Suppression of VEGF-induced angiogenesis and tumor growth by Eugenia jambolana, Musa paradisiaca, and Coccinia indica extracts

References

• Afsar T, Trembley JH, Salomon CE, Razak S, Khan MR, Ahmed K. 2016. Growth inhibition and apoptosis in cancer cells induced by polyphenolic compounds of Acacia hydaspica: involvement of multiple signal transduction pathways. Sci Rep. 6:23077.
   PubMed Web of Science ®Google Scholar
• Ali EM, Sheta M, El Mohsen MA. 2011. Elevated serum and tissue VEGF associated with poor outcome in breast cancer patients. Alexandria J Med. 47:217–224.
   Google Scholar
• Andzi-Barhé T, Massala KK, Obame LC, Engonga JL. 2015. Phytochemical studies, total phenolic and flavonoids content and evaluation of antiradical activity of the extracts of the leaves from Dischistocalyx sp. (Acanthaceae). J Pharmacogn Phytochem. 3:174–178.
   Google Scholar
• Baliga MS. 2011. Anticancer, chemopreventive and radioprotective potential of black plum (Eugenia jambolana Lam.). Asian Pac J Cancer Prev. 12:3–15.
   PubMedGoogle Scholar
• Bikfalvi A, Bicknell R. 2002. Recent advances in angiogenesis, anti-angiogenesis and vascular targeting. Trends Pharmacol Sci. 23:576–582.
   PubMed Web of Science ®Google Scholar
• Carbajo-Pescador S, Ordonez R, Benet M, Jover R, García-Palomo A, Mauriz JL, González-Gallego J. 2013. Inhibition of VEGF expression through blockade of Hif1α and STAT3 signalling mediates the anti-angiogenic effect of melatonin in HepG2 liver cancer cells. Br J Cancer. 109:83–91.
   PubMed Web of Science ®Google Scholar
• Carmeliet P, Jain RK. 2011. Molecular mechanisms and clinical applications of angiogenesis. Nature. 473:298–307.
   PubMed Web of Science ®Google Scholar
• Chatterjee K, Ali KM, Ghosh D. 2009. Antihyperglycaemic, antioxidative activities of a formulated polyherbal drug MTEC (Modified) in streptozotocin-induced diabetic rat. J Med Plant Res. 3:468–480.
   Google Scholar
• Claesson-Welsh L, Welsh M. 2013. VEGFA and tumor angiogenesis. J Intern Med. 273:14–127.
   Web of Science ®Google Scholar
• Dent SF. 2009. The role of VEGF in triple-negative breast cancer: where do we go from here? Ann Oncol. 20:1615–1617.
   PubMedGoogle Scholar
• Elkin M, Miao HQ, Nagler A, Aingorn E, Reich R, Hemo I, Dou HL, Pines M, Vlodavsky I. 2000. Halofuginone: a potent inhibitor of critical steps in angiogenesis progression. FASEB J. 14:2477–2485.
   PubMed Web of Science ®Google Scholar
• Eun JP, Koh GY. 2004. Suppression of angiogenesis by the plant alkaloid, sanguinarine. Biochem Biophys Res Commun. 317:618–624.
   PubMed Web of Science ®Google Scholar
• Fan TP, Yeh JC, Leung KW, Yue PY, Wong RN. 2006. Angiogenesis: from plants to blood vessels. Trends Pharmacol Sci. 27:297–309.
   PubMed Web of Science ®Google Scholar
• Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F. 2015. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 136:359–386.
   PubMed Web of Science ®Google Scholar
• Fukuda S, Kaga S, Zhan L, Bagchi D, Das DK, Bertelli A, Maulik N. 2006. Resveratrol ameliorates myocardial damage by inducing vascular endothelial growth factor-angiogenesis and tyrosine kinase receptor Flk-1. Cell Biochem Biophys. 44:43–49.
   PubMed Web of Science ®Google Scholar
• Ghosh D. 2015. In vitro antioxidant potential of ethyl acetate fraction of seed of Eugenia jambolana. Asian J Pharm Clin Res. 8:167–170.
   Google Scholar
• Goel HL, Mercurio AM. 2013. VEGF targets the tumour cell. Nat Rev Cancer. 13:871–882.
   PubMed Web of Science ®Google Scholar
• Gordaliza M. 2007. Natural products as leads to anticancer drugs. Clin Transl Oncol. 9:767–776.
   PubMed Web of Science ®Google Scholar
• Guo C, Buranych A, Sarkar D, Fisher PB, Wang XY. 2013. The role of tumor-associated macrophages in tumor vascularization. Vasc Cell. 5:1–20.
