Examining HPA-axis functioning as a mediator of the relationship between depression and cognition across the adult lifespan

References

• Ancelin, M. L., Scali, J., Norton, J., Ritchie, K., Dupuy, A-M., Chaudieu, I., & Ryan, J. (2017). The effect of an adverse psychological environment on salivary cortisol levels in the elderly differs by 5-HTTLPR genotype. Neurobiology of Stress, 7, 38–46.
   PubMed Web of Science ®Google Scholar
• Army Individual Test Battery. (1944). Manual of directions and scoring. Washington, DC: War Department, Adjutant General’s Office.
   Google Scholar
• Ballmaier, M., Narr, K. L., Toga, A. W., Elderkin-Thompson, V., Thompson, P. M., Hamilton, L., … Kumar, A. (2008). Hippocampal morphology and distinguishing late-onset from early-onset elderly depression. American Journal of Psychiatry, 165(2), 229–237.
   PubMed Web of Science ®Google Scholar
• Belanoff, J. K., Kalehzan, M., Sund, B., Fleming Ficek, S. K., & Schatzberg, A. F. (2001). Cortisol activity and cognitive changes in psychotic major depression. American Journal of Psychiatry, 158(10), 1612–1616.
   PubMed Web of Science ®Google Scholar
• Beluche, I., Carrière, I., Ritchie, K., & Ancelin, M. L. (2010). A prospective study of diurnal cortisol and cognitive function in community-dwelling elderly people. Psychological Medicine, 40(6), 1039–1049.
   PubMed Web of Science ®Google Scholar
• Bora, E., Harrison, B. J., Yücel, M., & Pantelis, C. (2013). Cognitive impairment in euthymic major depressive disorder: A meta-analysis. Psychological Medicine, 43, 2017–2026.
   PubMed Web of Science ®Google Scholar
• Bremmer, M. A., Deeg, D. J. H., Beekman, A. T. F., Penninx, B. W. J. H., Lips, P., & Hoogendijk, W. J. G. (2007). Major depression in late life is associated with both hypo- and hypercortisolemia. Biological Psychiatry, 62(5), 479–486.
   PubMed Web of Science ®Google Scholar
• Butters, M. A., Young, J. B., Lopez, O., Aizenstein, H. J., Mulsant, B. H., Reynolds III, C. F., … Becker, J. T. (2008). Pathways linking late-life depression to persistent cognitive impairment and dementia. Dialogues in Clinical Neuroscience, 10(3), 345–357.
   PubMedGoogle Scholar
• Comijs, H. C., Gerritsen, L., Penninx, B. W. J. H., Bremmer, M. A., Deeg, D. J. H., & Geerlings, M. I. (2010). The association between serum cortisol and cognitive decline in older persons. The American Journal of Geriatric Psychiatry, 18(1), 42–50.
   PubMed Web of Science ®Google Scholar
• Considine, C. M., Weisenbach, S. L., Walker, S. J., McFadden, E. M., Franti, L. M., Bieliauskas, L. A., … Langenecker, S. A. (2011). Auditory memory decrements, without dissimulation, among patients with major depressive disorder. Archives of Clinical Neuropsychology, 26(5), 445–453.
   PubMed Web of Science ®Google Scholar
• Daban, C., Vieta, E., Mackin, P., & Young, A. H. (2005). Hypothalamic-pituitary-adrenal Axis and Bipolar Disorder. Psychiatric Clinics of North America, 28, 469–480.
   PubMed Web of Science ®Google Scholar
• Delis, D. C., Kramer, J. H., Kaplan, E., & Ober, B. A. (1987). California verbal learning test: Adult version manual. San Antonio, TX: Psychological Corporation.
   Google Scholar
• Den Hartog, H. M., Nicolson, N. A., Derix, M. M. A., Van Bemmel, A. L., Kremer, B., & Jolles, J. (2003). Salivary cortisol patterns and cognitive speed in major depression: A comparison with allergic rhinitis and healthy control subjects. Biological Psychology, 63(1), 1–14.
