Aberrant methylation of miR-124 upregulates DNMT3B in colorectal cancer to accelerate invasion and migration

References

• Alipoor, B., et al., 2016. Association of miR-146a rs2910164 and miR-149 rs2292832 variants with susceptibility to type 2 diabetes. Clinical laboratory, 62 (8), 1553–1561.
   PubMed Web of Science ®Google Scholar
• Alwan, A., 2011. Global status report on noncommunicable diseases 2010. World Health Organization.
   Google Scholar
• Cai, Q.Q., et al., 2017. MiR-124 inhibits the migration and invasion of human hepatocellular carcinoma cells by suppressing integrin αV expression. Scientific reports, 7, 40733.
   PubMed Web of Science ®Google Scholar
• Chen, Z., et al., 2015. miR-124 and miR-506 inhibit colorectal cancer progression by targeting DNMT3B and DNMT1. Oncotarget, 6 (35), 38139–38150.
   PubMedGoogle Scholar
• Cheng, Y., et al., 2015. STAT3 is involved in miR-124-mediated suppressive effects on esophageal cancer cells. BMC cancer, 15 (1), 306.
   PubMedGoogle Scholar
• Chim, C., et al., 2001. Methylation of p15 and p16 genes in acute promyelocytic leukemia: potential diagnostic and prognostic significance. Journal of clinical oncology: official journal of the American Society of Clinical Oncology, 19 (7), 2033–2040.
   PubMed Web of Science ®Google Scholar
• Chim, C.-S., et al., 2004. SOCS1 and SHP1 hypermethylation in multiple myeloma: implications for epigenetic activation of the Jak/STAT pathway. Blood, 103 (12), 4630–4635.
   PubMed Web of Science ®Google Scholar
• Dill, H., et al., 2012. Intronic miR-26b controls neuronal differentiation by repressing its host transcript, ctdsp2. Genes & development, 26 (1), 25–30.
   PubMed Web of Science ®Google Scholar
• Dong, L-l., et al., 2015. Decreased expression of microRNA-124 is an independent unfavorable prognostic factor for patients with breast cancer. Diagnostic pathology, 10 (1), 45.
   PubMedGoogle Scholar
• Favoriti, P., et al., 2016. Worldwide burden of colorectal cancer: a review. Updates in surgery, 68 (1), 7–11.
   PubMed Web of Science ®Google Scholar
• Frank, D., et al., 2012. MicroRNA-20a inhibits stress-induced cardiomyocyte apoptosis involving its novel target Egln3/PHD3. Journal of molecular and cellular cardiology, 52 (3), 711–717.
   PubMed Web of Science ®Google Scholar
• Furuta, M., et al., 2010. miR-124 and miR-203 are epigenetically silenced tumor-suppressive microRNAs in hepatocellular carcinoma. Carcinogenesis, 31 (5), 766–776.
   PubMed Web of Science ®Google Scholar
• Geiger, T.R. and Peeper, D.S., 2009. Metastasis mechanisms. Biochim biophys acta, 1796 (2), 293–308.
   PubMed Web of Science ®Google Scholar
• Ghorbani, S., et al., 2018. Decreased serum microRNA-21 level is associated with obesity in healthy and type 2 diabetic subjects. Archives of physiology and biochemistry, 124 (4), 300–305.
   PubMed Web of Science ®Google Scholar
• Giordano, S. and Columbano, A., 2013. MicroRNAs: new tools for diagnosis, prognosis, and therapy in hepatocellular carcinoma? Hepatology (Baltimore, Md.), 57 (2), 840–847.
   PubMed Web of Science ®Google Scholar
• Honeywell, R.J., et al., 2018. DNA methyltransferases expression in normal tissues and various human cancer cell lines, xenografts and tumors. Nucleosides nucleotides nucleic acids, 37 (12), 696–708.
   PubMed Web of Science ®Google Scholar
• Jiang, X., et al., 2012. MiR-495 is a tumor-suppressor microRNA down-regulated in MLL-rearranged leukemia. Proceedings of the National Academy of Sciences of the United States of America, 109 (47), 19397–19402.
   PubMed Web of Science ®Google Scholar
• Leskelä, S., et al., 2011. The miR-200 family controls β-tubulin III expression and is associated with paclitaxel-based treatment response and progression-free survival in ovarian cancer patients. Endocrine-related cancer, 18 (1), 85–95.
   PubMed Web of Science ®Google Scholar
• Lin, H., et al., 2006. Suppression of intestinal neoplasia by deletion of Dnmt3b. Molecular and cellular biology, 26 (8), 2976–2983.
   PubMed Web of Science ®Google Scholar
• Liu, K., et al., 2013. MicroRNA-124 regulates the proliferation of colorectal cancer cells by targeting iASPP. Biomed research international, 2013, 867537.
   PubMedGoogle Scholar
• Livak, K.J. and Schmittgen, T.D., 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods (San Diego, Calif.), 25 (4), 402–408.
   PubMed Web of Science ®Google Scholar
• Long, Q.-Z., et al., 2015. miR-124 represses FZD5 to attenuate P-glycoprotein-mediated chemo-resistance in renal cell carcinoma. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 36 (9), 7017–7026.
   PubMedGoogle Scholar
• Lujambio, A., et al., 2007. Genetic unmasking of an epigenetically silenced microRNA in human cancer cells. Cancer research, 67 (4), 1424–1429.
   PubMed Web of Science ®Google Scholar
• Migliore, L., et al., 2011. Genetics, cytogenetics, and epigenetics of colorectal cancer. Journal of biomedicine and biotechnology, 2011, 1–19.
   Google Scholar
• Ponomarev, E.D., Veremeyko, T., and Barteneva, N.S., 2011. Visualization and quantitation of the expression of microRNAs and their target genes in neuroblastoma single cells using imaging cytometry. BMC research notes, 4 (1), 517.
