The Influence of Neuropathology on the fMRI Signal: A Measurement of Brain or Vein?

REFERENCES

• An , H. , Lin , W. , Celik , A. , & Lee , Y. Z. ( 2001 ). Quantitative measurements of cerebral metabolic rate of oxygen utilization using MRI: A volunteer study . NMR in Biomedicine , 14 ( 7–8 ), 441 – 447 .
   Google Scholar
• Au Duong , M. V. , Boulanouar , K. , Audoin , B. , Treseras , S. , Ibarrola , D. , et al. . ( 2005 ). Modulation of effective connectivity inside the working memory network in patients at the earliest stage of multiple sclerosis . Neuroimage , 24 ( 2 ), 533 – 538 .
   PubMed Web of Science ®Google Scholar
• Audoin , B. , Ibarrola , D. , Ranjeva , J. P. , Confort-Gouny , S. , Malikova , I. , et al. . ( 2003 ). Compensatory cortical activation observed by fMRI during a cognitive task at the earliest stage of ms . Human Brain Mapping , 20 ( 2 ), 51 – 58 .
   PubMed Web of Science ®Google Scholar
• Audoin , B. , Van Au Duong , M. , Ranjeva , J. P. , Ibarrola , D. , Malikova , I. , et al. . ( 2005 ). Magnetic resonance study of the influence of tissue damage and cortical reorganization on PASAT performance at the earliest stage of multiple sclerosis . Human Brain Mapping , 24 ( 3 ), 216 – 228 .
   PubMed Web of Science ®Google Scholar
• Barbier , E. L. , Lamalle , L. , & Decorps , M. ( 2001 ). Methodology of brain perfusion imaging . Journal of Magnetic Resonance Imaging , 13 ( 4 ), 496 – 520 .
   Web of Science ®Google Scholar
• Biagas , K. V. , Grundl , P. D. , Kochanek , P. M. , Schiding , J. K. , & Nemoto , E. M. ( 1996 ). Posttraumatic hyperemia in immature, mature, and aged rats: Autoradiographic determination of cerebral blood flow . Journal of Neurotrauma , 13 ( 4 ), 189 – 200 .
   Web of Science ®Google Scholar
• Biswal , B. , DeYoe , A. E. , & Hyde , J. S. ( 1996 ). Reduction of physiological fluctuations in fMRI using digital filters . Magnetic Resonance in Medicine , 35 ( 1 ), 107 – 113 .
   Web of Science ®Google Scholar
• Biswal , B. B. & Hyde , J. S. ( 1997 ). Contour-based registration technique to differentiate between task-activated and head motion-induced signal variations in fMRI . Magnetic Resonance in Medicine , 38 ( 3 ), 470 – 476 .
   PubMed Web of Science ®Google Scholar
• Biswal , B. B. , Pathak , A. P. , Ulmer , J. L. , & Hudetz , A. G. ( 2003 ). Decoupling of the hemodynamic and activation-induced delays in functional magnetic resonance imaging . Journal of Computer Assisted Tomography , 27 ( 2 ), 219 – 225 .
   PubMed Web of Science ®Google Scholar
• Bouma , G. J. , Muizelaar , J. P. , Choi , S. C. , Newlon , P. G. , & Young , H. F. ( 1991 ). Cerebral circulation and metabolism after severe traumatic brain injury: The elusive role of ischemia . Journal of Neurosurgery , 75 ( 5 ), 685 – 693 .
   PubMed Web of Science ®Google Scholar
• Chang , L. , Ernst , T. , Leonido-Yee , M. , & Speck , O. ( 2000 ). Perfusion mri detects rCBF abnormalities in early stages of HIV-cognitive motor complex . Neurology , 54 ( 2 ), 389 – 396 .
   PubMed Web of Science ®Google Scholar
• Chang , L. , Speck , O. , Miller , E. N. , Braun , J. , Jovicich , J. , et al. . ( 2001 ). Neural correlates of attention and working memory deficits in HIV patients . Neurology , 57 ( 6 ), 1001 – 1007 .
   PubMed Web of Science ®Google Scholar
• Chen , J. K. , Johnston , K. M. , Frey , S. , Petrides , M. , Worsley , K. , & Ptito , A. ( 2004 ). Functional abnormalities in symptomatic concussed athletes: An fMRI study . Neuroimage , 22 ( 1 ), 68 – 82 .
