Activation of SIRT1 by silibinin improved mitochondrial health and alleviated the oxidative damage in experimental diabetic neuropathy and high glucose-mediated neurotoxicity

References

• Aquilano, K., et al., 2010. Peroxisome proliferator-activated receptor γ co-activator 1 α (PGC-1α) and sirtuin 1 (SIRT1) reside in mitochondria: possible direct function in mitochondrial biogenesis. Journal of biological chemistry, 285 (28), 21590–21599.
   PubMed Web of Science ®Google Scholar
• Areti, A., et al., 2016. Potential therapeutic benefits of maintaining mitochondrial health in peripheral neuropathies. Current neuropharmacology, 14 (6), 593–609.
   PubMed Web of Science ®Google Scholar
• Areti, A., et al., 2017. Melatonin prevents mitochondrial dysfunction and promotes neuroprotection by inducing autophagy during oxaliplatin-evoked peripheral neuropathy. Journal of pineal research, 62 (3), e12393.
   Web of Science ®Google Scholar
• Athale, J., et al., 2012. Nrf2 promotes alveolar mitochondrial biogenesis and resolution of lung injury in Staphylococcus aureus pneumonia in mice. Free radical biology & medicine, 53 (8), 1584–1594.
   PubMed Web of Science ®Google Scholar
• Bass, D.A., et al., 1983. Flow cytometric studies of oxidative product formation by neutrophils: a graded response to membrane stimulation. Journal of immunology, 130 (4), 1910–1917.
   PubMed Web of Science ®Google Scholar
• Biessels, G.J., et al., 2014. Phenotyping animal models of diabetic neuropathy: a consensus statement of the diabetic neuropathy study group of the EASD (Neurodiab). Journal of the peripheral nervous system, 19 (2), 77–87.
   PubMed Web of Science ®Google Scholar
• Cadenas, E., et al., 1977. Production of superoxide radicals and hydrogen peroxide by NADH-ubiquinone reductase and ubiquinol-cytochrome c reductase from beef-heart mitochondria. Archives of biochemistry and biophysics, 180 (2), 248–257.
   PubMed Web of Science ®Google Scholar
• Cameron, N.E., et al., 1994. Anti-oxidant and pro-oxidant effects on nerve conduction velocity, endoneurial blood flow and oxygen tension in non-diabetic and streptozotocin-diabetic rats. Diabetologia, 37 (5), 449–459.
   PubMed Web of Science ®Google Scholar
• Chandrasekaran, K., et al., 2015. Mitochondrial transcription factor A regulation of mitochondrial degeneration in experimental diabetic neuropathy. American journal of physiology-endocrinology and metabolism, 309 (2), E132–E141.
   PubMed Web of Science ®Google Scholar
• Chen, N., et al., 2021. β2-adrenoreceptor agonist ameliorates mechanical allodynia in paclitaxel-induced neuropathic pain via induction of mitochondrial biogenesis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 144, 112331.
   PubMed Web of Science ®Google Scholar
• Choi, J., et al., 2014. PGC-1α regulation of mitochondrial degeneration in experimental diabetic neuropathy. Neurobiology of disease, 64, 118–130.
   PubMed Web of Science ®Google Scholar
• Cohen, K., et al., 2015. Pharmacological treatment of diabetic peripheral neuropathy. P & T, 40 (6), 372–388.
   PubMedGoogle Scholar
• du Sert, N.P., et al., 2020. The arrive guidelines 2.0: updated guidelines for reporting animal research. PLoS biology, 18 (7), 1–12.
   Web of Science ®Google Scholar
• Ellis, A. and Bennett, D.L.H., 2013. Neuroinflammation and the generation of neuropathic pain. British journal of anaesthesia, 111 (1), 26–37.
   PubMed Web of Science ®Google Scholar
• Fernyhough, P., 2015. Mitochondrial dysfunction in diabetic neuropathy: a series of unfortunate metabolic events. Current diabetes reports, 15 (11), 89.
