Long non-coding RNA MEG3 and its genetic variant rs941576 are associated with rheumatoid arthritis pathogenesis in Egyptian patients

References

• Afuwape, A.O., Kiriakidis, S., and Paleolog, E.M., 2002. The role of the angiogenic molecule VEGF in the pathogenesis of rheumatoid arthritis. Histology and histopathology, 17 (3), 961–972.
   PubMed Web of Science ®Google Scholar
• Alarcon, G.S., et al., 1982. Seronegative rheumatoid arthritis. A distinct immunogenetic disease? Arthritis and rheumatism, 25 (5), 502–507.
   PubMedGoogle Scholar
• Aletaha, D., et al., 2010. 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis and rheumatism, 62 (9), 2569–2581.
   PubMed Web of Science ®Google Scholar
• Al-Rugeebah, A., Alanazi, M., and Parine, N.R., 2019. MEG3: an oncogenic long non-coding RNA in different cancers. Pathology oncology research: pathology & oncology research, 25 (3), 859–874.
   PubMed Web of Science ®Google Scholar
• Arend, W.P., and Firestein, G.S., 2012. Pre-rheumatoid arthritis: predisposition and transition to clinical synovitis. Nature reviews. Rheumatology, 8 (10), 573–586.
   PubMed Web of Science ®Google Scholar
• Benetatos, L., Vartholomatos, G., and Hatzimichael, E., 2011. MEG3 imprinted gene contribution in tumorigenesis. International journal of cancer, 129 (4), 773–779.
   PubMed Web of Science ®Google Scholar
• Bottini, N., and Firestein, G.S., 2013. Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors. Nature reviews. rheumatology, 9 (1), 24–33.
   PubMed Web of Science ®Google Scholar
• Charan, J., and Biswas, T., 2013. How to calculate sample size for different study designs in medical research? Indian journal of psychological medicine, 35 (2), 121–126.
   PubMedGoogle Scholar
• Chimenti, M., et al., 2015. The interplay between inflammation and metabolism in rheumatoid arthritis. Cell death & disease, 6 (9), e1887
   PubMed Web of Science ®Google Scholar
• da Rocha, S.T., et al., 2008. Genomic imprinting at the mammalian Dlk1-Dio3 domain. Trends genet, 24 (6), 306–316.
   PubMed Web of Science ®Google Scholar
• Dechamethakun, S., and Muramatsu, M., 2017. Long noncoding RNA variations in cardiometabolic diseases. Journal of human genetics, 62 (1), 97–104.
   PubMed Web of Science ®Google Scholar
• Ghosh, S., and Castellanos-Rubio, A., 2019. Disease-associated SNPs in inflammation-related lncRNAs. Frontiers in immunology, 10, 420.
   PubMed Web of Science ®Google Scholar
• Guo, Q., et al., 2018. Rheumatoid arthritis: pathological mechanisms and modern pharmacologic therapies. Bone research, 6 (1), 15.
   PubMed Web of Science ®Google Scholar
• He, C., et al., 2017. Long Noncoding RNA MEG3 Negatively Regulates Proliferation and Angiogenesis in Vascular Endothelial Cells. DNA cell biol, 36 (6), 475–481.
   PubMed Web of Science ®Google Scholar
• Hu, F., et al., 2014. Hypoxia and hypoxia-inducible factor-1α provoke toll-like receptor signalling-induced inflammation in rheumatoid arthritis. Annals of the rheumatic diseases, 73 (5), 928–936.
   PubMed Web of Science ®Google Scholar
• Hu, X.Q., et al., 2017. Chronic hypoxia upregulates DNA methyltransferase and represses large conductance Ca2+-activated K + channel function in ovine uterine arteries. Biology of reproduction, 96 (2), 424–434.
   PubMed Web of Science ®Google Scholar
• Ivan, M., et al., 2001. HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science (New York, N.Y.), 292 (5516), 464–468.
   PubMed Web of Science ®Google Scholar
• Kiani, A.K., et al., 2015. Genetic link of type 1 diabetes susceptibility loci with rheumatoid arthritis in Pakistani patients. Immunogenetics, 67 (5–6), 277–282.
   PubMed Web of Science ®Google Scholar
• Knijff-Dutmer, E., et al., 2002. Rheumatoid factor measured by fluoroimmunoassay: a responsive measure of rheumatoid arthritis disease activity that is associated with joint damage. Annals of the rheumatic diseases, 61 (7), 603–607.
   PubMed Web of Science ®Google Scholar
• Li, H., and Wan, A., 2013. Apoptosis of rheumatoid arthritis fibroblast-like synoviocytes: possible roles of nitric oxide and the thioredoxin 1. Mediators of inflammation, 2013, 953462.
   PubMed Web of Science ®Google Scholar
• Liang, J., Chen, W., and Lin, J., 2019. LncRNA: an all-rounder in rheumatoid arthritis. Journal of translational internal medicine, 7 (1), 3–9.
