Pharmacokinetics of gallic acid and protocatechuic acid in humans after dosing with Relinqing (RLQ) and the potential for RLQ-perpetrated drug–drug interactions on organic anion transporter (OAT) 1/3

References

• Akimitsu M, Shuichi T, Kentarou U, Yoshikatsu K, Hitoshi E, Kazuyuki S, Etsuko M, Akio F. 2010. Drug interaction between celecoxib and methotrexate in organic anion transporter 3-transfected renal cells and in rats in vivo. Eur J Pharmacol. 640:168–171.
   PubMed Web of Science ®Google Scholar
• Alvarez AI, Pérez M, Prieto JG, Molina AJ, Real R, Merino G. 2008. Fluoroquinolone efflux mediated by ABC transporters. J Pharm Sci. 97:3483–3493.
   PubMed Web of Science ®Google Scholar
• Benevides Bahiense J, Marques FM, Figueira MM, Vargas TS, Kondratyuk TP, Endringer DC, Scherer R, Fronza M. 2017. Potential anti-inflammatory, antioxidant and antimicrobial activities of Sambucus australis. Pharm Biol. 55(1):991–997.
   PubMed Web of Science ®Google Scholar
• Chiba S, Ikawa T, Takeshita H, Kanno S, Nagai T, Takada M, Mukai T, Wempe MF. 2013. Human organic cation transporter 2 (hOCT2): inhibitor studies using S2-hOCT2 cells. Toxicology. 310:98–103.
   PubMed Web of Science ®Google Scholar
• Chinese Pharmacopoeia Commission. 2020. Pharmacopoeia of the People's Republic of China. Beijing, China: China Chemical Industry Press; p. 1454.
   Google Scholar
• Ebert B, Seidel A, Lampen A. 2006. Phytochemicals induce breast cancer resistance protein in Caco-2 cells and enhance the transport of benzo[a]pyrene-3-sulfate. Toxicol Sci. 96:227–236.
   PubMed Web of Science ®Google Scholar
• Geerlings SE. 2016. Clinical presentations and epidemiology of urinary tract infections. Microbiol Spectr. 4:1–11.
   Web of Science ®Google Scholar
• Hartigan SM, Dmochowski RR. 2020. Gender-specific pharmacokinetic and pharmacodynamic considerations for antimuscarinic drugs for overactive bladder treatment. Expert Opin Drug Metab Toxicol. 16:103–110.
   PubMed Web of Science ®Google Scholar
• Haslam IS, Wright JA, O’Reilly DA, Sherlock DJ, Coleman T, Simmons NL. 2011. Intestinal ciprofloxacin efflux: the role of breast cancer resistance protein (ABCG2). Drug Metab Disp. 39:2321–2328.
   PubMed Web of Science ®Google Scholar
• Huang Y, Sun HY, Qin XL, Li YJ, Liao SG, Gong ZP, Lu Y, Wang YL, Wang AM, Lan YY, et al. 2017. A UPLC-MS/MS method for simultaneous determination of free and total forms of a phenolic acid and two flavonoids in rat plasma and its application to comparative pharmacokinetic studies of Polygonum capitatum extract in rats. Molecules. 22(3):353–313.
   PubMed Web of Science ®Google Scholar
• Huang Y, Zhou Z, Yang W, Gong Z, Li Y, Chen S, Wang Y, Wang A, Lan Y, Liu T, et al. 2019. Comparative pharmacokinetics of gallic acid, protocatechuic acid, and quercitrin in normal and pyelonephritis rats after oral administration of a Polygonum capitatum extract. Molecules. 24(21):3873–3813.
   PubMed Web of Science ®Google Scholar
• Kim C, Ji J, Ho Baek S, Lee JH, Ha IJ, Lim SS, Yoon HJ, Je Nam Y, Ahn KS. 2019. Fermented dried Citrus unshiu peel extracts exert anti-inflammatory activities in LPS-induced RAW264.7 macrophages and improve skin moisturizing efficacy in immortalized human HaCaT keratinocytes. Pharm Biol. 57:392–402.
   PubMed Web of Science ®Google Scholar
• Klein RD, Hultgren SJ. 2020. Urinary tract infections: microbial pathogenesis, host-pathogen interactions and new treatment strategies. Nat Rev Microbiol. 18(4):211–226.