   PubMed Web of Science ®Google Scholar
• Deuschle, M., Gotthardt, U., Schweiger, U., Weber, B., Körner, A., Schmider, J., … Heuser, I. (1997). With aging in humans the activity of the hypothalamus-pituitary-adrenal system increases and its diurnal amplitude flattens. Life Sciences, 61(22), 2239–2246.
   PubMed Web of Science ®Google Scholar
• Du, X., & Pang, T. Y. (2015). Is dysregulation of the HPA-axis a core pathophysiology mediating co-morbid depression in neurodegenerative diseases? Frontiers in Psychiatry, 6. doi:10.3389/fpsyt.2015.00032
   PubMed Web of Science ®Google Scholar
• Egeland, J., Lund, A., Landrø, N. I., Rund, B. R., Sundet, K., Asbjørnsen, A., … Stordal, K. I. (2005). Cortisol level predicts executive and memory function in depression, symptom level predicts psychomotor speed. Acta Psychiatrica Scandinavica, 112(6), 434–441.
   PubMed Web of Science ®Google Scholar
• Fiocco, A. J., Wan, N., Weekes, N., Pim, H., & Lupien, S. J. (2006). Diurnal cycle of salivary cortisol in older adult men and women with subjective complaints of memory deficits and/or depressive symptoms: Relation to cognitive functioning. Stress, 9(3), 143–152.
   PubMed Web of Science ®Google Scholar
• First, M. B., Spitzer, R. L., Gibbon, M., Williams, J. B. W., Davies, M., Borus, J., … Rounsaville, B. (1995). The structured clinical interview for DSM-III-R personality disorders (SCID-II). Part II: Multi-site test-retest reliability study. Journal of Personality Disorders, 9(2), 92–104.
   Web of Science ®Google Scholar
• Geerlings, M. I., & Gerritsen, L. (2017). Late-life depression, hippocampal volumes, and hypothalamic-pituitary-adrenal axis regulation: A systematic review and meta-analysis. Biological Psychiatry, 82(5), 339–350.
   PubMed Web of Science ®Google Scholar
• Geerlings, M. I., Sigurdsson, S., Eiriksdottir, G., Garcia, M. E., Harris, T. B., Gudnason, V., & Launer, L. J. (2015). Salivary cortisol, brain volumes, and cognition in community-dwelling elderly without dementia. Neurology, 85(11), 976–983.
   PubMed Web of Science ®Google Scholar
• Gomez, R. G., Fleming, S. H., Keller, J., Flores, B., Kenna, H., DeBattista, C., … Schatzberg, A. F. (2006). The neuropsychological profile of psychotic major depression and its relation to cortisol. Biological Psychiatry, 60(5), 472–478.
   PubMed Web of Science ®Google Scholar
• Gomez, R., A., Posener, J., Keller, J., DeBattista, C., Solvason, H., & Schatzberg, A. (2009). Effects of major depression diagnosis and cortisol levels on indices of neurocognitive function. Psychoneuroendocrinology, 34, 1012–1018.
   PubMed Web of Science ®Google Scholar
• Halbreich, U., Asnis, G. M., Zumoff, B., Nathan, R. S., & Shindledecker, R. (1984). Effect of age and sex on cortisol secretion in depressives and normals. Psychiatry Research, 13(3), 221–229.
   PubMed Web of Science ®Google Scholar
• Hamilton, M. (1960). A rating scale for depression. Journal of Neurology, Neurosurgery, and Psychiatry, 23(1), 56–62.
   PubMed Web of Science ®Google Scholar
• Hayes, A. F. (2017). Introduction to mediation, moderation, and conditional process analysis second edition: A regression-based approach. New York, NY: Guilford Publications, Inc.
