Association study of common functional genetic polymorphisms in SLC6A4 (5-HTT) and MAOA genes with obesity in portuguese children

References

• Bonnet, G., et al., 2017. Serotonin-transporter promoter polymorphism modulates the ability to control food intake: Effect on total weight loss. Molecular Nutrition & Food Research., 61 (11). doi:10.1002/mnfr.201700494
   Web of Science ®Google Scholar
• Borkowska, A., et al., 2015. Effect of the 5-HTTLPR polymorphism on affective temperament, depression and body mass index in obesity. Journal of Affective Disorders, 184, 193–197.
   PubMed Web of Science ®Google Scholar
• Denney, R.M., Koch, H., and Craig, I.W., 1999. Association between monoamine oxidase A activity in human male skin fibroblasts and genotype ofthe MAOA promoter-associated variable number tandem repeat. Human Genetics, 105 (6), 542–551.
   PubMed Web of Science ®Google Scholar
• Dias, H., et al., 2016. Association of polymorphisms in 5-HTT (SLC6A4) and MAOA genes with measures of obesity in young adults of Portuguese origin. Archives of Physiology and Biochemistry, 122 (1), 8–13.
   PubMed Web of Science ®Google Scholar
• Drabe, M., et al., 2017. Serotonin transporter gene promoter methylation status correlates with in vivo prefrontal 5-HTT availability and reward function in human obesity. Translational Psychiatry, 7 (7), e1167–e1167.
   PubMedGoogle Scholar
• Ducci, F., et al., 2006. A functional polymorphism in the MAOA gene promoter (MAOA-LPR) predicts central dopamine function and body mass index. Molecular Psychiatry, 11 (9), 858–866.
   PubMed Web of Science ®Google Scholar
• Excoffier, L., and Lischer, H.E., 2010. Arlequin suite ver 3.5: A new series of programs to perform population genetics analyses under Linux and Windows. Molecular Ecology Resources, 10 (3), 564–567.
   PubMed Web of Science ®Google Scholar
• Fuemmeler, B.F., et al., 2008. Genes Implicated in Serotonergic and Dopaminergic Functioning Predict BMI Categories. Obesity (Silver Spring, Md.), 16 (2), 348–355.
   PubMed Web of Science ®Google Scholar
• Galvão, A., et al., 2012. Association of MAOA and COMT gene polymorphisms with palatable food intake in children. The Journal of Nutritional Biochemistry, 23 (3), 272–277.
   PubMed Web of Science ®Google Scholar
• Hainer, V., et al., 2006. Serotonin and norepinephrine reuptake inhibition and eating behavior. Annals of the New York Academy of Sciences, 1083, 252–269.
   PubMed Web of Science ®Google Scholar
• Halford, J.C., et al., 2007. Serotonergic drugs: effects on appetite expression and use for the treatment of obesity. Drugs, 67 (1), 27–55.
   PubMed Web of Science ®Google Scholar
• Hameed, A., et al., 2015. Genetic association analysis of serotonin transporter polymorphism (5-HTTLPR) with type 2 diabetes patients of Pakistani population. Diabetes Research and Clinical Practice, 108 (1), 67–71.
   PubMed Web of Science ®Google Scholar
• Heils, A., et al., 1996. Allelic variation of human serotonin transporter gene expression. Journal of Neurochemistry, 66 (6), 2621–2624.
   PubMed Web of Science ®Google Scholar
• Heisler, L.K., et al., 2006. Serotonin reciprocally regulates melanocortin neurons to modulate food intake. Neuron, 51 (2), 239–249.
   PubMed Web of Science ®Google Scholar
• Hill, J.O., Wyatt, H.R., and Peters, J.C., 2013. The Importance of Energy Balance. European Endocrinology, 9 (2), 111–115.
   PubMedGoogle Scholar
• Klein Gunnewiek, T.M., Homberg, J.R., and Kozicz, T., 2018. Modulation of glucocorticoids by the serotonin transporter polymorphism: A narrative review. Neuroscience and Biobehavioral Reviews, 92, 338–349.
