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Research Article

Synthesis and screening of anti-cancer, antioxidant, and anti-inflammatory activities of novel galloyl pyrazoline derivatives

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Pages 854-863 | Received 18 Oct 2008, Accepted 27 Dec 2008, Published online: 09 Jun 2009

References

  • Abdel-Aziz M, Matsuda K, Otsuka M, Uyeda M, Okawara T, Suzuki K (2004): Inhibitory activities against topoisomerase I and II by polyhydroxybenzoyl amide derivatives and their structure-activity relationship. Bioorg Med Chem Lett 14: 1669–1672.
  • Amir M, Kumar H, Khan SA (2008): Synthesis and pharmacological evaluation of pyrazoline derivatives as new anti- inflammatory and analgesic agents. Bioorg Med Chem Lett 18: 918–922.
  • Bansal E, Srivastava VK, Kumar A (2001): Synthesis and anti-inflammatory activity of 1-acetyl-5-substituted aryl-3-(beta-aminonaphthyl)-2-pyrazolines and beta-(substituted aminoethyl) amidonaphthalenes. Eur J Med Chem 36: 81–92.
  • Barsoum FF, Hosni HM, Girgis AS (2006): Novel bis(1-acyl-2-pyrazolines) of potential anti-inflammatory and molluscicidal properties. Bioorg Med Chem 14: 3929–3937.
  • Beckman KB, Ames BN (1998): The free radical theory of aging matures. Physiol Rev 78: 447–581.
  • Bhat BA, Dhar KL, Puri SC, Saxena AK, Shanmugavel M, Qazi GN (2005): Isolation, characterization and biological evaluation of datura lactones as potential immunomodulators. Bioorg Med Chem Lett 15: 3177–3180.
  • Block G (1992): The data support a role for antioxidants in reducing cancer risk. Nutr Rev 50: 207–213.
  • Gazit A, Yaish P, Gilon C, Levitzki A (1989): Tyrphostins I: Synthesis and biological activity of protein tyrosine kinase inhibitors. J Med Chem 32: 2344–2352.
  • Gerhäuser C, Klimo K, Heiss E, Neumann I, Gamal-Eldeen A, Knauft J, Liu JU, Sitthimonchai S, Frank N (2003): Mechanism-based in vitro screening of potential cancer chemopreventive agents. Mutat Res 523–524: 163–172.
  • Girotti M, Evans JH, Burke D, Leslie CC (2004): Cytosolic phospholipase A2 translocates to forming phagosomes during phagocytosis of zymosan in macrophages. J Biol Chem 279: 19113–19121.
  • Hansen MB, Nielsen SE, Berg K (1989): Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill. J Immunol Methods 119: 203–210.
  • Hu L, Gunn C, Beckman J (1992): Bactericidal activity of peroxynitrite. Arch Biochem Biophys 298: 452–457.
  • Jang M, Cai L, Udeani OG, Slowing VK, Thomas FC, et al. (1997): Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 275: 218–220.
  • Karthikeyan MS, Holla BS, Kumari NS (2007): Synthesis and antimicrobial studies on novel chloro-fluorine containing hydroxy pyrazolines. Eur J Med Chem 42: 30–36.
  • MacMicking J, Xie QW, Nathan C (1997): Nitric oxide and macrophage function. Annu Rev Immunol 15:323–350.
  • Nazir N, Koul S, Qurishi MA, Taneja SC, Ahmad SF, Bani Sg, Qazi GN (2007): Immunomodulatory effect of bergenin and norbergenin against adjuvant-induced arthritis: a flow cytometric study. J Ethnopharmacol 112: 401–405.
  • Oh GS, Pae HO, Oh H, Hong SG, Kim IK, Chai KY, Yun YG, Kwon TO, Chung HT (2001): In vitro anti-proliferative effect of 1,2,3,4,6-penta-O-galloyl-beta-D-glucose on human hepatocellular carcinoma cell line, SK-HEP-1 cells. Cancer Lett 174: 17–24.
  • Okuda T (2005): Systematics and health effects of chemically distinct tannins in medicinal plants. Phytochemistry 66: 2012–2031.
  • Palaska E, Erol D, Demirdamar R (1996): Synthesis and antidepressant activities of some 1,3,5-triphenyl-2-pyrazolines. Eur J Med Chem 31: 43–47.
  • Rani P, Srivastava VK, Kumar A (2004): Synthesis and antiinflammatory activity of heterocyclic indole derivatives. Eur J Med Chem 39: 449–452.
  • Rice-Evans AC, Miller NJ, Paganga G (1996): Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Radic Biol Med 20: 933–956.
  • Smith PK, Krohn R, Hermanson GT, Mallia AK, Gartner FH, Provenzano MD, Fujimoto EK, Goeke NM, Olson BJ, Klenk DC (1985): Measurement of protein using bicinchoninic acid. Anal Biochem 150: 76–80.
  • Soni N, Pande K, Kalsi R, Gupta TK, Parmer SS, Barthwal JP (1987): Inhibition of rat brain monoamine oxidase and succinic dehydrogenase by anticonvulsant pyrazolines. Res Commun Chem Pathol Pharm 56: 129–132.
  • Torres de Pinedo A, Peñalver P, Morales JC (2007): New phenolic-based antioxidants: structure-activity relationships. Food Chem 103: 55–61.
  • Van Amsterdam FT, Roveri A, Maiorino M, Ratti E, Ursini F (1992) Lacidipine: A dihydropyridine calcium antagonist with antioxidant activity. Bio Med 12: 183–187.
  • Visioli F, Bellomo G, Montedoro G, Galli C (1995): Low density lipoprotein oxidation is inhibited in vitro by olive oil constituents. Atherosclerosis 117: 25–32.
  • Yokozawa T, Chen CP, Dong E, Tanaka T, Nonaka G-I, Nishioka I (1998): Study on the inhibitory effect of tannins and flavonoids against the 1,1-diphenyl-2-picrylhydrazyl radical. Biochem Pharmacol 56: 213–222.
  • Zitouni GT, Chevallet P, Kiliç; FS, Erol K (2000): Synthesis of some thiazolyl-pyrazoline derivatives and preliminary investigation of their hypotensive activity. Eur J Med Chem 35:635–641.
  • Zitouni GT, Özdemir A, Gűven K (2005a): Synthesis of Some 1-[(N, N-substituted thiocar bamoylthio)acetyl]-3-(2-thienyl)-5-aryl-2-pyrazoline derivatives and investigation of their antibacterial and antifungal activities. Arch Pharm 338: 96–104.
  • Zitouni GT, Özdemir A, Kaplancikli ZA, Chevallet P, Tunali Y (2005b): Synthesis and antimicrobial activities of some 1-[(N,N-disubstitutedthiocarbamoylthio)acetyl]-3,5- diaryl-2-pyrazolines Phosphorus Sulfur Silicon Relat Elem 180:2717–2724.

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