   PubMedGoogle Scholar
• Gururaj AE, Belakavadi M, Venkatesh DA, Marmé D, Salimath BP. 2002. Molecular mechanisms of anti-angiogenic effect of curcumin. Biochem Biophys Res Commun. 97:934–942.
   Google Scholar
• Hojjat-Farsangi M. 2014. Small-molecule inhibitors of the receptor tyrosine kinases: promising tools for targeted cancer therapies. Int J Mol Sci. 15:13768–13801.
   PubMed Web of Science ®Google Scholar
• Lee JS, Shukla S, Kim JA, Kim M. 2015. Anti-angiogenic effect of Nelumbo nucifera leaf extracts in human umbilical vein endothelial cells with antioxidant potential. PLoS One. 10:e0118552.
   PubMed Web of Science ®Google Scholar
• Lingaraju SM, Keshavaiah K, Salimath BP. 2008. Inhibition of in vivo angiogenesis by Anacardium occidentale L. involves repression of the cytokine VEGF gene expression. Drug Discov Ther. 2:234–244.
   PubMedGoogle Scholar
• Loboda A, Jazwa A, Wegiel B, Jozkowicz A, Dulak J. 2005. Heme oxygenase-1-dependent and -independent regulation of angiogenic genes expression: effect of cobalt protoporphyrin and cobalt chloride on VEGF and IL-8 synthesis in human microvascular endothelial cells. Cell Mol Biol. 51:347.
   PubMed Web of Science ®Google Scholar
• Lu K, Bhat M, Basu S. 2016. Plants and their active compounds: natural molecules to target angiogenesis. Angiogenesis. 19:287–295.
   PubMed Web of Science ®Google Scholar
• Mallick C, De D, Ghosh D. 2009. Correction of protein metabolic disorders by composite extract of Musa paradisiaca and Coccinia indica in streptozotocin-induced diabetic albino rat: an approach through the pancreas. Pancreas. 38:322–329.
   PubMed Web of Science ®Google Scholar
• Mallick C, Maiti R, Ghosh D. 2006. Antidiabetogenic effects of separate and composite extract of seed of Jamun (Eugenia jambolana) and root of Kadali (Musa paradisiaca) in streptozotocin-induced diabetic male albino rat: a comparative study. Int J Pharmacol. 2:492–503.
   Google Scholar
• Miao S, Shi X, Zhang H, Wang S, Sun J, Hua W, Miao Q, Zhao Y, Zhang C. 2011. Proliferation-attenuating and apoptosis-inducing effects of tryptanthrin on human chronic myeloid leukemia K562 cell line in vitro. Int J Mol Sci. 12:3831–3845.
   PubMed Web of Science ®Google Scholar
• Miller KD, Rahman ZU, Sledge Jr GW. 2001. Selection bias in clinical trials. Breast Dis. 14:31–40.
   PubMedGoogle Scholar
• Min JK, Han KY, Kim EC, Kim YM, Lee SW, Kim OH, Kim KW, Gho YS, Kwon YG. 2004. Capsaicin inhibits in vitro and in vivo angiogenesis. Cancer Res. 64:644–651.
   PubMed Web of Science ®Google Scholar
• Nadumane VK, Timsina B. 2014. Anti-cancer potential of banana flower extract: an in vitro study. Bangladesh J. Pharmacol. 9:628–635.
   Web of Science ®Google Scholar
• Nagaraj SRM, Shilpa P, Rachaiah K, Salimath BP. 2015. Crosstalk between VEGF and MTA1 signaling pathways contribute to aggressiveness of breast carcinoma. Mol Carcinog. 54:333–350.
   PubMed Web of Science ®Google Scholar
• Nataraj NB, Salimath BP. 2013. Crosstalk between VEGF and novel angiogenic protein regulates tumor angiogenesis and contributes to aggressiveness of breast carcinoma. Cell Signal. 25:277–294.
   PubMed Web of Science ®Google Scholar
• Neal C, Berry D, Doucas H, Manson M, Steward W, Garcea G. 2006. Clinical aspects of natural anti-angiogenic drugs. Curr Drug Targets. 7:371–383.
   PubMed Web of Science ®Google Scholar
• Pratheeshkumar P, Budhraja A, Son YO, Wang X, Zhang Z, Ding S, Wang L, Hitron A, Lee JC, Xu M, et al. 2012. Quercetin inhibits angiogenesis mediated human prostate tumor growth by targeting VEGFR- 2 regulated AKT/mTOR/P70S6K signaling pathways. PloS One. 7:e47516.
