Moringa oleifera Lam. leaf extracts reverse metabolic syndrome in Sprague Dawley rats fed high-fructose high fat diet for 60-days

References

• Angelova, P., and Boyadjiev, N., 2013. A review on the models of obesity and metabolic syndrome in rats. Theological journals search, 1, 5–12.
   Google Scholar
• Chinedu, A.A., Alani, S.O., and Olaide, A.O., 2015. Effect of the ethanolic leaf extract of Moringa oleifera on insulin resistance in streptozotocin induced diabetic rats. Joural of plant sciences, 2, 5–12.
   Google Scholar
• Daba, M.H., El-masry, A., and El-Karef, A., 2016. Effect of Moringa oleifera with and without metformin on an experimental model of metabolic syndrome in rats. British journal of medicine and medical research, 16 (2), 1–1632.
   Google Scholar
• DeFronzo, R.A., 1992. Insulin resistance, hyperinsulinemia, coronary artery disease: a complex metabolic web. Coronary artery disease, 3 (1), 11–116.
   Web of Science ®Google Scholar
• Fasshauer, M., et al., 2004. Growth hormone is a positive regulator of adiponectin receptor 2 in 3T3‐L1 adipocytes. FEBS letters, 558 (1–3), 27–32.
   PubMed Web of Science ®Google Scholar
• Ford, E.S., 2005. Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: a summary of the evidence. Diabetes care, 28 (7), 1769–1778.
   PubMed Web of Science ®Google Scholar
• Ghasi, S., Nwobodo, E., and Ofili, J.O., 2000. Hypocholesterolemic effects of crude extracts of leaf of Moringa oleifera Lam in high-fat diet fed wistar rats. Journal of ethnopharmacology., 69 (1), 21–25.
   PubMed Web of Science ®Google Scholar
• Glagov, S., et al., 1987. Compensatory enlargement of human atherosclerotic coronary arteries. New England journal of medicine, 316 (22), 1371–1375.
   PubMed Web of Science ®Google Scholar
• Grundy, S.M., et al., 2004. Definition of metabolic syndrome report of the National Heart, Lung, and Blood Institute/American Heart Association Conference on scientific issues related to definition. Circulation, 109 (3), 433–438.
   PubMed Web of Science ®Google Scholar
• Guide for the Care and Use of Laboratory Animals. 2011. Committee for the update of the Guide for the Care and Use of Laboratory Animals. 8th ed. Washington, (DC), US: The National Academies Press. Available from: https://grants.nih.gov/grants/olaw/Guidefor–the-care-and-use-of-laboratory-animals.pdf.
   Google Scholar
• Irfan, H.M., et al., 2016. Effect of ethanolic extract of Moringa oleifera Lam. leaves on body weight and hyperglycemia of diabetic rats. Pakistan journal of nutrition, 15 (2), 112–117.
   Google Scholar
• Johnson, R.J., et al., 2013. Sugar, uric acid, and the etiology of diabetes and obesity. Diabetes, 62 (10), 3307–3315.
   PubMed Web of Science ®Google Scholar
• Johnston, T.P., and Palmer, W.K., 1993. Mechanism of poloxamer 407-induced hypertriglyceridemia in the rat. Biochemical Pharmacology., 46 (6), 1037–1042.
   PubMed Web of Science ®Google Scholar
• Kho, M.C., et al., 2016. Fermented Red Ginseng potentiates improvement of metabolic dysfunction in metabolic syndrome rat models. Nutrients, 8 (6), 369.
   Web of Science ®Google Scholar
• Klein, A.V., and Kiat, H., 2015. The mechanisms underlying fructose-induced hypertension: a review. Journal of Hypertension, 33 (5), 912–920.
   PubMed Web of Science ®Google Scholar
• Kovacs, P., and Stumvoll, M., 2005. Fatty acids and insulin resistance in muscle and liver. Best practice and research clinical endocrinology and metabolism, 19 (4), 625–635.
   PubMed Web of Science ®Google Scholar
• López, M., et al., 2018. Effects of Moringa oleifera leaf powder on metabolic syndrome induced in male Wistar rats: a preliminary study. Journal of international medical research, 46 (8), 3327–3336.
