Medicinal plants and natural products in amelioration of arsenic toxicity: a short review

References

• Abdul KSM, Jayasinghe SS, Chandana EPS, Jayasumana C, De Silva PMCS. 2015. Arsenic and human health effects: a review. Environ Toxicol Pharmacol. 40:828–846.
   PubMed Web of Science ®Google Scholar
• Acharyya N, Chattopadhyay S, Maiti S. 2014. Chemoprevention against arsenic-induced mutagenic DNA breakage and apoptotic liver damage in rat via antioxidant and SOD1 upregulation by green tea (Camellia sinensis) which recovers broken DNA resulted from arsenic-H2O2 related in vitro oxidant stress. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 32:338–361.
   PubMed Web of Science ®Google Scholar
• Adegboyega AM, Odunola OO. 2012. The modulatory effects of aqueous extracts of Viscum album and garlic on sodium arsenite induced toxicity in Wistar albino rat. J Chem Pharm Res. 4:4698–4701.
   Google Scholar
• Ahmad SA, Faruquee MH, Sayed MHSU, Khan MH, Jalil MA, Ahmed R, Hadi SA. 1998. Chronic arsenicosis: management by vitamin A, E, C regimen. J Prev Soc Med. 17:19–26.
   Google Scholar
• Banu GS, Kumar G, Murugesan AG. 2009. Effects of leaves extract of Ocimum sanctum L. on arsenic-induced toxicity in Wistar albino rats. Food Chem Toxicol. 47:490–495.
   PubMed Web of Science ®Google Scholar
• Bashar T, Misbahuddin M, Hossain MA. 2014. A double-blind, randomize, placebo-control trial to evaluate the effect of Nigella sativa on palmer arsenical keratosis patients. Bangladesh J Pharmacol. 9:15–21.
   Web of Science ®Google Scholar
• Baxla SL, Gora RH, Kerketta P, Patnaik S, Roy BK. 2014. Hepatoprotective activity of Tephrosia purpurea against arsenic induced toxicity in rats. Indian J Pharmacol. 46:197–200.
   PubMed Web of Science ®Google Scholar
• Bhattacharya S, Das SK, Haldar PK. 2014. Arsenic induced myocardial toxicity in rats: alleviative effect of Trichosanthes dioica fruit. J Diet Suppl. 11:248–261.
   PubMedGoogle Scholar
• Bhattacharya S, Haldar PK. 2012a. Ameliorative effect Trichosanthes dioica root against experimentally induced arsenic toxicity in male albino rats. Environ Toxicol Pharmacol. 33:394–402.
   PubMed Web of Science ®Google Scholar
• Bhattacharya S, Haldar PK. 2012b. Ameliorative effect Trichosanthes dioica root against arsenic-induced brain toxicity in albino rats. Toxicol Environ Chem. 94:769–778.
   Web of Science ®Google Scholar
• Bhattacharya S, Haldar PK. 2012c. Trichosanthes dioica fruit ameliorates experimentally induced arsenic toxicity in male albino rats through the alleviation of oxidative stress. Biol Trace Elem Res. 148:232–241.
   PubMed Web of Science ®Google Scholar
• Bhattacharya S, Haldar PK. 2013a. The triterpenoid fraction from Trichosanthes dioica root suppresses experimentally induced inflammatory ascites in rats. Pharm Biol. 51:1477–1479.
   PubMed Web of Science ®Google Scholar
• Bhattacharya S, Haldar PK. 2013b. Trichosanthes dioica root alleviates arsenic induced myocardial toxicity in rats. J Environ Pathol Toxicol Oncol. 32:251–261.
   PubMed Web of Science ®Google Scholar
• Biswas J, Roy S, Mukherjee S, Sinha D, Roy M. 2010. Indian spice curcumin may be an effective strategy to combat the genotoxicity of arsenic in Swiss albino mice. Asian Pacific J Cancer Prev. 11:239–246.
   PubMedGoogle Scholar
• Chandronitha C, Ananthi S, Ramakrishnan G, Lakshmisundaram R, Gayathri V, Vasanthi HR. 2010. Protective role of tannin-rich fraction of Camellia sinensis in tissue arsenic burden in Sprague Dawley rats. Hum Exp Toxicol. 29:705–719.
