Advanced search
Publication Cover
Pharmaceutical Biology Volume 59, 2021 - Issue 1
Submit an article Journal homepage
2,706
Views
14
CrossRef citations to date
0
Altmetric
Research Article

Ginsenoside Rg2 alleviates myocardial fibrosis by regulating TGF-β1/Smad signalling pathway

Quanwei Wanga Departments of Cardiovascular Medicine, First Hospital, Jilin University, Changchun, PR ChinaView further author information
,
Wenwen Fub Department of Pharmacology, School of Pharmacy, Jilin University, Changchun, PR ChinaView further author information
,
Xiaofeng Yub Department of Pharmacology, School of Pharmacy, Jilin University, Changchun, PR ChinaView further author information
,
Huali Xub Department of Pharmacology, School of Pharmacy, Jilin University, Changchun, PR ChinaView further author information
,
Dayun Suib Department of Pharmacology, School of Pharmacy, Jilin University, Changchun, PR ChinaView further author information
&
Yeling Wanga Departments of Cardiovascular Medicine, First Hospital, Jilin University, Changchun, PR ChinaCorrespondence[email protected]
View further author information
Pages 104-111 | Received 10 Jul 2020, Accepted 16 Dec 2020, Published online: 03 Feb 2021

References

  • Ahn H, Han BC, Kim J, Kang SG, Kim PH, Jang KH, So SH, Lee SH, Lee GS. 2019. Nonsaponin fraction of Korean Red Ginseng attenuates cytokine production via inhibition of TLR4 expression. J Ginseng Res. 43(2):291–299.
  • Benjamin EJ, Virani SS, Callaway CW, Chamberlain AM, Chang AR, Cheng S, Chiuve SE, Cushman M, Delling FN, Deo R, et al. 2018. Heart disease and stroke statistics-2018 update: a report from the American Heart Association. Circulation. 137(12):e67–e492.
  • Dobaczewski M, Chen W, Frangogiannis NG. 2011. Transforming growth factor (TGF)-β signaling in cardiac remodeling. J Mol Cell Cardiol. 51(4):600–606.
  • Dobaczewski M, de Haan JJ, Frangogiannis NG. 2012. The extracellular matrix modulates fibroblast phenotype and function in the infarcted myocardium. J Cardiovasc Transl Res. 5(6):837–847.
  • Fan DC, Qi JY, Zhang MZ. 2017. Insights of Chinese medicine on ventricular remodeling: Multiple-targets, individualized-treatment. Chin J Integr Med. 23(9):643–647.
  • Gao S, Li L, Li L, Ni J, Guo R, Mao J, Fan G. 2019. Effects of the combination of tanshinone IIA and puerarin on cardiac function and inflammatory response in myocardial ischemia mice. J Mol Cell Cardiol. 137:59–70.
  • Hashimoto H, Olson EN, Bassel-Duby R. 2018. Therapeutic approaches for cardiac regeneration and repair. Nat Rev Cardiol. 15(10):585–600.
  • Hausenloy DJ, Yellon DM. 2013. Myocardial ischemia-reperfusion injury: a neglected therapeutic target. J Clin Invest. 123(1):92–100.
  • Laflamme MA, Murry CE. 2005. Regenerating the heart. Nat Biotechnol. 23(7):845–856.
  • Li YL, Hao WJ, Chen BY, Chen J, Li GQ. 2018a. Cardiac Fibroblast-Specific activating transcription factor 3 promotes myocardial repair after myocardial infarction. Chin Med J (Engl). 131(19):2302–2309.
  • Li L, Pan CS, Yan L, Cui YC, Liu YY, Mu HN, He K, Hu BH, Chang X, Sun K, et al. 2018b. Ginsenoside Rg1 ameliorates rat myocardial ischemia-reperfusion injury by modulating energy metabolism pathways. Front Physiol. 9:78eCollection.
  • Li CY, Yang P, Jiang YL, Lin Z, Pu YW, Xie LQ, Sun L, Lu D. 2020. Ginsenoside Rb1 attenuates cardiomyocyte apoptosis induced by myocardial ischemia reperfusion injury through mTOR signal pathway. Biomed Pharmacother. 125:109913.
  • Ngu JMC, Ruel M, Sun LY. 2018. Left ventricular function recovery after revascularization: comparative effects of percutaneous coronary intervention and coronary artery bypass grafting. Curr Opin Cardiol. 33(6):633–637.
  • Prabhu SD, Frangogiannis NG. 2016. The biological basis for cardiac repair after myocardial infarction: from inflammation to fibrosis. Circ Res. 119(1):91–112.
  • Shi Y, Massagué J. 2003. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell. 113(6):685–700.
  • Shinde AV, Humeres C, Frangogiannis NG. 2017. The role of α-smooth muscle actin in fibroblast-mediated matrix contraction and remodeling. Biochim Biophys Acta Mol Basis Dis. 1863(1):298–309.
  • Shuangyan W, Ruowu S, Hongli N, Bei Z, Yong S. 2012. Protective effects of Rg2 on hypoxia-induced neuronal damage in hippocampal neurons. Artif Cells Blood Substit Immobil Biotechnol. 40(1-2):142–145.
  • van den Borne SW, Diez J, Blankesteijn WM, Verjans J, Hofstra L, Narula J. 2010. Myocardial remodeling after infarction: the role of myofibroblasts. Nat Rev Cardiol. 7(1):30–37.
  • Wang QW, Yu XF, Xu HL, Zhao XZ, Sui DY. 2019. Ginsenoside Re improves isoproterenol-induced myocardial fibrosis and heart failure in rats. Evid Based Complement Alternat Med. 2019:3714508.
  • Zhang K, Liu Y, Wang C, Li J, Xiong L, Wang Z, Liu J, Li P. 2019. Evaluation of the gastroprotective effects of 20 (S)-ginsenoside Rg3 on gastric ulcer models in mice. J Ginseng Res. 43(4):550–561.
  • Zhang G, Liu A, Zhou Y, San X, Jin T, Jin Y. 2008. Panax ginseng ginsenoside-Rg2 protects memory impairment via anti-apoptosis in a rat model with vascular dementia. J Ethnopharmacol. 115(3):441–448.
  • Zhang W, Zhang J, Liu YK, Liu J, Wang X, Xu Q, Wang Y, Xu X, Dai G. 2014. Cardioprotective effects of oxymatrine on isoproterenol-induced heart failure via regulation of DDAH/ADMA metabolism pathway in rats. Eur J Pharmacol. 745:29–35.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.