Hepatoprotective effect of Xiayuxue decoction ethyl acetate fraction against carbon tetrachloride-induced liver fibrosis in mice via inducing apoptosis and suppressing activation of hepatic stellate cells

References

• Aouacheria A, Cibiel A, Guillemin Y, Gillet G, Lalle P. 2007. Modulating mitochondria-mediated apoptotic cell death through targeting of Bcl-2 family proteins. Recent Pat DNA Gene Seq. 1:43–61.
   PubMedGoogle Scholar
• Bataller R, Brenner DA. 2005. Liver fibrosis. J Clin Invest. 115:209–218.
   PubMed Web of Science ®Google Scholar
• Bogoyevitch MA, Kobe B. 2006. Uses for JNK: the many and varied substrates of the c-Jun N-terminal kinases. Microbiol Mol Biol Rev. 70:1061–1095.
   PubMed Web of Science ®Google Scholar
• Chaudhary NI, Roth GJ, Hilberg F, Müller-Quernheim J, Prasse A, Zissel G, Schnapp A, Park JE. 2007. Inhibition of PDGF, VEGF and FGF signalling attenuates fibrosis. Eur Respir J. 29:976–985.
   PubMed Web of Science ®Google Scholar
• Chen XH. 2013. Xia-yu-xue decoction treatment on 45 cases of early cirrhosis. Zhejiang J TCM. 48:705.
   Google Scholar
• Chen SL, Du GL, Ding N, Jin HX, Chen DX. 2012. Comparative study of Xiayuxue decoction and its ingredients recipe against porcine serum induced liver fbrosis in rats. Chin J Exp Trad Med Formulae. 18:154–157.
   Google Scholar
• Chi XL, Shi MJ, Xiao HM, Xie YB, Cai GS. 2016. The score model containing Chinese medicine syndrome element of blood stasis presented a better performance compared to APRI and FIB-4 in diagnosing advanced fibrosis in patients with chronic hepatitis B. Evid Based Complement Alternat Med. 2016:3743427.
   PubMed Web of Science ®Google Scholar
• DeLeve LD. 2015. Liver sinusoidal endothelial cells in hepatic fibrosis. Hepatology. 61:1740–1746.
   PubMed Web of Science ®Google Scholar
• DeLeve LD, Wang XD, Guo YM. 2008a. Sinusoidal endothelial cells prevent rat stellate cell activation and promote reversion to quiescence. Hepatology. 48:920–930.
   PubMed Web of Science ®Google Scholar
• DeLeve LD, Wang XD, Hu LP, McCuskey MK, McCuskey RS. 2004. Rat liver sinusoidal endothelial cell phenotype is maintained by paracrine and autocrine regulation. Am J Physiol Gastrointest Liver Physiol. 287:757–763.
   PubMed Web of Science ®Google Scholar
• DeLeve LD, Wang X, Kanel GC, Atkinson RD, McCuskey RS. 2008b. Prevention of hepatic fibrosis in a murine model of metabolic syndrome with nonalcoholic steatohepatitis. Am J Pathol. 173:993–1001.
   PubMed Web of Science ®Google Scholar
• Dhanasekaran DN, Reddy EP. 2008. JNK signaling in apoptosis. Oncogene. 27:6245–6251.
   PubMed Web of Science ®Google Scholar
• Ding SD, Liu BC, Liu Y, Dong QT, Li ZP, Yu Z. 2012. Proteomic study of Xiayuxue decoction on liver cirrhosis of rats. Zhong Cao Yao. 43:131–138.
   Google Scholar
• Dong S, Cai FF, Chen QL, Song YN, Sun Y, Wei B, Li XY, Hu YY, Liu P, Su SB. 2018. Chinese herbal formula Fuzheng Huayu alleviates CCl4-induced liver fibrosis in rats: a transcriptomic and proteomic analysis. Acta Pharmacol Sin. 39:930–941.
   PubMed Web of Science ®Google Scholar
• Eissa LA, Kenawy HI, El-Karef A, Elsherbiny NM, El-Mihi KA. 2018. Antioxidant and anti-inflammatory activities of berberine attenuate hepatic fibrosis induced by thioacetamide injection in rats. Chem Biol Interact. 294:91–100.
   PubMed Web of Science ®Google Scholar
• Ellis EL, Mann DA. 2012. Clinical evidence for the regression of liver fibrosis. J Hepatol. 56:1171–1180.
   PubMed Web of Science ®Google Scholar
• Friedman SL. 2003. Liver fibrosis-from bench to bedside. J Hepatol. 38:38–53.
   PubMed Web of Science ®Google Scholar
• Kohsuke T, Isao N, Hideki N, Atsushi M, Hidenori I. 2011. Apoptosis signaling kinases: from stress response to health outcomes. Antioxid Redox Signal. 15:719–761.
   PubMed Web of Science ®Google Scholar
• Lee UE, Friedman SL. 2011. Mechanisms of hepatic fibrogenesis. Best Pract Res Clin Gastroenterol. 25:195–206.
   PubMed Web of Science ®Google Scholar
• Li XM, Peng JH, Sun ZL, Tian HJ, Duan XH, Liu L, Ma X, Feng Q, Liu P, Hu YY. 2016. Chinese medicine CGA formula ameliorates DMN-induced liver fibrosis in rats via inhibiting MMP2/9, TIMP1/2 and the TGF-β/Smad signaling pathways. Acta Pharmacol Sin. 37:783–793.