   PubMedGoogle Scholar
• Qin, W., et al., 2014. MicroRNA-124 regulates TGF-α-induced epithelial-mesenchymal transition in human prostate cancer cells. International journal of oncology, 45 (3), 1225–1231.
   PubMed Web of Science ®Google Scholar
• Qin, Z., et al., 2016. miRNA-124 in immune system and immune disorders. Frontiers in immunology, 7, 406.
   PubMed Web of Science ®Google Scholar
• Ralfkiaer, U., et al., 2011. Diagnostic microRNA profiling in cutaneous T-cell lymphoma (CTCL). Blood, 118 (22), 5891–5900.
   PubMed Web of Science ®Google Scholar
• Roll, J.D., et al., 2008. DNMT3b overexpression contributes to a hypermethylator phenotype in human breast cancer cell lines. Molecular cancer, 7 (1), 15.
   PubMedGoogle Scholar
• Roshandel, G., et al., 2019. Cancer incidence in Iran in 2014: results of the Iranian National Population-based Cancer Registry. Cancer epidemiology, 61, 50–58.
   PubMed Web of Science ®Google Scholar
• Schliekelman, M.J., et al., 2011. Targets of the tumor suppressor miR-200 in regulation of the epithelial-mesenchymal transition in cancer. Cancer research, 71 (24), 7670–7682.
   PubMed Web of Science ®Google Scholar
• Siegel, R., Naishadham, D., and Jemal, A., 2013. Cancer statistics, 2013. CA: a cancer journal for clinicians, 63 (1), 11–30.
   PubMed Web of Science ®Google Scholar
• Slabáková, E., et al., 2011. TGF-β1-induced EMT of non-transformed prostate hyperplasia cells is characterized by early induction of SNAI2/Slug. The prostate, 71 (12), 1332–1343.
   PubMed Web of Science ®Google Scholar
• Subramaniam, D., et al., 2014. DNA methyltransferases: a novel target for prevention and therapy. Frontiers in oncology, 4, 80.
   PubMedGoogle Scholar
• Sun, Y., et al., 2014. miR-429 identified by dynamic transcriptome analysis is a new candidate biomarker for colorectal cancer prognosis. Omics : a journal of integrative biology, 18 (1), 54–64.
   PubMed Web of Science ®Google Scholar
• Sun, Y., et al., 2015. NF-κB-mediated miR-124 suppresses metastasis of non-small-cell lung cancer by targeting MYO10. Oncotarget, 6 (10), 8244–8254.
   PubMedGoogle Scholar
• Tang, H., et al., 2012. LRRC4 inhibits glioma cell growth and invasion through a miR-185-dependent pathway. Current cancer drug targets, 12 (8), 1032–1042.
   PubMed Web of Science ®Google Scholar
• Tang, H., et al., 2013. miR-200b and miR-200c as prognostic factors and mediators of gastric cancer cell progression. Clinical cancer research : an official journal of the American Association for Cancer Research, 19 (20), 5602–5612.
   PubMed Web of Science ®Google Scholar
• Tang, H., et al., 2014. miR-185 suppresses tumor proliferation by directly targeting E2F6 and DNMT1 and indirectly upregulating BRCA1 in triple-negative breast cancer. Molecular cancer therapeutics, 13 (12), 3185–3197.
   PubMed Web of Science ®Google Scholar
• Taniguchi, K., et al., 2015. MicroRNA-124 inhibits cancer cell growth through PTB1/PKM1/PKM2 feedback cascade in colorectal cancer. Cancer letters, 363 (1), 17–27.
   PubMed Web of Science ®Google Scholar
• Thiery, J.P., et al., 2009. Epithelial-mesenchymal transitions in development and disease. Cell, 139 (5), 871–890.
   PubMed Web of Science ®Google Scholar
• Ueda, Y., et al., 2014. DNA methylation of microRNA-124a is a potential risk marker of colitis-associated cancer in patients with ulcerative colitis. Digestive diseases and sciences, 59 (10), 2444–2451.
   PubMed Web of Science ®Google Scholar
• Wang, M.-J., et al., 2013. Downregulation of microRNA-124 is an independent prognostic factor in patients with colorectal cancer. International journal of colorectal disease, 28 (2), 183–189.
   PubMed Web of Science ®Google Scholar
• Wang, P., et al., 2014. Methylation-mediated silencing of the miR-124 genes facilitates pancreatic cancer progression and metastasis by targeting Rac1. Oncogene, 33 (4), 514–524.
   PubMed Web of Science ®Google Scholar
• Wilting, S.M., et al., 2010. Methylation-mediated silencing and tumour suppressive function of hsa-miR-124 in cervical cancer. Molecular cancer, 9 (1), 167.
   PubMedGoogle Scholar
• Winawer, S.J. and Zauber, A.G., 2002. The advanced adenoma as the primary target of screening. Gastrointestinal endoscopy clinics of North America, 12 (1), 1–9.
   PubMedGoogle Scholar
• Zhang, J., et al., 2013. MiR-124 suppresses growth of human colorectal cancer by inhibiting STAT3. Plos one, 8 (8), e70300.
   PubMed Web of Science ®Google Scholar
• Zheng, Q., et al., 2017. Prognostic role of microRNAs in human gastrointestinal cancer: a systematic review and meta-analysis. Oncotarget, 8 (28), 46611–46623.
   PubMedGoogle Scholar
• Zhou, L., et al., 2016. MicroRNA-124 (MiR-124) inhibits cell proliferation, metastasis and invasion in colorectal cancer by downregulating Rho-associated protein kinase 1 (ROCK1). Cellular physiology and biochemistry, 38 (5), 1785–1795.
   PubMedGoogle Scholar