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Archives of Physiology and Biochemistry
The Journal of Metabolic Diseases
Volume 128, 2022 - Issue 4
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Review Article

PBMCs: a new source of diagnostic and prognostic biomarkers

, , , , &
Pages 1081-1087 | Received 20 Dec 2019, Accepted 31 Mar 2020, Published online: 15 Apr 2020

Refrences

  • Ajit, S.K., 2012. Circulating microRNAs as biomarkers, therapeutic targets, and signaling molecules. Sensors, 12 (3), 3359–3369.
  • Baine, M.J., et al., 2011. Transcriptional profiling of peripheral blood mononuclear cells in pancreatic cancer patients identifies novel genes with potential diagnostic utility. PLoS One, 6 (2), e17014.
  • Bartel, D.P., 2009. MicroRNAs: target recognition and regulatory functions. Cell, 136 (2), 215–233.
  • Bartels, C.L., and Tsongalis, G.J., 2009. MicroRNAs: novel biomarkers for human cancer. Clinical chemistry, 55 (4), 623–631.
  • Barwari, T., Joshi, A., and Mayr, M., 2016. MicroRNAs in cardiovascular disease. Journal of the American college of cardiology, 68 (23), 2577–2584.
  • Bluth, M., et al., 2008. Use of gene expression profiles in cells of peripheral blood to identify new molecular markers of acute pancreatitis. Archives of surgery, 143 (3), 227–233.
  • Bronkhorst, A.J., Ungerer, V., and Holdenrieder, S., 2019. The emerging role of cell-free DNA as a molecular marker for cancer management. Biomolecular detection and quantification, 17, 100087.
  • Burczynski, M.E., et al., 2005. Transcriptional profiles in peripheral blood mononuclear cells prognostic of clinical outcomes in patients with advanced renal cell carcinoma. Clinical cancer research: an official journal of the American association for cancer research, 11 (3), 1181–1189.
  • Chang, Y., et al., 2017. Review of the clinical applications and technological advances of circulating tumor DNA in cancer monitoring. Therapeutics and clinical risk management, 13, 1363–1374.
  • Chen, K.-D., et al., 2011. Gene expression profiling of peripheral blood leukocytes identifies and validates ABCB1 as a novel biomarker for Alzheimer’s disease. Neurobiology of disease, 43 (3), 698–705.
  • Chen, X., et al., 2008. Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell research, 18 (10), 997–1006.
  • Corral-Fernández, N., et al., 2013. Dysregulated miR-155 expression in peripheral blood mononuclear cells from patients with type 2 diabetes. Experimental and clinical endocrinology & diabetes, 121 (06), 347–353.
  • Edwards, C.J., et al., 2007. Molecular profile of peripheral blood mononuclear cells from patients with rheumatoid arthritis. Molecular medicine, 13 (1–2), 40–58.
  • Gavin, D.P., and Sharma, R.P., 2009. Chromatin from peripheral blood mononuclear cells as biomarkers for epigenetic abnormalities in schizophrenia. Cardiovascular psychiatry and neurology, 2009, 1–4.
  • Gilad, S., et al., 2008. Serum microRNAs are promising novel biomarkers. PLoS One, 3 (9), e3148.
  • Gupta, S.K., Bang, C., and Thum, T., 2010. Circulating microRNAs as biomarkers and potential paracrine mediators of cardiovascular disease. Circulation: cardiovascular genetics, 3 (5), 484–488.
  • Han, Y., et al., 2017. LINE-1 methylation in peripheral blood leukocytes and clinical characteristics and prognosis of prostate cancer patients. Oncotarget, 8 (55), 94020.
  • Hartwell, L., et al., 2006. Cancer biomarkers: a systems approach. Nature biotechnology, 24 (8), 905–908.
  • Hayes, J., Peruzzi, P.P., and Lawler, S., 2014. MicroRNAs in cancer: biomarkers, functions and therapy. Trends in molecular medicine, 20 (8), 460–469.
  • Herman, J.G., ed., 1999. Hypermethylation of tumor suppressor genes in cancer. Seminars in cancer biology, 9 (5), 359–367.
  • Hoekstra, M., et al., 2010. The peripheral blood mononuclear cell microRNA signature of coronary artery disease. Biochemical and biophysical research communications, 394 (3), 792–797.