   Google Scholar
• Heaton, R. K., Chelune, G. J., Talley, J. L., Grant, D. A., & Berg, E. A. (1993). Wisconsin card sorting test: Revised and expanded. Psychological Assessment Resources (PAR), Odessa, FL.
   Google Scholar
• Heim, C., Shugart, M., Craighead, W. E., & Nemeroff, C. B. (2010). Neurobiological and psychiatric consequences of child abuse and neglect. Developmental Psychobiology, 52(7), 671–690.
   PubMed Web of Science ®Google Scholar
• Herbert, J., Goodyer, I. M., Grossman, A. B., Hastings, M. H., De Kloet, E. R., Lightman, S. L., … Seckl, J. R. (2006). Do corticosteroids damage the brain? Journal of Neuroendocrinology, 18(6), 393–411.
   PubMed Web of Science ®Google Scholar
• Hickie, I., Naismith, S., Ward, P., Turner, K., Scott, E., Mitchell, P., … Parker, G. (2005). Reduced hippocampal volumes and memory loss in patients with early- and late-onset depression. The British Journal of Psychiatry: the Journal of Mental Science, 186, 197–202.
   PubMed Web of Science ®Google Scholar
• Hinkelmann, K., Moritz, S., Botzenhardt, J., Riedesel, K., Wiedemann, K., Kellner, M., & Otte, C. (2009). Cognitive impairment in major depression: Association with salivary cortisol. Biological Psychiatry, 66(9), 879–885.
   PubMed Web of Science ®Google Scholar
• Holland, J. M., Schatzberg, A. F., O’Hara, R., Marquett, R. M., & Gallagher-Thompson, D. (2013). Pretreatment cortisol levels predict posttreatment outcomes among older adults with depression in cognitive behavioral therapy. Psychiatry Research, 210(2), 444–450.
   PubMed Web of Science ®Google Scholar
• Joseph, J. J., & Golden, S. H. (2017). Cortisol dysregulation: The bidirectional link between stress, depression, and type 2 diabetes mellitus. Annals of the New York Academy of Sciences, 1391(1), 20–34.
   PubMed Web of Science ®Google Scholar
• Keller, J., Gomez, R., Williams, G., Lembke, A., Lazzeroni, L., Murphy, G. M., & Schatzberg, A. F. (2017). HPA axis in major depression: Cortisol, clinical symptomatology and genetic variation predict cognition. Molecular Psychiatry, 22(4), 527–536.
   PubMed Web of Science ®Google Scholar
• Köhler, S., Thomas, A. J., Lloyd, A., Barber, R., Almeida, O. P., & O’Brien, J. T. (2010). White matter hyperintensities, cortisol levels, brain atrophy and continuing cognitive deficits in late-life depression. The British Journal of Psychiatry, 196(2), 143–149.
   PubMed Web of Science ®Google Scholar
• Langenecker, S. A., Bieliauskas, L. A., Rapport, L. J., Zubieta, J.-K., Wilde, E. A., & Berent, S. (2005). Face emotion perception and executive functioning deficits in depression. Journal of Clinical and Experimental Neuropsychology, 27(3), 320–333.
   PubMed Web of Science ®Google Scholar
• Langenecker, S. A., Caveney, A. F., Giordani, B., Young, E. A., Nielson, K. A., Rapport, L. J., … Zubieta, J.-K. (2007). The sensitivity and psychometric properties of a brief computer-based cognitive screening battery in a depression clinic. Psychiatry Research, 152(2), 143–154.
   PubMed Web of Science ®Google Scholar
• Lockwood, K. A., Alexopoulos, G. S., & Van Gorp, W. G. (2002). Executive dysfunction in geriatric depression. American Journal of Psychiatry, 159(7), 1119–1126.
   PubMed Web of Science ®Google Scholar
• McEwen, B. S. (1999). Stress and hippocampal plasticity. Annual Review of Neuroscience, 22(1), 105–122.