   PubMed Web of Science ®Google Scholar
• Li L, Song F, Tu M, Wang K, Zhao L, Wu XD, Zhou H, Xia ZL, Jiang HD. 2014. In vitro interaction of clopidogrel and its hydrolysate with OCT1, OCT2 and OAT1. Inter J Pharm. 465(1–2):5–10.
   PubMedGoogle Scholar
• Liao SG, Zhang LJ, Sun F, Wang Z, He X, Wang AM, Li YJ, Huang Y, Lan YY, Zhang BL. 2013. Identification and characterisation of phenolics in Polygonum capitatum by ultrahigh-performance liquid chromatography with photodiode array detection and tandem mass spectrometry. Phytochem Anal. 24:556–568.
   PubMed Web of Science ®Google Scholar
• Liao SG, Zhang LJ, Sun F, Zhang JJ, Chen AY, Lan YY, Li YJ, Wang AM, He X, Xiong Y, et al. 2011. Antibacterial and anti-inflammatory effects of extracts and fractions from Polygonum capitatum. J Ethnopharmacol. 134(3):1006–1009.
   PubMed Web of Science ®Google Scholar
• Lu Y, Gong ZP, Xie YM, Pan J, Sun J, Li YT, Chen SY, Li YJ, Wang YL, Huang Y. 2016. Herb-drug interaction: effects of Relinqing® granule on the pharmacokinetics of ciprofloxacin, sulfamethoxazole, and trimethoprim in rats. Evid Based Comp Altern Med. 2016:1–6.
   Web of Science ®Google Scholar
• Ma F, Gong X, Zhou X, Zhao Y, Li M. 2015. An UHPLC-MS/MS method for simultaneous quantification of gallic acid and protocatechuic acid in rat plasma after oral administration of Polygonum capitatum extract and its application to pharmacokinetics. J Ethnopharmacol. 162:377–383.
   PubMed Web of Science ®Google Scholar
• Ma FW, Deng QF, Zhou X, Gong XJ, Zhao Y, Chen HG, Zhao C. 2016. The tissue distribution and urinary excretion study of gallic acid and protocatechuic acid after oral administration of Polygonum capitatum extract in rats. Molecules. 21:1–14.
   Web of Science ®Google Scholar
• Mai Y, Dou L, Murdan S, Basit AW. 2018. An animal's sex influences the effects of the excipient PEG 400 on the intestinal P-gp protein and mRNA levels, which has implications for oral drug absorption. Eur J Pharm Sci. 120:53–60.
   PubMed Web of Science ®Google Scholar
• Millner R, Becknell B. 2019. Urinary tract infections. Pediatr Clin North Am. 66:1–13.
   PubMed Web of Science ®Google Scholar
• Mulgaonkar A, Venitz J, Gründemann D, Sweet DH. 2013. Human organic cation transporters 1 (SLC22A1), 2 (SLC22A2), and 3 (SLC22A3) as disposition pathways for fluoroquinolone antimicrobials. Antimicrob Agents Chemother. 57(6):2705–2711.
   PubMed Web of Science ®Google Scholar
• Qindeel M, Barani M, Rahdar A, Arshad R, Cucchiarini M. 2021. Nanomaterials for the diagnosis and treatment of urinary tract infections. Nanomaterials. 11(2):546–521.
   Web of Science ®Google Scholar
• Ren Y, Li H, Liu X. 2019. Effects of Ginkgo leaf tablets on the pharmacokinetics of atorvastatin in rats. Pharm Biol. 57:403–406.
   PubMed Web of Science ®Google Scholar
• Reznicek J, Ceckova M, Ptackova Z, Martinec O, Tupova L, Cerveny L, Staud F. 2017. MDR1 and BCRP transporter-mediated drug-drug interaction between rilpivirine and abacavir; effect on intestinal absorption. Antimicrob Agents Chemother. 61(9):837–817.
   PubMed Web of Science ®Google Scholar
• Tamadonfar KO, Omattage NS, Spaulding CN, Hultgren SJ. 2019. Reaching the end of the line: urinary tract infections. Microbiol Spectr. 7:1–16.
   Web of Science ®Google Scholar
• Tandogdu Z, Wagenlehner FM. 2016. Global epidemiology of urinary tract infections. Curr Opin Infect Dis. 29:73–79.
   PubMed Web of Science ®Google Scholar
• Tang L, Liu Y, Zheng L, Liao SG, Huang Y. 2013. Determination of five components in Relinqing granules by UPLC-MS/MS. Chin J Pharm. 44:1029–1032.
