Advanced search
Publication Cover
Pharmaceutical Biology Volume 61, 2023 - Issue 1
Submit an article Journal homepage
3,334
Views
5
CrossRef citations to date
0
Altmetric
Research Article

Salvianolic acid B attenuates tubulointerstitial fibrosis by inhibiting EZH2 to regulate the PTEN/Akt pathway

Pinglan Lina Department of Nephrology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine;b TCM Institute of Kidney Disease, Shanghai University of Traditional Chinese Medicine, Shanghai, P. R. China;c Key Laboratory of Liver and Kidney Diseases (Shanghai University of Traditional Chinese Medicine), Ministry of Education, Shanghai, P. R. ChinaView further author information
,
Furong Qiud Laboratory of Clinical Pharmacokinetics, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, P. R. ChinaView further author information
,
Ming Wua Department of Nephrology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine;b TCM Institute of Kidney Disease, Shanghai University of Traditional Chinese Medicine, Shanghai, P. R. China;c Key Laboratory of Liver and Kidney Diseases (Shanghai University of Traditional Chinese Medicine), Ministry of Education, Shanghai, P. R. ChinaView further author information
,
Lin Xua Department of Nephrology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine;b TCM Institute of Kidney Disease, Shanghai University of Traditional Chinese Medicine, Shanghai, P. R. China;c Key Laboratory of Liver and Kidney Diseases (Shanghai University of Traditional Chinese Medicine), Ministry of Education, Shanghai, P. R. ChinaView further author information
,
Di Huanga Department of Nephrology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine;b TCM Institute of Kidney Disease, Shanghai University of Traditional Chinese Medicine, Shanghai, P. R. China;c Key Laboratory of Liver and Kidney Diseases (Shanghai University of Traditional Chinese Medicine), Ministry of Education, Shanghai, P. R. ChinaView further author information
,
Chen Wanga Department of Nephrology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine;b TCM Institute of Kidney Disease, Shanghai University of Traditional Chinese Medicine, Shanghai, P. R. China;c Key Laboratory of Liver and Kidney Diseases (Shanghai University of Traditional Chinese Medicine), Ministry of Education, Shanghai, P. R. ChinaView further author information
,
Xuejun Yanga Department of Nephrology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine;b TCM Institute of Kidney Disease, Shanghai University of Traditional Chinese Medicine, Shanghai, P. R. China;c Key Laboratory of Liver and Kidney Diseases (Shanghai University of Traditional Chinese Medicine), Ministry of Education, Shanghai, P. R. ChinaView further author information
&
Chaoyang Yea Department of Nephrology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine;b TCM Institute of Kidney Disease, Shanghai University of Traditional Chinese Medicine, Shanghai, P. R. China;c Key Laboratory of Liver and Kidney Diseases (Shanghai University of Traditional Chinese Medicine), Ministry of Education, Shanghai, P. R. ChinaCorrespondence[email protected]
View further author information
 show all
Pages 23-29 | Received 08 Apr 2022, Accepted 10 Nov 2022, Published online: 16 Dec 2022