   PubMed Web of Science ®Google Scholar
• Forbes, J.M. and Cooper, M.E., 2013. Mechanisms of diabetic complications. Physiological reviews, 93 (1), 137–188.
   PubMed Web of Science ®Google Scholar
• Galicia-Garcia, U., et al., 2020. Pathophysiology of type 2 diabetes mellitus. International journal of molecular sciences, 21 (17), 6275.
   PubMed Web of Science ®Google Scholar
• Ganesh Yerra, V., et al., 2013. Potential therapeutic effects of the simultaneous targeting of the Nrf2 and NF-κB pathways in diabetic neuropathy. Redox biology, 1 (1), 394–397.
   PubMed Web of Science ®Google Scholar
• Giacco, F. and Brownlee, M., 2010. Oxidative stress and diabetic complications. Circulation research, 107 (9), 1058–1070.
   PubMed Web of Science ®Google Scholar
• Gong, W., et al., 2017. Polydatin promotes Nrf2-ARE anti-oxidative pathway through activating CKIP-1 to resist HG-induced up-regulation of FN and ICAM-1 in GMCs and diabetic mice kidneys. Free radical biology & medicine, 106, 393–405.
   PubMed Web of Science ®Google Scholar
• Green, S., et al., 2018. ‘Extreme’ organisms and the problem of generalization: interpreting the Krogh principle. History and philosophy of the life sciences, 40 (4), 65.
   PubMed Web of Science ®Google Scholar
• Herskovits, A.Z. and Guarente, L., 2013. Sirtuin deacetylases in neurodegenerative diseases of aging. Cell research, 23 (6), 746–758.
   PubMed Web of Science ®Google Scholar
• Höke, A., 2012. Animal models of peripheral neuropathies. Neurotherapeutics, 9 (2), 262–269.
   PubMed Web of Science ®Google Scholar
• Huang, K., Gao, X., and Wei, W., 2017. The crosstalk between Sirt1 and Keap1/Nrf2/ARE anti-oxidative pathway forms a positive feedback loop to inhibit FN and TGF-β1 expressions in rat glomerular mesangial cells. Experimental cell research, 361 (1), 63–72.
   PubMed Web of Science ®Google Scholar
• Intine, R.V. and Sarras, M.P., 2012. Metabolic memory and chronic diabetes complications: potential role for epigenetic mechanisms. Current diabetes reports, 12 (5), 551–559.
   PubMed Web of Science ®Google Scholar
• Joe, Y., et al., 2015. Cilostazol attenuates murine hepatic ischemia and reperfusion injury via heme oxygenase-dependent activation of mitochondrial biogenesis. American journal of physiology. Gastrointestinal and liver physiology, 309 (1), G21–G29.
   PubMed Web of Science ®Google Scholar
• Joshi, R.P., et al., 2013. SNEDDS curcumin formulation leads to enhanced protection from pain and functional deficits associated with diabetic neuropathy: an insight into its mechanism for neuroprotection. Nanomedicine, 9 (6), 776–785.
   PubMed Web of Science ®Google Scholar
• Kadıoğlu, E., et al., 2021. Beneficial effects of bardoxolone methyl, an Nrf2 activator, on crush-related acute kidney injury in rats. European journal of trauma and emergency surgery, 47 (1), 241–250.
   PubMed Web of Science ®Google Scholar
• Kalvala, A.K., et al., 2020a. Bardoxolone methyl ameliorates hyperglycemia induced mitochondrial dysfunction by activating the keap1-Nrf2-ARE pathway in experimental diabetic neuropathy. Molecular neurobiology, 57 (8), 3616–3631.
   PubMed Web of Science ®Google Scholar
• Kalvala, A.K., et al., 2020b. Chronic hyperglycemia impairs mitochondrial unfolded protein response and precipitates proteotoxicity in experimental diabetic neuropathy: focus on LonP1 mediated mitochondrial regulation. Pharmacological reports, 72 (6), 1627–1644.