   PubMedGoogle Scholar
• Morimoto, S. S., Gunning, F. M., Kanellopoulos, D., Murphy, C. F., Klimstra, S. A., Kelly, R. E., & Alexopoulos, G. S. (2012). Semantic organizational strategy predicts verbal memory and remission rate of geriatric depression. International Journal of Geriatric Psychiatry, 27(5), 506–512.
   PubMed Web of Science ®Google Scholar
• Murri, M. B., Pariante, C., Mondelli, V., Masotti, M., Atti, A. R., Mellacqua, Z., … Amore, M. (2014). HPA axis and aging in depression: Systematic review and meta-analysis. Psychoneuroendocrinology, 41, 46–62.
   PubMed Web of Science ®Google Scholar
• Naismith, S. L., Norrie, L. M., Mowszowski, L., & Hickie, I. B. (2012). The neurobiology of depression in later-life: Clinical, neuropsychological, neuroimaging and pathophysiological features. Progress in Neurobiology, 98(1), 99–143.
   PubMed Web of Science ®Google Scholar
• Nemeroff, C. B. (2016). Paradise lost: The neurobiological and clinical consequences of child abuse and neglect. Neuron, 89(5), 892–909.
   PubMed Web of Science ®Google Scholar
• O’Brien, J. T., Lloyd, A., McKeith, I., Gholkar, A., & Ferrier, N. (2004). A longitudinal study of hippocampal volume, cortisol levels, and cognition in older depressed subjects. American Journal of Psychiatry, 161(11), 2081–2090.
   PubMed Web of Science ®Google Scholar
• O’Hara, R., Schröder, C. M., Mahadevan, R., Schatzberg, A. F., Lindley, S., Fox, S., … Hallmayer, J. F. (2007). Serotonin transporter polymorphism, memory and hippocampal volume in the elderly: Association and interaction with cortisol. Molecular Psychiatry, 12(6), 544–555.
   PubMed Web of Science ®Google Scholar
• Otte, C., Hart, S., Neylan, T. C., Marmar, C. R., Yaffe, K., & Mohr, D. C. (2005). A meta-analysis of cortisol response to challenge in human aging: Importance of gender. Psychoneuroendocrinology, 30(1), 80–91.
   PubMed Web of Science ®Google Scholar
• Otte, C., Wingenfeld, K., Kuehl, L. K., Kaczmarczyk, M., Richter, S., Quante, A., … Hinkelmann, K. (2015). Mineralocorticoid receptor stimulation improves cognitive function and decreases cortisol secretion in depressed patients and healthy individuals. Neuropsychopharmacology, 40(2), 386–393.
   PubMed Web of Science ®Google Scholar
• Otte, C., Wingenfeld, K., Kuehl, L. K., Richter, S., Regen, F., Piber, D., & Hinkelmann, K. (2015). Cognitive function in older adults with major depression: Effects of mineralocorticoid receptor stimulation. Journal of Psychiatric Research, 69(SupplementC), 120–125.
   PubMedGoogle Scholar
• Penninx, B. W. J. H., Beekman, A. T. F., Corsi, A. M., Bremmer, M., Hoogendijk, W. J., Guralnik, J. M., … Bandinelli, S. (2007). Late-life depressive symptoms are associated with both hyperactivity and hypoactivity of the hypothalamo-pituitary-adrenal axis. The American Journal of Geriatric Psychiatry, 15(6), 522–529.
   PubMed Web of Science ®Google Scholar
• Pruessner, J. C., Kirschbaum, C., Meinlschmid, G., & Hellhammer, D. H. (2003). Two formulas for computation of the area under the curve represent measures of total hormone concentration versus time-dependent change. Psychoneuroendocrinology, 28(7), 916–931.
   PubMed Web of Science ®Google Scholar
• Reppermund, S., Zihl, J., Lucae, S., Horstmann, S., Kloiber, S., Holsboer, F., & Ising, M. (2007). Persistent cognitive impairment in depression: The role of psychopathology and altered hypothalamic-pituitary-adrenocortical (HPA) system regulation. Biological Psychiatry, 62(5), 400–406.