   PubMed Web of Science ®Google Scholar
• Christodoulou , C. , DeLuca , J. , Ricker , J. H. , Madigan , N. K. , Bly , B. M. , et al. . ( 2001 ). Functional magnetic resonance imaging of working memory impairment after traumatic brain injury . Journal of Neurology, Neurosurgery and Psychiatry , 71 ( 2 ), 161 – 168 .
   PubMed Web of Science ®Google Scholar
• D'Esposito , M. , Deouell , L. Y. , & Gazzaley , A. ( 2003 ). Alterations in the bold fMRI signal with ageing and disease: A challenge for neuroimaging . Nature Reviews Neuroscience , 4 ( 11 ), 863 – 872 .
   PubMed Web of Science ®Google Scholar
• D'Esposito , M. , Zarahn , E. , Aguirre , G. K. , & Rypma , B. ( 1999 ). The effect of normal aging on the coupling of neural activity to the bold hemodynamic response . Neuroimage , 10 ( 1 ), 6 – 14 .
   PubMed Web of Science ®Google Scholar
• Desmond , J. E. & Annabel Chen , S. H. ( 2002 ). Ethical issues in the clinical application of fMRI: Factors affecting the validity and interpretation of activations . Brain and Cognition , 50 ( 3 ), 482 – 497 .
   PubMed Web of Science ®Google Scholar
• Ernst , T. , Chang , L. , & Arnold , S. (2003). Increased glial metabolites predict increased working memory network activation in HIV brain injury. Neuroimage , 19(4), 1686–1693.
   Web of Science ®Google Scholar
• Ernst , T. , Chang , L. , Jovicich , J. , Ames , N. , & Arnold , S. ( 2002 ). Abnormal brain activation on functional MRI in cognitively asymptomatic HIV patients . Neurology , 59 ( 9 ), 1343 – 1349 .
   PubMed Web of Science ®Google Scholar
• Forbes , M. L. , Hendrich , K. S. , Kochanek , P. M. , Williams , D. S. , Schiding , J. K. , et al. . ( 1997 ). Assessment of cerebral blood flow and Co2 reactivity after controlled cortical impact by perfusion magnetic resonance imaging using arterial spin-labeling in rats . Journal of Cerebral Blood Flow and Metabolism , 17 ( 8 ), 865 – 874 .
   PubMed Web of Science ®Google Scholar
• Golding , E. M. ( 2002 ). Sequelae following traumatic brain injury. The cerebrovascular perspective . Brain Research and Brain Research Review , 38 ( 3 ), 377 – 388 .
   PubMed Web of Science ®Google Scholar
• Grossman , M. , Koenig , P. , DeVita , C. , Glosser , G. , Moore , P. , et al. . ( 2003a ). Neural basis for verb processing in Alzheimer's disease: An fMRI study . Neuropsychology , 17 ( 4 ), 658 – 674 .
   PubMed Web of Science ®Google Scholar
• Grossman , M. , Koenig , P. , Glosser , G. , DeVita , C. , Moore , P. , et al. . ( 2003b ). Neural basis for semantic memory difficulty in Alzheimer's disease: An fMRI study . Brain , 126 ( Pt 2 ), 292 – 311 .
   Google Scholar
• Harrison-Felix , C. , Newton , N. , Hall , K. M. , & Kreutzer , J. S. ( 1996 ). Descriptive findings from the traumatic brain injury model systems national database . Journal of Head Trauma Rehabilitation , 11 ( 5 ), 1 – 14 .
   Web of Science ®Google Scholar
• Hattori , N. , Huang , S. C. , Wu , H. M. , Liao , W. , Glenn , T. C. , et al. . ( 2003 ). Pet investigation of post-traumatic cerebral blood volume and blood flow . Acta Neurochirurgica Supplement , 86 , 49 – 52 .
   PubMedGoogle Scholar
• Hattori , N. , Huang , S. C. , Wu , H. M. , Liao , W. , Glenn , T. C. , et al. . ( 2004 ). Acute changes in regional cerebral (18)f-FDG kinetics in patients with traumatic brain injury . Journal of Nuclear Medicine , 45 ( 5 ), 775 – 783 .
   Web of Science ®Google Scholar
• Hennig , J. , Speck , O. , Koch , M. A. , & Weiller , C. ( 2003 ). Functional magnetic resonance imaging: A review of methodological aspects and clinical applications . Journal of Magnetic Resonance Imaging , 18 ( 1 ), 1 – 15 .
