Brazilian native fruit extracts act as preventive agents modulating the purinergic and cholinergic signalling in blood cells and serum in a rat model of metabolic syndrome

References

• Abdalla, F.H., et al., 2014. Protective effect of quercetin in ecto-enzymes, cholinesterases, and myeloperoxidase activities in the lymphocytes of rats exposed to cadmium. Molecular and cellular biochemistry, 396 (1–2), 201–211.
   PubMed Web of Science ®Google Scholar
• Akinyemi, A.J., et al., 2016. Effect of ginger and turmeric rhizomes on inflammatory cytokines levels and enzyme activities of cholinergic and purinergic systems in hypertensive rats. Planta medica, 82, 612–620.
   PubMed Web of Science ®Google Scholar
• Badshah, H., et al., 2013. Anthocyanins attenuate body weight gain via modulating neuropeptide Y and GABAB1 receptor in rats hypothalamus. Neuropeptides, 47 (5), 347–353.
   PubMed Web of Science ®Google Scholar
• Bagatini, M.D., et al., 2008. Hydrolysis of adenine nucleotides in platelets from patients with acute myocardial infarction. Clinical biochemistry, 41 (14–15), 1181–1185.
   PubMed Web of Science ®Google Scholar
• Bhaswant, M., et al., 2015. Cyanidin 3-glucoside improves diet-induced metabolic syndrome in rats. Pharmacological research, 102, 208–217.
   PubMed Web of Science ®Google Scholar
• Bordignon, C.L., et al., 2009. Influência do pH da solução extrativa no teor de antocianinas em frutos de morango. Ciência e tecnologia de alimentos, 29, 183–188.
   Google Scholar
• Böyum, A., 1968. Isolation of mononuclear cells and granulocytes from human blood. Isolation of mononuclear cells by one centrifugation and of granulocytes by combining centrifugation and sedimentation at 1 g. Scandinavian journal of clinical and laboratory investigation, 97, 77–89.
   Google Scholar
• Bradford, M., 1976. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein–dye binding. Analytical biochemistry, 72 (1–2), 248–254.
   PubMed Web of Science ®Google Scholar
• Brown, L., Poudyal, H., and Panchal, S.K., 2015. Functional foods as potential therapeutic options for metabolic syndrome. Obesity reviews, 16, 914–941.
   PubMed Web of Science ®Google Scholar
• Bullo, C.A.P., et al., 2007. Inflammation, obesity and comorbidities: the role of diet. Public health nutrition, 10, 1164–1172.
   PubMed Web of Science ®Google Scholar
• Cardoso, S.J., et al., 2018. Antioxidant, antihyperglycemic and antidyslipidemic effects of Brazilian-native fruit extracts in an animal model of insulin resistance. Redox report, 23, 41–46.
   PubMed Web of Science ®Google Scholar
• Das, U.N., 2007. Acetylcholinesterase and butyrylcholinesterase as possible markers of low-grade systemic inflammation. Medical science monitor, 13, 214–221.
   Web of Science ®Google Scholar
• De Bona, K.S., et al., 2012. Lymphocytic enzymes and lipid peroxidation in patients with metabolic syndrome. Clinical biochemistry, 45 (13–14), 1081–1085.
   PubMed Web of Science ®Google Scholar
• De Bona, K.S., et al., 2013. Butyrylcholinesterase and γ-glutamyltransferase activities and oxidative stress markers are altered in metabolic syndrome, but are not affected by body mass index. Inflammation, 36 (6), 1539–1547.
   PubMed Web of Science ®Google Scholar
• Debom, G., et al., 2016. Preventive effects of blueberry extract on behavioral and biochemical dysfunctions in rats submitted to a model of manic behavior induced by ketamine. Brain research bulletin, 27, 260–269.
   Google Scholar
• Devalaraja, S., Jain, S., and Yadav, H., 2011. Exotic fruits as therapeutic complements for diabetes, obesity and metabolic syndrome. Food research international, 44 (7), 1856–1865.
   PubMed Web of Science ®Google Scholar
• Dragano, N.R.V., et al., 2013. Freeze-dried jaboticaba peel powder improves insulin sensitivity in high-fat-fed mice. British journal of nutrition, 110 (3), 447–455.