   PubMed Web of Science ®Google Scholar
• Rock, P. L., Roiser, J. P., Riedel, W. J., & Blackwell, A. D. (2013). Cognitive impairment in depression: A systematic review and meta-analysis. Psychological Medicine, 1–12. doi:10.1017/S0033291713002535
   Web of Science ®Google Scholar
• Ruff, R. M., Light, R. H., Parker, S. B., & Levin, H. S. (1996). Benton controlled oral word association test: Reliability and updated norms. Archives of Clinical Neuropsychology, 11(4), 329–338.
   PubMed Web of Science ®Google Scholar
• Schatzberg, A. F., Keller, J., Tennakoon, L., Lembke, A., Williams, G., Kraemer, F. B., … Murphy, G. M. (2014). HPA axis genetic variation, cortisol and psychosis in major depression. Molecular Psychiatry, 19(2), 220–227.
   PubMed Web of Science ®Google Scholar
• Segerstrom, S. C., Geiger, P. J., Boggero, I. A., Schmitt, F. A., & Sephton, S. E. (2016). Endogenous cortisol exposure and declarative verbal memory: A longitudinal study of healthy older adults. Psychosomatic Medicine, 78(2), 182.
   PubMed Web of Science ®Google Scholar
• Sexton, C. E., McDermott, L., Kalu, U. G., Herrmann, L. L., Bradley, K. M., Allan, C. L., … Ebmeier, K. P. (2012). Exploring the pattern and neural correlates of neuropsychological impairment in late-life depression. Psychological Medicine, 42(6), 1195–1202.
   PubMed Web of Science ®Google Scholar
• Smart, C., Strathdee, G., Watson, S., Murgatroyd, C., & McAllister-Williams, R. H. (2015). Early life trauma, depression and the glucocorticoid receptor gene – An epigenetic perspective. Psychological Medicine, 45(16), 3393–3410.
   PubMed Web of Science ®Google Scholar
• Starkman, M. N., Giordani, B., Berent, S., Schork, M. A., & Schteingart, D. E. (2001). Elevated cortisol levels in Cushing’s disease are associated with cognitive decrements. Psychosomatic Medicine, 63(6), 985–993.
   PubMed Web of Science ®Google Scholar
• Stetler, C., & Miller, G. E. (2011). Depression and hypothalamic-pituitary-adrenal activation: A quantitative summary of four decades of research. Psychosomatic Medicine, 73(2), 114–126.
   PubMed Web of Science ®Google Scholar
• Taylor, W. D., Aizenstein, H. J., & Alexopoulos, G. S. (2013). The vascular depression hypothesis: Mechanisms linking vascular disease with depression. Molecular Psychiatry, 18(9), mp201320.
   Web of Science ®Google Scholar
• Vythilingam, M., Vermetten, E., Anderson, G. M., Luckenbaugh, D., Anderson, E. R., Snow, J., … Bremner, J. D. (2004). Hippocampal volume, memory, and cortisol status in major depressive disorder: Effects of treatment. Biological Psychiatry, 56(2), 101–112.
   PubMed Web of Science ®Google Scholar
• Yeh, Y.-C., Tsang, H.-Y., Lin, P.-Y., Kuo, Y.-T., Yen, C.-F., Chen, -C.-C., … Chen, C.-S. (2011). Subtypes of mild cognitive impairment among the elderly with major depressive disorder in remission. The American Journal of Geriatric Psychiatry, 19(11), 923–931.
   PubMed Web of Science ®Google Scholar
• Yokoyama, K., Yamada, T., Mitani, H., Yamada, S., Pu, S., Yamanashi, T., … Kaneko, K. (2015). Relationship between hypothalamic–Pituitary–Adrenal axis dysregulation and insulin resistance in elderly patients with depression. Psychiatry Research, 226(2), 494–498.
   PubMed Web of Science ®Google Scholar