   PubMed Web of Science ®Google Scholar
• Chang SI, Jin B, Youn P, Park C, Park JD, Ryu DY. 2007. Arsenic-induced toxicity and the protective role of ascorbic acid in mouse testis. Toxicol Appl Pharmacol. 218:196–203.
   PubMed Web of Science ®Google Scholar
• Chatterjee A, Chatterji U. 2011. All-trans retinoic acid protects against arsenic-induced uterine toxicity in female Sprague-Dawley rats. Toxicol Appl Pharmacol. 257:250–263.
   PubMed Web of Science ®Google Scholar
• Cheng Y, Xue J, Jiang H, Wang M, Gao L, Ma D, Zhang Z. 2014. Neuroprotective effect of resveratrol on arsenic trioxide-induced oxidative stress in feline brain. Hum Exp Toxicol. 33:737–747.
   PubMed Web of Science ®Google Scholar
• Cheng Y, Xue J, Yao C, Gao L, Ma D, Liu Y, Zhang Z. 2013. Resveratrol ameliorates the oxidative damage induced by arsenic trioxide in the feline lung. J Vet Med Sci. 75:1139–1146.
   PubMed Web of Science ®Google Scholar
• Chowdhury NJA, Misbahuddin M, Rahman MS. 2009. Corn extracts lower tissue arsenic level in rat. Bangladesh Med Res Counc Bull. 35:21–25.
   PubMedGoogle Scholar
• Chowdhury R, Dutta A, Chaudhuri SR, Sharma N, Giri AK, Chaudhuri K. 2008. In vitro and in vivo reduction of sodium arsenite induced toxicity by aqueous garlic extract. Food Chem Toxicol. 46:740–751.
   PubMed Web of Science ®Google Scholar
• Das AK, Bag S, Sahu R, Dua TK, Sinha MK, Gangopadhyay M, Zaman K, Dewanjee S. 2010a. Protective effect of Corchorus olitorius leaves on sodium arsenite-induced toxicity in experimental rats. Food Chem Toxicol. 48:326–335.
   PubMed Web of Science ®Google Scholar
• Das AK, Dewanjee S, Sahu R, Dua TK, Gangopadhyay M, Sinha MK. 2010c. Protective effect of Corchorus olitorius leaves against arsenic-induced oxidative stress in rat brain. Environ Toxicol Pharmacol. 29:64–69.
   PubMed Web of Science ®Google Scholar
• Das AK, Sahu R, Dua TK, Bag S, Gangopadhyay M, Sinha MK, Dewanjee S. 2010b. Arsenic-induced myocardial injury: Protective role of Corchorus olitorius leaves. Food Chem Toxicol. 48:1210–1217.
   PubMed Web of Science ®Google Scholar
• Das R, Das A, Roy A, Kumari U, Bhattacharya S, Haldar PK. 2015. β-Carotene ameliorates arsenic-induced toxicity in albino mice. Biol Trace Elem Res. 164:226–233.
   PubMed Web of Science ®Google Scholar
• DuaTK, DewanjeeS, GangopadhyayG, KhanraR, Zia-Ul-HaqM, FeoVD. 2015. Ameliorative effect of water spinach, Ipomea aquatica (Convolvulaceae), against experimentally induced arsenic toxicity. J Translat Med. 13:81.
   PubMed Web of Science ®Google Scholar
• Fan Y, Wang C, Zhang Y, Hang P, Liu Y, Pan Z, Wang N, Du Z. 2013. Genistein ameliorates adverse cardiac effects induced by arsenic trioxide through preventing cardiomyocytes apoptosis. Cell Physiol Biochem. 31:80–91.
   PubMed Web of Science ®Google Scholar
• Flora SJ, Bhadauria S, Kannan GM, Singh N. 2007. Arsenic induced oxidative stress and the role of antioxidant supplementation during chelation: a review. J Environ Biol. 28:333–347.
   PubMed Web of Science ®Google Scholar
• Gao S, Duan X, Wang X, Dong D, Liu D, Li X, Sun G, Li B. 2013. Curcumin attenuates arsenic-induced hepatic injuries and oxidative stress in experimental mice through activation of Nrf2 pathway, promotion of arsenic methylation and urinary excretion. Food Chem Toxicol. 59:739–747.