   Google Scholar
• Ueno K, Hiromi S. 2012. Sex-related differences in pharmacokinetics and pharmacodynamics of anti-hypertensive drugs. Hypertens Res. 35:245–250.
   PubMed Web of Science ®Google Scholar
• US Food and Drug Administration (FDA). 2020. In vitro drug interaction studies, cytochrome P450 enzyme- and transporter-mediated drug interactions guidance for industry. Rockville (MD): Food and Drug Administration. [accessed 2020 Aug 15]. https://www.fda.gov/media/134582/download.
   Google Scholar
• US Food and Drug Administration. 2018. Bioanalytical method validation guidance for industry. Rockville (MD): Food and Drug Administration. [accessed 2020 Aug 15]. https://www.fda.gov/media/70858/download.
   Google Scholar
• Vanwert AL, Srimaroeng C, Sweet DH. 2008. Organic anion transporter 3 (OAT3/SLC22A8) interacts with carboxyfluoroquinolones, and deletion increases systemic exposure to ciprofloxacin. Mol Pharmacol. 74(1):122–131.
   PubMed Web of Science ®Google Scholar
• Wang L, Sweet DH. 2012. Potential for food-drug interactions by dietary phenolic acids on human organic anion transporters 1 (SLC22A6), 3 (SLC22A8), and 4 (SLC22A11). Biochem Pharmacol. 84:1088–1095.
   PubMed Web of Science ®Google Scholar
• Wang SY, Duan KM, Li Y, Mei Y, Sheng H, Liu H, Mei X, Ouyang W, Zhou HH, Liu ZQ. 2013. Effect of quercetin on P-glycoprotein transport ability in Chinese healthy subjects. Eur J Clin Nutr. 67:390–394.
   PubMed Web of Science ®Google Scholar
• Xiao Y, Deng J, Liu X, Huang JJ, Sun YX, Dai RK, Hong M. 2014. Different binding sites of bovine organic anion-transporting polypeptide1a2 are involved in the transport of different fluoroquinolones. Drug Metab Disp. 42:1261–1267.
   PubMed Web of Science ®Google Scholar
• Yang T, Zheng TH, Zhao Q, Liu W, Li SP, Tao YY, Wang CH, Liu CH. 2020. Effects of Fuzheng Huayu recipe on entecavir pharmacokinetics in normal and dimethylnitrosamine-induced hepatic fibrosis rats. Pharm Biol. 58:1–7.
   PubMed Web of Science ®Google Scholar
• Zakelj S, Sturm K, Kristl A. 2006. Ciprofloxacin permeability and its active secretion through rat small intestine in vitro. Int J Pharm. 313:175–180.
   PubMed Web of Science ®Google Scholar
• Zhang H, Han X, Li Y, Li H, Guo X. 2019. Effects of Danshen tablets on pharmacokinetics of amlodipine in rats. Pharm Biol. 57:306–309.
   PubMed Web of Science ®Google Scholar
• Zhang K, Zhang J, Wei S, Jing W, Wang Y, Liu A. 2013. Development and validation of HPLC coupled with triple quadrupole MS for the simultaneous determination of six phenolic acids, six flavonoids, and a lignan in Polygonum capitatum. J Sep Science. 36(15):2407–2413.
   PubMed Web of Science ®Google Scholar
• Zhang S, Huang J, Xie X, He Y, Mo F, Luo Z. 2017. Quercetin from Polygonum capitatum protects against gastric inflammation and apoptosis associated with Helicobacter pylori infection by affecting the levels of p38MAPK, BCL-2 and BAX. Molecules. 22(5):744–717.
   PubMed Web of Science ®Google Scholar
• Zheng L, Lu Y, Cao X, Huang Y, Liu Y, Tang L, Liao SG, Wang AM, Li YJ, Lan YY, et al. 2014. Evaluation of the impact of Polygonum capitatum, a traditional Chinese herbal medicine, on rat hepatic cytochrome P450 enzymes by using a cocktail of probe drugs. J Ethnopharmacol. 158:276–282.
   PubMed Web of Science ®Google Scholar
• Zimmermann ES, de Miranda SC, Neris C, da Silva Torres BG, Schmidt S, Costa TD. 2019. Population pharmacokinetic modeling to establish the role of P-glycoprotein on ciprofloxacin distribution to lung and prostate following intravenous and intratracheal administration to Wistar rats. Eur J Pharm Sci. 127:319–329.
   PubMed Web of Science ®Google Scholar