   PubMed Web of Science ®Google Scholar
• Liu, Y.R., et al., 2019. Long noncoding RNA MEG3 regulates rheumatoid arthritis by targeting NLRC5. Journal of cellular physiology, 234 (8), 14270–14284.
   PubMed Web of Science ®Google Scholar
• Lu, X., and Qian, J., 2019. Downregulated MEG3 participates in rheumatoid arthritis via promoting proliferation of fibroblast-like synoviocytes. Experimental and therapeutic medicine, 17 (3), 1637–1642.
   PubMed Web of Science ®Google Scholar
• Luo, G., et al., 2015. Long Non-Coding RNA MEG3 Inhibits Cell Proliferation and Induces Apoptosis in Prostate Cancer. Cellular physiology and biochemistry: international journal of experimental cellular physiology, biochemistry, and pharmacology, 37 (6), 2209–2220.
   PubMedGoogle Scholar
• Mann, D.A., 2014. Epigenetics in liver disease. Hepatology (Baltimore, Md.), 60 (4), 1418–1425.
   PubMed Web of Science ®Google Scholar
• Motterle, A., Sanchez-Parra, C., and Regazzi, R., 2016. Role of long non-coding RNAs in the determination of beta-cell identity. Diabetes, obesity and metabolism, 18 (Suppl. 1), 41–50.
   PubMedGoogle Scholar
• Nourshargh, S., and Alon, R., 2014. Leukocyte migration into inflamed tissues. Immunity, 41 (5), 694–707.
   PubMed Web of Science ®Google Scholar
• Peschansky, V.J., and Wahlestedt, C., 2014. Non-coding RNAs as direct and indirect modulators of epigenetic regulation. Epigenetics, 9 (1), 3–12.
   PubMed Web of Science ®Google Scholar
• Qin, G., et al., 2006. Cell cycle regulator E2F1 modulates angiogenesis via p53-dependent transcriptional control of VEGF. Proceedings of the National Academy of Sciences of the United States of America, 103 (29), 11015–11020.
   PubMed Web of Science ®Google Scholar
• Quiñonez-Flores, C.M., González-Chávez, S.A., and Pacheco-Tena, C., 2016. Hypoxia and its implications in rheumatoid arthritis. Journal of biomedical science, 23 (1), 62.
   PubMedGoogle Scholar
• Ruhrmann, S., et al., 2015. Genomic imprinting: a missing piece of the multiple sclerosis puzzle? The international journal of biochemistry & cell biology, 67, 49–57.
   PubMed Web of Science ®Google Scholar
• Rutenberg-Schoenberg, M., Sexton, A.N., and Simon, M.D., 2016. The properties of long noncoding RNAs that regulate chromatin. Annual review of genomics and human genetics, 17, 69–94.
   PubMed Web of Science ®Google Scholar
• Smolen, J.S., et al., 2018. Rheumatoid arthritis. Nature reviews. disease primers, 4, 18001.
   PubMed Web of Science ®Google Scholar
• Su, W., et al., 2015. The long noncoding RNA MEG3 is downregulated and inversely associated with VEGF levels in osteoarthritis. BioMed research international, 2015, 356893.
   PubMed Web of Science ®Google Scholar
• Sulaiman, F.N., et al., 2019. Anti-cyclic citrullinated peptide antibody is highly associated with rheumatoid factor and radiological defects in rheumatoid arthritis patients. Medicine, 98 (12), e14945.
   Google Scholar
• van der Heijde, D.M., et al., 1990. Judging disease activity in clinical practice in rheumatoid arthritis: first step in the development of a disease activity score. Annals of the rheumatic diseases, 49 (11), 916–920.
   PubMed Web of Science ®Google Scholar
• Wallace, C., et al., 2010. The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes. Nature Genetics, 42 (1), 68–71.
   PubMed Web of Science ®Google Scholar
• Wang, G.L., et al., 1995. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proceedings of the National Academy of Sciences of the United States of America, 92 (12), 5510–5514.
   PubMed Web of Science ®Google Scholar
• Weinmann, M., et al., 2004a. Cyclic exposure to hypoxia and reoxygenation selects for tumor cells with defects in mitochondrial apoptotic pathways. FASEB journal: official publication of the federation of American societies for experimental biology, 18 (15), 1906–1908.
   PubMedGoogle Scholar
• Weinmann, M., et al., 2004b. Molecular ordering of hypoxia-induced apoptosis: critical involvement of the mitochondrial death pathway in a FADD/caspase-8 independent manner. Oncogene, 23 (21), 3757–3769.
   PubMed Web of Science ®Google Scholar
• Zhang, X., et al., 2019. LncRNA MEG3 inhibits cell proliferation and induces apoptosis in laryngeal cancer via miR-23a/APAF-1 axis. Journal of cellular and molecular medicine, 23 (10), 6708–6719.
   PubMed Web of Science ®Google Scholar
• Zhao, J., et al., 2005. Hypermethylation of the promoter region is associated with the loss of MEG3 gene expression in human pituitary tumors. The journal of clinical endocrinology and metabolism, 90 (4), 2179–2186.
   PubMed Web of Science ®Google Scholar