   PubMed Web of Science ®Google Scholar
• Hillary , F. G. , Chiaravalloti , N. D. , Ricker , J. H. , Steffener , J. , Bly , B. M. , et al. . ( 2003 ). An investigation of working memory rehearsal in multiple sclerosis using fMRI . Journal of Clinical and Experimental Neuropsychology , 25 ( 7 ), 965 – 978 .
   PubMed Web of Science ®Google Scholar
• Kamper , A. M. , Spilt , A. , de Craen , A. J. , van Buchem , M. A. , Westendorp , R. G. , & Blauw , G. J. ( 2004 ). Basal cerebral blood flow is dependent on the nitric oxide pathway in elderly but not in young healthy men . Experimental Gerontology , 39 ( 8 ), 1245 – 1248 .
   Web of Science ®Google Scholar
• Kannurpatti , S. S. , Biswal , B. B. , & Hudetz , A. G. , ( 2003 ). Regional dynamics of the fMRI-BOLD signal response to hypoxia-hypercapnia in the rat brain . Journal of Magnetic Resonance Imaging , 17 ( 6 ), 641 – 647 .
   Web of Science ®Google Scholar
• Kastrup , A. , Kruger , G. , Neumann-Haefelin , T. , & Moseley , M. E. ( 2001 ). Assessment of cerebrovascular reactivity with functional magnetic resonance imaging: Comparison of co(2) and breath holding . Magnetic Resonance Imaging , 19 ( 1 ), 13 – 20 .
   Web of Science ®Google Scholar
• Kastrup , A. , Li , T. Q. , Glover , G. H. , & Moseley , M. E. ( 1999 ). Cerebral blood flow-related signal changes during breath-holding . AJNR American Journal of Neuroradiology , 20 ( 7 ), 1233 – 1238 .
   Web of Science ®Google Scholar
• Kastrup , A. , Li , T. Q. , Takahashi , A. , Glover , G. H. , & Moseley , M. E. ( 1998 ). Functional magnetic resonance imaging of regional cerebral blood oxygenation changes during breath holding . Stroke , 29 ( 12 ), 2641 – 2645 .
   Web of Science ®Google Scholar
• Kochanek , P. M. , Hendrich , K. S. , Dixon , C. E. , Schiding , J. K. , Williams , D. S. , & Ho , C. ( 2002 ). Cerebral blood flow at one year after controlled cortical impact in rats: Assessment by magnetic resonance imaging . Journal of Neurotrauma , 19 ( 9 ), 1029 – 1037 .
   Web of Science ®Google Scholar
• Kochanek , P. M. , Marion , D. W. , Zhang , W. , Schiding , J. K. , White , M. , et al.. (1995). Severe controlled cortical impact in rats: Assessment of cerebral edema, blood flow, and contusion volume. Journal of Neurotrauma , 12(6), 1015–1025.
   Web of Science ®Google Scholar
• Law , M. , Saindane , A. M. , Ge , Y. , Babb , J. S. , Johnson , G. , et al. . ( 2004 ). Microvascular abnormality in relapsing-remitting multiple sclerosis: Perfusion MR imaging findings in normal-appearing white matter . Radiology , 231 ( 3 ), 645 – 652 .
   PubMed Web of Science ®Google Scholar
• Levin , H. S. ( 1995 ). Prediction of recovery from traumatic brain injury . Journal of Neurotrauma , 12 ( 5 ), 913 – 922 .
   PubMed Web of Science ®Google Scholar
• Li , T. Q. , Kastrup , A. , Takahashi , A. M. , & Moseley , M. E. ( 1999 ). Functional MRI of human brain during breath holding by BOLD and FAIR techniques . Neuroimage , 9 ( 2 ), 243 – 249 .
   Web of Science ®Google Scholar
• Mainero , C. , Caramia , F. , Pozzilli , C. , Pisani , A. , Pestalozza , I. , et al. . ( 2004 ). fMRI evidence of brain reorganization during attention and memory tasks in multiple sclerosis . Neuroimage , 21 ( 3 ), 858 – 867 .
   PubMed Web of Science ®Google Scholar
• Maini , C. L. , Pigorini , F. , Pau , F. M. , Volpini , V. , Galgani , S. , et al. . ( 1990 ). Cortical cerebral blood flow in HIV-1-related dementia complex . Nuclear Medicine Communications , 11 ( 9 ), 639 – 648 .
