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Archives of Physiology and Biochemistry
The Journal of Metabolic Diseases
Volume 129, 2023 - Issue 1
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Original Articles

L-Carnitine supplementation reduces biomarkers of inflammatory and oxidative stress in patients with coronary artery disease: a randomised controlled trial

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Pages 61-68 | Received 05 Feb 2020, Accepted 09 Jul 2020, Published online: 20 Aug 2020

References

  • Alvarez de Sotomayor, M., et al., 2007. L-Carnitine and its propionate: improvement of endothelial function in SHR through superoxide dismutase-dependent mechanisms. Free radical research, 41 (8), 884–891.
  • Askarpour, M., et al., 2019. Effects of L-carnitine supplementation on blood pressure: a systematic review and meta-analysis of randomized controlled trials. Journal of human hypertension, 33 (10), 725–734.
  • Bhutani, N. and Tangadi, D., 2020. Endothelial nitric oxide synthase (T-786C) gene polymorphism and coronary artery disease: a review. International journal of science and healthcare research, 5 (1), 32–41.
  • Chistiakov, D.A., et al., 2017. How do macrophages sense modified low-density lipoproteins? International journal of cardiology, 230, 232–240.
  • de Freitas Brito, A., et al., 2018. Oxidative stress and vascular diseases: effect of physical exercise. In: R. Ahmad, ed. Free radicals, antioxidants and diseases. Rijeka, Croatia: IntechOpen, 25.
  • Dehghan Ba, S., Mozaffari, H., and Ahmadi, S., 2019. Effects of oral L-carnitine supplementation on visceral proteins, C-reactive protein, homocysteine and blood lipid of hemodialysis patients: a randomized clinical trial. Asian journal of biological sciences, 12 (2), 242–250.
  • Doodnauth, S.A., Grinstein, S., and Maxson, M.E., 2019. Constitutive and stimulated macropinocytosis in macrophages: roles in immunity and in the pathogenesis of atherosclerosis. Philosophical transactions of the Royal Society B: biological sciences, 374 (1765), 20180147.
  • Ebrahimian, T., et al., 2018. Chronic exposure to external low-dose gamma radiation induces an increase in anti-inflammatory and anti-oxidative parameters resulting in atherosclerotic plaque size reduction in ApoE-/- Mice. Radiation research, 189 (2), 187–196.
  • Fathizadeh, H., et al., 2019. The effects of L-carnitine supplementation on glycemic control: a systematic review and meta-analysis of randomized controlled trials. EXCLI journal, 18, 631–643.
  • Fesharaki, M.G. and Azad, E., 2011. Evaluation of the reliability and validity of Azad-Fesharaki’s physical activity questionnaire (AFPAQ). Arak Medical University journal, 14 (56), 36–44.
  • Flanagan, J.L., et al., 2010. Role of carnitine in disease. Nutrition & metabolism, 7 (1), 30.
  • Ghafarpour, M., et al., 1999. The manual for household measures, cooking yields factors and edible portion of food. Tehran, Iran: Keshaverzi Press.
  • Glovaci, D., Fan, W., and Wong, N.D., 2019. Epidemiology of diabetes mellitus and cardiovascular disease. Current cardiology reports, 21 (4), 21.
  • Granger, D.N. and Kvietys, P.R., 2015. Reperfusion injury and reactive oxygen species: the evolution of a concept. Redox biology, 6, 524–551.
  • Hansson, G.K., 2005. Inflammation, atherosclerosis, and coronary artery disease. The New England journal of medicine, 352 (16), 1685–1695.
  • He, F. and Zuo, L., 2015. Redox roles of reactive oxygen species in cardiovascular diseases. International journal of molecular sciences, 16 (11), 27770–27780.
  • Johri, A., et al., 2014. Carnitine therapy for the treatment of metabolic syndrome and cardiovascular disease: evidence and controversies. Nutrition, metabolism, and cardiovascular diseases : NMCD, 24 (8), 808–814.
  • Le Borgne, F., et al., 2017. L-Carnitine protects C2C12 cells against mitochondrial superoxide overproduction and cell death. World journal of biological chemistry, 8 (1), 86–94.