References

  • An CL, Jiao BH, Du H, Tran M, Zhou D, Wang YL. 2022. Myeloid PTEN deficiency aggravates renal inflammation and fibrosis in angiotensin II-induced hypertension. J Cell Physiol. 237(1):983–991.
  • Duan R, Du WF, Guo WJ. 2020. EZH2: a novel target for cancer treatment. J Hematol Oncol. 13(1):104.
  • Hu Y, Wang M, Pan YZ, Li QJ, Xu L. 2020. Salvianolic acid B attenuates renal interstitial fibrosis by regulating the HPSE/SDC1 axis. Mol Med Rep. 22(2):1325–1334.
  • Huang Y, Yu SH, Zhen WX, Cheng T, Wang D, Lin JB, Wu YH, Wang YF, Chen Y, Shu LP, et al. 2021. Tanshinone I, a new EZH2 inhibitor restricts normal and malignant hematopoiesis through upregulation of MMP9 and ABCG2. Theranostics. 11(14):6891–6904.
  • Humphreys BD. 2018. Mechanisms of renal fibrosis. Annu Rev Physiol. 80:309–326.
  • Jiang LX, Wang JH, Ju JR, Dai JD. 2020. Salvianolic acid B and sodium tanshinone II A sulfonate prevent pulmonary fibrosis through anti-inflammatory and anti-fibrotic process. Eur J Pharmacol. 883:173352.
  • Lan AP, Du J. 2015. Potential role of Akt signaling in chronic kidney disease. Nephrol Dial Transplant. 30(3):385–394.
  • Li TT, Yu C, Zhuang SG. 2021. Histone methyltransferase EZH2: a potential therapeutic target for kidney diseases. Front Physiol. 12:640700.
  • Lin PL, Wu M, Qin JY, Yang J, Ye CY, Wang C. 2019. Magnesium lithospermate B improves renal hemodynamics and reduces renal oxygen consumption in 5/6th renal ablation/infarction rats. BMC Nephrol. 20(1):49.
  • Liu BC, Tang TT, Lv LL, Lan HY. 2018. Renal tubule injury: a driving force toward chronic kidney disease. Kidney Int. 93(3):568–579.
  • Liu J, Zhang Y, Qu D, Zhang HN, Wang L, Lau CW, Han JY, Pingcuo DZ, Huang Y, Liu LM. 2021. Salvianolic acid B ameliorates vascular endothelial dysfunction through influencing a bone morphogenetic protein 4-ROS cycle in diabetic mice. Life Sci. 286:120039.
  • Ma LK, Tang LL, Yi Q. 2019. Salvianolic acids: potential source of natural drugs for the treatment of fibrosis disease and cancer. Front Pharmacol. 10:97.
  • Nastase MV, Zeng-Brouwers JY, Wygrecka M, Schaefer L. 2018. Targeting renal fibrosis: mechanisms and drug delivery systems. Adv Drug Deliv Rev. 129:295–307.
  • Ruiz-Ortega M, Rayego-Mateos S, Lamas S, Ortiz A, Rodrigues-Diez RR. 2020. Targeting the progression of chronic kidney disease. Nat Rev Nephrol. 16(5):269–288.
  • Shao MH, Ye CY, Bayliss G, Zhuang SG. 2021. New insights into the effects of individual Chinese herbal medicines on chronic kidney disease. Front Pharmacol. 12:774414.
  • Webster AC, Nagler EV, Morton RL, Masson P. 2017. Chronic kidney disease. Lancet. 389(10075):1238–1252.
  • Wu C, Chen WY, Ding HY, Li D, Wen GH, Zhang C, Lu WP, Chen M, Yang Y. 2019. Salvianolic acid B exerts anti-liver fibrosis effects via inhibition of MAPK-mediated phospho-Smad2/3 at linker regions in vivo and in vitro. Life Sci. 239:116881.
  • Wu YL, Xu SW, Tian XY. 2020. The effect of salvianolic acid on vascular protection and possible mechanisms. Oxid Med Cell Longev. 2020:5472096.
  • Zhou XX, Xiong CX, Tolbert E, Zhao TC, Bayliss G, Zhuang SG. 2018. Targeting histone methyltransferase enhancer of zeste homolog-2 inhibits renal epithelial-mesenchymal transition and attenuates renal fibrosis. FASEB J. 32(11):5976–5989.
  • Zhou XX, Zang XJ, Ponnusamy M, Masucci MV, Tolbert E, Gong RJ, Zhao TC, Liu N, Bayliss G, Dworkin LD, et al. 2016. Enhancer of zeste homolog 2 inhibition attenuates renal fibrosis by maintaining Smad7 and phosphatase and tensin homolog expression. J Am Soc Nephrol. 27(7):2092–2108.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.