catalase. In: H.U. Bergmeyer, ed. Methods of enzymatic analysis. New York: Academic Press.
   Google Scholar
• Aggarwal, S., et al., 2016. Human CD133(+) renal progenitor cells induce erythropoietin production and limit fibrosis after acute tubular injury. Scientific reports, 6 (1), 37270.
   PubMed Web of Science ®Google Scholar
• Bonventre, J.V. and Zuk, A., 2004. Ischemic acute renal failure: an inflammatory disease? Kidney international, 66 (2), 480–485.
   PubMed Web of Science ®Google Scholar
• Burne-Taney, M.J., et al., 2003. Acute renal failure after whole body ischemia is characterized by inflammation and T cell-mediated injury. American journal of physiology-renal physiology, 285 (1), F87–F94.
   PubMed Web of Science ®Google Scholar
• Cetin, A., Ciftci, O., and Otlu, A., 2016. Protective effect of hesperidin on oxidative and histological liver damage following carbon tetrachloride administration in Wistar rats. Archives of medical science, 12, 486–493.
   PubMed Web of Science ®Google Scholar
• Chang, M.W., et al., 2015. Sitagliptin protects rat kidneys from acute ischemia-reperfusion injury via upregulation of GLP-1 and GLP-1 receptors. Acta pharmacologica sinica, 36 (1), 119–130.
   PubMed Web of Science ®Google Scholar
• Chang, Y.-K., et al., 2016. Dapagliflozin, SGLT2 Inhibitor, Attenuates Renal Ischemia-Reperfusion Injury. Plos one, 11 (7), e0158810.
   PubMed Web of Science ®Google Scholar
• Chatterjee, P.K., et al., 2000. Tempol, a membrane-permeable radical scavenger, reduces oxidant stress-mediated renal dysfunction and injury in the rat. Kidney international, 58 (2), 658–673.
   PubMed Web of Science ®Google Scholar
• Coca, S.G., et al., 2009. Long-term risk of mortality and other adverse outcomes after acute kidney injury: a systematic review and meta-analysis. American journal of kidney diseases, 53 (6), 961–973.
   PubMed Web of Science ®Google Scholar
• Deacon, C.F., 2011. Dipeptidyl peptidase-4 inhibitors in the treatment of type 2 diabetes: a comparative review. Diabetes, obesity and metabolism, 13 (1), 7–18.
   PubMed Web of Science ®Google Scholar
• Devarajan, P., 2008. Emerging urinary biomarkers in the diagnosis of acute kidney injury. Expert Opinion on medical diagnostics, 2 (4), 387–398.
   PubMedGoogle Scholar
• Drucker, D.J., 2002. Biological actions and therapeutic potential of the glucagon-like peptides. Gastroenterology, 122 (2), 531–544.
   PubMed Web of Science ®Google Scholar
• Ellman, G.L., 1959. Tissue sulfhydryl groups. Archives of biochemistry and biophysics, 82 (1), 70–77.
   PubMed Web of Science ®Google Scholar
• Guan, Z., et al., 2006. Renal endothelial dysfunction and impaired autoregulation after ischemia-reperfusion injury result from excess nitric oxide. American journal of physiology-renal physiology, 291 (3), F619–28.
   PubMed Web of Science ®Google Scholar
• Hassoun, H.T., et al., 2009. Kidney ischemia-reperfusion injury induces caspase-dependent pulmonary apoptosis. American journal of physiology-renal physiology, 297 (1), F125–37.
   PubMed Web of Science ®Google Scholar
• Helal, M.G., Zaki, M.M.F., and Said, E., 2018. Nephroprotective effect of saxagliptin against gentamicin-induced nephrotoxicity, emphasis on anti-oxidant, anti-inflammatory and anti-apoptic effects. Life sciences, 208, 64–71.
   PubMed Web of Science ®Google Scholar
• Hocher, B., Reichetzeder, C., and Alter, M.L., 2012. Renal and cardiac effects of DPP4 inhibitors – from preclinical development to clinical research. Kidney and blood pressure research, 36 (1), 65–84.
   PubMed Web of Science ®Google Scholar
• Hou, S.H., et al., 1983. Hospital-acquired renal insufficiency: a prospective study. The American journal of medicine, 74 (2), 243–248.
