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Short Communication

D-4F, an apolipoprotein A-I mimetic, suppresses IL-4 induced macrophage alternative activation and pro-fibrotic TGF-β1 expression

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Pages 470-476 | Received 20 May 2019, Accepted 02 Jul 2019, Published online: 23 Jul 2019

References

  • Anantharamaiah GM, Mishra VK, Garber DW, Datta G, Handattu SP, Palgunachari MN, Chaddha M, Navab M, Reddy ST, Segrest JP, et al. 2007. Structural requirements for antioxidative and anti-inflammatory properties of apolipoprotein A-I mimetic peptides. J Lipid Res. 48:1915–1923.
  • Bloedon LT, Dunbar R, Duffy D, Pinell-Salles P, Norris R, DeGroot BJ, Movva R, Navab M, Fogelman AM, Rader DJ. 2008. Safety, pharmacokinetics, and pharmacodynamics of oral apoA-I mimetic peptide D-4F in high-risk cardiovascular patients. J Lipid Res. 49:1344–1352.
  • Choe JY, Jung HJ, Park KY, Kum YS, Song GG, Hyun DS, Park SH, Kim SK. 2010. Anti-fibrotic effect of thalidomide through inhibiting TGF-beta-induced ERK1/2 pathways in bleomycin-induced lung fibrosis in mice. Inflamm Res. 59:177–188.
  • Demedts M, Behr J, Buhl R, Costabel U, Dekhuijzen R, Jansen HM, MacNee W, Thomeer M, Wallaert B, Laurent F, et al. 2005. High-dose acetylcysteine in idiopathic pulmonary fibrosis. N Engl J Med. 353:2229–2242.
  • Getz GS, Reardon CA. 2011. Apolipoprotein A-I and A-I mimetic peptides: a role in atherosclerosis. J Inflamm Res. 4:83–92.
  • Gordon S. 2003. Alternative activation of macrophages. Nat Rev Immunol. 3:23–35.
  • Gross TJ, Hunninghake GW. 2001. Idiopathic pulmonary fibrosis. N Engl J Med. 345:517–525.
  • Iyer SN, Margoli SB, Hyde DM, Giri SN. 1998. Lung fibrosis is ameliorated by pirfenidone fed in diet after the second dose in a three-dose bleomycin-hamster model. Exp Lung Res. 24:119–132.
  • Kasai H, Allen JT, Mason RM, Kamimura T, Zhang Z. 2005. TGF-beta1 induces human alveolar epithelial to mesenchymal cell transition (EMT). Respir Res. 6:56–71.
  • Kim TH, Lee YH, Kim KH, Lee SH, Cha JY, Shin EK, Jung S, Jang AS, Park SW, Uh ST, et al. 2010. Role of lung apolipoprotein A-I in idiopathic pulmonary fibrosis: antiinflammatory and antifibrotic effect on experimental lung injury and fibrosis. Am J Respir Crit Care Med. 182:633–642.
  • Kwiterovich PO. 1998. The antiatherogenic role of high-density lipoprotein cholesterol. Am J Cardiol. 82:13Q–21Q.
  • Lee EH, Lee EJ, Kim HJ, Jang A, Koh E, Uh ST, Kim Y, Park SW, Park CS. 2013. Overexpression of apolipoprotein A1 in the lung abrogates fibrosis in experimental silicosis. PLoS ONE. 8:e55827.
  • Meltzer EB, Noble PW. 2008. Idiopathic pulmonary fibrosis. Orphanet J Rare Dis. 3:8.
  • Moodley Y, Rigby P, Bundell C, Bunt S, Hayashi H, Misso N, McAnulty R, Laurent G, Scaffidi A, Thompson P, et al. 2003. Macrophage recognition and phagocytosis of apoptotic fibroblasts is critically dependent on fibroblast-derived thrombospondin 1 and CD36. Am J Pathol. 162:771–779.
  • Nandedkar SD, Weihrauch D, Xu H, Shi Y, Feroah T, Hutchins W, Rickaby DA, Duzgunes N, Hillery CA, Konduri KS, et al. 2011. D-4F, an apoA-1 mimetic, decreases airway hyperresponsiveness, inflammation, and oxidative stress in a murine model of asthma. J Lipid Res. 52:499–508.
  • Navab M, Anantharamaiah GM, Hama S, Garber DW, Chaddha M, Hough G, Lallone R, Fogelman AM. 2002. Oral administration of an Apo A-I mimetic peptide synthesized from D-amino acids dramatically reduces atherosclerosis in mice independent of plasma cholesterol. Circulation. 105:290–292.