   PubMed Web of Science ®Google Scholar
• Lan, M.Y., et al., 2009. Serotonin transporter gene promoter polymorphism is associated with body mass index and obesity in nonelderly stroke patients. Journal of Endocrinological Investigation, 32 (2), 119–122.
   PubMed Web of Science ®Google Scholar
• Lesch, K.-P., et al., 1994. Organization of the human serotonin transporter gene. Journal of Neural Transmission. General Section, 95 (2), 157–162.
   PubMed Web of Science ®Google Scholar
• MacKenzie, A., and Quinn, J., 1999. A serotonin transporter gene intron 2 polymorphic region, correlated with affective disorders, has allele-dependent differential enhancer-like properties in the mouse embryo. Proceedings of the National Academy of Sciences of the United States of America, 96 (26), 15251–15255.
   PubMed Web of Science ®Google Scholar
• Manco, L., et al., 2019. Physical activity and the association between the FTO rs9939609 polymorphism and obesity in Portuguese children aged 3 to 11 years. American Journal of Human Biology : The Official Journal of the Human Biology Council, 31 (6), e23312.
   PubMed Web of Science ®Google Scholar
• Markus, C.R., and Capello, A.E., 2012. Contribution of the 5-HTTLPR gene by neuroticism on weight gain in male and female participants. Psychiatric Genetics, 22 (6), 279–285.
   PubMed Web of Science ®Google Scholar
• Mergen, H., et al., 2007. LEPR, ADBR3, IRS-1 and 5-HTT genes polymorphisms do not associate with obesity. Endocrine Journal, 54 (1), 89–94.
   PubMed Web of Science ®Google Scholar
• Miranda, R.C., et al., 2017. Biallelic and triallelic approaches of 5-HTTLPR polymorphism are associated with food intake and nutritional status in childhood. J. Nutr. Biochem, 43, 47–52.
   PubMed Web of Science ®Google Scholar
• Need, A.C., et al., 2006. Obesity is associated with genetic variants that alter dopamine availability. Annals of Human Genetics, 70 (Pt 3), 293–303.
   PubMedGoogle Scholar
• Purcell, S., et al., 2007. PLINK: a tool set for whole-genome association and population-based linkage analyses. American Journal of Human Genetics, 81 (3), 559–575.
   PubMed Web of Science ®Google Scholar
• Sabol, S.Z., Hu, S., and Hamer, D., 1998. A functional polymorphism in the monoamine oxidase A gene promoter. Human Genetics, 103 (3), 273–279.
   PubMed Web of Science ®Google Scholar
• Say, Y.H., 2017. The association of insertions/deletions (INDELs) and variable number tandem repeats (VNTRs) with obesity and its related traits and complications. Journal of Physiological Anthropology, 36 (1), 25.
   PubMedGoogle Scholar
• Silventoinen, K., et al., 2010. The genetic and environmental influences on childhood obesity: a systematic review of twin and adoption studies. International Journal Obesity (Lond)), 34 (1), 29–40.
   PubMed Web of Science ®Google Scholar
• Sookoian, S., et al., 2007. Short allele of serotonin transporter gene promoter is a risk factor for obesity in adolescents. Obesity (Obesity), 15 (2), 271–276.
   PubMed Web of Science ®Google Scholar
• Uzun, M., et al., 2015. Association of VNTR polymorphisms in DRD4, 5-HTT and DAT1 genes with obesity. Archives of Physiology and Biochemistry, 121 (2), 75–79.
   PubMed Web of Science ®Google Scholar
• Wallmeier, D., et al., 2013. Genetic modulation of the serotonergic pathway: influence on weight reduction and weight maintenance. Genes & Nutrition, 8 (6), 601–610.
   Web of Science ®Google Scholar
• Wardle, J., et al., 2008. Evidence for a strong genetic influence on childhood adiposity despite the force of the obesogenic environment. The American Journal of Clinical Nutrition, 87 (2), 398–404.
   PubMed Web of Science ®Google Scholar
• Wyler, S.C., et al., 2017. Serotonergic control of metabolic homeostasis. Frontiers in Cellular Neuroscience, 11, 277.
   PubMed Web of Science ®Google Scholar