   PubMed Web of Science ®Google Scholar
• Mandeville , J. B. , Marota , J. J. , Kosofsky , B. E. , Keltner , J. R. , Weissleder , R. , et al. . ( 1998 ). Dynamic functional imaging of relative cerebral blood volume during rat forepaw stimulation . Magnetic Resonance in Medicine , 39 ( 4 ), 615 – 624 .
   PubMed Web of Science ®Google Scholar
• Mandzia , J. , Black , S. , Grady , C. , McAndrews , M. P. , & Graham , S. ( 2002 ). Encoding and retrieval in aging and memory loss, a fMRI study . Brain and Cognition , 49 ( 2 ), 225 – 228 .
   Web of Science ®Google Scholar
• Manoach , D. S. , Gollub , R. L. , Benson , E. S. , Searl , M. M. , Goff , D. C. , et al. . ( 2000 ). Schizophrenic subjects show aberrant fMRI activation of dorsolateral prefrontal cortex and basal ganglia during working memory performance . Biological Psychiatry , 48 ( 2 ), 99 – 109 .
   PubMed Web of Science ®Google Scholar
• Martin , N. A. , Patwardhan , R. V. , Alexander , M. J. , Africk , C. Z. , Lee , J. H. , et al. . ( 1997 ). Characterization of cerebral hemodynamic phases following severe head trauma: Hypoperfusion, hyperemia, and vasospasm . Journal of Neurosurgery , 87 ( 1 ), 9 – 19 .
   PubMed Web of Science ®Google Scholar
• McAllister , T. W. , Saykin , A. J. , Flashman , L. A. , Sparling , M. B. , Johnson , S. C. , et al. . ( 1999 ). Brain activation during working memory 1 month after mild traumatic brain injury: A functional MRI study . Neurology , 53 ( 6 ), 1300 – 1308 .
   PubMed Web of Science ®Google Scholar
• McAllister , T. W. , Sparling , M. B. , Flashman , L. A. , Guerin , S. J. , Mamourian , A. C. , & Saykin , A. J. ( 2001 ). Differential working memory load effects after mild traumatic brain injury . Neuroimage , 14 ( 5 ), 1004 – 1012 .
   PubMed Web of Science ®Google Scholar
• Meltzer , C. C. , Cantwell , M. N. , Greer , P. J. , Ben-Eliezer , D. , Smith , G. , et al. . ( 2000 ). Does cerebral blood flow decline in healthy aging? A pet study with partial-volume correction . Journal of Nuclear Medicine , 41 ( 11 ), 1842 – 1848 .
   Web of Science ®Google Scholar
• Perlstein , W. M. , Carter , C. S. , Noll , D. C. , & Cohen , J. D. ( 2001 ). Relation of prefrontal cortex dysfunction to working memory and symptoms in schizophrenia . American Journal of Psychiatry , 158 ( 7 ), 1105 – 1113 .
   PubMed Web of Science ®Google Scholar
• Perlstein , W. M. , Cole , M. A. , Demery , J. A. , Seignourel , P. J. , Dixit , N. K. , et al. . ( 2004 ). Parametric manipulation of working memory load in traumatic brain injury: Behavioral and neural correlates . Journal of the International Neuropsychological Society , 10 ( 5 ), 724 – 741 .
   PubMed Web of Science ®Google Scholar
• Perlstein , W. M. , Dixit , N. K. , Carter , C. S. , Noll , D. C. , & Cohen , J. D. ( 2003 ). Prefrontal cortex dysfunction mediates deficits in working memory and prepotent responding in schizophrenia . Biological Psychiatry , 53 ( 1 ), 25 – 38 .
   PubMed Web of Science ®Google Scholar
• Prigatano , G. P. , Johnson , S. C. , & Gale , S. D. (2004). Neuroimaging correlates of the Halstead finger tapping test several years post-traumatic brain injury. Brain Injury , 18(7), 661–669.
   PubMed Web of Science ®Google Scholar
• Ricker , J. H. , Hillary , F. G. , & DeLuca , J. ( 2001 ). Functionally activated brain imaging (o-15 PET and fMRI) in the study of learning and memory after traumatic brain injury . Journal of Head Trauma Rehabilitation , 16 ( 2 ), 191 – 205 .