   PubMed Web of Science ®Google Scholar
• Duarte, M.M.F., et al., 2007. Enzymes that hydrolyze adenine nucleotides of patients with hypercholesterolemia and inflammatory processes. The FEBS journal, 274 (11), 2707–2714.
   PubMed Web of Science ®Google Scholar
• Ellman, G.L., et al., 1961. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochemical pharmacology, 7 (2), 88–95.
   PubMed Web of Science ®Google Scholar
• Figuerôa, E.O., et al., 2013. Evaluation of antioxidant, immunomodulatory, and cytotoxic action of fractions from Eugenia uniflora L. and Eugenia malaccensis L.: correlation with polyphenol and flavonoid content. The scientific world journal, 2013, 125027.
   Google Scholar
• Giusti, G. and Galanti, B., 1984. Colorimetric method. Adenosine deaminase. In: H.U. Bergmeyer, ed. Methods of enzymatic analysis. 3rd ed. Weinheim, Germany: Verlag Chemie, 315–323.
   Google Scholar
• Giusti, G. and Gakis, C., 1971. Temperature conversion factors, activation energy, relative substrate specificity and optimum pH of adenosine deaminase from human serum and tissues. Enzyme, 12 (4), 417–425.
   PubMedGoogle Scholar
• Hajer, G.R., Van Haeften, T.W., and Visseren, F.L.J., 2008. Adipose tissue dysfunction in obesity, diabetes, and vascular diseases. European heart journal, 29 (24), 2959–2971.
   PubMed Web of Science ®Google Scholar
• Hanhineva, K., et al., 2010. Impact of dietary polyphenols on carbohydrate metabolism. International journal of molecular sciences, 11 (4), 1365–1402.
   PubMed Web of Science ®Google Scholar
• Jaques, J.A., et al., 2011. A method for isolation of rat lymphocyte-rich mononuclear cells from lung tissue useful for determination of nucleoside triphosphate diphosphohydrolase activity. Analytical biochemistry, 410 (1), 34–39.
   PubMed Web of Science ®Google Scholar
• Jayarathne, S., et al., 2017. Anti-Inflammatory and anti-obesity properties of food bioactive components: effects on adipose tissue. Preventive nutrition and food science, 22 (4), 251–262.
   PubMedGoogle Scholar
• Joo, H.K., et al., 2018. Anthocyanin-rich extract from red Chinese cabbage alleviates vascular inflammation in endothelial cells and apo e-/- mice. International journal of molecular sciences, 19 (3), 816–816.
   Web of Science ®Google Scholar
• Ju, S.Y., Lee, J.Y., and Kim, D.H., 2017. Association of metabolic syndrome and its components with all-cause and cardiovascular mortality in the elderly. Medicine, 96 (45), e8491.
   PubMed Web of Science ®Google Scholar
• Karlsen, A., et al., 2007. Anthocyanins inhibit nuclear factor-kappa B activation in monocytes and reduce plasma concentrations of pro-inflammatory mediators in healthy adults. The journal of nutrition, 137 (8), 1951–1954.
   PubMed Web of Science ®Google Scholar
• Leal, D.B., et al., 2005. Characterization of NTPDase (NTPDase 1: ectoapyrase; ectodiphosphohydrolase; CD39; E.C. 3.6.1.5) activity in human lymphocytes. Biochimica et biophysica acta, 1721 (1–3), 9–11.
   PubMed Web of Science ®Google Scholar
• Leibowitz, A.Z., et al., 2014. Red grape berry-cultured cells reduce blood pressure in rats with metabolic-like syndrome. European journal of nutrition, 53 (3), 973–980.
   PubMed Web of Science ®Google Scholar
• Li, L., et al., 2014. Anthocyanin-rich fractions from red raspberries attenuate inflammation in both RAW264. 7 macrophages and a mouse model of colitis. Scientific reports, 4, 6211–6231.
   PubMed Web of Science ®Google Scholar
• Lunkes, G.I., et al., 2004. NTPDase and 50-nucleotidase activities in rats with alloxan- induced diabetes. Diabetes research and clinical practice, 65 (1), 1–6.
   PubMed Web of Science ®Google Scholar
• Lunkes, G.I., et al., 2008. Effect of high glucose levels in human platelet NTPDase and 5’-nucleotidase activities. Diabetes research and clinical practice, 81 (3), 351–357.
