Anti-inflammatory effect of Barringtonia angusta methanol extract is mediated by targeting of Src in the NF-κB signalling pathway

References

• Alafiatayo AA, Lai K-S, Syahida A, Mahmood M, Shaharuddin NA. 2019. Phytochemical evaluation, embryotoxicity, and teratogenic effects of Curcuma longa extract on Zebrafish (Danio rerio). Evid Based Complement Alternat Med. 2019:3807207.
   PubMed Web of Science ®Google Scholar
• Arold ST, Ulmer TS, Mulhern TD, Werner JM, Ladbury JE, Campbell ID, Noble MEM. 2001. The role of the Src homology 3-Src homology 2 interface in the regulation of Src kinases. J Biol Chem. 276:17199–17205.
   PubMed Web of Science ®Google Scholar
• Aziz N, Kim M-Y, Cho JY. 2018. Anti-inflammatory effects of luteolin: A review of in vitro, in vivo, and in silico studies. J Ethnopharmacol. 225:342–358.
   PubMed Web of Science ®Google Scholar
• Behbahani M, Ali AM, Muse R, Mohd NB. 2007. Anti-oxidant and anti-inflammatory activities of leaves of Barringtonia racemosa. J Med Plant Res. 1:95–102.
   Google Scholar
• Chen CC, Huang WC, Chen JJ. 2003. c-Src-dependent tyrosine phosphorylation of IKKβ is involved in tumor necrosis factor-α-induced intercellular adhesion molecule-1 expression. J Biol Chem. 278:9944–9952.
   PubMedGoogle Scholar
• Chen L, Deng H, Cui H, Fang J, Zuo Z, Deng J, Li Y, Wang X, Zhao L. 2018. Inflammatory responses and inflammation-associated diseases in organs. Oncotarget. 9:7204–7218.
   PubMedGoogle Scholar
• Chen Z, Shao Z, Mei S, Yan Z, Ding X, Billiar T, Li Q. 2018. Sepsis upregulates CD14 expression in a MyD88-dependent and TRIF-independent pathway. Shock. 49:82–89.
   PubMed Web of Science ®Google Scholar
• Choi E, Cho JY, Kim MY. 2019. Anti-inflammatory activities of Canarium subulatum Guillaumin methanol extract operate by targeting Src and Syk in the NF-κB pathway. J Ethnopharmacol. 238:238:111848.
   PubMed Web of Science ®Google Scholar
• Choi E, Kim E, Kim JH, Yoon K, Kim S, Lee J, Cho JY. 2019. AKT1-targeted proapoptotic activity of compound K in human breast cancer cells. J Ginseng Res. 43:692–698.
   PubMed Web of Science ®Google Scholar
• Christian F, Smith EL, Carmody RJ. 2016. The regulation of NF-κB subunits by phosphorylation. Cells. 5(1):12–19.
   PubMed Web of Science ®Google Scholar
• Comalada M, Camuesco D, Sierra S, Ballester I, Xaus J, Galvez J, Zarzuelo A. 2005. In vivo quercitrin anti-inflammatory effect involves release of quercetin, which inhibits inflammation through down-regulation of the NF-kappa B pathway. Eur J Immunol. 35:584–592.
   PubMed Web of Science ®Google Scholar
• Fang P, Li X, Dai J, Cole L, Camacho JA, Zhang Y, Ji Y, Wang J, Yang XF, Wang H. 2018. Immune cell subset differentiation and tissue inflammation. J Hematol Oncol. 11:97.
   PubMed Web of Science ®Google Scholar
• Ferrero-Miliani L, Nielsen OH, Andersen PS, Girardin SE. 2007. Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1β generation. Clin Exp Immunol. 147:227–235.
   PubMed Web of Science ®Google Scholar
• Funakoshi-Tago M, Andoh K, Sonoda Y, Kasahara T, Tago K, Tominaga SI. 2005. Functional role of c-Src in IL-1-induced NF-κB activation: c-Src is a component of the IKK complex. J Biochem. 137:189.
   PubMed Web of Science ®Google Scholar
• Giorgi VS, Peracoli MT, Peracoli JC, Witkin SS, Bannwart-Castro CF. 2012. Silibinin modulates the NF-kappab pathway and pro-inflammatory cytokine production by mononuclear cells from preeclamptic women. J Reprod Immunol. 95:67–72.
   PubMed Web of Science ®Google Scholar
• Guzik TJ, Korbut R, Adamek-Guzik T. 2003. Nitric oxide and superoxide in inflammation and immune regulation. J Physiol Pharmacol. 54:469–487.
   PubMed Web of Science ®Google Scholar
• Han SY, Kim J, Kim E, Kim SH, Seo DB, Kim JH, Shin SS, Cho JY. 2018. AKT-targeted anti-inflammatory activity of Panax ginseng calyx ethanolic extract. J Ginseng Res. 42:496–503.