   PubMed Web of Science ®Google Scholar
• Gbadegesin MA, Adegoke AM, Ewere EG, Odunola OA. 2014. Hepatoprotective and anticlastogenic effects of ethanol extract of Irvingia gabonensis (IG) leaves in sodium arsenite-induced toxicity in male Wistar rats. Niger J Physiol Sci. 29:29–36.
   PubMedGoogle Scholar
• Ghosh A, Mandal AK, Sarkar S, Panda S, Das N. 2009. Nanoencapsulation of quercetin enhances its dietary efficacy in combating arsenic-induced oxidative damage in liver and brain of rats. Life Sci. 84:75–80.
   PubMed Web of Science ®Google Scholar
• Gupta R, Kannan GM, Sharma M, Flora SJS. 2005. Therapeutic effects of Moringa oleifera on arsenic-induced toxicity in rats. Environ Toxicol Pharmacol. 20:456–464.
   PubMed Web of Science ®Google Scholar
• Herrera A, Pineda J, Antonio MT. 2013. Toxic effects of perinatal arsenic exposure on the brain of developing rats and the beneficial role of natural antioxidants. Environ Toxicol Pharmacol. 36:73–79.
   PubMed Web of Science ®Google Scholar
• Jahan S, Iftikhar N, Ullah H, Rukh G, Hussain I. 2015. Alleviative effect of quercetin on rat testis against arsenic: a histological and biochemical study. Syst Biol Reprod Med. 61:89–95.
   PubMed Web of Science ®Google Scholar
• Jomova K, Jenisova Z, Feszterova M, Baros S, Liska J, Hudecova D, Rhodes CJ, Valko M. 2011. Arsenic: toxicity, oxidative stress and human disease. J Appl Toxicol. 31:95–107.
   PubMed Web of Science ®Google Scholar
• Kadirvel R, Sundaram K, Mani S, Samuel S, Elango N, Panneerselvam C. 2007. Supplementation of ascorbic acid and alpha-tocopherol prevents arsenic-induced protein oxidation and DNA damage induced by arsenic in rats. Hum Exp Toxicol. 26:939–946.
   PubMed Web of Science ®Google Scholar
• Kapaj S, Peterson H, Liber K, Bhattacharya P. 2006 . Human health effects from chronic arsenic poisoning-a review. J Environ Sci Health A Tox Hazard Subst Environ Eng. 41:2399–2428.
   PubMed Web of Science ®Google Scholar
• Khan MAK, Choudhury SAR, Misbahuddin M, Islam AZMM, Shahjahan M. 2001. Effects of Spirulina in the treatment of chronic arsenic poisoning in Bangladesh. Bangladesh J Med Sci. 7:223–231.
   Google Scholar
• Khandker S, Dey RK, Islam AZMM, Ahmad SA, Al-Mahmud I. 2006. Arsenic-safe drinking water and antioxidants for the management of arsenicosis patients. Bangladesh J Pharmacol. 1:42–50.
   Google Scholar
• Kim HS, Kim YJ, Seo YR. 2015. An overview of carcinogenic heavy metal: molecular toxicity mechanism and prevention. J Cancer Prev. 20:232–240.
   PubMedGoogle Scholar
• Kumar A, Kumar R, Rahman MS, Iqubal MA, Anand G, Niraj PK, Ali M. 2015a. Phytoremedial effect of Withania somnifera against arsenic-induced testicular toxicity in Charles Foster rats. Avicenna J Phytomed. 5:355–364.
   PubMed Web of Science ®Google Scholar
• Kumar A, Kumar R, Rahman MS, Iqubal MA, Anand G, Niraj PK, Ali M. 2015b. Antidote effects of plants of Himalayan sub-origin against arsenic induced toxicity. Biol Chem Res. 2015:99–109.
   Google Scholar
• Lakshmi BVS, Sudhakar M, Sudha FJ, Gopal MV. 2015. Ameliorative effect of Triticum aestivum Linn against experimentally induced arsenic toxicity in male albino rats. Der Pharmacia Lettre. 7:202–211.
   Google Scholar
• Li SG, Ding YS, Niu Q, Xu SZ, Pang LJ, Ma RL, Jing MX, Feng GL, Liu JM, Guo SX. 2015. Grape seed proanthocyanidin extract alleviates arsenic-induced oxidative reproductive toxicity in male mice. Biomed Environ Sci. 28:272–280.
