Does the rs9939609 FTO gene polymorphism affect fat percentage? A meta-analysis

References

• Abarca-Gömez, L., et al., 2017. Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults. The lancet, 390 (10113), 2627–2642.
   PubMed Web of Science ®Google Scholar
• Ağagündüz, D., and Gezmen-Karadağ, M., 2019. Association of FTO common variant (rs9939609) with body fat in Turkish individuals. Lipids in health and disease, 18 (1), 212.
   PubMed Web of Science ®Google Scholar
• Church, C., et al., 2010. Overexpression of Fto leads to increased food intake and results in obesity. Nature genetics, 42 (12), 1086–1092.
   PubMed Web of Science ®Google Scholar
• Claussnitzer, M., et al., 2015. FTO obesity variant circuitry and adipocyte browning in humans. The New England journal of medicine, 373 (10), 895–907.
   PubMed Web of Science ®Google Scholar
• Dina, C., et al., 2007. Variation in FTO contributes to childhood obesity and severe adult obesity. Nature genetics, 39 (6), 724–726.
   PubMed Web of Science ®Google Scholar
• Fall, T., and Ingelsson, E., 2014. Genome-wide association studies of obesity and metabolic syndrome. Molecular and cellular endocrinology, 382 (1), 740–757.
   PubMed Web of Science ®Google Scholar
• Fredriksson, R., et al., 2008. The obesity gene, FTO, is of ancient origin, up-regulated during food deprivation and expressed in neurons of feeding-related nuclei of the brain. Endocrinology, 149 (5), 2062–2071.
   PubMed Web of Science ®Google Scholar
• Fruhbeck, G., et al., 2001. The adipocyte: a model for integration of endocrine and metabolic signaling in energy metabolism regulation. American journal of physiology. Endocrinology and metabolism, 280 (6), E827–E847.
   PubMed Web of Science ®Google Scholar
• Gholamalizadeh, M., et al., 2018. Influence of fat mass-and obesity-associated genotype, body mass index, and dietary intake on effects of iroquois-related homeobox 3 gene on body weight. Chinese medical journal (England), 131 (17), 2113–2112.
   Google Scholar
• Grunnet, L.G., et al., 2009. Regulation and function of FTO mRNA expression in human skeletal muscle and subcutaneous adipose tissue. Diabetes, 58 (10), 2402–2408.
   PubMed Web of Science ®Google Scholar
• Gulati, P., and Yeo, G.S., 2013. The biology of FTO: from nucleic acid demethylase to amino acid sensor. Diabetologia, 56 (10), 2113–2121.
   PubMed Web of Science ®Google Scholar
• Haslam, D.W., and James, W.P., 2005. Obesity. The lancet), 366 (9492), 1197–1209.
   PubMed Web of Science ®Google Scholar
• Kowalska, I., et al., 2012. Impact of the FTO gene variation on fat oxidation and its potential influence on body weight in women with polycystic ovary syndrome. Clinical endocrinology, 77 (1), 120–125.
   PubMed Web of Science ®Google Scholar
• Kowalska, I., et al., 2009. The FTO gene modifies weight, fat mass and insulin sensitivity in women with polycystic ovary syndrome, where its role may be larger than in other phenotypes. Diabetes & metabolism, 35 (4), 328–331.
   PubMed Web of Science ®Google Scholar
• Livingstone, K.M., et al., 2015. Associations between FTO genotype and total energy and macronutrient intake in adults: a systematic review and meta-analysis. Obesity reviews: an official journal of the international association for the study of obesity, 16 (8), 666–678.
   PubMed Web of Science ®Google Scholar
• Moher, D., Liberati, A., Tetzlaff, J., and Altman, D., 2009. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS medicine, 6 (7), e1000097.
   PubMed Web of Science ®Google Scholar
• Mook-Kanamori, D.O., et al., 2011. No association of obesity gene FTO with body composition at the age of 6 months. The generation R study. Journal of endocrinological investigation, 34 (1), 16–20.
   PubMed Web of Science ®Google Scholar
• Moraes, G.G., et al., 2016. Genotypic carriers of the obesity-associated FTO polymorphism exhibit different cardiometabolic profiles after an intervention. Anais da academia Brasileira de ciencias, 88 (4), 2331–2339.
   PubMed Web of Science ®Google Scholar
• Rutters, F., et al., 2011. Associations between a single nucleotide polymorphism of the FTO gene (rs9939609) and obesity-related characteristics over time during puberty in a Dutch children cohort. The journal of clinical endocrinology & metabolism, 96 (6), E939–E942.
   PubMed Web of Science ®Google Scholar
• Scuteri, A., et al., 2007. Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS genetics, 3 (7), e115.
   PubMed Web of Science ®Google Scholar
• Speakman, J.R., Rance, K.A., and Johnstone, A.M., 2008. Polymorphisms of the FTO gene are associated with variation in energy intake, but not energy expenditure. Obesity (Silver Spring, Md.), 16 (8), 1961–1965.
   PubMed Web of Science ®Google Scholar
• Timpson, N.J., et al., 2008. The fat mass–and obesity-associated locus and dietary intake in children. The American journal of clinical nutrition, 88 (4), 971–978.
   PubMed Web of Science ®Google Scholar
• Zhao, N.N., et al., 2019. FTO gene polymorphisms and obesity risk in Chinese population: a meta-analysis. World journal of pediatrics, 15 (4), 382–389.
   PubMed Web of Science ®Google Scholar
• Zou, Y., et al., 2017. IRX3 promotes the browning of white adipocytes and its rare variants are associated with human obesity risk. EBioMedicine, 24, 64–75.
   PubMed Web of Science ®Google Scholar