   PubMed Web of Science ®Google Scholar
• Iwai, T., et al., 2006. Glucagon-like peptide-1 inhibits LPS-induced IL-1beta production in cultured rat astrocytes. Neuroscience research, 55 (4), 352–360.
   PubMed Web of Science ®Google Scholar
• Jungraithmayr, W., et al., 2012. CD26/DPP-4 inhibition recruits regenerative stem cells via stromal cell-derived factor-1 and beneficially influences ischaemia-reperfusion injury in mouse lung transplantation. European journal of cardio-thoracic surgery, 41 (5), 1166–1173.
   PubMed Web of Science ®Google Scholar
• Kamel, N.M., et al., 2019. Novel repair mechanisms in a renal ischaemia/reperfusion model: Subsequent saxagliptin treatment modulates the pro-angiogenic GLP-1/cAMP/VEGF, ANP/eNOS/NO, SDF-1alpha/CXCR4, and Kim-1/STAT3/HIF-1alpha/VEGF/eNOS pathways. European journal of pharmacology, 861, 172620.
   PubMed Web of Science ®Google Scholar
• Kato, N., et al., 2009. The E-selectin ligand basigin/CD147 is responsible for neutrophil recruitment in renal ischemia/reperfusion. Journal of the American society of nephrology, 20 (7), 1565–1576.
   PubMed Web of Science ®Google Scholar
• Kellum, J.A., 2008. Acute kidney injury. Critical care medicine, 36 (Suppl), S141–S145.
   PubMed Web of Science ®Google Scholar
• Kellum, J.A., et al., 2002. Developing a consensus classification system for acute renal failure. Current opinion in critical care, 8 (6), 509–514.
   PubMedGoogle Scholar
• Kelly, K.J., 2003. Distant effects of experimental renal ischemia/reperfusion injury. Journal of the American society of nephrology, 14 (6), 1549–1558.
   PubMed Web of Science ®Google Scholar
• Koyner, J.L., et al.; for the TRIBE-AKI Consortium, 2012. Biomarkers predict progression of acute kidney injury after cardiac surgery. Journal of the American society of nephrology, 23 (5), 905–914.
   PubMed Web of Science ®Google Scholar
• Lafrance, J.P. and Miller, D.R., 2010. Acute kidney injury associates with increased long-term mortality. Journal of the American society of nephrology, 21 (2), 345–352.
   PubMed Web of Science ®Google Scholar
• Li, L., et al., 2019. The dipeptidyl peptidase-4 inhibitor sitagliptin ameliorates renal injury in type 1 diabetic mice via inhibiting the TGF-β/Smad signal pathway. Die pharmazie, 74 (4), 239–242.
   PubMed Web of Science ®Google Scholar
• Lonborg, J., et al., 2012. Exenatide reduces reperfusion injury in patients with ST-segment elevation myocardial infarction. European heart journal, 33, 1491–1499.
   PubMed Web of Science ®Google Scholar
• Malek, M. and Nematbakhsh, M., 2015. Renal ischemia/reperfusion injury; from pathophysiology to treatment. Journal of renal injury prevention, 4 (2), 20–27.
   PubMed Web of Science ®Google Scholar
• Mentlein, R., 1999. Dipeptidyl-peptidase IV (CD26)-role in the inactivation of regulatory peptides. Regulatory peptides, 85 (1), 9–24.
   PubMed Web of Science ®Google Scholar
• Mihara, M. and Uchiyama, M., 1978. Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Analytical biochemistry, 86, 271–278.
   PubMed Web of Science ®Google Scholar
• Nuransoy, A., et al., 2015. Protective effect of sitagliptin against renal ischemia reperfusion injury in rats. Renal failure, 37 (4), 687–693.
   PubMed Web of Science ®Google Scholar
• O’neill, J., et al., 2015. Acute SGLT inhibition normalizes O2 tension in the renal cortex but causes hypoxia in the renal medulla in anaesthetized control and diabetic rats. American journal of physiology-renal physiology, 309, F227–F234.
   PubMed Web of Science ®Google Scholar
• Oeseburg, H., et al., 2010. Glucagon-like peptide 1 prevents reactive oxygen species-induced endothelial cell senescence through the activation of protein kinase A. Arteriosclerosis, thrombosis, and vascular biology, 30 (7), 1407–1414.