   PubMed Web of Science ®Google Scholar
• Li SG, Xu SZ, Niu Q, Ding YS, Pang LJ, Ma RL, Jing MX, Wang K, Ma XM, Feng GL, et al. 2016. Lutein alleviates arsenic-induced reproductive toxicity in male mice via Nrf2 signaling. Hum Exp Toxicol. 35:491–500.
   PubMed Web of Science ®Google Scholar
• Manna P, Sinha M, Sil PC. 2007. Protection of arsenic-induced hepatic disorder by arjunolic acid. Basic Clin Pharmacol Toxicol. 101:333–338.
   PubMed Web of Science ®Google Scholar
• Manna P, Sinha M, Sil PC. 2008a. Arsenic-induced oxidative myocardial injury: protective role of arjunolic acid. Arch Toxicol. 82:137–149.
   PubMed Web of Science ®Google Scholar
• Manna P, Sinha M, Sil PC. 2008b. Protection of arsenic-induced testicular oxidative stress by arjunolic acid. Redox Rep. 13:67–77.
   PubMed Web of Science ®Google Scholar
• Mazumder DNG, De BK, Santra A, Ghosh N, Das S, Lahiri S, Das T. 2001. Randomized placebo-controlled trial of 2,3-dimercapto-1-propanesulfonate (DMPS) in therapy of chronic arsenicosis due to drinking arsenic-contaminated water. J Toxicol Clin Toxicol. 39:665–674.
   PubMed Web of Science ®Google Scholar
• Mazumder DNG, Ghoshal UC, Saha J, Santra A, De BK, Chatterjee A, Dutta S, Angle CR, Centeno JA. 1998. Randomized placebo-controlled trial of 2,3-dimercaptosuccinic acid in therapy of chronic arsenicosis due to drinking arsenic-contaminated subsoil water. J Toxicol Clin Toxicol. 36:683–690.
   PubMed Web of Science ®Google Scholar
• Mazumder DNG. 2008. Chronic arsenic toxicity and human health. Indian J Med Res. 128:436–447.
   PubMed Web of Science ®Google Scholar
• Melkonian S, Argos M, Chen Y, Parvez F, Pierce B, Ahmed A, Islam T, Ahsan H. 2012. Intakes of several nutrients are associated with incidence of arsenic-related keratotic skin lesions in Bangladesh. J Nutr. 142:2128–2134.
   PubMed Web of Science ®Google Scholar
• Mershiba SD, Dassprakash MV, Saraswathy SD. 2013. Protective effect of naringenin on hepatic and renal dysfunction and oxidative stress in arsenic intoxicated rats. Mol Biol Rep. 40:3681–3691.
   PubMed Web of Science ®Google Scholar
• Misbahuddin M, Bashar T, Hossain MA. 2013. Effectiveness of garlic oil in the treatment of arsenical palmer keratosis. Bangladesh J Pharmacol. 8:22–27.
   Web of Science ®Google Scholar
• Misbahuddin M, Islam AZMM, Khandker S, Mahmud IA, Islam N. Anjumanara 2006. Efficacy of spirulina extract plus zinc in patients of chronic arsenic poisoning: a randomized placebo-controlled study. Clinical Toxicol. 44:135–141.
   PubMed Web of Science ®Google Scholar
• Mittal M, Flora SJ. 2007. Vitamin E supplementation protects oxidative stress during arsenic and fluoride antagonism in male mice. Drug Chem Toxicol. 30:263–281.
   PubMed Web of Science ®Google Scholar
• Mukherjee S, Roy M, Dey S, Bhattacharya RK. 2007. A mechanistic approach for modulation of arsenic toxicity in human lymphocytes by curcumin, an active constituent of medicinal herb Curcuma longa Linn. J Clin Biochem Nutr. 41:32–42.
   PubMed Web of Science ®Google Scholar
• Mukhopadhyay PK, Dey A, Mukherjee S, Pradhan NK. 2013. The effect of co-administration of α-tocopherol and ascorbic acid on arsenic trioxide-induced testicular toxicity in adult rats. J Basic Clin Physiol Pharmacol. 24:245–253.