  • Huang, H., et al., 2010. Novel blood biomarkers of pancreatic cancer-associated diabetes mellitus identified by peripheral blood-based gene expression profiles. The American journal of gastroenterology, 105 (7), 1661–1669.
  • Ishizone, S., et al., 2006. Clinical utility of quantitative RT‐PCR targeted to α1, 4‐N‐acetylglucosaminyltransferase mRNA for detection of pancreatic cancer. Cancer science, 97 (2), 119–126.
  • Kaur, S., et al., 2012. Early diagnosis of pancreatic cancer: challenges and new developments. Biomarkers in medicine, 6 (5), 597–612.
  • Kazazian, H.H., and Moran, J.V., 1998. The impact of L1 retrotransposons on the human genome. Nature Genetics, 19 (1), 19–24.
  • Kim, B-H., et al., 2009. CpG island hypermethylation and repetitive DNA hypomethylation in premalignant lesion of extrahepatic cholangiocarcinoma. Virchows Archiv, 455 (4), 343–351.
  • Kitkumthorn, N., et al., 2012. LINE-1 methylation in the peripheral blood mononuclear cells of cancer patients. Clinica chimica acta, 413 (9–10), 869–874.
  • Kongruttanachok, N., et al., 2010. Replication independent DNA double-strand break retention may prevent genomic instability. Molecular cancer, 9 (1), 70.
  • Ludwig, J.A., and Weinstein, J.N., 2005. Biomarkers in cancer staging, prognosis and treatment selection. Nature reviews cancer, 5 (11), 845–856.
  • Ma, J., et al., 2015. Differential miRNA expressions in peripheral blood mononuclear cells for diagnosis of lung cancer. Laboratory investigation, 95 (10), 1197–1206.
  • Ma, Z., et al., 2013. Midkine mRNA level in peripheral blood mononuclear cells is a novel biomarker for primary non-small cell lung cancer: a prospective study. Journal of cancer research and clinical oncology, 139 (4), 557–562.
  • Milagro, F.I., et al., 2013. High-throughput sequencing of microRNAs in peripheral blood mononuclear cells: identification of potential weight loss biomarkers. PLoS one, 8 (1), e54319.
  • Mishra, S., et al., 2015. Circulating miRNAs revealed as surrogate molecular signatures for the early detection of breast cancer. Cancer letters, 369 (1), 67–75.
  • Mosallaei, M., and Simonian, M., 2019. MicroRNAs as novel potential biomarker in gastric cancer: diagnostic and prognostic biomarkers. Acta medica iranica, 10, 25–26.
  • Mosallaei, M., et al., 2018. Single nucleotide polymorphism rs4648298 in miRNAs hsa-miR21 and hsa-miR590 binding site of COX gene is a strong colorectal cancer determinant. Journal of gastrointestinal oncology, 9 (3), 448–457.
  • Nardo, G., et al., 2011. Amyotrophic lateral sclerosis multiprotein biomarkers in peripheral blood mononuclear cells. PLoS one, 6 (10), e25545.
  • Parikh, N.I. and Vasan, R.S., 2007. Assessing the clinical utility of biomarkers in medicine. Biomarkers in medicine, 1, 419–436.
  • Pauley, K.M., et al., 2008. Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients. Arthritis research & therapy, 10 (4), R101.
  • Romaine, S.P., et al., 2015. MicroRNAs in cardiovascular disease: an introduction for clinicians. Heart, 101 (12), 921–928.
  • Salehi, R., et al., 2015. Methylation pattern of ALX4 gene promoter as a potential biomarker for blood-based early detection of colorectal cancer. Advanced biomedical research, 4 (1), 252.
  • Sharma, P., et al., 2005. Early detection of breast cancer based on gene-expression patterns in peripheral blood cells. Breast cancer research, 7 (5), R634.
  • Showe, M.K., et al., 2009. Gene expression profiles in peripheral blood mononuclear cells can distinguish patients with non–small cell lung cancer from patients with nonmalignant lung disease. Cancer research, 69 (24), 9202–9210.
  • Silva, D. C. P. d., et al., 2018. Role of miRNAs on the pathophysiology of cardiovascular diseases. Arquivos Brasileiros de Cardiologia, 111 (5), 738–746.
