Publication Cover
Archives of Physiology and Biochemistry
The Journal of Metabolic Diseases
Volume 128, 2022 - Issue 5
431
Views
7
CrossRef citations to date
0
Altmetric
Original Articles

Screening inhibitory effects of selected flavonoids on human recombinant aldose reductase enzyme: in vitro and in silico study

, , &
Pages 1368-1374 | Received 27 Jan 2020, Accepted 14 May 2020, Published online: 28 May 2020

References

  • Adem, S., et al., 2014. Investigation of the effects of some phenolic compounds on the activities of glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase from human erythrocytes. Journal of biochemical and molecular toxicology, 28 (11), 510–514.
  • Akileshwari, C., et al., 2012. Inhibition of aldose reductase by Gentiana lutea extracts. Experimental diabetes research, 2012, 147965.
  • Akileshwari, C., et al., 2014. Bioflavonoid ellagic acid inhibits aldose reductase: Implications for prevention of diabetic complications. Journal of functional foods, 6, 374–383.
  • Alim, Z., et al., 2017. Inhibition behaviours of some phenolic acids on rat kidney aldose reductase enzyme: an in vitro study. Journal of enzyme inhibition and medicinal chemistry, 32 (1), 277–284.
  • Androutsopoulos, V.P., et al., 2010. Dietary flavonoids in cancer therapy and prevention: substrates and inhibitors of cytochrome P450 CYP1 enzymes. Pharmacology & therapeutics, 126 (1), 9–20.
  • Aslan, E. and Adem, S., 2015. Investigation of the effects of some drugs and phenolic compounds on human dihydrofolate reductase activity. Journal of biochemical and molecular toxicology, 29 (3), 135–139.
  • Aslan, E., Guler, C., and Adem, S., 2016. In vitro effects of some flavonoids and phenolic acids on human pyruvate kinase isoenzyme M2. Journal of enzyme inhibition and medicinal chemistry, 31 (2), 314–317.
  • Balasuriya, B.N. and Rupasinghe, H.V., 2011. Plant flavonoids as angiotensin converting enzyme inhibitors in regulation of hypertension. Functional foods in health and disease, 1, 172–188.
  • Brownlee, M., 1992. Glycation products and the pathogenesis of diabetic complications. Diabetes care, 15 (12), 1835–1843.
  • Chalk, C., Benstead, T.J., and Moore, F., 2007. Aldose reductase inhibitors for the treatment of diabetic polyneuropathy. Cochrane database of systematic reviews, (4), CD004572.
  • Chethan, S., Dharmesh, S.M., and Malleshi, N.G., 2008. Inhibition of aldose reductase7 from cataracted eye lenses by finger millet (Eleusine coracana) polyphenols. Bioorganic & medicinal chemistry, 16 (23), 10085–10090.
  • Cunha-Vaz, J.G., et al., 1986. Effect of sorbinil on blood-retinal barrier in early diabetic retinopathy. Diabetes, 35 (5), 574–578.
  • Demir, Y., et al., 2017. Phenolic compounds inhibit the aldose reductase enzyme from the sheep kidney. Journal of biochemical and molecular toxicology, 31 (9), e21936.
  • Demir, Y., et al., 2019a. Antidiabetic properties of dietary phenolic compounds: inhibition effects on α-amylase, aldose reductase, and α-glycosidase. Biotechnology and applied biochemistry, 66 (5), 781–786.
  • Demir, Y., et al., 2019b. Inhibition effects of quinones on aldose reductase: antidiabetic properties. Environmental toxicology and pharmacology, 70, 103195.
  • Dunlop, M., 2000. Aldose reductase and the role of the polyol pathway in diabetic nephropathy. Kidney international, 58, S3–S12.
  • Elliott, A.J., et al., 1992. Inhibition of glutathione reductase by flavonoids: a structure-activity study. Biochemical pharmacology, 44 (8), 1603–1608.
  • Hamada, Y., et al., 1996. Role of polyol pathway in nonenzymatic glycation. Nephrology dialysis transplantation, 11 (supp5), 95–98.
  • Harding, J., 1991. Cataract. Biochemistry epidemiology and pharmacology. 1st ed. London: Chapman & Hall.
  • Israël, M. and Schwartz, L., 2011. On the metabolic origin of cancer: substances that target tumor metabolism. Biomedical research, 22, 132–166.
  • Jeong, H.-J., et al., 1999. Inhibition of aromatase activity by flavonoids. Archives of pharmacal research, 22 (3), 309–312.
  • Jung, H.A., et al., 2011. Extraction and identification of three major aldose reductase inhibitors from Artemisia montana. Food and Chemical Toxicology : An International Journal Published for the British Industrial Biological Research Association, 49 (2), 376–384.
  • Kador, P.F., Kinoshita, J.H., and Sharpless, N.E., 1985. Aldose reductase inhibitors: a potential new class of agents for the pharmacological control of certain diabetic complications. Journal of medicinal chemistry, 28 (7), 841–849.
  • Kinoshita, T., et al., 2002. The structure of human recombinant aldose reductase complexed with the potent inhibitor zenarestat. Acta crystallographica. Section D, biological crystallography, 58 (Pt 4), 622–626.
