Anticarcinogenic activity of Muntingia calabura leaves methanol extract against the azoxymethane-induced colon cancer in rats involved modulation of the colonic antioxidant system partly by flavonoids

References

• Al-Numair KS, Waly MI, Ali A, Essa MM, Farhat MF, Alsaif MA. 2011. Dietary folate protects against azoxymethane-induced aberrant crypt foci development and oxidative stress in rat colon. Exp Biol Med (Maywood). 236:1005–1111.
   PubMed Web of Science ®Google Scholar
• Caderni G, Giannini A, Lancioni L, Luceri C, Biggeri A, Dolara P. 1995. Characterization of aberrant crypt foci in carcinogen-treated rats: association with intestinal carcinogenesis. Br J Cancer. 71:763–769.
   PubMed Web of Science ®Google Scholar
• Cedó L, Castell-Auví A, Pallarès V, Macià A, Blay M, Ardévol A, Motilva MJ, Pinent M. 2014. Gallic acid is an active component for the anticarcinogenic action of grape seed procyanidins in pancreatic cancer cells. Nutr Cancer. 66:88–96.
   PubMed Web of Science ®Google Scholar
• Derry MM, Rasina K, Balaiya V, Jain AK, Shrotriya S, Huber KM, Serkova NJ, Agarwal R, Agarwal C. 2013. Grape seed extract efficacy against azoxymethane-induced colon tumorigenesis in A/J mice: interlinking miRNA with cytokine signaling and inflammation. Cancer Prev Res. 6:625–633.
   PubMed Web of Science ®Google Scholar
• Devasagayam TPA, Tilak JC, Boloor KK, Sane KS, Ghaskadbi SS, Lele RD. 2004. Free radicals and antioxidants in human health: current status and future prospects. J Assoc Physicians India. 52:794–803.
   PubMedGoogle Scholar
• Gautam R, Singh M, Gautam S, Rawat JK, Saraf SA, Kaithwas G. 2016. Rutin attenuates intestinal toxicity induced by methotrexate linked with anti-oxidative and anti-inflammatory effects. BMC Complement Altern Med. 16:99.
   PubMed Web of Science ®Google Scholar
• Ghafar SAA, Yazan LS, Tahir PM, Ismail M. 2012. Kenaf seed supercritical fluid extract reduces aberrant crypt foci formation in azoxymethane-induced rats. Exp Toxicol Pathol. 64:247–251.
   PubMed Web of Science ®Google Scholar
• Giftson JS, Jayathi S, Nalini N. 2010. Chemopreventive efficacy of gallic acid, an antioxidant and anticarcinogenic polyphenol, against 1,2-dimethyl hydrazine induced rat colon carcinogenesis. Invest New Drugs. 28:251–259.
   PubMed Web of Science ®Google Scholar
• Haggar FA, Boushey RP. 2009. Colorectal cancer epidemiology: incidence, mortality, survival, and risk factors. Clin Colon Rectal Surg. 22:191–197.
   PubMedGoogle Scholar
• Hamiza OO, Rehman MU, Tahir M, Khan Q, Lateef A, Ali F, Sultana S. 2012. Amelioration of 1,2-dimethylhydrazine (DMH) induced colon oxidative stress, inflammation and tumor promotion response by tannic acid in Wistar rats. Asian Pac J Cancer Prev. 13:4393–4402.
   PubMedGoogle Scholar
• Henley SJ. 2002. Nonsteroidal anti-inflammatory drugs as anticancer agents: mechanistic, pharmacologic, and clinical issues. J Natl Cancer Inst. 94:252–266.
   PubMedGoogle Scholar
• Kawabata K, Yamamoto T, Hara A, Shimizu M, Yamada Y, Matsunaga K, Tanaka T, Mori H. 2000. Modifying effects of ferulic acid on azoxymethane-induced colon carcinogenesis in F344 rats. Cancer Lett. 157:15–21.