   PubMed Web of Science ®Google Scholar
• Hong YH, Kim D, Nam G, Yoo S, Han SY, Jeong SG, Kim E, Jeong D, Yoon K, Kim S, et al. 2018. Photoaging protective effects of BIOGF1K, a compound-K-rich fraction prepared from Panax ginseng. J Ginseng Res. 42:81–89.
   PubMed Web of Science ®Google Scholar
• Irtegun S, Wood RJ, Ormsby AR, Mulhern TD, Hatters DM. 2013. Tyrosine 416 is phosphorylated in the closed, repressed conformation of c-Src. PLoS One. 8(7):e71035–9.
   PubMed Web of Science ®Google Scholar
• Jafari R, Almqvist H, Axelsson H, Ignatushchenko M, Lundback T, Nordlund P, Molina DM. 2014. The cellular thermal shift assay for evaluating drug target interactions in cells. Nat Protoc. 9:2100–2122.
   PubMed Web of Science ®Google Scholar
• Jeong HY, Sung GH, Kim JH, Yoon JY, Yang Y, Park JG, Kim SH, Yi YS, Yang WS, Yoon DH, et al. 2014. Syk and Src are major pharmacological targets of a Cerbera manghas methanol extract with kaempferol-based anti-inflammatory activity. J Ethnopharmacol. 151:960–969.
   PubMed Web of Science ®Google Scholar
• Kagan JC, Medzhitov R. 2006. Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling. Cell. 125:943–955.
   PubMed Web of Science ®Google Scholar
• Kang JL, Jung HJ, Lee K, Kim HR. 2006. Src tyrosine kinases mediate crystalline silica-induced NF-kappa B activation through tyrosine phosphorylation of I kappa B-alpha and p65 NF-kappa B in RAW 264.7 macrophages. Toxicol Sci. 90:470–477.
   PubMed Web of Science ®Google Scholar
• Kim E, Kang Y-G, Kim JH, Kim YJ, Lee TR, Lee J, Kim D, Cho JY. 2018. The antioxidant and anti-inflammatory activities of 8-hydroxydaidzein (8-HD) in activated macrophage-like RAW264.7 cells. IJMS. 19(7):1828.
   Google Scholar
• Kim HG, Choi S, Lee J, Hong YH, Jeong D, Yoon K, Yoon DH, Sung G-H, Lee S, Hong S, et al. 2018. Src is a prime target inhibited by Celtis choseniana methanol extract in its anti-inflammatory action. Evid Based Complement Alternat Med. 2018:3909038.
   PubMed Web of Science ®Google Scholar
• Kim SH, Park JG, Sung G-H, Yang S, Yang WS, Kim E, Kim JH, Van Thai H, Kim HG, Yi Y-S, et al. 2015. Kaempferol, a dietary flavonoid, ameliorates acute inflammatory and nociceptive symptoms in gastritis, pancreatitis, and abdominal pain. Mol Nutr Food Res. 59:1400–1405.
   PubMed Web of Science ®Google Scholar
• Li F, Cao Y, Luo Y, Liu T, Yan G, Chen L, Ji L, Wang L, Chen B, Yaseen A, et al. 2019. Two new triterpenoid saponins derived from the leaves of Panax ginseng and their antiinflammatory activity. J Ginseng Res. 43:600–605.
   PubMed Web of Science ®Google Scholar
• López-Bojórquez LN, Arechavaleta-Velasco F, Vadillo-Ortega F, Móntes-Sánchez D, Ventura-Gallegos JL, Zentella-Dehesa A. 2004. NF-kappaB translocation and endothelial cell activation is potentiated by macrophage-released signals co-secreted with TNF-alpha and IL-1beta. Inflamm Res. 53:567–575.
   PubMed Web of Science ®Google Scholar
• Medzhitov R. 2010. Inflammation 2010: New adventures of an old flame. Cell. 140:771–776.
   PubMed Web of Science ®Google Scholar
• Muralidhar A, Sainath RC, Someswara YA, Kedareeswari J, Sankaraiah B, Rama TL, Vijayakumar B, Varalakshmi G. 2013. Anti-inflammatory studies of Barringtonia acutangula (Linn) fruits on Wistar rats. Int J Phytomed. 5(350):350–355.
   Google Scholar
• Nackiewicz D, Dan M, He W, Kim R, Salmi A, Rutti S, Westwell-Roper C, Cunningham A, Speck M, Schuster-Klein C, et al. 2014. TLR2/6 and TLR4-activated macrophages contribute to islet inflammation and impair beta cell insulin gene expression via IL-1 and IL-6. Diabetologia. 57:1645–1654.
   PubMed Web of Science ®Google Scholar
• Osman NI, Sidik NJ, Awal A, Adam NA, Rezali NI. 2016. In vitro xanthine oxidase and albumin denaturation inhibition assay of Barringtonia racemosa L. and total phenolic content analysis for potential anti-inflammatory use in gouty arthritis. J Intercult Ethnopharmacol. 5:343–349.