   PubMed Web of Science ®Google Scholar
• Martins, C.C., et al., 2016a. Exercise training positively modulates the ectonucleotidase enzymes in lymphocytes of metabolic syndrome patients. International journal of sports medicine, 37, 930–936.
   PubMed Web of Science ®Google Scholar
• Martins, C.C., et al., 2016b. Regular exercise training reverses ectonucleotidase alterations and reduces hyperaggregation of platelets in metabolic syndrome patients. Clinica chimica acta, 454, 66–71.
   PubMed Web of Science ®Google Scholar
• Olefsky, J.M. and Glass, C.K., 2010. Macrophages, inflammation, and insulin resistance. Annual review of physiology, 72 (1), 219–246.
   PubMedGoogle Scholar
• Oliveira, P.S., et al., 2017a. Eugenia uniflora fruit (red type) standardized extract: a potential pharmacological tool to diet-induced metabolic syndrome damage management. Biomedicine & pharmacotherapy, 92, 935–941.
   PubMed Web of Science ®Google Scholar
• Oliveira, P.S., et al., 2017b. Vaccinium virgatum fruit extract as an important adjuvant in biochemical and behavioral alterations observed in animal model of metabolic syndrome. Biomedicine & pharmacotherapy, 88, 939–947.
   PubMed Web of Science ®Google Scholar
• Oliveira, P.S., et al., 2018. Southern Brazilian native fruit shows neurochemical, metabolic and behavioral benefits in an animal model of metabolic syndrome. Metabolic brain disease, 33 (5), 1551–1562.
   PubMed Web of Science ®Google Scholar
• Pilla, C., et al., 1996. ATP diphosphohydrolase activity (apyrase, EC 3.6.1.5) in human blood platelets. Platelets, 7 (4), 225–230.
   PubMed Web of Science ®Google Scholar
• Qin, B. and Anderson, R.A., 2012. An extract of chokeberry attenuates weight gain and modulates insulin, adipogenic and inflammatory signalling pathways in epididymal adipose tissue of rats fed a fructose-rich diet. British journal of nutrition, 108 (4), 581–587.
   PubMed Web of Science ®Google Scholar
• Rodrigues, R.G., et al., 2014. Alterations of ectonucleotidases and acetylcholinesterase activities in lymphocytes of Down syndrome subjects: relation with inflammatory parameters. Clinica chimica acta, 433, 105–110.
   PubMed Web of Science ®Google Scholar
• Santilli, F.N., et al., 2012. Platelet activation in obesity and metabolic syndrome. Obesity reviews, 13 (1), 27–42.
   PubMed Web of Science ®Google Scholar
• Schumacher, N.S.G., et al., 2015. Identification and antioxidant activity of the extracts of Eugenia uniflora leaves. Characterization of the anti-inflammatory properties of aqueous extract on diabetes expression in an experimental model of spontaneous type 1 diabetes (NOD mice). Antioxidants, 4 (4), 662–680.
   Web of Science ®Google Scholar
• Souza, C.G., et al., 2010. Effects of a highly palatable diet on lipid and glucose parameters, nitric oxide, and ectonucleotidases activity. Applied physiology, nutrition, and metabolism, 35 (5), 591–597.
   PubMed Web of Science ®Google Scholar
• Sparks, D.L. and Chatterjee, C., 2012. Purinergic signaling, dyslipidemia and inflammatory disease. Cellular physiology and biochemistry, 30 (6), 1333–13339.
   PubMedGoogle Scholar
• Spohr, L., et al., 2019. Combined actions of blueberry extract and lithium on neurochemical changes observed in an experimental model of mania: exploiting possible synergistic effects. Metabolic brain disease, 34, 605–619.
   PubMed Web of Science ®Google Scholar
• Sridhar, G.R., et al., 2010. Butyrylcholinesterase in metabolic syndrome. Medical hypotheses, 75 (6), 648–651.
   PubMed Web of Science ®Google Scholar
• Unduruti, N., 2011. Vagus nerve stimulation as a strategy to prevent and manage metabolic syndrome. Medical hypotheses, 76, 429–433.
   PubMed Web of Science ®Google Scholar