   PubMed Web of Science ®Google Scholar
• Kranz D, Dobbelstein M. 2012. A killer promoting survival: p53 as a selective means to avoid side effects of chemotherapy. Cell Cycle. 11:2053–2054.
   PubMed Web of Science ®Google Scholar
• Liu R, Gao M, Yang ZH, Du GH. 2008. Pinocembrin protects rat brain against oxidation and apoptosis induced by ischemia-reperfusion both in vivo and in vitro. Brain Res. 1216:104–115.
   PubMed Web of Science ®Google Scholar
• Mahmood ND, Nasir NLM, Rofiee MS, Tohid SFM, Ching SM, Teh LK, Salleh MZ, Zakaria ZA. 2014. Muntingia calabura L.: a review on its traditional uses, chemical properties and pharmacological observations. Pharm Biol. 52:1598–1623.
   PubMed Web of Science ®Google Scholar
• Marino T, Galano A, Russo N. 2014. Radical scavenging ability of gallic acid toward OH and OOH radicals. Reaction mechanism and rate constants from the density functional theory. J Phys Chem B. 118:10380–10389.
   PubMed Web of Science ®Google Scholar
• McPherson C. 1980. Regulation of animal care and research? NIH's opinion. J Anim Sci. 51:492–496.
   PubMed Web of Science ®Google Scholar
• Rasul A, Millimouno FM, Ali Eltayb W, Ali M, Li J, Li X. 2013. Pinocembrin: a novel natural compound with versatile pharmacological and biological activities. BioMed Res Int. 2013:9.
   Google Scholar
• Rayburn ER, Ezell SJ, Zhang R. 2009. Anti-inflammatory agents for cancer therapy. Mol Cell Pharmacol. 1:29–43.
   PubMedGoogle Scholar
• Rofiee MS, Yusof MIM, Abdul Hisam EE, Bannur Z, Zakaria ZA, Somchit MN, Teh LK, Salleh MZ. 2015. Isolating the metabolic pathways involved in the hepatoprotective effect of Muntingia calabura against CCl4-induced liver injury using LCMS Q-TOF. J Ethnopharmacol. 106:109–118.
   Google Scholar
• Santos AC, Uyemura SA, Lopes JL, Bazon JN, Mingatto FE, Curti C. 1998. Effect of naturally occurring flavonoids on lipid peroxidation and membrane permeability transition in mitochondria. Free Radic Biol Med. 24:1455–1461.
   PubMed Web of Science ®Google Scholar
• Srinivasan M, Sudheer AR, Menon VP. 2007. Ferulic acid: therapeutic potential through its antioxidant property. J Clin Biochem Nutr. 40:92–100.
   PubMed Web of Science ®Google Scholar
• Volate SR, Davenport DM, Muga SJ, Wargovich MJ. 2005. Modulation of aberrant crypt foci and apoptosis by dietary herbal supplements (quercetin, curcumin, silymarin, ginseng and rutin). Carcinogenesis. 26:1450–1456.
   PubMed Web of Science ®Google Scholar
• Vogelstein B, Fearon ER, Hamilton SR, Kern SE, Preisinger AC, Leppert M, Smits AM, Bos JL. 1988. Genetic alterations during colorectal-tumor development. N Engl J Med. 319:525–532.
   PubMed Web of Science ®Google Scholar
• Waly MI, Ali A, Guizani N, Al-Rawahi AS, Farooq SA, Rahman MS. 2012. Pomegranate (Punica granatum) peel extract efficacy as a dietary antioxidant against azoxymethane-induced colon cancer in rat. Asian Pac J Cancer Prev. 13:4051–4055.
   PubMedGoogle Scholar
• Zakaria ZA, Balan T, Suppaiah V, Ahmad S, Jamaludin F. 2014. Mechanism(s) of action involved in the gastroprotective activity of Muntingia calabura. J Ethnopharmacol. 151:1184–1193.
   PubMed Web of Science ®Google Scholar