  • Kinoshita, J.H. and Nishimura, C., 1988. The involvement of aldose reductase in diabetic complications. Diabetes/metabolism reviews, 4 (4), 323–337.
  • Kumar, S. and Pandey, A.K., 2013. Chemistry and biological activities of flavonoids: an overview. The scientific world journal, 2013, 1–16.
  • Lee, J., et al., 2017. Determination of flavonoids from Perilla frutescens var. japonica seeds and their inhibitory effect on aldose reductase. Applied biological chemistry, 60 (2), 155–162.
  • Mathebula, S.D., 2015. Polyol pathway: a possible mechanism of diabetes complications in the eye. African vision and eye health, 74 (1), 5.
  • Michael, R. and Bron, A., 2011. The ageing lens and cataract: a model of normal and pathological ageing. Philosophical transactions of the Royal Society B: biological sciences, 366 (1568), 1278–1292.
  • Molegro, A., 2019. MVD 7.0 Molegro Virtual Docker. Aarhus C, Denmark.
  • Muthenna, P., Akileshwari, C., and Reddy, G.B., 2012. Ellagic acid, a new antiglycating agent: its inhibition of Nϵ-(carboxymethyl)lysine. The biochemical journal, 442 (1), 221–230.
  • Oguntibeju, O., 2013. Diabetes mellitus: insights and perspectives. InTech.
  • Ottanà, R., et al., 2011. Identification of 5-arylidene-4-thiazolidinone derivatives endowed with dual activity as aldose reductase inhibitors and antioxidant agents for the treatment of diabetic complications. European journal of medicinal chemistry, 46 (7), 2797–2806.
  • Özaslan, M.S., et al., 2019. Inhibition effects of some antidepressant drugs on pentose phosphate pathway enzymes. Environmental toxicology and pharmacology, 72, 103244.
  • Patel, D., et al., 2012. Pharmacologically tested aldose reductase inhibitors isolated from plant sources – a concise report. Chinese journal of natural medicines, 10 (5), 388–400.
  • Patil, K.K. and Gacche, R.N., 2017. Inhibition of glycation and aldose reductase activity using dietary flavonoids: a lens organ culture studies. International journal of biological macromolecules, 98, 730–738.
  • Ramirez, M.A. and Borja, N.L., 2008. Epalrestat: an aldose reductase inhibitor for the treatment of diabetic neuropathy. Pharmacotherapy, 28 (5), 646–655.
  • Rao, A.R., Veeresham, C., and Asres, K., 2013. In vitro and in vivo inhibitory activities of four Indian medicinal plant extracts and their major components on rat aldose reductase and generation of advanced glycation endproducts. Phytotherapy research : PTR, 27 (5), 753–760.
  • Rawel, H.M., Meidtner, K., and Kroll, J., 2005. Binding of selected phenolic compounds to proteins. Journal of agricultural and food chemistry, 53 (10), 4228–4235.
  • Singh Grewal, A., et al., 2016. Updates on aldose reductase inhibitors for management of diabetic complications and non-diabetic diseases. Mini reviews in medicinal chemistry, 16 (2), 120–162.
  • Srivastava, S.K., Ramana, K.V., and Bhatnagar, A., 2005. Role of aldose reductase and oxidative damage in diabetes and the consequent potential for therapeutic options. Endocrine reviews, 26 (3), 380–392.
  • Tadera, K., et al., 2006. Inhibition of alpha-glucosidase and alpha-amylase by flavonoids. Journal of nutritional science and vitaminology, 52 (2), 149–153.
  • Türkeş, C., Demir, Y., and Beydemir, Ş., 2019. Anti-diabetic properties of calcium channel blockers: inhibition effects on aldose reductase enzyme activity. Applied biochemistry and biotechnology, 189 (1), 318–329.
  • Varma, S., Mikuni, I., and Kinoshita, J., 1975. Flavonoids as inhibitors of lens aldose reductase. Science (New York, N.Y.), 188 (4194), 1215–1216.
  • Veeresham, C., et al., 2013. In vitro and in vivo aldose reductase inhibitory activity of standardized extracts and the major constituent of Andrographis paniculata. Phytotherapy research : PTR, 27 (3), 412–416.
  • Wang, Q.-Q., et al., 2013. Synthesis of organic nitrates of luteolin as a novel class of potent aldose reductase inhibitors. Bioorganic & medicinal chemistry, 21 (14), 4301–4310.
  • Whiting, D.R., et al., 2011. IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes research and clinical practice, 94 (3), 311–321.
  • Xiao, J., et al., 2015. Advance in dietary polyphenols as aldose reductases inhibitors: structure-activity relationship aspect. Critical reviews in food science and nutrition, 55 (1), 16–31.
  • Yabe-Nishimura, C., 1998. Aldose reductase in glucose toxicity: a potential target for the prevention of diabetic complications. Pharmacological reviews, 50 (1), 21–34.
  • Yki‐Järvinen, H., 1998. Toxicity of hyperglycaemia in type 2 diabetes. Diabetes/metabolism reviews, 14 (S1), S45–S50.
  • Ziegler, D., 2004. Polyneuropathy in the diabetic patient-update on pathogenesis and management. Nephrology, Dialysis, Transplantation: official Publication of the European Dialysis and Transplant Association – European Renal Association, 19 (9), 2170–2175.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.