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Research Article

Quercetin promotes gastrointestinal motility and mucin secretion in loperamide-induced constipation of SD rats through regulation of the mAChRs downstream signal

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Pages 309-317 | Received 30 Jan 2018, Accepted 24 Apr 2018, Published online: 28 Jun 2018

References

  • Abbas S, Bashir S, Khan A, Mehmood MH, Gilani AH. 2012. Gastrointestinal stimulant effect of Urginea indica Kunth. and involvement of muscarinic receptors. Phytother Res: PTR. 26:704–708.
  • Andrews CN, Storr M. 2011. The pathophysiology of chronic constipation. Can J Gastroenterol. 25:16B–21B.
  • Busti AJ, Murillo JR, Cryer B. 2004. Tegaserod-induced myocardial infarction: case report and hypothesis. Pharmacotherapy. 24:526–531.
  • Caulfield MP. 1993. Muscarinic receptors-characterization, coupling and function. Pharmacol Ther. 58:319–379.
  • Choi JS, Kim JW, Cho HR, Kim KY, Lee JK, Sohn JH, Ku SK. 2014. Laxative effects of fermented rice extract in rats with loperamide-induced constipation. Exp Ther Med. 8:1847–1854.
  • Ehlert FJ, Pak KJ, Griffin MT. 2012. Muscarinic agonists and antagonists: effects on gastrointestinal function. Handb Exp Pharmacol. 208:343–374.
  • Guarize L, Costa JC, Dutra LB, Mendes RF, Lima IVA, Scio E. 2012. Anti-inflammatory, laxative and intestinal motility effects of Senna macranthera leaves. Nat Prod Res. 26:331–343.
  • Han SH, Park K, Kim EY, Ahn SH, Lee HS, Suh HJ. 2017. Cactus (Opuntia humifusa) water extract ameliorates loperamide-induced constipation in rats. BMC Complement Altern Med. 17:49.
  • Hussain AI, Rathore HA, Sattar MZ, Chatha SA, Sarker SD, Gilani AH. 2014. Citrullus colocynthis (L.) Schrad (bitter apple fruit): a review of its phytochemistry, pharmacology, traditional uses and nutritional potential. J Ethnopharmacol. 155:54–66.
  • Ishii M, Kurachi Y. 2006. Muscarinic acetylcholine receptors. Curr Pharm Des. 12:3573–3581.
  • Kim BJ. 2013. Shengmai san regulates pacemaker potentials in interstitial cells of cajal in mice. J Pharmacopunct. 16:36–42.
  • Kim JE, Go J, Koh EK, Song SH, Sung JE, Lee HA, Lee YH, Hong JT, Hwang DY. 2016. Gallotannin-enriched extract isolated from Galla Rhois may be a functional candidate with laxative effects for treatment of loperamide-induced constipation of SD rats. PLoS One. 11:e0161144.
  • Kim JE, Lee YJ, Kwak MH, Go J, Hong JT, Hwang DY. 2013. Aqueous extracts of Liriope platyphylla induced significant laxative effects on loperamide-induced constipation of SD rats. BMC Complement Altern Med. 13:333.
  • Kistemaker LE, Gosens R. 2015. Acetylcholine beyond bronchoconstriction: roles in inflammation and remodeling. Trends Pharmacol Sci. 36:164–171.
  • Kolahian S, Gosens R. 2012. Cholinergic regulation of airway inflammation and remodeling. J Allergy. 2012:681258.
  • Lee HA, Kim JE, Song SH, Sung JE, Jung MG, Kim DS, Son HJ, Lee CY, Lee HS, Hwang DY. 2016. Effects of an aqueous extract of Asparagus cochinchinensis on the regulation of nerve growth factor in neuronal cells. J Life Sci. 26:509–518.
  • Lembo A, Camilleri M. 2003. Chronic constipation. N Engl J Med. 349:1360–1368.
  • Mehmood MH, Rehman A, Rehman NU, Gilani AH. 2013. Studies on prokinetic, laxative and spasmodic activities of Phyllanthus emblica in experimental animals. Phytother Res: PTR. 27:1054–1060.
  • Meite S, Bahi C, Yeo D, Datte JY, Djaman JA, Nguessan DJ. 2010. Laxative activities of Mareya micrantha (Benth.) Müll. Arg. (Euphorbiaceae) leaf aqueous extract in rats. BMC Complement Altern Med. 10:7–10.
  • Michael GL, Peter CH, Martijn BK. 1992. Content of potentially anticarcinogenic flavonoids of 28 vegetables and 9 fruits commonly consumed in The Netherlands. J Agric Food Chem. 40:2379–2383.
  • Miles SL, McFarland M, Niles RM. 2014. Molecular and physiological actions of quercetin: need for clinical trials to assess its benefits in human disease. Nutr Rev. 72:720–734.
  • Najeeb-ur-Rehman, Mehmood MH, Al-Rehaily AJ, Mothana RA, Gilani AH. 2012. Species and tissue-specificity of prokinetic, laxative and spasmodic effects of Fumaria parviflora. BMC Complement Altern Med. 12:16.
  • Parajuli SP, Choi S, Lee J, Kim YD, Park CG, Kim MY, Kim HI, Yeum CH, Jun JY. 2010. The inhibitory effects of hydrogen sulfide on pacemaker activity of interstitial cells of cajal from mouse small intestine. Korean J Physiol Pharmacol. 14:83–89.
  • Pearce FL, Befus AD, Bienenstock J. 1984. Mucosal mast cells. III. Effect of quercetin and other flavonoids on antigen-induced histamine secretion from rat intestinal mast cells. J Allergy Clin Immunol. 73:819–823.
  • Rümenapp U, Asmus M, Schablowski H, Woznicki M, Han L, Jakobs KH, Fahimi-Vahid M, Michalek C, Wieland T, Schmidt M. 2001. The M3 muscarinic acetylcholine receptor expressed in HEK-293 cells signals to phospholipase D via G12 but not Gq-type G proteins. Regulators of G proteins as tools to dissect pertussis toxin resistant G proteins in receptor-effector coupling. J Biol Chem. 276:2474–2479.
  • Swaminathan M, Chee CF, Chin SP, Buckle MJC, Raman NA, Doughty SW, Chung LY. 2014. Flavonoids with M1 muscarinic acetylcholine receptor binding activity. Molecules. 19:8933–8948.
  • Trowers E, Tischler M. 2014. Gastrointestinal physiology: a clinical approach. New York (NY): Springer.
  • van Koppen CJ, Kaiser B. 2003. Regulation of muscarinic acetylcholine receptor signaling. Pharmacol Ther. 98:197–220.
  • Voderholzer WA, Schatke W, Muhldorfer BE, Klauser AG, Birkner B, Muller-Lissner SA. 1997. Clinical response to dietary fiber treatment of chronic constipation. Am J Gastroenterol. 92:95–98.
  • Walia R, Mahajan L, Steffen R. 2009. Recent advances in chronic constipation. Curr Opin Pediatr. 21:661–666.
  • Wintola OA, Sunmonu TO, Afolayan AJ. 2010. The effect of Aloe ferox Mill. in the treatment of loperamide-induced constipation in Wistar rats. BMC Gastroenterol. 10:95.
  • Yu B, Jiang Y, Jin L, Ma T, Yang H. 2016. Role of quercetin in modulating chloride transport in the intestine. Front Physiol. 7:549.