   PubMed Web of Science ®Google Scholar
• Kashiwagi, Y., et al., 2021. Mitochondrial biogenesis factor PGC-1α suppresses spinal morphine tolerance by reducing mitochondrial superoxide. Experimental neurology, 339, 113622.
   PubMed Web of Science ®Google Scholar
• Lagouge, M., et al., 2006. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell, 127 (6), 1109–1122.
   PubMed Web of Science ®Google Scholar
• Li, Y., et al., 2020. SIRT1 mediates neuropathic pain induced by sciatic nerve chronic constrictive injury in the VTA-NAc pathway. Pain research and management, 2020, 1–9.
   Web of Science ®Google Scholar
• Liang, F., Kume, S., and Koya, D., 2009. SIRT1 and insulin resistance. Nature reviews. Endocrinology, 5 (7), 367–373.
   PubMed Web of Science ®Google Scholar
• Liang, H. and Ward, W.F., 2006. PGC-1alpha: a key regulator of energy metabolism. Advances in physiology education, 30 (4), 145–151.
   PubMed Web of Science ®Google Scholar
• Lu, W., et al., 2016. Mitochondrial protein PGAM5 regulates mitophagic protection against cell necroptosis. PLOS one, 11, e0147792.
   PubMed Web of Science ®Google Scholar
• Martin-Montalvo, A. and De Cabo, R., 2013. Mitochondrial metabolic reprogramming induced by calorie restriction. Antioxidants & redox signaling, 19 (3), 310–320.
   PubMed Web of Science ®Google Scholar
• Massicot, F., et al., 2013. P2X7 cell death receptor activation and mitochondrial impairment in oxaliplatin-induced apoptosis and neuronal injury: cellular mechanisms and in vivo approach. PLOS one, 8 (6), e66830.
   PubMed Web of Science ®Google Scholar
• Meissner, C., et al., 2015. Intramembrane protease PARL defines a negative regulator of PINK1- and PARK2/Parkin-dependent mitophagy. Autophagy, 11 (9), 1484–1498.
   PubMed Web of Science ®Google Scholar
• Negi, G., et al., 2011. Oxidative stress and Nrf2 in the pathophysiology of diabetic neuropathy: old perspective with a new angle. Biochemical and biophysical research communications, 408 (1), 1–5.
   PubMed Web of Science ®Google Scholar
• Negi, G., Kumar, A., and Sharma, S.S., 2011a. Nrf2 and NF-κB modulation by sulforaphane counteracts multiple manifestations of diabetic neuropathy in rats and high glucose-induced changes. Current neurovascular research, 8 (4), 294–304.
   PubMed Web of Science ®Google Scholar
• Negi, G., Kumar, A., and Sharma, S.S., 2011b. Melatonin modulates neuroinflammation and oxidative stress in experimental diabetic neuropathy: effects on NF‐κB and Nrf2 cascades. Journal of pineal research, 50 (2), 124–131.
   PubMed Web of Science ®Google Scholar
• Nemoto, S., Fergusson, M.M., and Finkel, T., 2005. SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}. Journal of biological chemistry, 280 (16), 16456–16460.
   PubMed Web of Science ®Google Scholar
• North, A.C., Shilcock, A., and Hargreaves, D.J., 2003. The effect of musical style on restaurant customers’ spending. Environment and behavior, 35 (5), 712–718.
   Web of Science ®Google Scholar
• North, B.J. and Verdin, E., 2004. Sirtuins: Sir2-related NAD-dependent protein deacetylases. Genome biology, 5 (5), 224.
   PubMed Web of Science ®Google Scholar
• Nunnari, J. and Suomalainen, A., 2012. Mitochondria: in sickness and in health. Cell, 148 (6), 1145–1159.
   PubMed Web of Science ®Google Scholar
• Ogurtsova, K., et al., 2022. IDF diabetes Atlas: global estimates of undiagnosed diabetes in adults for. Diabetes research and clinical practice, 183, 109118.
