Metformin mediates MicroRNA-21 regulated circulating matrix metalloproteinase-9 in diabetic nephropathy: an in-silico and clinical study

References

• Choi, S.Y., et al., 2020. Metformin ameliorates animal models of dermatitis. Inflammopharmacology, 28 (5), 1293–1300.
   PubMed Web of Science ®Google Scholar
• Cotto, K.C., et al., 2018. DGIdb 3.0: a redesign and expansion of the drug-gene interaction database. Nucleic Acids Research, 46 (D1), D1068–D1073.
   PubMedGoogle Scholar
• Fan, Y., Habib, M., and Xia, J., 2018. Xeno-miRNet: a comprehensive database and analytics platform to explore xeno-miRNAs and their potential targets. PeerJ., 6, e5650.
   PubMed Web of Science ®Google Scholar
• Fan, Y., and Xia, J., 2018. miRNet—functional analysis and visual exploration of miRNA–target interactions in a network context. In: L. von Stechow and A. Santos Delgado, eds. Computational Cell Biology. New York, NY: Springer New York, 215–233.
   Google Scholar
• Huret, J.-L., et al., 2013. Atlas of genetics and cytogenetics in oncology and haematology in 2013. Nucleic Acids Research, 41 (Database issue), D920–924.
   PubMedGoogle Scholar
• Khokhar, M., et al., 2020. Perspectives on the role of PTEN in diabetic nephropathy: an update. Critical Reviews in Clinical Laboratory Sciences, 57 (7), 470–483.
   PubMed Web of Science ®Google Scholar
• Kluger, M.A., et al., 2013. Leukocyte-derived MMP9 is crucial for the recruitment of proinflammatory macrophages in experimental glomerulonephritis. Kidney International, 83 (5), 865–877.
   PubMed Web of Science ®Google Scholar
• Kolling, M., et al., 2017. Therapeutic miR-21 silencing ameliorates diabetic kidney disease in mice. Molecular Therapy : The Journal of the American Society of Gene Therapy, 25 (1), 165–180.
   PubMed Web of Science ®Google Scholar
• La Sala, L., et al., 2018. Glucose-sensing microRNA-21 disrupts ROS homeostasis and impairs antioxidant responses in cellular glucose variability. Cardiovascular Diabetology, 17 (1), 105.
   PubMedGoogle Scholar
• Lee, Y.-S., et al., 2010. AMP kinase acts as a negative regulator of RANKL in the differentiation of osteoclasts. Bone, 47 (5), 926–937.
   PubMed Web of Science ®Google Scholar
• Lelongt, B., et al., 2001. Matrix metalloproteinase 9 protects mice from anti-glomerular basement membrane nephritis through its fibrinolytic activity. The Journal of Experimental Medicine, 193 (7), 793–802.
   PubMed Web of Science ®Google Scholar
• Lewandowski, K.C., et al., 2011. Matrix metalloproteinases in type 2 diabetes and non-diabetic controls: effects of short-term and chronic hyperglycaemia. Archives of Medical Science, 2, 294–303.
   Google Scholar
• Li, S.-Y., et al., 2014. Matrix metalloproteinase-9 deficiency attenuates diabetic nephropathy by modulation of podocyte functions and dedifferentiation. Kidney International, 86 (2), 358–369.
   PubMed Web of Science ®Google Scholar
• Li, W.-D., et al., 2017. Metformin inhibits endothelial progenitor cell migration by decreasing matrix metalloproteinases, MMP-2 and MMP-9, via the AMPK/mTOR/autophagy pathway. International Journal of Molecular Medicine, 39 (5), 1262–1268.
   PubMed Web of Science ®Google Scholar
• Luo, M., et al., 2017. MiRNA-21 mediates the antiangiogenic activity of metformin through targeting PTEN and SMAD7 expression and PI3K/AKT pathway. Scientific Reports, 7, 43427.