   PubMedGoogle Scholar
• Page TH, Smolinska M, Gillespie J, Urbaniak AM, Foxwell BMJ. 2009. Tyrosine kinases and inflammatory signalling. Curr Mol Med. 9:69–85.
   PubMed Web of Science ®Google Scholar
• Patil KR, Patil CR. 2017. Anti-inflammatory activity of bartogenic acid containing fraction of fruits of Barringtonia racemosa Roxb. in acute and chronic animal models of inflammation. J Tradit Complement Med. 7:86–93.
   PubMedGoogle Scholar
• Se Eun B, Young-Su Y, Jueun O, Byong Chul Y, Sungyoul H, Jae Youl C. 2012. The role of Src kinase in macrophage-mediated inflammatory responses. Mediators Inflamm. 2012:23209344.
   Web of Science ®Google Scholar
• Shi Hyoung K, Jae Gwang P, Jongsung L, Woo Seok Y, Gye Won P, Han Gyung K, Young-Su Y, Kwang-Soo B, Nak Yoon S, Muhammad Jahangir H, et al. 2015. The dietary flavonoid kaempferol mediates anti-inflammatory responses via the Src, Syk, IRAK1, and IRAK4 molecular targets. Mediators Inflamm. 2015:904142.
   PubMed Web of Science ®Google Scholar
• Singh N, Baby D, Rajguru JP, Patil PB, Thakkannavar SS, Pujari VB. 2019. Inflammation and cancer. Ann Afr Med. 18:121–126.
   PubMed Web of Science ®Google Scholar
• Smolinska MJ, Horwood NJ, Page TH, Smallie T, Foxwell BMJ. 2008. Chemical inhibition of Src family kinases affects major LPS-activated pathways in primary human macrophages. Mol Immunol. 45:990–1000.
   PubMed Web of Science ®Google Scholar
• Stephens M, Liao S, von DWP. 2019. Mesenteric lymphatic alterations observed during DSS induced intestinal inflammation are driven in a TLR4-PAMP/DAMP discriminative manner. Front Immunol. 10(557):1–12.
   PubMedGoogle Scholar
• Sun YL, In YH, Choon SJ. 2017. Protective effects of cinnamic acid derivatives on gastric lesion. Nat Prod Sci. 23:299–305.
   Google Scholar
• Surh YJ, Chun KS, Cha HH, Han SS, Keum YS, Park KK, Lee SS. 2001. Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-κB activation. Mutat Res. 480-481:243–268.
   PubMed Web of Science ®Google Scholar
• Thai HV, Kim E, Kim SC, Jeong D, Yang S, Baek K-S, Kim Y, Ratan ZA, Yoon KD, Kim J-H, et al. 2015. Boerhavia diffusa L. ethanol extract suppresses inflammatory responses via inhibition of Src/Syk/TRAF6. J Funct Foods. 17:476–490.
   Web of Science ®Google Scholar
• To Thi Mai D, Lee J, Kim E, Yoo BC, Van Thai H, Kim Y, Yoon DH, Hong S, Baek K-S, Sung NY, et al. 2015. Anti-inflammatory activities of Gouania leptostachya methanol extract and its constituent resveratrol. Phytother Res. 29:381–392.
   PubMed Web of Science ®Google Scholar
• Tripathi P, Tripathi P, Kashyap L, Singh V. 2007. The role of nitric oxide in inflammatory reactions. FEMS Immunol Med Microbiol. 51:443–452.
   PubMed Web of Science ®Google Scholar
• Yamamoto M, Sato S, Hemmi H, Hoshino K, Kaisho T, Sanjo H, Takeuchi O, Sugiyama M, Okabe M, Takeda K, et al. 2003. Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science. 301:640–643.
   PubMed Web of Science ®Google Scholar
• Yoo S, Kim M-Y, Cho JY. 2018. Syk and Src-targeted anti-inflammatory activity of aripiprazole, an atypical antipsychotic. Biochem Pharmacol. 148:1–12.
   PubMed Web of Science ®Google Scholar
• Youn CK, Park SJ, Lee MY, Cha MJ, Kim OH, You HJ, Chang IY, Yoon SP, Jeon YJ. 2013. Silibinin inhibits LPS-induced macrophage activation by blocking p38 MAPK in RAW 264.7 cells. Biomol Ther. 21:258–263.
   PubMed Web of Science ®Google Scholar
• Zafar Imam M, Sultana S, Akter S. 2012. Antinociceptive, antidiarrheal, and neuropharmacological activities of Barringtonia acutangula. Pharm Biol. 50(9):1078–1084.
   PubMed Web of Science ®Google Scholar
• Zheng W, Feng Z, Lou Y, Chen C, Zhang C, Tao Z, Li H, Cheng L, Ying X. 2017. Silibinin protects against osteoarthritis through inhibiting the inflammatory response and cartilage matrix degradation in vitro and in vivo. Oncotarget. 8:99649–99665.
   PubMedGoogle Scholar