   PubMedGoogle Scholar
• Muthumani M, Prabu SM. 2012. Silibinin potentially protects arsenic-induced oxidative hepatic dysfunction in rats. Toxicol Mech Methods. 22:277–288.
   PubMed Web of Science ®Google Scholar
• Muthumani M, Prabu SM. 2013. Silibinin attenuates arsenic induced alterations in serum and hepatic lipid profiles in rats. J Appl Pharm Sci. 3:132–138.
   Google Scholar
• Niu M, Li S, Niu Q, Xu S, Xiao J, Ding L, Liu J, Wen H, Feng G. 2015. Preventive effects of lutein on liver toxicity in mice induced by arsenic. Wei Sheng Yan Jiu. 44:615–619.
   PubMedGoogle Scholar
• Oyewole OI. 2011. Ameliorating effect of methanolic leaf extract of Azadirachta indica (neem) on arsenic induced oxidative damage in rat liver. Int J Toxicol Appl Pharmacol. 1:25–28.
   Google Scholar
• Prabu SM, Muthumani M. 2012. Silibinin ameliorates arsenic induced nephrotoxicity by abrogation of oxidative stress, inflammation and apoptosis in rats. Mol Biol Rep. 39:11201–11216.
   PubMed Web of Science ®Google Scholar
• Prabu SM, Sumedha NC. 2014 . Ameliorative effect of diallyl trisulphide on arsenic-induced oxidative stress in rat erythrocytes and DNA damage in lymphocytes. J Basic Clin Physiol Pharmacol. 25:181–197.
   PubMedGoogle Scholar
• Quayum SL. 2007. Effect of water hyacinth root extract on arsenic level in different organs of arsenic-treated rat. Bangladesh J Pharmacol. 2:73–80.
   Google Scholar
• Raihan SZ, Chowdhury AK, Rabbani GH, Marni F, Ali MS, Nahar L, Sarker SD. 2009. Effect of aqueous extracts of black and green teas in arsenic-induced toxicity in rabbits. Phytother Res. 23:1603–1608.
   PubMed Web of Science ®Google Scholar
• Ramanathan K, Anusuyadevi M, Shila S, Panneerselvam C. 2005. Ascorbic acid and alpha-tocopherol as potent modulators of apoptosis on arsenic induced toxicity in rats. Toxicol Lett. 156:297–306.
   PubMed Web of Science ®Google Scholar
• Ramanathan K, Balakumar BS, Panneerselvam C. 2002. Effects of ascorbic acid and alpha-tocopherol on arsenic-induced oxidative stress. Hum Exp Toxicol. 21:675–680.
   PubMed Web of Science ®Google Scholar
• Rana T, Bera AT, Das S, Pan D, Bandyopadhyay S, Bhattacharya D, De S, Sikdar S, Das SK. 2010. Effect of ascorbic acid on blood oxidative stress in experimental chronic arsenicosis in rodents. Food Chem Toxicol. 48:1072–1077.
   PubMed Web of Science ®Google Scholar
• Ratnaike RN. 2003. Acute and chronic arsenic toxicity. Postgrad Med J. 79:391–396.
   PubMed Web of Science ®Google Scholar
• Roy A, Das A, Das R, Haldar S, Bhattacharya S, Haldar PK. 2014. Naringenin, a citrus flavonoid, ameliorates arsenic-induced toxicity in Swiss albino mice. J Environ Pathol Toxicol Oncol. 33:195–204.
   PubMed Web of Science ®Google Scholar
• Roy M, Roy S. 2011. Ameliorative potential of Psidium guajava in induced arsenic toxicity in Wistar rats. Veterinary World. 4:82–83.
   Google Scholar
• RoyChoudhury A, Das T, Sharma A, Talukder G. 1996. Dietary garlic extract in modifying clastogenic effects of inorganic arsenic in mice: two-generation studies. Mutat Res. 359:165–170.
   PubMed Web of Science ®Google Scholar
• Saha SK, Misbahuddin M, Khatun R, Mamun IR. 2005 . Effect of hexane extract of spirulina in the removal of arsenic from isolated liver tissues of rat. Mymensingh Med J. 14:191–195.
   PubMedGoogle Scholar
• Sankar P, Gopal Telang A, Kalaivanan R, Karunakaran V, Manikam K, Sarkar SN. 2015. Effects of nanoparticle-encapsulated curcumin on arsenic-induced liver toxicity in rats. Environ Toxicol. 30:628–637.