  • Smiraglia, D.J., and Plass, C., 2002. The study of aberrant methylation in cancer via restriction landmark genomic scanning. Oncogene, 21 (35), 5414–5426.
  • Srivastava, S., 2017. Biomarkers in cancer screening and early detection. New York, NY: John Wiley & Sons.
  • Sun, C.-J., Zhang, L., and Zhang, W.-Y., 2009. Gene expression profiling of maternal blood in early onset severe preeclampsia: identification of novel biomarkers. Journal of perinatal medicine, 37 (6), 609–616.
  • Sun, X-Y., et al., 2015. Aberrant microRNA expression in peripheral plasma and mononuclear cells as specific blood-based biomarkers in schizophrenia patients. Journal of clinical neuroscience, 22 (3), 570–574.
  • Thum, T., Catalucci, D., and Bauersachs, J., 2008. MicroRNAs: novel regulators in cardiac development and disease. Cardiovascular research, 79 (4), 562–570.
  • Thum, T., et al., 2007. MicroRNAs in the human heart. Circulation, 116 (3), 258–267.
  • Tie, Y., et al., 2009. Circulating miRNA and cancer diagnosis. Science in China series C: life sciences, 52 (12), 1117–1122.
  • Twine, N.C., et al., 2003. Disease-associated expression profiles in peripheral blood mononuclear cells from patients with advanced renal cell carcinoma. Cancer research, 63 (18), 6069–6075.
  • Ulivi, P., et al., 2013. Peripheral blood miR-328 expression as a potential biomarker for the early diagnosis of NSCLC. International journal of molecular sciences, 14 (5), 10332–10342.
  • Ultimo, S., et al., 2018. Cardiovascular disease-related miRNAs expression: potential role as biomarkers and effects of training exercise. Oncotarget, 9 (24), 17238.
  • Vahed, S.Z., et al., 2019. Expression pattern of miR-21, miR-25 and PTEN in peripheral blood mononuclear cells of patients with significant or insignificant coronary stenosis. Gene, 698, 170–178.
  • Vatandoost, N., et al., 2015. Dysregulated miR-103 and miR-143 expression in peripheral blood mononuclear cells from induced prediabetes and type 2 diabetes rats. Gene, 572 (1), 95–100.
  • Voellenkle, C., et al., 2010. MicroRNA signatures in peripheral blood mononuclear cells of chronic heart failure patients. Physiological genomics, 42 (3), 420–426.
  • Wagner, P.D., Verma, M., and Srivastava, S., 2004. Challenges for biomarkers in cancer detection. Annals of the New York academy of sciences, 1022 (1), 9–16.
  • Whitney, A.R., et al., 2003. Individuality and variation in gene expression patterns in human blood. Proceedings of the national academy of sciences, 100 (4), 1896–1901.
  • Winger, E.E., Reed, J.L., and Ji, X., 2014. First trimester PBMC microRNA predicts adverse pregnancy outcome. American journal of reproductive immunology, 72 (5), 515–526.
  • Xu, J., et al., 2012. Circulating microRNAs: novel biomarkers for cardiovascular diseases. Journal of molecular medicine, 90 (8), 865–875.
  • Xu, S., et al., 2015. Downregulation of miR-129 in peripheral blood mononuclear cells is a diagnostic and prognostic biomarker in prostate cancer. International journal of clinical and experimental pathology, 8 (11), 14335.
  • Yang, B., et al., 2016. MicroRNA-21 in peripheral blood mononuclear cells as a novel biomarker in the diagnosis and prognosis of prostate cancer. Cancer biomarkers, 17 (2), 223–230.
  • Yang, Y.-L., et al., 2015. Prognostic value of microRNA-10b overexpression in peripheral blood mononuclear cells of nonsmall-cell lung cancer patients. Tumor biology, 36 (9), 7069–7075.
  • Zeng, X-l., et al., 2013. Altered miR-143 and miR-150 expressions in peripheral blood mononuclear cells for diagnosis of non-small cell lung cancer. Chinese medical journal, 126 (23), 4510–4516.
  • Zhuang, Z.-G., et al., 2017. The circular RNA of peripheral blood mononuclear cells: Hsa_circ_0005836 as a new diagnostic biomarker and therapeutic target of active pulmonary tuberculosis. Molecular immunology, 90, 264–272.

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