  • Navab M, Anantharamaiah GM, Reddy ST, Hama S, Hough G, Grijalva VR, Yu N, Ansell BJ, Datta G, Garber DW, et al. 2005. Apolipoprotein A-I mimetic peptides. Arterioscler Thromb Vasc Biol. 25:1325–1331.
  • Navab M, Anantharamaiah GM, Reddy ST, Fogelman AM. 2006. Apolipoprotein A-I mimetic peptides and their role in atherosclerosis prevention. Nat Clin Pract Cardiovasc Med. 3:540–547.
  • Pechkovsky DV, Prasse A, Kollert F, Engel KM, Dentler J, Luttmann W, Friedrich K, Müller-Quernheim J, Zissel G. 2010. Alternatively activated alveolar macrophages in pulmonary fibrosis-mediator production and intracellular signal transduction. Clin Immunol. 137:89–101.
  • Pini A, Shemesh R, Samuel CS, Bathgate RA, Zauberman A, Hermesh C, Wool A, Bani D, Rotman G. 2010. Prevention of bleomycin-induced pulmonary fibrosis by a novel antifibrotic peptide with relaxin-like activity. J Pharmacol Exp Ther. 335:589–599.
  • Prasse A, Pechkovsky DV, Toews GB, Jungraithmayr W, Kollert F, Goldmann T, Vollmer E, Müller-Quernheim J, Zissel G. 2006. A vicious circle of alveolar macrophages and fibroblasts perpetuates pulmonary fibrosis via CCL18. Am J Respir Crit Care Med. 173:781–792.
  • Selman M, King TE, Pardo A. 2001. Idiopathic pulmonary fibrosis: prevailing and evolving hypotheses about its pathogenesis and implications for therapy. Ann Intern Med. 134:136–151.
  • Selman M, Pardo A. 2003. The epithelial/fibroblastic pathway in the pathogenesis of idiopathic pulmonary fibrosis. Am J Respir Cell Mol Biol. 29:S93–S97.
  • Shearer JD, Richards JR, Mills CD, Caldwell MD. 1997. Differential regulation of macrophage arginine metabolism: a proposed role in wound healing. Am J Physiol. 272:E181–E190.
  • Smythies LE, White CR, Maheshwari A, Palgunachari MN, Anantharamaiah GM, Chaddha M, Kurundkar AR, Datta G. 2010. Apolipoprotein A-I mimetic 4F alters the function of human monocyte-derived macrophages. Am J Physiol Cell Physiol. 298:C1538–C1548.
  • Song E, Ouyang N, Horbelt M, Antus B, Wang M, Exton MS. 2000. Influence of alternatively and classically activated macrophages on fibrogenic activities of human fibroblasts. Cell Immunol. 204:19–28.
  • Van Lenten BJ, Wagner AC, Navab M, Anantharamaiah GM, Hui EK, Nayak DP, Fogelman AM. 2004. D-4F, an apolipoprotein A-I mimetic peptide, inhibits the inflammatory response induced by influenza A infection of human type II pneumocytes. Circulation. 110:3252–3258.
  • White CR, Smythies LE, Crossman DK, Palgunachari MN, Anantharamaiah GM, Datta G. 2012. Regulation of pattern recognition receptors by the apolipoprotein A-I mimetic peptide 4F. Arterioscler Thromb Vasc Biol. 32:2631–2639.
  • Willis BC, Liebler JM, Luby-Phelps K, Nicholson AG, Crandall ED, du Bois RM, Borok Z. 2005. Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-beta1: potential role in idiopathic pulmonary fibrosis. Am J Pathol. 166:1321–1332.
  • Wilson MS, Wynn TA. 2009. Pulmonary fibrosis: pathogenesis, etiology and regulation. Mucosal Immunol. 2:103–121.
  • Wynn TA, Barron L. 2010. Macrophages: master regulators of inflammation and fibrosis. Semin Liver Dis. 30:245–257.
  • Wynn TA, Ramalingam TR. 2012. Mechanisms of fibrosis: therapeutic translation for fibrotic disease. Nat Med. 18:1028–1040.
  • You J, Wang J, Xie L, Zhu C, Xiong J. 2016. D-4F, an apolipoprotein A-I mimetic, inhibits TGF-β1 induced epithelial-mesenchymal transition in human alveolar epithelial cell. Exp Toxicol Pathol. 68:533–541.