   PubMed Web of Science ®Google Scholar
• Sárközi K, Papp A, Máté Z, Horváth E, Paulik E, Szabó A. 2015. Rutin, a flavonoid phytochemical, ameliorates certain behavioral and electrophysiological alterations and general toxicity of oral arsenic in rats. Acta Biol Hung. 66:14–26.
   PubMed Web of Science ®Google Scholar
• Sayed S, Ahsan N, Kato M, Ohgami N, Rashid A, Akhand AA. 2015. Protective effects of Phyllanthus emblica leaf extract on sodium arsenite-mediated adverse effects in mice. Nagoya J Med Sci. 77:145–153.
   PubMed Web of Science ®Google Scholar
• Sharma A, Sharma MK, Kumar M. 2007. Protective effect of Mentha piperita against arsenic-induced toxicity in liver of Swiss albino mice. Basic Clin Pharmacol Toxicol. 100:249–257.
   PubMed Web of Science ®Google Scholar
• Sharma G, Kumar M. 2014. Amelioration by Chlorophytum borivilianum upon arsenic induced oxidative stress in Swiss albino mice. Int J Pharmacol Toxicol. 2:62–69.
   Google Scholar
• Sheikh A, Yeasmin F, Agarwal S, Rahman M, Islam K, Hossain E, Hossain S, Karim MR, Nikkon F, Saud ZA, et al. 2014. Protective effects of Moringa oleifera Lam. leaves against arsenic-induced toxicity in mice. Asian Pac J Trop Biomed. 4:S353–S358.
   PubMedGoogle Scholar
• Shi H, Shi X, Liu KJ. 2004. Oxidative mechanism of arsenic toxicity and carcinogenesis. Mol Cell Biochem. 255:67–78.
   PubMed Web of Science ®Google Scholar
• Sikder MS, Islam AZMM, Khan MAK, Huq MA, Choudhury SAR, Misbahuddin M. 2000. Effect of Spirulina in the treatment of chronic arsenicosis. Bangladesh J Dermatol Venereal Leprol. 17:9–13.
   Google Scholar
• Singh AK. 2006. Chemistry of arsenic in groundwater of Ganges-Brahmaputra river basin. Curr Sci. 91:599–606.
   Web of Science ®Google Scholar
• Singh MK, Yadav SS, Gupta V, Khattri S. 2013. Immunomodulatory role of Emblica officinalis in arsenic induced oxidative damage and apoptosis in thymocytes of mice. BMC Complement Altern Med. 13:193.
   PubMed Web of Science ®Google Scholar
• Singh N, Kumari D. 2013. Amelioration of genotoxicity by papaya extract induced by arsenic contaminated drinking water. The Bioscan. 8:623–626.
   Google Scholar
• Singh S, Rana SVS. 2007. Amelioration of arsenic toxicity by L-ascorbic acid in laboratory rat. J Environ Biol. 28:377–384.
   PubMed Web of Science ®Google Scholar
• Sinha D, Roy S, Roy M. 2010. Antioxidant potential of tea reduces arsenite induced oxidative stress in Swiss albino mice. Food Chem Toxicol. 48:1032–1039.
   PubMed Web of Science ®Google Scholar
• Sinha M, Manna P, Sil PC. 2008a. Protective effect of arjunolic acid against arsenic-induced oxidative stress in mouse brain. J Biochem Mol Toxicol. 22:15–26.
   PubMed Web of Science ®Google Scholar
• Sinha M, Manna P, Sil PC. 2008b. Arjunolic acid attenuates arsenic-induced nephrotoxicity. Pathophysiology. 15:147–156.
   PubMedGoogle Scholar
• Soria EA, Goleniowski ME, Cantero JJ, Bongiovanni GA. 2008. Antioxidant activity of different extracts of Argentinian medicinal plants against arsenic-induced toxicity in renal cells. Hum Exp Toxicol. 27:341–346.
   PubMed Web of Science ®Google Scholar
• Soria EA, Quiroga PL, Albrecht C, Ramos Elizagaray SI, Cantero JJ, Bongiovanni GA. 2014. Development of an antioxidant phytoextract of Lantana grisebachii with lymphoprotective activity against in vitro arsenic toxicity. Adv Pharmacol Sci. 2014:416761.
