Publication Cover
Archives of Physiology and Biochemistry
The Journal of Metabolic Diseases
Volume 129, 2023 - Issue 3
102
Views
8
CrossRef citations to date
0
Altmetric
Original Articles

Thymus atlanticus polyphenol-rich extract regulates cholesterol metabolism by inhibiting its biosynthesis without affecting its excretion in hamsters fed a high-fat diet

, ORCID Icon, , , , , , , , & show all
Pages 618-625 | Received 13 Sep 2020, Accepted 16 Nov 2020, Published online: 15 Dec 2020

References

  • Bellakhdar, J., et al., 1991. Repertory of standard herbal drugs in the Moroccan pharmacopoea. Journal of ethnopharmacology, 35 (2), 123–143.
  • Briand, F., et al., 2010., Liver X receptor activation promotes macrophage-to-feces reverse cholesterol transport in a dyslipidemic hamster model, 51.
  • Chambers, K.F., et al., 2019. Polyphenol effects on cholesterol metabolism via bile acid biosynthesis, CYP7A1: A review. Nutrients, 11 (11), 2588–2523.
  • Chan, Y.K., et al., 2016. High fat diet induced atherosclerosis is accompanied with low colonic bacterial diversity and altered abundances that correlates with plaque size, plasma A-FABP and cholesterol: a pilot study of high fat diet and its intervention with Lactobacillus rhamno. BMC Microbiology, 16 (1), 1–13.
  • Chiang, J. Y. L., 2013. Bile Acid Metabolism and Signaling. Comprehensive Physiology, 3 (3), 1191–1212.
  • Chiang, J.Y.L., 2017. Recent advances in understanding bile acid homeostasis. F1000Research, 6, 2029–2028.
  • DeBose-Boyd, R.A., and Ye, J., 2018. SREBPs in lipid metabolism, insulin signaling, and beyond. Trends in biochemical sciences, 43 (5), 358–368.
  • Geisler, C.E., and Renquist, B.J., 2017. Hepatic lipid accumulation: Cause and consequence of dysregulated glucoregulatory hormones. The journal of endocrinology, 234 (1), R1–21.
  • Goh, B. H., and Tan, J. B. L., 2020. Cardiovascular benefits of dietary polyphenols. In: Plant-derived Bioactives: Production, Properties and Therapeutic Applications. Springer: Singapore, 239–257.
  • Haug, A., and Høstmark, A.T., 1987. Lipoprotein lipases, lipoproteins and tissue lipids in rats fed fish oil or coconut oil. The journal of nutrition, 117 (6), 1011–1017.
  • He, T., et al., 2019. High-fat diet exacerbates SIV pathogenesis and accelerates disease progression. The Journal of Clinical Investigation, 129 (12), 5474–5488.
  • Hmidani, A., et al., 2019a. Antioxidant, anti-inflammatory and anticoagulant activities of three Thymus species grown in southeastern Morocco. Future journal of pharmaceutical sciences, 5, 4.
  • Hmidani, A., et al., 2019b. Effect of extraction methods on antioxidant and anticoagulant activities of Thymus atlanticus aerial part. Scientific African, 5, e00143.
  • Khouya, T., et al., 2015. Anti-inflammatory, anticoagulant and antioxidant effects of aqueous extracts from Moroccan thyme varieties. Asian Pacific journal of tropical biomedicine, 5 (8), 636–644.
  • Khouya, T., et al., 2020. Anti-inflammatory and anticoagulant effects of polyphenol-rich extracts from Thymus atlanticus: An in vitro and in vivo study. Journal of ethnopharmacology, 252, 112475.
  • Lei, X., and Yang, Y., 2020. Vitexin and an HMG-Co A reductase inhibitor prevent the risks of atherosclerosis in high-fat atherogenic diet fed rats. Journal of King Saud University - Science, 32 (3), 2088–2095.
  • Luo, J., Yang, H., and Song, B.L., 2020. Mechanisms and regulation of cholesterol homeostasis. Nature reviews molecular cell biology, 21 (4), 225–245.
  • Mc Auley, M.T., 2020. Effects of obesity on cholesterol metabolism and its implications for healthy ageing. Nutrition research reviews, 33 (1), 121–133.
  • Patel, S.B., Graf, G.A., and Temel, R.E., 2018. ABCG5 and ABCG8: more than a defense against xenosterols. Journal of lipid research, 59 (7), 1103–1113.
  • Ramchoun, M., et al., 2012. Hypolipidemic and antioxidant effect of polyphenol-rich extracts from Moroccan thyme varieties. e-SPEN journal, 7 (3), e119–8.
  • Ramchoun, M., et al., 2020a. Effect of aqueous extract and polyphenol fraction derived from thymus atlanticus leaves on acute hyperlipidemia in the Syrian golden hamsters. Evidence-based complementary and alternative medicine: Ecam, 2020, 3282596–3282599.
  • Ramchoun, M., et al., 2020b. Effect of polyphenol, flavonoid, and saponin fractions from Thymus atlanticus on acute and chronic hyperlipidemia in mice. Future journal of pharmaceutical sciences, 6, 69.
  • Stack, P.S., and Ogola, G.O., 2020. Survey of Personal Use of Statins by Prescribers. The American journal of cardiology, 125 (4), 549–552.
  • Tarantino, G., Citro, V., and Capone, D., 2019. Nonalcoholic Fatty Liver Disease: A Challenge from Mechanisms to Therapy. Journal of clinical medicine, 9 (1), 15.
  • Tréguier, M., et al., 2011. Diet-induced dyslipidemia impairs reverse cholesterol transport in hamsters. European journal of clinical investigation, 41 (9), 921–928.
  • Wang, J., et al., Hobbs, H.H., 2015. Relative roles of ABCG5/ABCG8 in liver and intestine. Journal of lipid research, 56 (2), 319–330.
  • Wu, N., et al., 2013. Activation of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase during high fat diet feeding. Biochimica et Biophysica Acta, 1832 (10), 1560–1568.
  • Van Der Wulp, M.Y.M., Verkade, H.J., and Groen, A.K., 2013. Regulation of cholesterol homeostasis. Molecular and cellular endocrinology, 368 (1-2), 1–16.
  • Yu, X.H., et al., 2014. ABCG5/ABCG8 in cholesterol excretion and atherosclerosis. Clinica chimica acta; international journal of clinical chemistry, 428, 82–88.
  • Yu, X.H., et al., 2019. Cholesterol transport system: An integrated cholesterol transport model involved in atherosclerosis. Progress in lipid research, 73, 65–91.
  • Zein, A.A., et al., 2019. ABCG5/G8: A structural view to pathophysiology of the hepatobiliary cholesterol secretion. Biochemical society transactions, 47 (5), 1259–1268.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.