   PubMed Web of Science ®Google Scholar
• Lian LH, Park EJ, Piao HS, Zhao YZ, Sohn DH. 2005. Aloe emodin-induced apoptosis in t-HSC/Cl-6 cells involves a mitochondria-mediated pathway. Basic Clin Pharmacol Toxicol. 96:495–502.
   PubMed Web of Science ®Google Scholar
• Lian Y, Xia X, Zhao H, Zhu Y. 2017. The potential of chrysophanol in protecting against high fat-induced cardiac injury through Nrf2-regulated anti-inflammation, anti-oxidant and anti-fibrosis in Nrf2 knockout mice. Biomed Pharmacother. 93:1175–1189.
   PubMed Web of Science ®Google Scholar
• Lin YL, Wu CF, Huang YT. 2008. Phenols from the roots of Rheum palmatum attenuate chemotaxis in rat hepatic stellate cells. Planta Med. 74:1246–1252.
   PubMed Web of Science ®Google Scholar
• Liu C, Yuan X, Tao L, Cheng ZA, Dai XQ, Sheng X, Xue YD. 2015. Xia-yu-xue decoction (XYXD) reduces carbon tetrachloride (CCl4)-induced liver fibrosis through inhibition hepatic stellate cell activation by targeting NF-κB and TGF-β1 signaling pathways. BMC Complement Altern Med. 15:201–208.
   PubMed Web of Science ®Google Scholar
• Lv J, Zhao ZM, Chen Y, Wang QL, Tao YY, Yang L, Fan TP, Liu CH. 2012. The Chinese herbal decoction Danggui Buxue Tang inhibits angiogenesis in a rat model of liver fibrosis. Evid Based Complement Alternat Med. 5:284963.
   Google Scholar
• Ma W, Tao L, Zhang W, Zhu Y, Xue D, Zhang J, Liu C. 2017. Xia-Yu-Xue decoction inhibits intestinal epithelial cell apoptosis in CCl4-induced liver fibrosis. Cell Physiol Biochem. 44:333–344.
   PubMedGoogle Scholar
• Mederacke I, Hsu CC, Troeger JS, Huebener P, Mu X, Dapito DH, Pradere JP, Schwabe RF. 2013. Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology. Nat Commun. 4:2823.
   PubMed Web of Science ®Google Scholar
• Poisson J, Lemoinne S, Boulanger C, Durand F, Moreau R, Valla D, Rautou PE. 2017. Liver sinusoidal endothelial cells: physiology and role in liver diseases. J Hepatol. 66:212–227.
   PubMed Web of Science ®Google Scholar
• Poon RY. 2016. Cell cycle control: a system of interlinking oscillators. Methods Mol Biol. 1342:3–19.
   PubMedGoogle Scholar
• Schuppan D, Afdhal NH. 2008. Liver cirrhosis. Lancet. 371:838–851.
   PubMed Web of Science ®Google Scholar
• Schuppan D, Kim YO. 2013. Evolving therapies for liver fibrosis. J Clin Invest. 123:1887–1901.
   PubMed Web of Science ®Google Scholar
• Thabut D, Shah V. 2010. Intrahepatic angiogenesis and sinusoidal remodeling in chronic liver disease: new targets for the treatment of portal hypertension? J Hepatol. 53:976–980.
   PubMed Web of Science ®Google Scholar
• Tsuchida T, Friedman SL. 2017. Mechanisms of hepatic stellate cell activation. Nat Rev Gastroenterol Hepatol. 14:397–411.
   PubMed Web of Science ®Google Scholar
• Wagner EF, Nebreda AR. 2009. Signal integration by JNK and p38 MAPK pathways in cancer development. Nat Rev Cancer. 9:537–549.
   PubMed Web of Science ®Google Scholar
• Wang X, Niu C, Zhang X, Dong M. 2018. Emodin suppresses activation of hepatic stellate cells through p38 mitogen-activated protein kinase and Smad signaling pathways in vitro. Phytother Res. 32:2436–2446.
   PubMed Web of Science ®Google Scholar
• Woo SW, Nan JX, Lee SH, Park EJ, Zhao YZ, Sohn DH. 2002. Aloe emodin suppresses myofibroblastic differentiation of rat hepatic stellate cells in primary culture. Pharmacol Toxicol. 90:193–198.
   PubMedGoogle Scholar
• Xie GH, Wang XD, Wang L, Wang L, Atkinson RD, Kanel GC, Gaarde WA, DeLeve LD. 2012. Role of differentiation of liver sinusoidal endothelial cells in progression and regression of hepatic fibrosis in rats. Gastroenterology. 142:918–927.
   PubMed Web of Science ®Google Scholar
• Zhang LJ, Sun MY, Ning BB, Zhang WM, Chen GF, Mu YP, Zhang H, Liu J, Bian YQ, Liu P. 2014. Xiayuxue decoction attenuates hepatic stellate cell activation and sinusoidal endothelium defenestration in CCl4-induced fibrotic liver of mice. Chin J Integr Med. 20:516–523.
   PubMed Web of Science ®Google Scholar
• Zhou YN, Sun MY, Mu YP, Yang T, Ning BB, Ren S, Chen JM, Liu P. 2014. Xuefuzhuyu decoction inhibition of angiogenesis attenuates liver fibrosis induced by CCl4 in mice. J Ethnopharmacol. 153:659–666.
   PubMed Web of Science ®Google Scholar