   PubMedGoogle Scholar
• Sun G, Li X, Pi J, Sun Y, Li B, Jin Y, et al. 2006. Current research problems of chronic arsenicosis in China. J Health Popul Nutr. 24:176–181.
   PubMed Web of Science ®Google Scholar
• Tandan N, Roy M, Roy S. 2012. Ameliorative potential of Psidium guajava on hemato-biochemical alterations in arsenic-exposed Wistar rats. Toxicol Int. 19:121–124.
   PubMedGoogle Scholar
• Umar BU. 2007. Effect of hexane extract of spinach in the removal of arsenic from rat. Bangladesh J Pharmacol. 2:27–34.
   Google Scholar
• Verma R, Trivedi M, Keshwani H, Choksi P, Sangai N. 2007. Ameliorative effect of three medicinal plants (P. fraternus, Terminelia a., and Moringa oleifera) on arsenic trioxide induced alteration of lipid peroxidation and protein contents in chicken liver homogenate: an in vitro study. Acta Poloniae Pharmaceutica Drug Res. 63:417–421.
   Google Scholar
• Verma RJ, Vasu A, Saiyed AA. 2004. Arsenic toxicity in mice and its possible amelioration. J Environ Sci (China). 16:447–453.
   PubMed Web of Science ®Google Scholar
• Verret WJ, Chen Y, Ahmed A, Islam T, Parvez F, Kibriya MG, Graziano JH, Ahsan H. 2005 . A randomized, double-blind placebo-controlled trial evaluating the effects of vitamin E and selenium on arsenic-induced skin lesions in Bangladesh. J Occup Environ Med. 47:1026–1035.
   PubMed Web of Science ®Google Scholar
• Vineetha VP, Girija S, Soumya RS, Raghu KG. 2014. Polyphenol-rich apple (Malus domestica L.) peel extract attenuates arsenic trioxide induced cardiotoxicity in H9c2 cells via its antioxidant activity. Food Funct. 5:502–511.
   PubMed Web of Science ®Google Scholar
• Vineetha VP, Prathapan A, Soumya RS, Raghu KG. 2013 . Arsenic trioxide toxicity in H9c2 myoblasts-damage to cell organelles and possible amelioration with Boerhavia diffusa. Cardiovasc Toxicol. 13:123–137.
   PubMed Web of Science ®Google Scholar
• Xinjuan P, Dai Y, Li X, Niu N, Li W, Liu F, Zhao Y, Yu Z. 2011. Inhibition of arsenic induced-rat liver injury by grape seed exact through suppression of NADPH oxidase and TGF-β/Smad activation. Toxicol Appl Pharmacol. 254:323–331.
   PubMed Web of Science ®Google Scholar
• Yousef MI, El-Demerdash FM, Radwan FME. 2008. Sodium arsenite induced biochemical perturbations in rats: ameliorating effect of curcumin. Food Chem Toxicol. 46:3506–3511.
   PubMed Web of Science ®Google Scholar
• Zhang W, Xue J, Ge M, Yu M, Liu L, Zhang Z. 2013b. Resveratrol attenuates hepatotoxicity of rats exposed to arsenic trioxide. Food Chem Toxicol. 51:87–92.
   PubMed Web of Science ®Google Scholar
• Zhang W, Yao C, Ge M, Xue J, Ma D, Liu Y, Liu J, Zhang Z. 2013a. Attenuation of arsenic retention by resveratrol in lung of arsenic trioxide-exposed rats. Environ Toxicol Pharmacol. 36:35–39.
   PubMed Web of Science ®Google Scholar
• Zhang Z, Gao L, Cheng Y, Jiang J, Chen Y, Jiang H, Yu H, Shan A, Cheng B. 2014. Resveratrol, a natural antioxidant, has a protective effect on liver injury induced by inorganic arsenic exposure. Biomed Res Int. 2014:617202.
   PubMedGoogle Scholar
• Zhao XY, Li GY, Liu Y, Chai LM, Chen JX, Zhang Y, Du ZM, Lu YJ, Yang BF. 2008. Resveratrol protects against arsenic trioxide-induced cardiotoxicity in vitro and in vivo. Br J Pharmacol. 154:105–113.
   PubMed Web of Science ®Google Scholar