   PubMed Web of Science ®Google Scholar
• Ohkawa, H., Ohishi, N., and Yagi, K., 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Analytical biochemistry, 95 (2), 351–358.
   PubMed Web of Science ®Google Scholar
• Palikaras, K. and Tavernarakis, N., 2014. Mitochondrial homeostasis: the interplay between mitophagy and mitochondrial biogenesis. Experimental gerontology, 56, 182–188.
   PubMed Web of Science ®Google Scholar
• Pergola, P.E., et al., 2011. Effect of bardoxolone methyl on kidney function in patients with T2D and Stage 3b-4 CKD. American journal of nephrology, 33 (5), 469–476.
   PubMed Web of Science ®Google Scholar
• Phan, C.W., et al., 2013. Neurite outgrowth stimulatory effects of culinary-medicinal mushrooms and their toxicity assessment using differentiating Neuro-2a and embryonic fibroblast BALB/3T3. BMC complementary and alternative medicine, 13 (1), 261.
   PubMedGoogle Scholar
• Reddy, M.A., Zhang, E., and Natarajan, R., 2015. Epigenetic mechanisms in diabetic complications and metabolic memory. Diabetologia, 58 (3), 443–455.
   PubMed Web of Science ®Google Scholar
• Rolo, A.P. and Palmeira, C.M., 2006. Diabetes and mitochondrial function: role of hyperglycemia and oxidative stress. Toxicology and applied pharmacology, 212, 167–178.
   PubMed Web of Science ®Google Scholar
• Ruiz, K., et al., 2019. Functional role of PGAM5 multimeric assemblies and their polymerization into filaments. Nature communications, 10 (1), 531.
   PubMedGoogle Scholar
• Russell, J.W., et al., 2002. High glucose-induced oxidative stress and mitochondrial dysfunction in neurons. FASEB journal, 16 (13), 1738–1748.
   PubMed Web of Science ®Google Scholar
• Sack, M.C.N. and Finkel, T., 2012. Mitochondrial metabolism, sirtuins, and aging. Cold Spring Harbor perspectives in biology, 4 (12), a013102.
   PubMed Web of Science ®Google Scholar
• Salomone, F., et al., 2017. Silibinin restores NAD+ levels and induces the SIRT1/AMPK pathway in non-alcoholic fatty liver. Nutrients, 9 (10), 1086.
   PubMed Web of Science ®Google Scholar
• Sandireddy, R., et al., 2014. Neuroinflammation and oxidative stress in diabetic neuropathy: futuristic strategies based on these targets. International journal of endocrinology, 2014, 1–10.
   Web of Science ®Google Scholar
• Sandireddy, R., et al., 2016. Fisetin imparts neuroprotection in experimental diabetic neuropathy by modulating Nrf2 and NF-κB pathways. Cellular and molecular neurobiology, 36 (6), 883–892.
   PubMed Web of Science ®Google Scholar
• Santos, J.M. and Kowluru, R.A., 2011. Role of mitochondria biogenesis in the metabolic memory associated with the continued progression of diabetic retinopathy and its regulation by lipoic acid. Investigative ophthalmology & visual science, 52 (12), 8791–8798.
   PubMed Web of Science ®Google Scholar
• Shanks, N., Greek, R., and Greek, J., 2009. Are animal models predictive for humans? Philosophy, ethics, and humanities in medicine, 4 (1), 2.
   PubMedGoogle Scholar
• Shi, G., et al., 2011. Functional alteration of PARL contributes to mitochondrial dysregulation in Parkinson’s disease. Human molecular genetics, 20 (10), 1966–1974.
   PubMed Web of Science ®Google Scholar
• Singh, R., et al., 2022. Animal models of diabetic microvascular complications: relevance to clinical features. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 145, 112305.
   PubMed Web of Science ®Google Scholar
• Song, F.H., et al., 2022. SIRT1: a promising therapeutic target for chronic pain. CNS neuroscience & therapeutics, 28 (6), 818–828.