   PubMed Web of Science ®Google Scholar
• Lv, Z., and Guo, Y., 2020. Metformin and Its Benefits for Various Diseases. Frontiers in Endocrinology, 11, 191.
   PubMed Web of Science ®Google Scholar
• Malekpour-Dehkordi, Z., et al., 2019. Metformin reduces fibrosis factors in insulin resistant and hypertrophied adipocyte via integrin/ERK, collagen VI, apoptosis, and necrosis reduction. Life Sciences, 233, 116682.
   PubMed Web of Science ®Google Scholar
• Mastenbroek, T.G., et al., 2015. Platelet-Associated Matrix Metalloproteinases Regulate Thrombus Formation and Exert Local Collagenolytic Activity. Arteriosclerosis, Thrombosis, and Vascular Biology, 35 (12), 2554–2561.
   PubMed Web of Science ®Google Scholar
• Moczulski, D.K., et al., 2007. Expression pattern of genes in peripheral blood mononuclear cells in diabetic nephropathy. Diabetic Medicine : a Journal of the British Diabetic Association, 24 (3), 266–271.
   PubMed Web of Science ®Google Scholar
• Otasek, D., et al., 2019. Cytoscape automation: empowering workflow-based network analysis. Genome Biology, 20 (1), 185.
   PubMed Web of Science ®Google Scholar
• Pulito, C., et al., 2017. Metformin-induced ablation of microRNA 21-5p releases Sestrin-1 and CAB39L antitumoral activities. Cell Discovery, 3, 17022.
   PubMed Web of Science ®Google Scholar
• Roy, D., et al., 2020. MicroRNA 21 emerging role in diabetic complications: a critical update. Current Diabetes Reviews, 17 (2), 122–135.
   Web of Science ®Google Scholar
• Santos, M.C.L.G., et al., 2004. Inhibition of human pulpal gelatinases (MMP-2 and MMP-9) by zinc oxide cements. Journal of Oral Rehabilitation, 31 (7), 660–664.
   PubMed Web of Science ®Google Scholar
• Sena, C.M., et al., 2010. Diabetes mellitus: new challenges and innovative therapies. The EPMA Journal, 1 (1), 138–163.
   PubMedGoogle Scholar
• Szklarczyk, D., et al., 2019. STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets. Nucleic Acids Research, 47 (D1), D607–D613.
   PubMed Web of Science ®Google Scholar
• Ugarte-Berzal, E., et al., 2019. MMP-9/gelatinase B degrades immune complexes in systemic lupus erythematosus. Frontiers in Immunology, 10, 538.
   PubMed Web of Science ®Google Scholar
• Van Lint, P., and Libert, C., 2007. Chemokine and cytokine processing by matrix metalloproteinases and its effect on leukocyte migration and inflammation. Journal of Leukocyte Biology, 82 (6), 1375–1381.
   PubMed Web of Science ®Google Scholar
• Vujic, I., et al., 2015. Metformin and trametinib have synergistic effects on cell viability and tumor growth in NRAS mutant cancer. Oncotarget, 6 (2), 969–978.
   PubMedGoogle Scholar
• Wang, J., et al., 2013. Effect of miR-21 on renal fibrosis by regulating MMP-9 and TIMP1 in kk-ay diabetic nephropathy mice. Cell Biochemistry and Biophysics, 67 (2), 537–546.
   PubMed Web of Science ®Google Scholar
• Wornle, M., et al., 2009. Role of matrix metalloproteinases in viral-associated glomerulonephritis. Nephrology, Dialysis, Transplantation : official Publication of the European Dialysis and Transplant Association - European Renal Association, 24 (4), 1113–1121.
   PubMed Web of Science ®Google Scholar
• Xu, X., et al., 2014. A glimpse of matrix metalloproteinases in diabetic nephropathy. Current Medicinal Chemistry, 21 (28), 3244–3260.
   PubMed Web of Science ®Google Scholar