   Web of Science ®Google Scholar
• Rosenthal , M. , & Ricker , J. H. ( 2000 ). Traumatic brain injury . In R. G. Frank & T. R. Elliot (Eds.), Handbook of rehabilitation psychology (pp. 56 – 57 ). Washington DC : American Psychological Association .
   Google Scholar
• Schroder , M. L. , Muizelaar , J. P. , Kuta , A. J. , & Choi , S. C. ( 1996 ). Thresholds for cerebral ischemia after severe head injury: Relationship with late CT findings and outcome . Journal of Neurotrauma , 13 ( 1 ), 17 – 23 .
   PubMed Web of Science ®Google Scholar
• Segatore , M. , & Way , C. ( 1992 ). The Glasgow Coma Scale: Time for a change . Heart & Lung , 21 , 548 – 557 .
   PubMed Web of Science ®Google Scholar
• Sierra , C. , de la Sierra , A. , Chamorro , A. , Larrousse , M. , Domenech , M. , & Coca , A. ( 2004 ). Cerebral hemodynamics and silent cerebral white matter lesions in middle-aged essential hypertensive patients . Blood Pressure , 13 ( 5 ), 304 – 309 .
   PubMed Web of Science ®Google Scholar
• Staffen , W. , Mair , A. , Zauner , H. , Unterrainer , J. , Niederhofer , H. , et al. . ( 2002 ). Cognitive function and fMRI in patients with multiple sclerosis: Evidence for compensatory cortical activation during an attention task . Brain , 125 ( Pt 6 ), 1275 – 1282 .
   Google Scholar
• Sutton , R. L. , Hovda , D. A. , Adelson , P. D. , Benzel , E. C. , & Becker , D. P. ( 1994 ). Metabolic changes following cortical contusion: Relationships to edema and morphological changes . Acta Neurochirurgica Supplement (Wien) , 60 , 446 – 448 .
   PubMedGoogle Scholar
• Swank , R. L. , Roth , J. G. , & Woody , D. C. Jr. ( 1983 ). Cerebral blood flow and red cell delivery in normal subjects and in multiple sclerosis . Neurological Research , 5 ( 1 ), 37 – 59 .
   Google Scholar
• Tran Dinh , Y. R. , Mamo , H. , Cervoni , J. , Caulin , C. , & Saimot , A. C. ( 1990 ). Disturbances in the cerebral perfusion of human immune deficiency virus-1 seropositive asymptomatic subjects: A quantitative tomography study of 18 cases . Journal of Nuclear Medicine , 31 ( 10 ), 1601 – 1607 .
   PubMed Web of Science ®Google Scholar
• Turner , R. , Le Bihan , D. , Moonen , C. T. , Despres , D. , & Frank , J. ( 1991 ). Echo-planar time course MRI of cat brain oxygenation changes . Magnetic Resonance in Medicine , 22 ( 1 ), 159 – 166 .
   Web of Science ®Google Scholar
• Wishart , H. A. , Saykin , A. J. , McDonald , B. C. , Mamourian , A. C. , Flashman , L. A. , et al. . ( 2004 ). Brain activation patterns associated with working memory in relapsing-remitting MS . Neurology , 62 ( 2 ), 234 – 238 .
   PubMed Web of Science ®Google Scholar
• Yamaki , T. , Imahori , Y. , Ohmori , Y. , Yoshino , E. , Hohri , T. , et al. . ( 1996a ). Cerebral hemodynamics and metabolism of severe diffuse brain injury measured by pet . Journal of Nuclear Medicine , 37 ( 7 ), 1166 – 1170 .
   Web of Science ®Google Scholar
• Yamaki , T. , Yoshino , E. , Fujimoto , M. , Ohmori , Y. , Imahori , Y. , & Ueda , S. ( 1996b ). Chronological positron emission tomographic study of severe diffuse brain injury in the chronic stage . Journal of Trauma , 40 ( 1 ), 50 – 56 .
   PubMed Web of Science ®Google Scholar
• Zaharchuk , G. , Mandeville , J. B. , Bogdanov , A. A. Jr. , Weissleder , R. , Rosen , B. R. , & Marota , J. J. ( 1999 ). Cerebrovascular dynamics of autoregulation and hypoperfusion. An MRI study of CBF and changes in total and microvascular cerebral blood volume during hemorrhagic hypotension . Stroke , 30 ( 10 ), 2197 – 2204 ; discussion, 2204–2195 .
   Web of Science ®Google Scholar