   PubMed Web of Science ®Google Scholar
• Song, X., et al., 2016. Protective effect of silibinin on learning and memory impairment in LPS-treated rats via ROS–BDNF–TrkB pathway. Neurochemical research, 41 (7), 1662–1672.
   PubMed Web of Science ®Google Scholar
• Spinazzi, M. and De Strooper, B., 2016. PARL: the mitochondrial rhomboid protease. Seminars in cell & developmental biology, 60, 19–28.
   PubMed Web of Science ®Google Scholar
• Sun, J., et al., 2021. Nrf2 activation attenuates chronic constriction injury-induced neuropathic pain via induction of PGC-1 α-mediated mitochondrial biogenesis in the spinal cord. Oxidative medicine and cellular longevity, 2021, 1–17.
   Web of Science ®Google Scholar
• Sun, J., et al., 2022. Sestrin2 overexpression attenuates osteoarthritis pain via induction of AMPK/PGC-1α-mediated mitochondrial biogenesis and suppression of neuroinflammation. Brain, behavior, and immunity, 102, 53–70.
   PubMed Web of Science ®Google Scholar
• Tang, B.L. and Chua, C.E.L., 2008. SIRT1 and neuronal diseases. Molecular aspects of medicine, 29 (3), 187–200.
   PubMed Web of Science ®Google Scholar
• Tesfaye, S., et al., 2010. Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treatments. Diabetes care, 33 (10), 2285–2293.
   PubMed Web of Science ®Google Scholar
• Yerra, V.G., et al., 2018. Adenosine monophosphate-activated protein kinase modulation by berberine attenuates mitochondrial deficits and redox imbalance in experimental diabetic neuropathy. Neuropharmacology, 131, 256–270.
   PubMed Web of Science ®Google Scholar
• Vincent, A.M., et al., 2005. Short-term hyperglycemia produces oxidative damage and apoptosis in neurons. FASEB journal, 19 (6), 1–24.
   PubMedGoogle Scholar
• Wang, Q., et al., 2021. An in vitro model of diabetic retinal vascular endothelial dysfunction and neuroretinal degeneration. Journal of diabetes research, 2021, 1–12.
   Google Scholar
• Yacoub, R., Lee, K., and He, J.C., 2014. The role of SIRT1 in diabetic kidney disease. Frontiers in endocrinology, 5, 166.
   PubMed Web of Science ®Google Scholar
• Yadranji Aghdam, S., et al., 2013. High glucose and diabetes modulate cellular proteasome function: implications in the pathogenesis of diabetes complications. Biochemical and biophysical research communications, 432 (2), 339–344.
   PubMed Web of Science ®Google Scholar
• Yerra, V.G., Areti, A., and Kumar, A., 2017. Adenosine monophosphate-activated protein kinase abates hyperglycaemia-induced neuronal injury in experimental models of diabetic neuropathy: effects on mitochondrial biogenesis, autophagy and neuroinflammation. Molecular neurobiology, 54 (3), 2301–2312.
   PubMed Web of Science ®Google Scholar
• Youle, R.J. and Narendra, D.P., 2011. Mechanisms of mitophagy. Nature reviews. Molecular cell biology, 12 (1), 9–14.
   PubMed Web of Science ®Google Scholar
• Zhang, L.-Q., et al., 2022. 5-HT 1F receptor agonist ameliorates mechanical allodynia in neuropathic pain via induction of mitochondrial biogenesis and suppression of neuroinflammation. Frontiers in pharmacology, 13, 834570.
   PubMed Web of Science ®Google Scholar
• Zhou, Y.Q., et al., 2021. The therapeutic potential of Nrf2 inducers in chronic pain: evidence from preclinical studies. Pharmacology & therapeutics, 225, 107846.
   PubMed Web of Science ®Google Scholar
• Zhou, Y., et al., 2020. Nrf2 activation ameliorates mechanical allodynia in paclitaxel-induced neuropathic pain. Acta pharmacologica sinica, 41 (8), 1041–1048.
   PubMed Web of Science ®Google Scholar