  • Lee, B.-J., et al., 2014. Effects of L-carnitine supplementation on oxidative stress and antioxidant enzymes activities in patients with coronary artery disease: a randomized, placebo-controlled trial. Nutrition journal, 13 (1), 79.
  • Lee, B.-J., et al., 2015. Antiinflammatory effects of L-carnitine supplementation (1000 mg/d) in coronary artery disease patients. Nutrition, 31 (3), 475–479.
  • Lee, B.-J., et al., 2016. Effects of L-carnitine supplementation on lipid profiles in patients with coronary artery disease. Lipids in health and disease, 15 (1), 107.
  • Moeinian, M., et al., 2013. Synergistic effect of probiotics, butyrate and L-carnitine in treatment of IBD. Journal of medical hypotheses and ideas, 7 (2), 50–53.
  • Ndrepepa, G., 2019. Myeloperoxidase – a bridge linking inflammation and oxidative stress with cardiovascular disease. Clinica chimica acta, 493, 36–51.
  • Osman, J., et al., 2019. Sudden cardiac death (SCD) – risk stratification and prediction with molecular biomarkers. Journal of biomedical science, 26 (1), 39.
  • Ou, H., et al., 2017. The characteristics and roles of advanced oxidation protein products in atherosclerosis. Cardiovascular toxicology, 17 (1), 1–12.
  • Parvanova, A., et al., 2018. Blood pressure and metabolic effects of acetyl-L-carnitine in type 2 diabetes: DIABASI randomized controlled trial. Journal of the Endocrine Society, 2 (5), 420–436.
  • Pourfarzam, M., et al., 2013. Association between plasma myeloperoxidase and free 3-nitrotyrosine levels in patients with coronary artery disease. International journal of clinical medicine, 4 (3), 158–164.
  • Ramachandra, C.J., et al., 2020. Myeloperoxidase as a multifaceted target for cardiovascular protection. Antioxidants & redox signaling, 32 (15), 1135–1149.
  • Ribas, G.S., Vargas, C.R., and Wajner, M., 2014. L-Carnitine supplementation as a potential antioxidant therapy for inherited neurometabolic disorders. Gene, 533 (2), 469–476.
  • Sarrafzadegan, N. and Mohammadifard, N., 2019. Cardiovascular disease in Iran in the last 40 years: prevalence, mortality, morbidity, challenges and strategies for cardiovascular prevention. Archives of Iranian medicine (AIM), 22 (4), 204–210.
  • Scioli, M.G., et al., 2019. Oxidative stress-induced endothelial dysfunction contributes to cardiovascular disease. Revista cubana de investigaciones biomédicas, 38 (1).
  • Shrivastava, A.K., et al., 2015. C-reactive protein, inflammation and coronary heart disease. The Egyptian heart journal, 67 (2), 89–97.
  • Singhai, A., Yadav, V., and Jha, R.K., 2017. Effect of L-carnitine supplementation on inflammatory marker of coronary artery disease. International journal of advances in medicine, 4 (2), 467.
  • Talenezhad, N., et al., 2020. Effects of L-carnitine supplementation on weight loss and body composition: a systematic review and meta-analysis of 37 randomized controlled clinical trials with dose-response analysis. Clinical nutrition ESPEN, 37, 9–23.
  • Teng, N., et al., 2017. The roles of myeloperoxidase in coronary artery disease and its potential implication in plaque rupture. Redox report : communications in free radical research, 22 (2), 51–73.
  • Volek, J.S., et al., 2008. Effects of carnitine supplementation on flow-mediated dilation and vascular inflammatory responses to a high-fat meal in healthy young adults. The American journal of cardiology, 102 (10), 1413–1417.
  • Wang, Z.-Y., et al., 2018. L-Carnitine and heart disease. Life sciences, 194, 88–97.
  • Wright, C. and Sim, J., 2003. Intention-to-treat approach to data from randomized controlled trials: a sensitivity analysis. Journal of clinical epidemiology, 56 (9), 833–842.
  • Zuluaga, M., et al., 2018. Astaxanthin-antioxidant impact on excessive reactive oxygen species generation induced by ischemia and reperfusion injury. Chemico-biological interactions, 279, 145–158.

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