   PubMed Web of Science ®Google Scholar
• Mamikutty, N., et al., 2014. The establishment of metabolic syndrome model by induction of fructose drinking water in male Wistar rats. Biomed research international, 2014, 1–8.
   Web of Science ®Google Scholar
• Martínez-González, C.L., et al., 2017. Moringa oleifera, a species with potential analgesic and anti-inflammatory activities. Biomedicine and Pharmacotherapy, 87, 482–488.
   PubMed Web of Science ®Google Scholar
• Mendizábal, Y., Llorens, S., and Nava, E., 2013. Hypertension in metabolic syndrome: vascular pathophysiology. International journal of hypertension, 2013, 1–15.
   Google Scholar
• Muhammad, N., et al., 2019. Moringa oleifera Lam. prevents the development of high fructose diet-induced fatty liver. South African journal of botany. doi:10.1016/J.sajb.2018.12.003
   Web of Science ®Google Scholar
• Omodanisi, E.I., Aboua, G.Y., and Oguntibeju, O.O., 2017. Therapeutic potentials and pharmacological properties of Moringa oleifera Lam in the treatment of diabetes mellitus and related complications. Tropical journal of pharmaceutical research, 16 (7), 1737–1746.
   Web of Science ®Google Scholar
• Othman, A.I., et al., 2019. Moringa oleifera leaf extract ameliorated high-fat diet-induced obesity, oxidative stress and disrupted metabolic hormones. Clinical phytoscience, 5 (1), 48.
   Google Scholar
• Palanisamy, N., and Venkataraman, A.C., 2013. Beneficial effect of genistein on lowering blood pressure and kidney toxicity in fructose-fed hypertensive rats. British journal of nutrition, 109 (10), 1806–1812.
   PubMed Web of Science ®Google Scholar
• Panchal, S.K., and Brown, L., 2011. Rodent models for metabolic syndrome research. Journal of biomedicine and biotechnology, 2011, 1–14.
   Google Scholar
• Sayin, F.K., et al., 2016. Effects of Silybum marianum extract on high-fat diet induced metabolic disorders in rats. Polish journal of food and nutrition sciences, 66 (1), 43–50.
   Web of Science ®Google Scholar
• Shapiro, A., et al., 2008. Fructose-induced leptin resistance exacerbates weight gain in response to subsequent high-fat feeding. American journal of physiology-regulatory, integrative and comparative physiology, 295 (5), R1370–R1375.
   PubMed Web of Science ®Google Scholar
• Soumyanath, A., 2005. Traditional medicines for modern times: anti-diabetic plants. 1st ed. Boca Raton, FL: Taylor and Francis Group, 45.
   Google Scholar
• Stevens, G.C., Baiyeri, K.P., and Akinnnagbe, O., 2013. Ethno-medicinal and culinary uses of Moringa oleifera Lam. in Nigeria. Journal of medicinal plants research, 7, 799–804.
   Google Scholar
• Subramanian, R., Asmawi, M.Z., and Sadikun, A., 2008. In vitro alpha-glucosidase and alpha-amylase enzyme inhibitory effects of Andrographis paniculata extract and andrographolide. Acta biochimica polonica, 55 (2), 391–398.
   PubMed Web of Science ®Google Scholar
• Sutherland, J.P., McKinley, B., and Eckel, R.H., 2004. The metabolic syndrome and inflammation. Metabolic syndrome and related disorders, 2 (2), 82–104.
   PubMed Web of Science ®Google Scholar
• Tappy, L., and Lê, K.A., 2010. Metabolic effects of fructose and the worldwide increase in obesity. Physiological reviews, 90 (1), 23–46.
   PubMed Web of Science ®Google Scholar
• Vargas-Sánchez, K., Garay-Jaramillo, E., and González-Reyes, R.E., 2019. Effects of Moringa oleifera on glycaemia and insulin levels: a review of animal and human studies. Nutrients, 11 (12), 2907.
   Web of Science ®Google Scholar
• Yadav, A., et al., 2013. Role of leptin and adiponectin in insulin resistance. Clinica chimica acta, 417, 80–84.
   PubMed Web of Science ®Google Scholar