   PubMed Web of Science ®Google Scholar
• Ozdemir, R., et al., 2006. Selective endothelin a (ETA) receptor antagonist (BQ-123) reduces both myocardial infarct size and oxidant injury. Toxicology, 219 (1–3), 142–149.
   PubMed Web of Science ®Google Scholar
• Paglia, D.E. and Valentine, W.N., 1967. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. The journal of laboratory and clinical medicine, 70 (1), 158–169.
   PubMed Web of Science ®Google Scholar
• Parikh, C.R., et al.; for the TRIBE-AKI Consortium, 2011. Postoperative biomarkers predict acute kidney injury and poor outcomes after adult cardiac surgery. Journal of the American society of nephrology, 22 (9), 1748–1757.
   PubMed Web of Science ®Google Scholar
• Parlakpinar, H., et al., 2005. Protective role of caffeic acid phenethyl ester (cape) on gentamicin-induced acute renal toxicity in rats. Toxicology, 207 (2), 169–177.
   PubMed Web of Science ®Google Scholar
• Parlakpinar, H., et al., 2009. Beneficial effects of apricot-feeding on myocardial ischemia-reperfusion injury in rats. Food and chemical toxicology, 47 (4), 802–808.
   PubMed Web of Science ®Google Scholar
• Reichetzeder, C., et al., 2017. Head-to-head comparison of structurally unrelated dipeptidyl peptidase 4 inhibitors in the setting of renal ischemia reperfusion injury. British journal of pharmacology, 174 (14), 2273–2286.
   PubMed Web of Science ®Google Scholar
• Sauve, M., et al., 2010. Genetic deletion or pharmacological inhibition of dipeptidyl peptidase-4 improves cardiovascular outcomes after myocardial infarction in mice. Diabetes, 59 (4), 1063–1073.
   PubMed Web of Science ®Google Scholar
• Selby, N.M., et al., 2012. Defining the cause of death in hospitalised patients with acute kidney injury. PLoS one, 7 (11), e48580.
   PubMed Web of Science ®Google Scholar
• Serteser, M., et al., 2002. Changes in hepatic TNF-alpha levels, antioxidant status, and oxidation products after renal ischemia/reperfusion injury in mice. Journal of surgical research, 107 (2), 234–240.
   PubMed Web of Science ®Google Scholar
• Sun, Y., Oberley, L.W., and Li, Y., 1988. A simple method for clinical assay of superoxide dismutase. Clinical chemistry, 34 (3), 497–500.
   PubMed Web of Science ®Google Scholar
• Vaghasiya, J., et al., 2011. Sitagliptin protects renal ischemia reperfusion induced renal damage in diabetes. Regulatory peptides, 166 (1-3), 48–54.
   PubMedGoogle Scholar
• Verma, S.K. and Molitoris, B.A., 2015. Renal endothelial injury and microvascular dysfunction in acute kidney injury. Seminars in nephrology, 35 (1), 96–107.
   PubMed Web of Science ®Google Scholar
• Vinas, J.L., et al., 2006. NO and NOS isoforms in the development of apoptosis in renal ischemia/reperfusion. Free radical biology and medicine, 40, 992–1003.
   PubMed Web of Science ®Google Scholar
• Wang, A., et al., 2012. Potency, selectivity and prolonged binding of saxagliptin to DPP4: maintenance of DPP4 inhibition by saxagliptin in vitro and ex vivo when compared to a rapidly-dissociating DPP4 inhibitor. BMC pharmacology, 12 (1), 2.
   PubMedGoogle Scholar
• Yilmaz, E., et al., 2018. The therapeutic effects of curcumin and capsaicin against cyclophosphamide side effects on the uterus in rats. Acta cirurgica brasileira, 33 (6), 499–507.
   PubMed Web of Science ®Google Scholar
• Youssef, M.I., Mahmoud, A.A., and Abdelghany, R.H., 2015. A new combination of sitagliptin and furosemide protects against remote myocardial injury induced by renal ischemia/reperfusion in rats. Biochemical pharmacology, 96 (1), 20–29.
   PubMed Web of Science ®Google Scholar