   PubMed Web of Science ®Google Scholar
• Pekamwar S, Kalyankar T, Kokate S. 2013. Pharmacological activities of Coccinia grandis. J Appl Pharm Sci. 3:114–119.
   Google Scholar
• Quesada AR, Muñoz-Chápuli R, Medina MA. 2006. Anti-angiogenic drugs: from bench to clinical trials. Med Res Rev. 26:483–530.
   PubMed Web of Science ®Google Scholar
• Raj MH, Yashaswini B, Rössler J, Salimath BP. 2016. Combinatorial treatment with anacardic acid followed by TRAIL augments induction of apoptosis in TRAIL resistant cancer cells by the regulation of p53, MAPK and NFκβ pathways. Apoptosis. 21:578–593.
   PubMed Web of Science ®Google Scholar
• Ramachandra S, D'Souza SS, Gururaj AE, Shaila MS, Salimath BP. 2009. Paracrine action of sFLT-1 secreted by stably-transfected Ehrlich ascites tumor cells and therapy using sFLT-1 inhibits ascites tumor growth in vivo. J Gene Med. 11:422–434.
   PubMed Web of Science ®Google Scholar
• Ribatti D, Finato N, Crivellato E, Marzullo A, Mangieri D, Nico B, Vacca A, Beltrami CA. 2005. Neovascularization and mast cells with tryptase activity increase simultaneously with pathologic progression in human endometrial cancer. Am J Obstet Gynecol. 193:1961–1965.
   PubMed Web of Science ®Google Scholar
• Roy M, Chakraborty S, Siddiqi M, Bhattacharya RK. 2002. Induction of apoptosis in tumor cells by natural phenolic compounds. Asian Pac J Cancer Prev. 3:61–67.
   PubMedGoogle Scholar
• Shivakumar S, Prabhakar BT, Jayashree K, Rajan MGR, Salimath BP. 2009. Evaluation of serum vascular endothelial growth factor (VEGF) and microvessel density (MVD) as prognostic indicators in carcinoma breast. J Cancer Res Clin Oncol. 135:627–636.
   PubMed Web of Science ®Google Scholar
• Steeg PS. 2006. Tumor metastasis: mechanistic insights and clinical challenges. Nat Med. 12:895–904.
   PubMed Web of Science ®Google Scholar
• Sun Q, Heilmann J, König B. 2015. Natural phenolic metabolites with anti-angiogenic properties – a review from the chemical point of view. Beilstein J Org Chem. 11:249–264.
   PubMed Web of Science ®Google Scholar
• Wagner H, Bladt S. 1996. Plant drug analysis: a thin layer chromatography atlas. Peabody, MA: Hendrickson Publishers.
   Google Scholar
• Wang S, Zheng Z, Weng Y, Yu Y, Zhang D, Fan W, Dai R, Hu Z. 2004. Angiogenesis and anti-angiogenesis activity of Chinese medicinal herbal extracts. Life Sci. 74:2467–2478.
   PubMed Web of Science ®Google Scholar
• Wang W, McKinnie SM, Patel VB, Haddad G, Wang Z, Zhabyeyev P, Das SK, Basu R, McLean B, Kandalam V, et al. 2013. Loss of Apelin exacerbates myocardial infarction adverse remodeling and ischemia-reperfusion injury: therapeutic potential of synthetic Apelin analogs. J Am Heart Assoc. 2:e000249.
   PubMed Web of Science ®Google Scholar
• Wu WB, Hung DK, Chang FW, Ong ET, Chen BH. 2012. Anti-inflammatory and anti-angiogenic effects of flavonoids isolated from Lycium barbarum Linnaeus on human umbilical vein endothelial cells. Food Funct. 3:1068–1081.
   PubMed Web of Science ®Google Scholar
• Yin WJ, Lu JS, Di GH, Lin YP, Zhou LH, Liu GY, Wu J, Shen KW, Han QX, Shen ZZ. 2009. Clinicopathological features of the triple-negative tumors in Chinese breast cancer patients. Breast Cancer Res Treat 115:325–333.
   PubMed Web of Science ®Google Scholar
• Yu ST, Chen TM, Chern JW, Tseng SY, Chen YH. 2009. Downregulation of GSTpi expression by tryptanthrin contributing to sensitization of doxorubicin-resistant MCF-7 cells through c-jun NH2-terminal kinase-mediated apoptosis. Anticancer Drugs. 20:382–388.
   PubMed Web of Science ®Google Scholar